Tshuaj "Sibutin": cov lus qhia rau kev siv, kev piav qhia thiab kev txheeb xyuas

Yuav ua li cas thiab thaum tus neeg mob yog tshuaj "Sibutin"? Cov lus qhia rau kev siv, tiag tiag counterparts thiab indications rau siv hais me ntsis ntxiv. Cov tsab xov xwm tseem tham txog nyob tus yeees ntawm cov tshuaj, nws daim ntawv thiab tso tawm txwv rau kev siv.

Zoo, kev piav qhia thiab muaj pes tsawg leeg

Kev npaj "Sibutin", cov lus qhia rau kev siv uas yog qhia hauv qab no, yog ua nyob rau hauv daim ntawv ntawm cov dawb round ntsiav tshuaj nrog lub cim rau ntawm ib sab. Lawv active tshuaj yog oxybutynin (nyob rau hauv daim ntawv ntawm cov oxybutynin hydrochloride). Tsis tas li ntawd lub medicament muaj xws li adjunct cov khoom xyaw, raws li nyob rau hauv daim ntawv ntawm cov lactose monohydrate, microcrystalline cellulose, qos starch thiab calcium stearate.

Pharmacological thaj chaw ntawm cov tshuaj

Yuav ua li cas puas "Sibutin"? Cov lus qhia rau kev siv, tiag tiag cov kws kho mob qhia tias lub mechanism ntawm qhov kev txiav txim ntawm cov tshuaj no yog nkaus vim lub efficiency ntawm nws active tshuaj.

Raws li cov kws txawj, "Sibutin" nruab nrab blocker M-cholinergic receptors, teej tug mus rau cov pab pawg neeg ntawm tertiary amines. Nyob rau hauv view ntawm lub M-ntsis anticholinergic kev ua si, qhov kev kawm neeg sawv cev muaj peev xwm sawv ntawm ncaj qha kev cuam tshuam rau cov tus cov nqaij ntshiv ntawm viscera. Nyob rau tib lub sij hawm nws muaj antispasmodic thiab myotropic kev txiav txim. Nyob rau hauv lwm yam lus, cov tshuaj no eliminates chua, thiab thiaj li muaj nqaij suab nrov ntawm cov hauv qab no lub cev: lub biliary ib ntsuj av tau, mob huam, mob txeeb zig, lub tsev menyuam thiab lub zais zis. Nws yuav tsum tau borne nyob rau hauv lub siab hais tias nyob rau hauv cov neeg uas muaj neurogenic kawg kawg oxybutynin yog tau so lub detrusor, txo nws txawj lus, txo lub zaus ntawm tso zis, raws li zoo raws li kom lub peev xwm ntawm lub zais zis.

Kinetics ntawm yeeb tshuaj

Absorbed lus seb xws li "Sibutin"? Cov lus qhia rau kev siv (ib feem ntawm cov tshuaj twb teev saum toj no) qhia tias tom qab siv ntawm oxybutynin ntsiav tshuaj haum sai absorbed ntawm lub digestive ib ntsuj av.

Kev tshawb fawb tau qhia tias cov nyiaj pab ntau tshaj concentration ntawm lub caij nyob rau hauv cov ntshav yog hais txog 8-13 ng / ml. Qhov no xam yog raug rau noj tshuaj npaum cas ntawm 7-10 mg saws tub ntxhais hluas thiab noj qab nyob zoo neeg. Tsis tas li ntawd, muaj teeb meem loj neeg variation nyob rau hauv tus nqi ntawm cov oxybutynin nyob rau hauv cov ntshav.

Nyob rau hauv view ntawm cov thawj cov zaj ntawm lub siab, lub meej mauj bioavailability ntawm cov tshuaj yeeb dej caw yog hais txog 6.2%.

Lub ntsiab metabolite ntawm oxybutynin yog active desethyloxybutynin. Tsis tas li ntawd tsim nyob rau hauv lub transformation txheej txheem, thiab lwm yam derivatives xws li feniltsiklogeksiglikolevaya acid, txawm li cas los, lawv yog tsaug zog.

Hais txog 0,02% tau txais lub medicament yog tso tawm nyob rau hauv cov zis. Kev sib txuas lus oxybutynin rau albumin yog hais txog 83-86%, thiab lub sij hawm ntawm nws ib nrab-lub neej yog ob teev.

Heev siv cov tshuaj nws cia hnab khib yog tsawg.

Indications rau kev siv ntawm cov tshuaj

Thaum tus neeg mob yuav raug muab tso rau "Sibutin"? Cov lus qhia rau kev siv (indications yuav tau los sib tham li hauv qab no), nws hais tias cov tshuaj yog dav siv nyob rau hauv cov kev kho mob ntawm urinary incontinence, vim lub khov ntawm lub zais zis uas neurogenic xwm (e.g., detrusor hyperreflexia, spina bifida los yog ntau yam sclerosis) los yog muaj idiopathic xwm.

Nws yuav tsum tau muab sau tseg tias cov txhais tau tias tej zaum yuav qhia rau nocturnal enuresis nyob rau hauv cov me nyuam muaj hnub nyoog tsib xyoos. Rau lub hom phiaj no lub medicament yog siv nyob rau hauv monotherapy, thiab nyob rau hauv ua ke nrog nrog lwm yam tshuaj.

Txwv rau kev siv ntawm cov ntsiav tshuaj

Thaum tsis muab mus rau ib tug neeg mob tshuaj "Sibutin"? Cov lus qhia rau Siv lub xeev uas contraindications tau txais cov tshuaj no yog cov nram no hais tias:

• plob tsis so tswj rhuav txhua;
• Npau taws me ntsis rau txhais tau tias yam;
• plab hnyuv atony;
• qhia mob ua khiav ntawm cov zis los ntawm lub zais zis;
• myasthenia Heavy kev;
• ulcerative mob plab (mob loj heev);
• expansion ntawm cov nyuv;
• cev xeeb tub;
• glaucoma;
• kev pub niam mis;
• lub hnub nyoog ntawm tsib.

Tshuaj "Sibutin": cov lus qhia rau kev siv

Ntsiav tshuaj "Sibutin" muab feem ntau cov neeg laus. Lawv yuav tsum coj 5 mg peb zaug ib hnub twg. Cov laus cov neeg mob active tshuaj yog pom zoo siv nyob rau hauv ib tug npaum li ntawm 5 mg ib hnub ob zaug.

Nyob rau hauv tshwj xeeb no, qhov no tshuaj yog muab rau cov me nyuam nyob rau hauv lub hnub nyoog ntawm tsib lub xyoos. Nyob rau hauv kev ua txhaum ntawm lub zais zis neurogenic xwm ntawm cov tshuaj siv los ntawm 5 mg ib hnub ob zaug, thiab thaum hmo ntuj enuresis - 5 mg peb zaug ib hnub twg. Nyob rau hauv cov ntaub ntawv no, lub xeem koob tshuaj yuav tsum tau coj txoj cai ua ntej yuav mus pw.

phiv

Yuav ua li cas yog lub tshua ib tug tsis zoo tus cwj pwm yog ib yam tshuaj "Sibutin"? Cov lus qhia rau kev siv qhia tias feem ntau ntawm cov teebmeem tshwm sim nyob rau ib feem ntawm lub digestive ib ntsuj av. Raws li ib tug txoj cai, lawv yuav tshwm sim qhov ncauj qhuav, quav tawv, xeev siab, mob plab tsis xis nyob thiab raws plab.

Tsis tas li ntawd suav hais tias yog tshuaj yuav ua rau:

• mob taub hau, qhov muag plooj tsis pom kev, nkees nkees, dilated cov menyuam kawm ntawv, kiv taub hau, muaj zog intraocular siab;
• qhuav daim tawv nqaij;
• tides (tshwm sim mas nyob rau hauv cov me nyuam), urinary tuav, nyuaj tso zis, arrhythmia, txo hws.

tus neeg mob ntawm overdose

Yuav ua li cas cov tsos mob tshwm sim thaum siv yeeb tshuaj overdose "Sibutin"? Cov lus qhia nyob rau hauv daim ntawv thov hais tias xws li ces muaj xws li cov nram qab no: ntxhov siab vim, muaj zog heev ntawm kev phiv tshuaj, ntxhov siab, ua pa thiab lub plawv tsis ua hauj lwm, uas tsis muaj ntshav siab, psychosis, coma thiab tuag tes tuag taw ntawm ua pa nqaij.

Rau cov kev kho mob ntawm xws tej yam kev mob thov pais plab lavage, raws li zoo raws li tso dej thawj coj ntawm physostigmine.

Thaum qhia excitation los yog ntxhov siab vim cov neeg mob muab "Diazepam" (w / w, 10 mg) nyob rau hauv kub cev symptomatic txoj kev kho, tachycardia illustrates npaj "propranolol" (w / w) nrog urinary tuav ua hnab cug zis ntawm lub zais zis, thaum tuag tes tuag taw ntawm lub pa nqaij thiab kev loj hlob kurarepodobnymi nyhuv muab cua.

Yuav ua li cas nws ua num ua ke nrog lwm yam tshuaj?

Kuv yuav siv lwm txoj kev npaj "Sibutin"? Cov lus qhia ntawm daim ntawv thov ntawm neeg pab leg ntaubntawv, uas thaum ua ke nrog lwm yam tshuaj xam tau tias yog ib yam tshuaj tej zaum yuav ua rau muaj zog sab tshua. Feem ntau, xws li ib cov nyhuv yog muab sau thaum uas tau txais "Sibutina" nrog neeg uas muaj ib tug anticholinergic kev txiav txim.

Sedative tshuaj thiab ethanol yuav ua rau kom kiv taub hau thiab nkees nkees ua kom nrov loj.

Ua ke nrog cov kev txais neeg kawm "itraconazole" oxybutynin tsub kom lub concentration hauv cov ntshav.

thaum lub sij hawm cev xeeb tub

Puas yuav ua tau thaum lub sij hawm ntawm tus me nyuam tos kom siv cov tshuaj nyob rau hauv lo lus nug? Kev Nyab Xeeb nyob rau hauv kev siv "Sibutina" tsis tau tsim thaum lub sij hawm lub sij hawm no. Yog li ntawd, qhov no qeb ntawm cov neeg mob, hais tias txhais tau hais tias tsis tsa. Nws yuav tsum tau muab sau tseg tias oxybutynin yuav kis tau mus rau hauv niam cov kua mis, yog li ntawd nws yuav tsum tsis txhob siv thaum lub sij hawm lactation. Yog hais tias nws yog tseem tsim nyog, kev pub niam mis yuav tsum tau txiav.

Cov ntaub ntawv

Yuav ua li cas koj yuav tsum paub tus neeg mob ua ntej yuav siv ib yam tshuaj "Sibutin"? Cov lus qhia rau kev siv (analogues nram qab no) hais tias nrog huab ceev faj cov tshuaj yuav tsum tau muab impaired cov neeg laus cov neeg mob, thiab cov neeg mob uas mob heev ntawm ob lub raum thiab lub siab thiab Neuro dystonia.

Ib yam li nrog rau lwm cov anticholinergics, nyob rau hauv daim ntawv thov "Sibutina" ceev faj cov neeg uas hernia diaphragm (esophageal aperture), uas yog ua raws li los ntawm reflux esophagitis.

Tiv thaiv lub keeb kwm ntawm cov tshuaj no tej zaum yuav ua rau kom tus neeg mob lub soj ntsuam ces ntawm arrhythmias, hyperthyroidism, prostatic hypertrophy, coronary artery kab mob thiab lub plawv tsis ua hauj lwm, ib tug mob xwm.

Nce ambient kub thaum uas siv cov yeeb tshuaj muaj peev xwm ntxias ua npaws thiab kuj mob ntawm lub plawv (ua nyob rau hauv txo hws).

Cov neeg uas koom nyob rau hauv tej chaw ua hauj lwm, uas yuav tsum tau tshwj xeeb mloog thiab ceev ntawm cov tshuaj tiv thaiv, nws yog tsim nyog los ceeb toom hais tias cov kev kawm tshuaj yuav ua rau qhov muag plooj tsis pom kev thiab nkees nkees.

Xyuas thiab analogues

Analogues ntawm cov tshuaj nyob rau hauv kev saib xyuas no muaj raws li nram no: "Vesicare," "Detruzitol", "npau suav APO", "Spazmeks", "Driptan", "Zevesin", "Uroholum", "Urotol" thiab lwm tus neeg.

Xyuas txog qhov no medicament ua tau raws li ib tug ntau. Ib txhia neeg twb txaus siab nrog cov hauj lwm zoo ntawm cov tshuaj. Lawv hais tias cov tshuaj yuav pab tswj tso zis, xws li thaum hmo ntuj. Txawm li cas los, muaj coob tus neeg tsis txaus siab txog cov kev loj hlob ntawm mob taub hau thiab ua xua thiab lwm yam kev phiv tshuaj. Nyob rau hauv no hais txog, lawv yuav tsum hloov nws txhais tau tias kev ruaj ntseg analogues.