Vitrification ntawm oocytes: yog dab tsi?

Nyob rau hauv xyoo tsis ntev los, nyob rau hauv vitro fertilization yog tsim heev sai sai. Qhov no txoj kev yog tsis tau hais tias yuav ib yam dab tsi zoo kawg thiab muab tsis cuag rau neeg zej zog. IVF yog nqa tawm thoob plaws lub ntiaj teb no. Tshwj Xeeb lub chaw soj nstuam thiab tsev kho mob yog muaj nyob rau hauv txhua txhua loj nroog. Txhua xyoo los tsim tshiab, zoo le caag los fertility. Los ntawm txoj kev loj hlob ntawm cov qauv no, muaj ntau yam infertile khub niam txiv twb tau mus ua niam ua txiv. Feem ntau tus sau los ntawm cov lus qhia txog IVF, cov poj niam lub ntsej muag ib lub sij hawm xws li vitrification ntawm oocytes. Qhov no lub sij hawm yog hais txog mus rau ib tug tshiab kuj txheej txheem uas tso cai rau koj los mus txhim kho qhov zoo ntawm lub qe.

Lub tswvyim ntawm "oocyte vitrification" - yog dab tsi?

Yuav kom to taub li cas cov txheej txheem ntawm vitrification, koj yuav tsum muaj ib lub tswv yim ntawm nyob rau hauv vitro fertilization. Qhov no txoj kev yuav sampling ntawm cov poj niam tus kab hlwb (oocytes) los ntawm lub zes qe menyuam. Ces muaj lawv cleansing thiab fertilization phev pub los yog khub (yog hais tias tus txiv yuav tsis muaj cov me nyuam). Tom qab no, lub sib qhia zygote yog muab tso rau hauv lub uterine kab noj hniav. Vitrification ntawm oocytes - ib tug txheej txheem zoo ib yam li lub cryopreservation ntawm oocytes. Txawm li cas los, nws yog ntau tshaj. Nyob rau hauv vitrification meant khov ntawm tsis paub qab hau kab hlwb. Raws li ib tug tshwm sim, lub oocytes yuav khaws cia rau ib ntev lub sij hawm. Txawm tias lub "frozen" xeev, Vitrified hlwb nyob twj ywm siv tau. Qhov no txoj kev yog hais tias yuav ib tug lossis loj txhob nyob rau hauv cov tshuaj, vim hais tias ua tsaug rau nws cov poj niam yuav tau muaj ib tug me nyuam, txawm nyob rau hauv lub qhaj ntawv ntawm me nyuam lub nruab nrog.

Yuav ua li cas yog lub hom phiaj ntawm oocyte vitrification yog nqa tawm?

Nyob rau hauv Teb chaws Europe, cov tswv yim xws li cryopreservation, vitrification ntawm embryos thiab oocytes, tau lub npe hu rau ib ntev lub sij hawm. Qhov no yuav pom nyob rau lub sab hnub poob zaj duab xis nyob rau cov tshuaj. Nyob rau hauv lub teb chaws ntawm lub qub Soviet Union, dhau lawm, cov kws kho mob paub txog cov ntsiab lus uas rau decades. Txawm li cas los, cov txheej txheem tau ua muaj rau cov neeg mob ntev los no. Nyob rau hauv feem ntau tus neeg mob, vitrification ntawm oocytes ua rau nyob rau hauv vitro fertilization. Thaum lub sij hawm khov ntawm tsis paub qab hau hlwb nyob rau hauv xws li ib tug txoj kev ib tug poj niam muaj ib tug ntau dua lub caij nyoog ntawm kev vam meej IVF. Tus thawj batch ntawm xaiv oocytes ntawm lub zes qe menyuam yuav tsis nyob twj ywm. Nyob rau hauv no re-zauv ntawm cov ntaub ntawv uas yog tsis yuav tsum tau, raws li muaj cov twb Vitrified hlwb. Nyob rau hauv tas li ntawd, muaj mob thaum ib tug menyuam tsis taus khub nug rau preservation ntawm oocytes rau ib ntev lub sij hawm. nws yog feem ntau yuav tsum tau nyob rau hauv ntau yam pathological tej yam kev mob nyob rau hauv uas ib tug poj niam yuav tsis muaj cov me nyuam. Tsis tas li ntawd, nrog xws li ib tug thov xa cov neeg mob npaj rau kev phais kom tshem tawm cov me nyuam nruab nrog cev.

Nyob rau hauv tsis muaj pathologies kom vitrification qe?

Vitrification ntawm oocytes thiab embryos - ib tug them nyiaj txoj kev muaj rau txhua leej txhua tus. Tshwj xeeb indications rau nws tsis muaj, li ntawd xwb, nws yog tsim nyog xwb nyob rau hauv ib rooj plaub ntug. Qhov no tsis tau txhais hais tias ib txhia poj niam yuav tsis muaj nyiaj vitrified lawv lub hlwb. Cuaj kaum, nyob rau hauv lub qhaj ntawv ntawm yog vim li cas rau lub khov ntawm oocytes nyob rau hauv ib tug zoo li zam rau cov neeg mob kom cryopreservation. Feem ntau cov feem ntau vitrification yog ua raws li nram qab no:

1. Txoj Kev Npaj yuav ovariectomy. Qhov no lub lag luam yog nqa tawm nyob rau hauv ntawm zes qe menyuam cancer thiab lub sijhawm twg los ntawm nws kev loj hlob. Qhov no yog vim li cas yog tsis heev thoob plaws, txij li thaum nyob rau hauv Feem ntau, gynecological cancer pathologies yog muab tshem tawm thiab lub tsev me nyuam.
2. Tsis muaj peev xwm mus muab tau cov phev txhua txhua hnub kom tsawg ntawm oocytes. Vim li no, lub hlwb yuav tsum tau khov li ntev raws li cov ntaub ntawv uas rau fertilization yuav tsis tau tso cai.
3. Cancer ntawm tej chaw. Txawm li cas los ntawm qhov chaw uas nws muaj ib tug mob cancer yuav tsum tau radiotherapy thiab kev kho mob tshuaj lom neeg (cytostatic) tshuaj. Txhua yam ntawm cov kev undesirable los cev xeeb tub. Tom qab cov kev kho mob puas tsis tsuas cancer, tab sis kuj noj qab nyob zoo lub hlwb, nrog rau oocytes.
4. Poj niam lub siab xav mus muaj cov me nyuam nyob rau hauv ib tug tej thaj chaw deb lub sij hawm, rau Piv txwv li, tom qab lawm. Nyob rau hauv xws li mob tsis tshua cryopreservation yog tsim vim hais tias lub qe cia kom khov nrog rau cov qauv zaum ntev. Yog li ntawd, cov kws kho mob muab ib lwm txoj kev - vitrification ntawm oocytes.
5. Ua IVF, yog hais tias tus thawj lub sij hawm lub qe yog tsis accustomed. Nyob rau hauv cov ntaub ntawv no, muab vitrification tsis tau cov ntaub ntawv uas peb lub sij hawm.

Vitrified oocytes pub - yog dab tsi?

Nyob rau hauv tej rooj plaub, ib tug menyuam tsis taus zog yog tsis tau xeeb tub ib tug me nyuam, txawm nrog kev pab los ntawm nyob rau hauv vitro fertilization. Peb yuav tau tham txog cov poj niam uas impaired muaj nuj nqi ntawm lub gonads. Rau lub hom phiaj no, lub tsev txhab nyiaj hloov oocytes tau tsim. Tu siab, lawv yog tsis muaj nyob rau hauv tag nrho cov teb chaws. Tag nrho cov tsis paub qab hau kab hlwb yog ib tug vitrified lub xeev, yog li ntawd lawv yuav tsum tau khaws cia. Indications rau IVF siv pub oocytes yog:

1. Txhob txiav txim pathology - ntawm zes qe menyuam tsis ua hauj lwm syndrome.
2. Qhaj ntawv ntawm oocytes vim lub hnub nyoog yam ntxwv ntawm cov me nyuam system (40 xyoo thiab tshaj saud).
3. Tsis muaj peev xwm mus tsim kho ovulation vim phais tiv thaiv nyob rau hauv lub zes qe menyuam, kws khomob raug.
4. Qhov uas ib tug me nyuam nrog ib tug kev tshuaj ntsuam genetic tus kab mob.
5. Ua IVF, tsis tau yielded tau raws li ib tug tshwm sim ntawm "neeg txom nyem zoo" ntawm lawv tus kheej lub qe.

Leej twg yuav ua ib tug neeg oocytes vitrified: yuav tsum muaj

Family Planning - qhov no yog ib tug heev loj kev txiav txim siab, tshwj xeeb tshaj yog nyob rau hauv tus neeg mob thaum lub ob peb yog yuam kom siv pub hlwb. Ua ntej koj yuav tau txais oocytes thiab raug lawv mus vitrification, tus kws kho mob nqa tawm heev heev kev tshawb fawb ntawm ob tus poj niam thiab cov ntaub ntawv. Ib tug ntawm cov tej yam kev mob tsim nyob rau hauv lub bank ntawm frozen ova, yog lawv. Hais tias yog, tus niam txiv tsis tau paub txog lub pub, thiab vice versa. Yuav tsum muaj rau cov poj niam uas xaiv lawv vitrified oocytes:

1. Hnub nyoog: 20-35 xyoos.
2. Qhov uas tsis muaj Somatic thiab caj kab mob.
3. Lub suab mos muag hais phenotype.
4. Lub xub ntiag ntawm lub pub tsawg kawg yog ib tug me nyuam ntawm lawv tus kheej.
5. Tso cai rau kev ceev ntiag tug.

Txheej txheem ntawm vitrification

Ua ntej koj yuav pib mus khov poj niam gametes, nyob ovulation stimulation. Nws yog tsim nyog tias oocytes ob peb, es ib tug. Tom qab ib txwm ripening tshwm sim thaum lub sij hawm ovulation thiab follicle tawm los ntawm tsuas yog ib ovum. Stimulation yog ua nrog tshuaj. Tom ntej no yog ua ib tug hu ua pelvic ultrasound. Yog hais tias koj pom tau hais tias ovulation tau pom tau hais thiab oocytes nyob rau hauv lub zes qe menyuam nyob rau hauv txaus kom muaj nuj nqis, cov IVF txoj kev yog txuas ntxiv. cell ntxawm yog nqa tawm nyob rau hauv kev tshuaj loog. Yuav kom hno rab koob ntaus nws muaj, qhov twg lub oocytes, tag nrho txoj kev yog ua nyob rau hauv ultrasound kev taw qhia. Tom qab noj cov khoom mus rau pib cov theem tom ntej - lub preservation ntawm tsis paub qab hau oocytes. Vitrification ntawm oocytes yog ua nyob rau hauv lub natural voj voog vim lub ceev ceev freezing txoj kev. Qhov no yog lub ntsiab feature ntawm no preservation txoj kev.

Qhov zoo ntawm cov vitrification ntawm oocytes

Muab hais tias vitrikatsii txheej txheem pib maj mam hloov lwm txoj kev preservation ntawm ova thiab embryos, nws yog preferable tsis tsuas mus rau cov kws kho mob tab sis kuj rau cov neeg mob. Qhov no txoj kev muaj cov nram qab zoo:

1. Cov tau laug sij hawm mus cev xeeb tub. Vim lub fact tias cov oocytes thiab embryos uas khov rau ib ntev lub sij hawm (nyob ntawm seb qhov kev txiav txim ntawm ib tug poj niam).
2. Muaj peev xwm rov IVF txoj kev tsis muaj noj cov khoom nyob rau hauv lub thib ob (los yog xav paub ntxiv) lub sij hawm.
3. Muaj peev xwm xeeb tub tom qab phais rau qhov chaw mos qog, tawg thiab cov kws khomob.

Yuav ua li cas yog qhov txawv ntawm cov vitrification thiab cryopreservation ntawm qe?

Raws li yog lub npe hu, cov txheej txheem kriokenservatsii thiab vitrification ntawm oocytes yog heev uas zoo sib xws. Ob txoj kev no yog tsim rau khov ntawm oocytes thiab embryos nyob rau hauv thiaj li yuav tswj lawv cov nqi. Cuaj kaum, muaj ib co sib txawv. Feem ntau, tsis paub qab hau oocyte cryopreservation puas. Qhov no yog vim lub fact tias qhov no txoj kev yuav qeeb khov khoom. Raws li ib tug tshwm sim, lub kua cytoplasm hloov dua siab tshiab rau hauv cov dej khov muaju. Hais tias lawv puas cell phab ntsa. Ib qho zoo heev txoj kev cryopreservation ntawm oocytes yog vitrification. Feem Pua defrost thaum nqa tawm nws ntau sab, raws li cov cua txias ntawm lub qe tshwm sim yuav luag instantly. Qhov ntawd yog lub ntsiab qhov txawv ntawm cryopreservation yog suav hais tias tshiab technology kom muaj ntev oocytes nyob rau hauv ib tug zaum lub xeev. Yuav kom ncua conception rau ib ntev lub sij hawm ua tau tsuas yog txoj kev vitrification. Cryopreservation tsis muab tej kav ntev tau.

Yuav ua li cas yog IVF tom qab vitrification ntawm oocytes?

Oocyte vitrification yog nqa tawm qhov txhia chaw. Cia kom khov ntawm gametes thiab embryos rau ib ntev lub sij hawm koom xwb nyob rau hauv heev tshwj xeeb lub chaw soj nstuam. Yuav luag txhua txhua lub tsev kho mob nrog cov khoom no muaj ib tug bank ntawm pub oocytes vitrified. Thaum ib tug poj niam tau txiav txim siab los xav xeeb tub ib tug me nyuam, lub hlwb raug rhawv. Ces siv lub ICSI txheej txheem yog ua fertilization. Cov uas ua embryo yog raug kuaj (3-5 hnub) thiab implanted rau hauv ib tug npaj endometrium. Qhov seem hlwb yuav fertilized dua vitrified. Thaum ib qho los mus cog IVF txoj kev yog rov qab.

Vitrification ntawm oocytes: xyuas ntawm cov kws kho mob

Tam sim no, vitrification thiab cia ntawm oocytes thiab embryos yog ua nyob rau hauv tag nrho cov loj lub zos ntawm cov tsim cov tshuaj. Thaum no txoj kev tau raug kuaj thiab muaj pov thawj nws tus kheej, cov kws kho mob hais txog nws zoo, appreciating zoo dua lwm yam (ua ntej lawm) cia cov txheej txheem qe. Them taus khov lawv tus kheej oocytes ntau ntau cov poj niam. Tus txheej txheem cov nqi hais txog 12 txhiab rubles. Qhov no tus nqi yog rau vitrification. Tus nqi ntawm cov cia ntawm lub khov hlwb yog 1000 rubles ib lub hlis.