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Cov tshuaj "Doxorubicin": phau ntawv qhia, xyuas, cov duab, tso tawm daim ntawv no, ntau npaum, cia. "Doxorubicin-hmuv": cov lus qhia rau kev siv

Lub cancer yog tsis tshua muaj txaus ntshai rau tib neeg lub neej. Nws muaj phem thiab uncontrolled proliferating hlwb, uas yuav muaj peev xwm mus txeem mus rau hauv lub surrounding cov ntaub so ntswg thiab metastasize rau lwm yam kabmob.

Cov kev loj hlob ntawm cov tshuaj thiab kev kho mob rau tej kab mob yog ib qho tseem ceeb ua hauj lwm. Tu siab, kom txog thaum uas tam sim no tsis muaj ib tug kom txog thaum kawg thiab kuv tsis tau txiav txim siab. Txawm hais tias muaj cov tseem tshuaj uas muaj peev xwm kom lub division ntawm mob hlwb. Ib tug ntawm lawv xa tshuaj "Doxorubicin". Cov lus qhia rau kev siv thiab ib tug yees duab ntawm cov tshuaj yuav tsum tau them nyob rau hauv no tsab xov xwm. Nyob rau hauv nws koj yuav nrhiav tau cov lus qhia txog yuav ua li cas kom hais tias txhais tau hais tias nyob rau hauv uas tsim nws yog muaj nyob rau muag, thiab tshaj.

Ntim, muaj pes tsawg leeg, zoo thiab cov hauj lwm

Nyob rau hauv dab tsi daim ntawv muag "Doxorubicin"? Cov lus qhia rau kev siv qhia cov nram qab no hom ntawm cov khoom:

  • Lyophilizate rau kev npaj ntawm cov tshuaj rau cov intravascular thiab intravesical kev txhaj tshuaj. Nws yog ib lub liab-daj ntxeem tau loj thiab muaj cov active tshuaj xws li doxorubicin hydrochloride. Raws li ntxiv cov khoom xyaw siv mannitol. Tshuaj yog muag nyob rau hauv hwj, uas xa tuaj nrog nyob rau hauv ib tug cardboard lub thawv.
  • Mloog zoo rau cov ib tug tov rau intravascular thiab intravesical kev txhaj tshuaj. Nws yog ib tug liab thiab pob tshab kua uas muaj doxorubicin hydrochloride thiab yog muaj nyob rau hauv hwj thiab cartons.

Lub pharmacology ntawm cov tshuaj

Yuav ua li cas yog cov tshuaj raws li "Doxorubicin"? Cov lus qhia rau kev siv (tso tawm hauv daim ntawv ntawm cov tshuaj twb qhia saum toj no) qhia tias nws yog ib tug anti-mob anthracycline tshuaj tua kab mob, uas yog cais los ntawm haiv neeg ntawm cov pwm Streptomyces peucetius. Nws yog tau pheev antimitotic thiab antiproliferative los.

Interacting nrog DNA, lub medicament cheeb RNA polymerase, DNA polymerase thiab topoisomerase hom 2, thiab kuj activates zus tau tej cov dawb radicals thiab ua rau lub cell phab ntsa. Raws li ib tug ntawm xws li tej yam slows DNA replication thiab lom nucleic acid synthesis.

Nws yog tsis yooj yim sua tsis kom nco ntsoov qhov tseeb hais tias peb yog xaiv cov txhais tau tias muaj ib tug ncaj qha cytotoxic nyhuv. Lub hlwb muaj ib tug kev rhiab heev mus rau yeeb tshuaj nyob rau hauv lub G2-theem thiab S-theem ntawm lawv lub neej.

kev tig tau zog

Yuav ua li cas tig tsis xam qhovkev nyob rau hauv cov tshuaj "Doxorubicin"? Cov lus qhia rau kev siv hais tias tom qab tso dej txhaj tshuaj, lub cuab tam ib txwm muab faib multiphase. Thaum lub sij hawm ua ntej 5 feeb ntawm lub medicament sai yog tej ntaub so ntswg, thiab nws cov concentration hauv cov ntshav tsawg sai heev. Raws li rau lub thib ob theem, nws yog nqa tawm qeeb tshuaj molecules los ntawm cov ntaub so ntswg.

Concentrates active tshuaj nyob rau hauv lub siab, ob lub raum, tus po, lub ntsws thiab myocardium. Nws kuj penetrates rau hauv lub tsev me nyuam thiab yog tas nrog niam cov kua mis.

Lo lus teb rau ntshav cov nqaijrog tshwm sim los ntawm 75%. Metabolism hauv cov tshuaj nyob rau hauv lub siab, li no txoj kev ua ib tug active derivative xws li doxorubicinol.

Thaum lub sij hawm yuav txo tau ntawm dawb radicals enzyme synthesis yuav cuam tshuam rau txoj kev loj hlob ntawm mob toxicity.

Ib nrab-lub neej ntawm doxorubicin thiab zoo sib xws doxorubicinol thiab yog hais txog 20-48 teev.

Kwv yees li 40% ntawm cov koob ntawm cov tshuaj no yog tso ua ke nrog cov kua tsib, thiab tsuas yog 6-11% ntawm doxorubicin thiab nws cov derivatives, rau 5 hnub yog pom nyob rau hauv cov zis.

indications

tshuaj "Doxorubicin" tej zaum yuav tau tsa nyob li cas cov kab mob?

Cov lus qhia rau kev siv (rau lub zais zis mob cancer yog ib tug uas siv ntau heev) nws hais tias cov tshuaj ua zoo thaum:

  • thyroid caj pas cancer, Kaposi lub sarcoma thiab Ewing;
  • Wilms 'qog, pais plab mob cancer, me me ntawm tes daim ntawv ntawm lub ntsws cancer;
  • insulinoma, mob cancer mis, Mesothelioma;
  • esophageal mob cancer, carcinoid, neuroblastoma;
  • osteogenic sarcoma, thawj hepatocellular carcinoma, uas tsis yog-Hodgkin lymphomas ;
  • Cancer ntawm lub prostate caj pas, mob cancer ntawm lub taub hau thiab lub caj dab, malignant thymoma;
  • lub tsev me nyuam mob cancer, tej yam testicular hlav;
  • uterine sarcoma, endometrial cancer, Hodgkin tus kab mob;
  • rhabdomyosarcoma, mob leukemia;
  • mob lymphocytic leukemia, ntau yam myeloma.

Contraindications

Yuav ua li cas yog cov kev mob ntawm tus neeg mob muab txwv tsis pub nws cov tshuaj "Doxorubicin"? Cov lus qhia rau kev siv, tiag tiag oncologists hais tias lub cuab tam proves tsis zoo heev nyob rau hauv:

  • sensitization rau doxorubicin los yog lwm yam yeeb tshuaj tshuaj, raws li zoo raws li cov neeg sawv cev ntawm anthracyclines thiab anthracenediones;
  • ua ntej txoj kev kho, los yog lwm tus neeg hauv anthracycline anthracenediones nyob rau hauv limiting koob, raws li zoo raws li lub siab tsis ua hauj lwm (mob loj heev), heart attack myocardial infarction, arrhythmias, mob tus kab mob thiab lub plawv tsis ua hauj lwm (tso dej raws leeg thawj coj);
  • phem hlav, germinating nyob rau hauv lub phab ntsa ntawm lub zais zis, mob txeeb zig thiab cystitis (rau intravesical).

Nrog huab ceev faj, cov tshuaj no yuav tsum tau siv rau cov neeg uas tau txais kev muab siab kho cov kws khomob, raws li zoo raws li lub muaj tej yam cardiotoxicity, ua txhaum ntawm lub siab, hloov hlwb pob txha infiltration ntawm cov mob cancer hlwb thiab rog.

Nyob rau hauv tas li ntawd, ua tib zoo suav hais tias yog tshuaj no yog tshuaj rau cov me nyuam thiab cov neeg tshaj lub hnub nyoog, thiab raws li ib feem ntawm ib tug multi-hom thiab multicomponent antitumor txoj kev kho.

Tshuaj "Doxorubicin": cov lus qhia rau kev siv, tshuaj

Raws li cov lus qhia, xam tau tias yog cov tshuaj yuav tau muab intraarterially, intravenously thiab intravesically. Nws yuav tsum raug sau tseg hais tias qhov no lub cuab tam yuav tsum tau siv singly los yog nyob rau hauv ua ke nrog nrog rau lwm cov cytostatic tshuaj nyob rau hauv txawv noj tshuaj npaum cas.

Reconstituted tshuaj tov "Doxorubicin" yog yuav tsum tau siv tam sim ntawd tom qab nws siv.

Tso dej txhaj tshuaj formulation

Thaum pom zoo ntau npaum ntawm monotherapy "Doxorubicin" ib lub voj voog yog 60-75 mg / sq. m txhua txhua peb lub lis piam. Feem ntau, cov tshuaj yog txhaj ib zaug. Txawm li cas los, qhov no koob tshuaj tej zaum yuav xeem thiab rau ntau yam tshuaj (nyob rau hauv ib tug npaum li ntawm 25-30 mg / sq. M ib hnub twg rau cov thawj 3 hnub ntawm lub voj voog).

Yuav kom txo tau cov tshuaj lom nyhuv ntawm txoj kev siv txhua lub limtiam thawj coj ntawm 10-20 mg / sq. m lub sij hawm ib lub lim tiam.

Thaum ua ke nrog rau lwm cov anticancer cov neeg ua hauj active medicament yog muab nyob rau hauv ib tug ntau npaum voj voog nyob rau hauv ib tug npaum li ntawm 30-60 mg / sq. m txhua txhua 4 lub lis piam.

Ua kev kawm ntawm kev kho mob nqa tawm tsuas yog tom qab tshem tawm ntawm tag nrho cov tsos mob ntawm tshuaj muaj taug.

Tag nrho cov koob tshuaj ntawm cov tshuaj yuav tsum tsis txhob yuav ntau tshaj 550 mg / sq. m.

Intra-arterial thawj coj ntawm ib tug neeg sawv cev

Yuav ua li cas yog lub intra-arterial txhaj "Doxorubicin" tshuaj? Coj xeev uas mus muab sidetone cov neeg uas muaj hepatocellular carcinoma active medicament yuav tsum tau muab rau tus ntau hepatic leeg nyob rau hauv ib tug ntau npaum ntawm 35-150 mg / sq. m. Nyob rau tib lub sij hawm Team sib ntawm mus yuav tsum sib npaug zos los ntawm 3 lub lis piam mus rau 3 lub hlis.

Cov kev taw qhia ntawm cov tshuaj mus rau hauv lub zais zis

Raws li lub zais zis txhaj tshuaj "Doxorubicin-Teva"? Cov lus qhia rau kev siv ua dlejnum hais tias qhov no ntau npaum txhais tau tias rau intravesical thawj coj yuav tsum 35-50 mg ib installation.

Kev kho mob cov txheej txheem yuav tsum tau nqa tawm ntawm ua mib ntawm 7-28 hnub, nyob ntawm seb lub hom phiaj (Kev tiv thaiv los yog kev kho mob).

Concentration ntawm cov tshuaj tov yuav tsum yog 1 mg / 1 ml dej tshuaj los yog lub cev.

Instillation yog ua tsis pub dhau 2 lub sij hawm. Qhov kawg ntawm tus neeg mob yuav tsum tau nchuav tag lub zais zis.

phiv

Kev npaj "Doxorubicin", uas cov kev qhia ntawv piav saum toj no tej zaum yuav ua rau cov nram qab no sab tshua:

  • ntuav, mob plab, xeev siab, mob plab, stomatitis, raws plab, esophagitis, qhov ncauj mucosa hyperpigmentation, anorexia, nce bilirubin concentration hauv cov ntshav, hnyuv los ntshav, nce hepatic transaminases;
  • KOOB-dependent reversible leukopenia, thrombocytopenia, anemia, leukopenia, neutropenia;
  • qhov ntswg tachycardia, atrioventricular thaiv, tachyarrhythmia daim ntawv txhaws lub plawv tsis ua hauj lwm, bradycardia, thrombophlebitis, Nws nras ceg thaiv, kev txawv txav nyob rau hauv ECG, ventricular arrythmia, pulmonary embolism, phlebitis, thromboembolic teeb meem;
  • amenorrhea, oligospermia, hyperuricemia, urinary liab uas tseg tau, azoospermia;
  • conjunctivitis, keratitis, lacrimation;
  • peripheral neurotoxicity, qaug dab peg, coma;
  • edema, reversible alopecia, photosensitivity, daim tawv nqaij hyperpigmentation, tawm pob, khaus, mob heev, tawm pob, erythema, noo epidermis;
  • dermatitis, tawm pob, bronchospasm, daim tawv nqaij yaug kais dej, anaphylaxis;
  • Local phlebitis, cim mob, fleboskleroz, thrombophlebitis, lub zos mob, ntaub so ntswg necrosis;
  • polyuria, nocturia, dysuria, necrosis ntawm lub zais zis week, hematuria, tsis xis nyob, mob tso zis;
  • erythematous striation ntawm lub qhov koob;
  • qaug zog, malaise, kub taub hau, ua daus no, txoj kev loj hlob ntawm lymphocytic los yog myelocytic leukemia (mob), hyperuricemia, tides, nephropathy;
  • rwj 12 duodenal / pais plab, biliary sclerosis.

tsos mob ntawm overdose

Yuav ua li cas yog lub cim ntawm overdose tshwm sim thaum koj siv ib tug loj tus naj npawb ntawm "Doxorubicin" tshuaj? Cov lus qhia rau Siv lub xeev uas ib tug overdose ntawm cov nyiaj yuav ua rau lom mob manifested los ntawm lub digestive system, raws li zoo raws li nyob rau hauv kev mob loj myelosuppression. Nyob rau hauv tas li ntawd, ntau dua koob tshuaj ntawm cov tshuaj yuav ua tau heev yooj yim mus ua mob mob plawv.

Ib tug antidote mus rau yeeb tshuaj "Doxorubicin" tsis muaj nyob. Nyob rau hauv overdose cuam tshuam muab symptomatic txoj kev kho. Tsis tas li ntawd, nws yog pw tsev kho mob thiab kho nrog antibacterial tshuaj.

tshuaj cov kev sib tshuam

Yog nws tau mus ua ke nrog lwm yam tshuaj tshuaj "Doxorubicin"? Cov lus qhia rau kev siv qhia tau hais tias thaum koj siv qhov cuab tam nyob rau hauv ua ke nrog nrog rau lwm cov cytotoxic tshuaj feem ntau manifested lawv additive toxicity.

Thaum ib tug ua ke yeeb tshuaj nrog rau lwm cov cytotoxic tshuaj, uas muaj cardiotoxicity (xws li, "FU" los yog "Cyclophosphamide"), yuav tsum tau ceev faj xyuas ntawm lub plawv thaum lub sij hawm tag nrho cov hoob kawm ntawm kev kho mob.

"Streptozocin" tsub kom lub ib nrab-lub neej "Doxorubicin".

Cov kev kho "Doxorubicin" tus neeg mob tej zaum yuav qhia tej yam tshwm sim ntawm mob hemorrhagic cystitis tom qab kev kho mob "cyclophosphamide", raws li zoo raws li ntu lub phenomenon ntawm daim siab toxicity tom qab kev kho mob "mercaptopurine."

Txoj kev siv "Paclitaxel" ua ntej lub sij taw qhia ntawm "Doxorubicin" tej zaum yuav ntxias ib qho kev nce rau hauv cov ntshav concentration ntawm lub yav tas.

Yuav ua li cas cov tshuaj yog txwv tsis pub siv cov tshuaj "Doxorubicin"? Cov lus qhia rau kev siv (rau cov tsiaj yog tsis muab) qhia tias qhov cuab tam yuav tsum tsis txhob yuav tov nrog lwm yam tshuaj. Piv txwv li, nws yog pharmaceutically tau tshaj cov "heparin", "Dexamethasone", sodium succinate, "hydrocortisone", "cephalothin", "aminophylline", "FU" thiab lwm yam anticancer tshuaj.

Thaum ua ke nrog nyob kab tshuaj tiv thaiv no tau tus kab mob replication thiab muaj zog sab tshua thiab txo antibody synthesis nyob rau hauv ib tug neeg mob lub cev nyob rau hauv cov lus teb rau qhov kev siv ntawm cov tshuaj tiv thaiv.

Cov tswv yim pom zoo nyob rau kev siv ntawm cov tshuaj

Yuav ua li cas koj yuav tsum paub ua ntej yuav siv lub "Doxorubicin-hmuv"? Cov lus qhia rau kev siv ntawd hais tias nyob rau hauv lub chav kawm ntawm kev kho mob antineoplastic agents tsim nyog los nqa tawm kev xyuas ntawm daim siab muaj nuj nqi, daim duab ntawm peripheral cov ntshav, ECG thiab ultrasound ntawm lub plawv.

kev muag khoom tej yam kev mob, txoj kev cia thiab txee-lub neej

Qhov twg yuav tsum cov tshuaj "Doxorubicin-hmuv"? Cov lus qhia rau kev siv qhia tias qhov cuab tam yuav tsum tau khaws cia nyob rau hauv ib tug qhuav thiab qhov chaw tsaus nyob qhov twg qhov kub thiab txias tsis pub tshaj tsib degrees.

Lub medicament yog tso tawm nyob rau hauv pharmacies los ntawm cov tshuaj xwb. Nws txee lub neej yog ob lub xyoos.

Nqe thiab analogues

Tus nqi ntawm cov tshuaj yog suav tias yog 120-150 rubles nyob rau hauv 5 ml. Yog hais tias tsim nyog nws yuav tsum tau hloov los ntawm xws li "Doxorubicin-Teva", "Lachema Doxorubicin", "Onkodoks 50", "10 Onkodoks", "Doxorubicin-Ebewe", "CRC-Doxorubicin" thiab lwm tus neeg.

Consumer xyuas ntawm cov tshuaj

Tam sim no koj paub yuav ua li cas siv cov tshuaj "Doxorubicin". Cov lus qhia rau kev siv thiab cia ntawm cov tshuaj tau hais saum toj no.

Kuj muaj coob tus neeg xyuas txuam nrog mob loj tshua uas tshwm sim thaum lub sij hawm kev kho mob nrog rau cov tshuaj. Rau cov teebmeem yog internal hloov khoom nruab nrog kev koom tes, ntev-ntev hnov muaj mob los, cov plaub hau tsis thiab tsim los ntawm ulcers ntawm lub qhov koob chaw.

Nyob rau hauv qhov kev zoo lawv yog cov tsis tshua muaj tsawg. Thiab qhov no yog vim li, txij li thaum cov hauj lwm zoo ntawm anticancer tshuaj yuav tsum soj ntsuam tsuas yog ib tug tej tus kws khomob tshwjxeeb, raws li nyob rau hauv ib tug loj tus naj npawb ntawm ntau yam tseem ceeb: lub hom monotherapy los yog thaum lawv tseem kho, ib tug mob cancer, tus neeg mob tus mob, thiab lwm yam long-term tau.

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