"DITT Depot": cov lus qhia rau kev siv, contraindications, phiv, xyuas, cov duab

Yuav ua li cas koj puas paub txog cov tshuaj no, xws li "DITT Depot"? Cov lus qhia rau kev siv, contraindications, xyuas thiab tshwm sim los ntawm cov tshuaj yuav tsum tau muab xam tau tias yog ntxiv.

Ntim thiab daim ntawv ntawm cov tshuaj, nws muaj pes tsawg leeg

Nyob rau hauv dab tsi daim ntawv tsim ib tug yeeb tshuaj raws li "DITT Depot"? Cov lus qhia rau kev siv cov ntawv qhia uas yuav tsum tau yuav nyob rau hauv daim ntawv ntawm ib tug oily tov rau intramuscular txhaj tshuaj. Lub ntsiab active ingredient ntawm cov tshuaj no yog fluphenazine decanoate. Raws li nws nkag mus rau lub qhov muag tsaus nti iav ampoules, pre-fej nyob rau hauv lub cell contour thiab daim ntawv packs, ntsig txog.

pharmacology

Yuav ua li cas yog cov lam zog xam qhovkev medicament "DITT Depot"? Cov lus qhia rau kev siv, xyuas hais tias qhov no yog ib tug ntev-sawv antipsychotic tshuaj. Nws belongs rau ib pab pawg neeg ntawm polyvalent neuroleptics thiab teev cov lus hais antipsychotic zog, uas yog nrog rau ib tug txhais thiab antiemetic nyhuv. Tsis tas li ntawd, qhov no tshuaj muaj ib tug me me sedative nyhuv.

Dab tsi ua rau cov hauj lwm zoo ntawm cov tshuaj "DITT Depot"? Cov lus qhia rau kev siv hais tias nws antipsychotic los txuam nrog lub blockade ntawm dopamine D2 receptors Mesocortical thiab mesolimbic systems.

Sedative thaj chaw ntawm no medicament thiab mob pesnrab qhia xwb cai thaum siab koob tshuaj ntawm cov tshuaj. Lawv yog vim blockade ntawm adrenergic receptors ntawm ib tug neeg seem ntawm lub hlwb qia.

Nrog kev xav txog cov anti-emetic los ntawm cov tshuaj, ces nws yog txuam nrog rau cov blockade ntawm dopamine D2 receptor txhais cheeb tsam ntawm lub ntuav chaw. Nws yuav tsum tau muab sau tseg tias hypothermic nyhuv ntawm cov tshuaj no qhia tau hais tias lub blockade ntawm dopamine receptors ntawm lub hypothalamus.

Yuav ua li cas muaj ntau yam tshuaj pib ua "DITT Depot"? Cov lus qhia rau kev siv (yees duab txhaj tshuaj nyob rau hauv daim ntawv no) qhia tias lub kho nyhuv ntawm cov tshuaj no feem ntau yog manifested tom qab 25-72 xuab moos tom qab txhaj tshuaj. Nws yuav tsum tau muab sau tseg tias thaj chaw ntawm lub antipsychotic tshuaj nyob rau hauv kev saib xyuas yog feem ntau cov lus hais nyob rau hauv lub sij hawm ntawm 49 mus rau 97 teev tom qab thawj coj ntawm cov tshuaj.

Lub kinetics ntawm cov tshuaj

Yuav ua li cas yog cov yam ntxwv ntawm cov tshuaj ntawm cov tshuaj "DITT Depot"? Cov lus qhia rau kev siv ntawm neeg pab leg ntaubntawv hais tias fluphenazine nyob rau hauv daim ntawv ntawm cov siab molecular yuag ester roj tov ntawm fatty acid yuav noog nyob rau hauv adipose depots, raws li zoo raws li maj mam tso.

Tom qab intramuscular txhaj ntawm ib tug tshaj plaws concentration ntawm lub caij yog tiav tom qab 25 teev nyob rau hauv ntshav. Nyob rau hauv cov ntaub ntawv no, fluphenazine uake mus rau cov ntshav ntws los ntawm 90%.

Saib yeeb tshuaj nkag crosses lub placental barrier thiab kis tau los ntawm cov ntshav-paj hlwb, thiab tsis tas los ntawm hemodialysis.

Fluphenazine kiag li thiab feem metabolised los ntawm lub siab enzyme system uas cytochrome P450. Los ntawm lub cev nws yog tas nrog cov kua tsib thiab zis. Active metabolites ntawm no lub caij no tsis yog tag nrho to taub.

Fluphenazine ib nrab-lub neej yog 7-10 teev.

zaj lus tim khawv

Nyob rau hauv tej rooj plaub, tus neeg mob yog tshuaj tshuaj "DITT Depot"? Cov lus qhia rau kev siv hais txog tej pov thawj raws li:

• exacerbation ntawm schizophrenia (rau kev tiv thaiv);
• heev txij nkawm kev kho mob ntawm tus kab mob schizophrenia.

Bans kev siv cov

Saib cov tshuaj yog txwv tsis pub nyob rau hauv cov nram no mob:

• nyob rau hauv hnyav SS cov kab mob, xws li nrog decompensated mob plawv tsis ua hauj lwm thiab hypotension;
• nyob rau ntawm ib kom rhiab heev ntawm tus neeg mob mus rau lub fluphenazine, raws li zoo raws li mus rau lwm cov ntsiab ntawm cov tshuaj;
• oppressed thaum lub sij hawm Cns thiab raw lub xeev;
• thaum lub sij hawm cev xeeb tub;
• ntawm pob txha taub hau raug mob thiab hnyav mauj cov kab mob ntawm lub paj hlwb thiab tus txha caj qaum;
• nyob rau hauv noj;
• nrog impaired siab muaj nuj nqi thiab cov ntshav system;
• mus txog 12 xyoo.

Ceev faj siv ntawm cov tshuaj

Yuav ceev faj "DITT Depot 'tshuaj kws kho rau:

• alcoholism, raws li zoo raws li ntau zog nyhav rau hepatotoxic tshua;
• pathological kev hloov nyob rau hauv cov ntshav, raws li zoo raws li nyob rau hauv yuam cai ntawm hematopoiesis;
• kev ua xua phenothiazines, xws li ib tug keeb kwm;
• kaw glaucoma;
• lub mis mob cancer;
• hepatic thiab / los yog lub raum tsis ua hauj lwm;
• ulcers ntawm lub digestive ib ntsuj av tau, xws li lub sij hawm ntawm mob mob;
• prostatic hyperplasia nrog soj ntsuam ces;
• myxedema;
• ailments, nrog thromboembolic teeb meem;
• Parkinson tus kab mob;
• mob kab mob nrog rau ua pa tsis ua hauj lwm (xws li cov me nyuam);
• Reye syndrome;
• qaug dabpeg, ntuav, qaug dab peg;
• cachexia;
• nyob rau hauv cov laus hnub nyoog.

Cov tshuaj tov "DITT Depot": cov lus qhia rau kev siv

Lub ampoules ntawm cov tshuaj no yog npaj rau long-term kawm ntawm txoj kev kho (tsawg kawg yog peb lub hlis). Nws pib koob rau feem ntau cov neeg mob yog 12.5-25 mg. Tom ntej koob, raws li zoo raws li lub caij nyoog nruab nrab nkaug tshuaj rau ntawm cov tshuaj yog txiav txim raws li tus kho nyhuv.

Kev kho mob ntawm cov neeg mob nrog npau taws me ntsis rau phenothiazines yuav tsum tau pib heev cautiously.

Cov laus yuav tsum tau lub sij hawm ntawm qis koob tshuaj tshaj yau cov neeg mob (kwv yees li 1/4 los 1/3 ntawm lub dosing). Nyob rau hauv cov ntaub ntawv no tom qab lawv xav tau qhov kev saib xyuas.

Tshwm sim los ntawm-cim

Cov tshuaj tov "DITT Depot" tej zaum yuav ua rau cov hauv qab no undesirable cov tshuaj tiv thaiv:

• extrapyramidal syndrome, akathisia, tardive dyskinesia, dystopia, oculogyric crises, hyperreflexia, opisthotonos;

• neuroleptic phem syndrome, uas yuav ua tau kom neeg tuag taus;
• orthostatic hypotension, tawm hws, ntshav siab hloov mus hloov los, xeev siab, hypotension, tsis qab los noj mov, glaucoma, ntev li salivation, atony zais zis, polyuria, plob tsis so tswj rhuav txhua, qhov ncauj qhuav, tachycardia, mob taub hau, qhov muag plooj tsis pom kev, cem quav, qhov ntswg congestion;
• ventricular arrhythmias, cia li tuag, ventricular tachycardia, cardiac ntes;
• txawv txav lactation, peripheral edema, coj khaub mob, hyponatremia, impotence nyob rau hauv cov txiv neej, cov kev hloov nyob rau hauv lub cev hnyav, kev hloov nyob rau hauv libido nyob rau hauv cov poj niam;
• pruritus, exfoliative dermatitis, erythema, seborrhea, urticaria, anaphylactic tshua, photosensitivity, angioedema, bronchial spasm, laryngeal edema;
• agranulocytosis, leukopenia, cholestatic daj ntseg;
• qaug dab peg, ua npaws, ECG hloov, irreversible diskinenziyu, ntuav, venous thromboembolism, lupus zoo li syndrome, thiab lwm tus neeg.

Testimonials

Tam sim no, koj paub, los ntawm dab tsi ua kev txhaj tshuaj "DITT Depot." Cov lus qhia rau kev siv, phiv, thiab contraindications rau kev siv ntawm cov tshuaj no kuj tau los sib tham saum toj no.

Raws li rau cov neeg mob yav tas los kho nrog ntau yam antipsychotic tshuaj, cov tshuaj "DITT Depot" ua hauj lwm ntau npaum li cas zoo thiab tshem tawm tag nrho cov tsis zoo tsos mob schizophrenia. Cov kev taw qhia ntawm cov tshuaj no yog heev ruaj khov thiab ntev-lub sij hawm txoj kev zam txim.

Lub tsuas drawback ntawm qhov cuab tam yog lub loj loj npaum ntawm los-cim tshua. Nyob rau hauv thawj hnub ntawm txoj kev kho nyob rau hauv ib co neeg cim hyperthermia, tawg thiab autonomic kawg. Tsis tas li ntawd, muaj ntau yam neeg mob yog pom ntawm giperkinezy nqaij ntawm lub qhov ncauj thiab lub ntsej muag, smacked nws daim di ncauj thiab tus nplaig zog. Tsis tas li ntawd, siv ntawm cov tshuaj no yog feem ntau tshwm sim los muaj kev nyuaj siab ntawm qhov ntau heev.