"Finoptin": cov lus qhia rau kev siv, muaj pes tsawg leeg, testimonials, analogues

Ntau tus neeg raug kev txom nyem los ntawm cov kab mob ntawm lub plawv thiab cov hlab ntsha. Tsis tas li ntawd, nrog lub hnub nyoog, qhov kev pheej hmoo ntawm xws li cov mob pathological nce significantly. Yuav kom txo tau txoj kev loj hlob ntawm cov txheej txheem loj hauv lub cev, cov kws kho mob pom zoo kom siv cov lus tshwj xeeb. Ntawm lawv yog cov tshwj xeeb yog nrov yog calcium channel blockers. Lawv yog ib pab pawg neeg heterogeneous. Lawv lub tswv yim ntawm kev ua haujlwm muaj feem xyuam rau kev muaj peev xwm los tiv thaiv kev nkag ntawm Ca ions los ntawm qhov chaw sib tshuam hauv kev nkag mus rau hauv lub hlwb ntawm cov hlab ntsha thiab lub plawv. Txo cov concentration ntawm cov ntsiab, cov tshuaj muaj ib tug vasodilating siv.

Cov tshuaj zoo tshaj plaws nrog rau cov khoom no yog "Finoptin". Cov lus qhia rau kev siv, sib xyaw, analogs, qhia txog kev siv yeeb tshuaj thiab nws cov kev mob tshwm sim tau piav qhia hauv qab no.

Daim ntawv, muaj pes tsawg leeg

Yam tshuaj twg yog hom tshuaj "Finoptin"? Cov lus qhia rau kev siv hais tias nws tuaj yeem muas tau nyob hauv daim ntawv hais txog kev txhaj tshuaj tiv thaiv thiab cov ntsiav tshuaj.

Raws li lub active khoom sib xyaw ntawm no siv tshuaj yaj yeeb yog verapamil hydrochloride. Tsis tas li ntawd, qhov muaj pes tsawg leeg ntawm cov tshuaj muaj xws li ntau yam koom ua ke (nyob ntawm daim ntawv tso tawm).

Pharmacological ua

Dab tsi yog qhov tsim nyog hauv kev npaj "Finoptin"? Cov lus qhia siv, tshuaj xyuas tias qhov no yog ib qho calcium channel blocker (xim) ntawm thawj chav kawm. Nws yog ib qho derivative ntawm diphenylalkylamine, thiab kuj tuaj yeem siv tshuaj tua kab mob, antihypertensive thiab antiarrhythmic kev txiav txim.

Cov tshuaj tua cov nyhuv ntawm cov tshuaj no yog cuam tshuam rau nws lub peev xwm los cuam tshuam rau myocardium thiab peripheral hemodynamics. Hauv lwm cov lus, cov tshuaj no txo lub suab ntawm cov hlab ntsha. Tsis tas li ntawd, nws txo cov kev hloov ntawm ATP zog, uas muaj nyob rau hauv cov qhabnias lag luam, ua haujlwm ua haujlwm thiab pab txhawb rau kev txo qis qis hauv lub cev ua pob liab liab.

Nws kuj tseem yuav tsum tau sau tseg tias kev siv cov tshuaj no ua rau txo tau qhov kev xav tau rau myocardium hauv O2, thiab tseem muaj qhov tsis zoo chrono-, qhov muaj txiaj ntsim zoo thiab tsis muaj zog.

Cov khoom ntawm kev npaj

Vim tias nws muaj pes tsawg leeg, cov tshuaj "Finoptin", analogues uas tau teev tseg hauv qab no, suppresses lub automaticity ntawm qhov ntswg, txo cov AV-conduction thiab nce lub sij hawm ntawm refractoriness.

Los ntawm kev ua kom lub sijhawm diastolic relaxation ntawm cov hlab ntsha (sab laug), cov tshuaj no txo lub suab ntawm phab ntsa ntawm myocardium, uas yog, nws yog ib qho kev pabcuam rau kev kho mob ntawm obstructive hypertrophic cardiomyopathy.

Nws kuj tseem yuav tsum tau sau tseg tias cov tshuaj nyob rau hauv nqe lus nug exhibits antiarrhythmic thaj chaw nyob rau hauv supraventricular arrhythmias.

Kinetics ntawm cov tshuaj

Cov tshuaj "Finoptin", cov kev qhia uas tau piav qhia hauv qab no, yog absorbed ntawm cov hnyuv (txog 90% ntawm cov tshuaj uas tau npaum li cas). Nws kev txuas nrog cov nqaijrog yog 90%.

Cov tshuaj yog metabolized thaum lub sij hawm tso cai (thawj) los ntawm lub siab. Qhov no ua rau ib qho kev cuam tshuam xws li norverapamil, uas muaj kev ua haujlwm tsawg dua li ntawm unaped verapamil.

Ib nrab ntawm lub neej ntawm cov tshuaj nrog ib koob tsuas yog 3-8 xuab moos. Thaum koj siv cov tshuaj ntau dua, qhov ntsuas no txawv (5-12 teev).

Yeeb tshuaj yog muab los ntawm txoj hnyuv thiab ob lub raum.

Kev qhia

Hauv cov mob zoo li cas yog tshuaj "Finoptin"? Cov lus qhia rau kev siv (ntsiav tshuaj thiab tshuaj tov muaj tib lub showy) hais tias qhov cuab tam yuav siv tau rau supraventricular tachycardia (xws li paroxysmal, syndrome Lown-Ganong-Levine thiab WPW-syndrome), cwj nrag (voltage, ruaj khov tsis muaj Angiospasm, ruaj khov vasospastic, sinus tachycardia, atrial flutter, ciliary tachyarrhythmia, atrial extrasystole, hypertensive ntsoog (rau intravenous saib xyuas), arterial hypertension, thawj kub siab nyob rau hauv ib lub tais me me nyob rau hauv kev, hypertrophic obstructive cardiomyopathy.

Contraindications

Thaum twg koj yuav tsum tsis txhob sau cov tshuaj "Finoptin"? Cov lus qhia rau kev siv (tshuaj thiab ntsiav tshuaj muaj qhov sib thooj tib yam) qhia tau hais tias cov tshuaj no txwv tsis pub siv rau kev siv ntshav qab zib heev, sinoatrial blockade thiab SSSU (tshwj tsis yog cov neeg mob pacemaker), AV blockade ntawm qib peb thiab qib thib ob, Laune syndrome -Ganong-Levin thiab WPW-syndrome nrog rau atrial fibrillation lossis flutter (tshwj tsis yog rau cov neeg muaj mob pacemaker), cev xeeb tub, mob siab rau qhov tseeb, pub mis niam.

Npaj "Finoptin": cov lus qhia rau siv

Kev siv tshuaj rau cov tshuaj no yog muab los ntawm tus kws kho mob ib leeg zuj zus.

Rau cov neeg laus cov neeg mob, cov ntsiav tshuaj tau hais ntawm ncauj ntawm thawj zaug ntawm 40-80 mg peb zaug hauv ib hnub. Rau kev siv tshuaj ntau npaum li cas nrog kev ua haujlwm ntev, yuav tsum noj ib zaug ib zaug xwb thiab tsawg dua ntawm kev tswj xyuas txo kom tsawg.

Cov menyuam yaus uas muaj hnub nyoog 6-14 xyoos, cov tshuaj no raug nquahu kom siv li 80-360 mg rau ib hnub, thiab mus txog 6 xyoo - hauv ib qho ntawm 40-60 mg ib hnub twg. Qhov kev noj tshuaj no yog 4 zaug ib hnub twg.

Yog hais tias tsim nyog, cov tshuaj nyob rau hauv cov lus nug yuav raug txhaj tshuaj intravenously (maj mam). Li no nws yog ib qho tsim nyog yuav tau saib xyuas lub tshuab electrocardiogram, lub siab thiab lub plawv ntawm tus neeg mob.

Ib koob tshuaj rau cov neeg laus yog 5-10 mg. Yog tias qhov kev kho mob tsis tuaj yeem tsis tuaj, ces tom qab 20 nas this tshuaj tuaj yeem rov ua dua tshiab (hauv tib lub sijhawm).

Siv tshuaj ib zaug rau ntawm cov tshuaj rau cov menyuam yaus 6-14 xyoos yog 2.5-3.5 mg, rau cov menyuam 1-5 xyoos - 2-3 mg, thiab rau ib tus menyuam txog ib xyoos - 0.75-2 mg.

Cov neeg mob uas muaj kev cuam tshuam ntawm daim siab txhua hnub yuav tsum tsis pub ntau tshaj 120 mg.

Qhov noj ntau tshaj plaws ntawm qhov ncauj noj txhua hnub yog 480 mg.

Tej Teebmeem

Cov tshuaj "Finoptin" yuav ua rau muaj kev tsis zoo rau cov kev mob tshwm sim nram qab no:

• Qhov hnyav nce, mob nqaij ntheev, ua mob rau lub cev, mob loj lossis mob plawv tsis ua hauj lwm, hyperprolactinemia, tachycardia, tsis pom kev tsis pom kev, peripheral edema;
• ntaus cim yuav txo tau ntawm cov ntshav siab, gynecomastia, galactorrhea, mob caj dab, angina, arrhythmia, pulmonary edema, AV-thaiv ntawm peb degree, asystole, thrombocytopenia asymptomatic, cev qhuav dej;
• Hloov siab, mob ntawm tes los yog ko taw, gingival hyperplasia, tsaus muag, nce qaug zog, muaj kev ntshaw ntxiv, ntxhov siab vim, kev ua kom muaj zog ntawm daim siab transaminase;
• daim tawv nqaij sawv pob, dias taub hau, cem quav los yog raws plab, mob taub hau, kev nyuaj siab, kev ua kom loog, extrapyramidal mob, qaug zog, kais ntawm daim tawv nqaij, tsaug zog, exudative erythema multiforme, pruritus.

Tshuaj Kev Sib Thoob

Kuv tuaj yeem muab cov tshuaj "Finoptin" nrog lwm yam tshuaj? Cov lus qhia nyob rau hauv daim ntawv thov hais tias ua ke nrog ntawm cov tshuaj mas siv nrog antihypertensive tshuaj nrog thiab txhawb nqa lawv antihypertensive nyhuv.

Nrog cov ntaub ntawv tso cai ntawm verapamil rau cov neeg uas nyuam qhuav tau txais cov koob tshuaj tiv thaiv kab mob beta-blockers, muaj kev pheej hmoo siab ntawm kev tsim hypotension (arterial) thiab asystole.

Nrog rau kev sib koom tes ntawm cov tshuaj "Finoptin" nrog beta-blockers, cov tshuaj siv rau kev nqus tshuaj loog thiab cov tshuaj antiarrhythmic, qhov kev pheej hmoo ntawm kev mob plawv, bradycardia, mob ntshav siab heev thiab AV blockade tsub ntxiv.

Nrog simultaneous txais tos nrog Amiodarone, bradycardia, tsis zoo inotropic nkaus, AV blockade thiab conduction disturbance nce.

Pom tau tias qhov tseeb hais tias verapamil inhibits tus CYP3A4 isoenzyme koom tes hauv cov metabolism hauv simvastatin, lovastatin thiab atorvastatin, qee qhov tshwm sim ntawm kev sib raug zoo yog tau los ntawm kev nce hauv concentration ntawm statins hauv cov ntshav. Muaj qee leej neeg mob rhabdomyolysis.

Thaum ua ke nrog nitrates, cov khoom tsis muaj zog ntawm "Finoptina" nce.

Nrog rau kev muab tshuaj rau ib qho tshuaj acetylsalicylic acid, lub sij hawm ntawm qhov hnoos tau nce vim yog cov tshuaj tiv thaiv kab mob.

Kuv puas noj cov tshuaj "Dizopiramid" nrog rau cov tshuaj "Finoptin"? Kev qhia rau kev siv qhia tias kev sib xyaw ua ke tuaj yeem ua rau mob ntshav siab heev thiab cev nqaij daim tawv, tshwj xeeb tshaj yog rau cov neeg uas muaj lub plawv tsis ua hauj lwm lossis kev mob plawv nres.

Nrog tib lub sij hawm siv cov ntsiav tshuaj thiab kev daws teeb meem nrog "Imipramine", nws cov concentration hauv cov ntshav nce ntxiv, vim tias muaj kev pheej hmoo ntawm cov kev hloov tsis raug cai ntawm ECG. Nws kuj tseem yuav tsum tau sau tseg tias verapamil ua rau kom muaj kev txaus siab ntawm "Imipramine", txo nws txoj kev ntshiab.

Thaum cov tshuaj sib xyaw nrog "Carbamazepine", qhov tshwm sim ntawm qhov tom kawg nce, thiab qhov kev pheej hmoo ntawm kev phiv los ntawm CNS nce.

Nyob rau tib lub sij hawm noj cov tshuaj noj "clonidine" muaj mob ntawm lub plawv tsis ua hauj lwm nyob rau hauv cov neeg uas kub siab.

Thaum sib txuas cov tshuaj nrog lithium carbonate, qhov tshwm sim ntawm kev sib raug zoo ntawm yeeb tshuaj yog unpredictable thiab ambiguous. Muaj qee zaum mob neurotoxicity, mob ntshav qab zib heev, muaj ntau yam tshuaj lithium thiab txo nws cov concentration hauv cov ntshav.

Rifampicin tau ua li cas rau Finoptin? Cov kev qhia paub tseeb tias qhov kev sib txuas ua ke ua rau kev ua haujlwm ntawm hepatic enzymes, accelerating cov metabolism ntawm verapamil. Thaum kawg, qhov no ua rau ib tug txo nyob rau hauv cov kev kho mob zoo ntawm cov tshuaj nyob rau hauv nqe lus nug.

Cov Lus Qhia Tshwj Xeeb

Kuv yuav tsum paub dab tsi ua ntej siv cov tshuaj "Finoptin" (40 mg)? Cov kev qhia no hais tias qhov kev kho no yog siv nrog ceev faj hauv AV blockade ntawm thawj qib, mob loj heev ntawm aortic aortic, bradycardia, myocardial infarction nrog rau sab laug voos tsis ua hauj lwm, mob plawv tsis ua hauj lwm, mob sib khuav xwb los yog mob me ntsis, mob ntsws los sis lub plab tsis zoo. Tsis tas li ntawd, cov tshuaj no yog xav kom cov laus neeg thiab cov menyuam yaus muaj hnub nyoog zoo.

Hauv kev mob hnyav, nws raug tso cai los ua ke nrog kev kho kev mob ntshav qab zib thiab angina los ntawm kev siv verapamil thiab beta-adrenoblockers. Txawm li cas los xij, nws yog ib qho tsim nyog kom tsis txhob siv tshuaj tua kab mob hauv tsev.

Tom qab noj cov tshuaj no, tus neeg mob yuav ua rau tus neeg muaj kev tsis haum siab xws li nkees nkees thiab kiv taub hau uas yuav ua rau tus neeg muaj peev xwm ua tau teeb meem kev ua si.

Lactation thiab cev xeeb tub

Nws puas tuaj yeem sau cov tshuaj "Finoptin" rau cov poj niam cev xeeb tub? Cov lus qhia siv rau lub sijhawm thaum cev xeeb tub hais tias qhov tshuaj no ua rau muaj kev cuam tshuam rau kev tsim kho ntawm tus me nyuam hauv plab. Nws tseem mus rau hauv cov kua mis. Yog li ntawd, nrog xws li tej yam kev mob, qhov tshuaj no yog ncaj qha contraindicated.

Kev Tshuaj Noj "Finoptin": analogues thiab cov nqi

Tus nqi ntawm qhov cuab yeej no yuav txawv. Raws li txoj cai, nws nyob ntawm daim ntawv ntawm kev tso tawm ntawm cov tshuaj, nws ntau los yog ntim. Tus nqi nruab nrab ntawm "Finoptina" yog 100-170 rubles.

Yog tias cov tshuaj no ua rau koj, ces nws yuav hloov los ntawm ib qho ntawm cov hauv qab no: Verapamil, Veragalide, Verapamil-OBL, Kaveril, Verapamil Sopharma, Verapamil-LekT, Verapamil-Ferein, Verapamil Ratiofarm, Isoptin, Verapamil-Eskom, Vero-Verapamil, Verapamil Hydrochloride, thiab Lekoptin.

Xyuas cov kws kho mob thiab cov neeg siv khoom

Cov kws kho mob hais tias cov ntsiav tshuaj thiab tshuaj "Finoptin" yog qhov zoo thiab pheej yig txhais tau hais tias tsim los kho ntshav siab, thiab ntxiv rau koj kev noj qab haus huv hauv lwm cov kab mob ntawm lub plawv thiab cov hlab ntsha.

Raws li rau cov neeg mob, feem ntau ntawm lawv yog cov txaus txaus nrog cov ntsiab lus ntawm kev kho mob nrog kev kho no. Tau txais cov ntsiav tshuaj los yog kua dej tso kua tshuaj pab ceev nrawm tshem tawm cov tsos mob ntawm kev kub ntxhov thiab lwm cov cim qhia ntawm cov kab mob ntawm cov hlab plawv.

Nws tseem yuav tsum tau sau tseg tias cov lus tsis zoo kuj muaj nyob rau ntawm cov tshuaj no. Lawv tham txog ntau cov kev phiv tshuaj uas tshwm sim tam sim ntawd tom qab siv tshuaj. Tsis tas li, ntau tus neeg tau txais kev tsis txaus siab txog ntau qhov kev tsis txaus siab.