Cov tshuaj "Proksium": cov lus qhia rau kev siv, tiag tiag counterparts

Yuav ua li cas siv cov tshuaj "Proksium"? Cov lus qhia rau kev siv ntawm cov tshuaj no yog piav nyob rau hauv tsab xov xwm ntaub ntawv. Nyob rau hauv nws koj yuav nrhiav tau cov lus qhia txog daim ntawv nyob rau hauv uas hais tias medicament yog ua, yog hais tias nws muaj tej yam analogues nyob rau hauv uas thiaj nws tau raug tsa thiab thiaj li nyob.

Tus duab, ntim, muaj pes tsawg leeg cov tshuaj

Nyob rau hauv dab tsi daim ntawv nws yog ua yog ib tug yeeb tshuaj raws li "Proksium"? Cov lus qhia rau kev siv qhia tias cov tshuaj no yog muaj raws li ib tug dawb cov ntsiav tshuaj nyob rau hauv cov duab los qhia packs, raws li zoo raws li ib tug lyophilizate nrog ampoule ntawm hnyav (10 mL).

Tus thawj daim ntawv ntawm cov tshuaj nws tus kheej muaj ib tug pantoprazole (40 mg), raws li zoo raws li ntxiv yam khoom. Nrog kev hwm rau lub minyuam lam fwj tshuaj ntawm lyophilizate, ces nws kuj muaj xws li 40 mg ntawm active ingredient + sodium hydroxide.

Pharmacodynamics medicament

Yuav ua li cas nta muaj cov tshuaj "Proksium"? Cov lus qhia rau kev siv qhia hais tias qhov no anti-rwj thiab antisecretory agents.

Tom qab noj cov tshuaj hauv nws blocks zus tau tej cov hydrochloric acid. Qhov no tshwm sim raws li ib tug tshwm sim ntawm inhibiting qhov kev txiav txim ntawm ib tug proton thov, uas yog nyob rau hauv lub parenteral hlwb ntawm lub plab.

Lub active tshuaj tshuaj uas muaj peev xwm ntawm kev txo basal thiab pentagastrin-tsa enzyme, khoom noj khoom haus thiab insulin, pais plab tso pa tawm. Nyob rau hauv tas li ntawd, cov tshuaj cheeb qhov uas cov tseem ceeb heev kev ua si ntawm cov kab mob Helicobacter pylori. Raws li nws yog lub npe hu, nrog nws cov active tu tub tu kiv attribute lub tsim ntawm ulcers thiab erosions nyob rau hauv lub qog ua kua week ntawm lub plab phab ntsa.

Nyob rau hauv tas li ntawd mus rau saum toj, suav hais tias cov tshuaj yuav tsub kom lub miv nyuas siv zug ntawm lwm yam antimicrobial agents.

Tshuaj ntawm cov tshuaj

Yuav ua li cas cov tshuaj muaj pharmacokinetic zog "Proksium"? Cov lus qhia rau kev siv yuav tau qhia rau cov neeg mob txog qhov tseeb hais tias tom qab cov thawj koob tshuaj ntawm cov tshuaj cov nyhuv yog tsim sai heev thiab kav rau hnub.

Qhov siab tshaj plaws cov ntsiab lus ntawm cov tshuaj nyob rau hauv cov ntshav ntshav cai plaub teev tom qab tau txais cov txheej txheem ntau npaum ntawm 40 mg. Lub degree ntawm coupling nrog cov nqaijrog 98%. Lub ib nrab-lub neej sij hawm ntawm cov tshuaj nce mus txog ob teev.

Muab tshuaj los ntawm ob lub raum thiab cov hnyuv.

Pantoprazole yog absorbed rau hauv lub me me hnyuv. Lub bioavailability ntawm cov tshuaj yeeb dej caw yog kwv yees li 75%.

Metabolism hauv cov tshuaj active muaj nyob rau hauv lub siab. Thaum zoo li no tshwm sim rau hauv lub conjugation cov tshuaj tiv thaiv, dealkylation thiab oxidation nrog lawv koom tes los ntawm ib qho enzyme xws li cytochrome P450.

Peb kuj yuav tsum nco ntsoov tias qhov suav hais tias cov tshuaj tau yooj yim crosses cov ntshav-hlwb barrier. Tsis tas li ntawd, nws stands nrog leej niam cov kua mis.

Nyob rau hauv cov neeg laus, cov ntshav concentration thiab bioavailability ntawm cov tshuaj yog ntau tshaj nyob rau hauv yau cov neeg mob.

Nyob rau hauv lub xub ntiag ntawm mob npuas paug tshuaj yuav outputted rau 9 teev.

Thaum muab?

Tam sim no koj paub yuav ua li cas cov tshuaj "Proksium". Cov lus qhia rau kev siv, xyuas txog cov tshuaj yuav qhia tau tias nws cov indications rau siv xws li cov nram qab no cov kab mob:

• plab ulcers thiab 12 duodenal rwj (xws li lub sij hawm ntawm exacerbation);
• kev kho mob ntawm cov kab mob Helicobacter pylori (yuav tsuas ib feem ntawm txoj kev kho);
• reflux esophagitis thiab Zollinger-Ellison syndrome;
• muaj zog zus ntawm pais plab kua txiv;
• ib tug me me daim ntawv ntawm reflux esophagitis.

Koj yuav tsis thov

tej contraindications muaj ib tug yeeb tshuaj raws li "Proksium" (ntsiav tshuaj)? Cov lus qhia rau kev siv yuav tau qhia rau cov neeg mob uas daim ntawv no ntawm cov tshuaj nyob rau hauv txhua rooj plaub yuav tsum tsis txhob muab yog hais tias:

• hepatic tsis ua hauj lwm, mob;
• cev xeeb tub;
• malignancies nyob rau hauv nruab nrog cev ntawm tus mob huam;
• kev pub niam mis;
• tsis haum rau cov tshuaj Cheebtsam;
• cov me nyuam nyob rau hauv 14 lub xyoos.

Nrog kev hwm rau cov tshuaj nyob rau hauv vials, nws yog tsis pom zoo rau cov neeg mob uas tsis haum tshuaj loj rau "Pantoprazole". Nyob rau hauv tas li ntawd, qhov no daim ntawv ntawm cov tshuaj nyob rau hauv txhua rooj plaub yuav tsis tau ua ke nrog lub "ATV".

Ntsiav tshuaj "Proksium": cov lus qhia rau kev siv

Analogs ntawm lub anti-rwj tshuaj yuav tsum tau muab nthuav rau ntawm qhov kawg ntawm tsab xov xwm. Nyob rau hauv seem no, peb yuav qhia rau koj txog yuav ua li cas cov tshuaj no yuav tsum tau coj nyob rau hauv tej yam kab mob.

Nyob rau hauv appointing cov tshuaj "Proksium" feem ntau cov kws kho mob preferring cov ntsiav tshuaj daim ntawv. Yog hais tias tus neeg mob muaj kev nyuaj nqos, ces nws muab tshuaj.

Cov tshuaj ntawm cov tshuaj, raws li zoo raws li lub tau txais hom yuav tsum tau txiav txim los ntawm koj tus kws kho mob nkaus xwb.

Yog li ntawd yuav ua li cas coj cov tshuaj "Proksium 40"? Instruction (marketed ntsiav tshuaj txhais tau tias tag nrho cov khw muag tshuaj) hais tias pom zoo ntau npaum ntawm cov tshuaj yog 40 mg ib hnub twg. Cov tshuaj noj thaum lub sij hawm los yog tom qab noj mov, haus dej kom ntau.

Thaum diagnosing pais plab rwj los yog yaig txhua txhua hnub koob tshuaj ntau zog rau 80 mg.

Rau cov kev kho mob ntawm 12 duodenal rwj tshuaj noj rau 15-30 hnub. Raws li rau reflux esophagitis, thiab pais plab ulcers, cov kev kho mob ntawm cov kab mob xws yuav tsum tau tsis muaj ntau tshaj li 2 lub hlis.

Yuav kom tshem tawm cov Helicobacter pylori cov kab mob tus neeg mob 1 ntsiav tshuaj ib hnub ob zaug. Lub caij ntawm qhov kev kho no yog 2 lub lis piam.

Cov neeg mob kev txom nyem los ntawm lub raum tsis ua hauj lwm, raws li zoo raws li cov neeg laus cov neeg txhua hnub ntau npaum yog tsis muab ntau tshaj 40 mg.

Thaum lub siab tsis ua hauj lwm thiab mob siab mob npuas paug tshuaj yog tau tso cai rau noj 1 lub tshuaj txhua txhua lwm hnub.

Cov tshuaj "Proksium": cov lus qhia rau kev siv

Lub ampoules xws npaj kws kho rau qhov ncauj thawj coj tsis yooj yim sua.

Mus rau hauv lub minyuam lam fwj tshuaj uas muaj qhov lyophilisate yog poured mus rau hauv 10 ml ntawm ib lub cev tov. Ib txhia kws txawj pom zoo xws li ib tug yeeb tshuaj yog ntxiv tov nrog 100 ml ntawm 5% zib tov.

Tso dej Txoj kev lis ntshav yuav tsum tau kav tsawg kawg yog ob feeb (dua li hais txog ¼ teev).

Cov tshuaj tov yuav tsum tau siv tam sim ntawd tom qab kev twb kev txuas ntawm tag nrho cov Cheebtsam. Yog hais tias qhov no yog tsis yuav tsum tau, ces cov tshuaj yuav tsum tau muab tso rau hauv ib tug txias chamber thiab thov tsis pub dhau 12 teev.

Lub caij ntawm txoj kev kho kom medicament zoo xws li cov ntsiav tshuaj daim ntawv. Qhov siab tshaj plaws lub sij hawm ntawm kev kho mob - 2 lub hlis.

Nyob rau hauv xws mob raws li reflux esophagitis, cov tshuaj yog muab nyob rau hauv ib tug npaum li ntawm ib tug raj mis txhua txhua hnub.

Rau cov kev kho mob ntawm los ntshav uas tshwm sim nyob rau ib lub rwj 12 duodenal rwj thiab lub plab mob cancer li zoo raws li rau kev tiv thaiv ntawm rov, cov tshuaj no yog siv nrog 80 ml ntawm intravenously (bolus).

Introduction ntawm cov tshuaj no qhia infusomats siv 8 mg ib teev.

Thaum Zollinger-Ellison syndrome thiab hypersecretion medicament tshuaj 80 mg. tus kws kho mob tej zaum yuav ua rau kom cov tshuaj mus rau 160 mg yog tias tsim nyog. Nyob rau hauv cov ntaub ntawv no, nws yuav tsum tau faib ua 2 koob tshuaj.

Yuav kom sai sai txo lub acidity ntawm pais plab kua txiv, feem ntau yog siv 80 mg ntawm cov tshuaj ib hnub ob zaug.

tus neeg mob ntawm overdose

Yuav ua li cas cov tsos mob tshwm sim thaum ntau dua koob tshuaj "Proksium" tshuaj (40 mg)? Phau ntawv hais tias tam sim no xws li mob muaj cov tsis muaj cov lus.

Thaum muab cov tshuaj intravenously (nyiaj pab ntau tshaj 240 mg) yog zam lub txim zoo heev. Yog hais tias koj siv ib tug loj npaum li cas ntawm cov tshuaj, nws yog tsim nyog los thov tus txij nkawm thiab detoxification txoj kev kho.

Kws txawj hais tias ib tug overdose "Proksium" tshuaj tej zaum yuav ua rau kom lub dag lub zog thiab zaus ntawm cov kev phiv. Nyob rau hauv cov ntaub ntawv no, tsis txhob noj cov ntsiav tshuaj.

phiv tshua

Yuav ua li cas pliaj los tej zaum yuav tshwm sim nyob rau hauv cov neeg mob uas tau txais "Proksium 40" tshuaj? Instruction hais tias kev siv ntawm no lub cuab tam feem ntau tau nyob rau hauv:

• cem quav, mob nyob rau hauv lub plab mog, raws plab thiab flatulence;
• cephalgia.

Tej zaum, cov neeg mob yuav:

• khaus thiab daim tawv nqaij ua pob ua xyua;
• ntuav;
• arthralgia;
• dryness ntawm txheej week;
• nce qab los noj mov;
• belching;
• Angioedema;
• tsis muaj zog thiab nkees nkees;
• kiv taub hau.

Tsis tas li ntawd, tus neeg mob hauv qab no txawv txav tau qhia tias lawv:

• kev nyuaj siab, myalgia, Lyell syndrome, tawm pob, Stevens-Johnson syndrome;
• nce kev ua ntawm daim siab enzymes, jaundice, puas hepatocytes, kub taub hau, nephritis;
• rhiab heev mus rau lub teeb, thrombocytopenia, leukopenia;
• thrombophlebitis (hais txog cov tshuaj no tshwm sim ntawm lub qhov koob);
• co, nervousness, txo nyob rau hauv lub rooj sib hais thiab pom kev;
• pob txuv, alopecia, hyperglycaemia.

tshuaj cov kev sib tshuam

Uas thaj chaw ntawm cov tshuaj rau tus neeg mob kom paub ua ntej koj noj cov tshuaj "Proksium"? no txhais tau tias cov kev qhia ntawv qhia cov nram qab no nta:

• Saib cov tshuaj yuav tag nrho nrog rau lub "Diclofenac" caffeine "glibenclamide" ethanol "phenytoin", "metoprolol", "diazepam" "nifedipine", "carbamazepine" "theophylline", "digoxin" thiab contraceptive hormonal agents "naproxen" thiab "digoxin".
• Nws yog undesirable coj lub cuab tam nrog rau cov "ATV".
• Tej anticoagulants yog coumarin li "phenprocoumon" thiab "warfarin" nyob rau hauv ua ke nrog nrog "Proksiumom" tej zaum yuav ua rau ib tug txo nyob rau hauv PB.
• Tsis clinically tseem ceeb tshuaj cov kev sib tshuam uas muaj "metronidazole", "amoxicillin" thiab "clarithromycin" tau lawm tias.
• Pantoprazole thiaj li absorbability ntawm cov tshuaj, lub bioavailability uas ncaj qha influences lub pH nqi ntawm cov pais plab kua txiv (piv txwv li, "Posaconazole", "ketoconazole" "Itraconazole" "Atazanavir", "Erlotinib").
• Ua ke nrog nrog qhov suav hais tias medicament "MTX" feem ntau ua rau ib qho kev nce nyob rau hauv lub caij nyoog kawg no toxicity.

tej tswv yim pom zoo

Uas nta ntawm cov tshuaj yuav tsum qhia rau tus kws kho mob ua ntej koj muab koj tus neeg mob xws cov tshuaj raws li "Proksium" (ntsiav tshuaj)? Cov kev cai annexed mus no medicament, yuav tsum tau nyeem. Nws tau hais tias cov tshuaj no yog txwv tsis pub nqa mus siv rau cov neeg uas muaj lub paj hlwb dyspepsia.

Thaum tau txais cov tshuaj rau ntau tshaj peb lub hlis, tus neeg mob tej zaum yuav tsim hypomagnesemia. Cov cim ntawm tus kab mob no yog: tu-sauv, qaug zog, tetany, fem, kiv taub hau thiab ventricular arrhythmia. Nyob rau hauv cov kev tshwm sim ntawm tej tsos mob cov tshuaj yuav tsum tau abolished thiab tam sim ntawd nrog koj tus kws kho mob.

Ua ntej kev kho mob thiab tom qab nws kaw gastroendoscope tas nqa tawm los mus txiav txim hauv lub xeev ntawm cov hnyuv. Nws yuav tsum tau borne nyob rau hauv lub siab hais tias pantoprazole yuav ua tau heev yooj yim mus npog tej yam tshwm sim ntawm malignancy.

Qhov siab tshaj plaws tshuaj ib hnub twg rau cov neeg laus thiab rau cov neeg mob uas mob nyob rau hauv lub raum ntawm 40 mg. Rau cov neeg mob uas mob npuas paug txhua hnub ntau npaum li cas ntawm cov tshuaj yuav tsum tau txo los ntawm ib nrab.

Therapy deals nrog cov txhais tau tias, nyob rau hauv uas tsis tshua muaj mob, ua rau txoj kev loj hlob ntawm campylobacteriosis thiab salmonellosis.

Proton twj tso kua mis inhibitors kom kev pheej hmoo ntawm cov pob txha lov nyob rau hauv cov neeg laus los ntawm hais txog 30% (long-term kev kho mob).

Analogs thiab txhais cov tshuaj

Tam sim no koj paub tias dab tsi yog thiab yuav ua li cas coj cov tshuaj "Proksium". kev siv lub txhais tau tias ntawm kev qhia ntawv tau piav nyob rau hauv kom meej saum toj no.

Yog hais tias yog vim li cas cov tshuaj tsis haum koj, nws yuav tsum tau hloov los ntawm xws li ntau counterparts, raws li cov "Barolo", "Emanera", "Geerdin", "esomeprazole", "Diaprazol", "Ortanol", "Nexium", " rabeprazole, "" Veloz "," Sanpraz "," lansoprazole "," Ezolong "," Gasek "," Ultop "," Deksilant "" Pariet "," Zulbeks "," omeprazole "," Omelik "," Ozol " "Losek", "Omez", "Epicurus", "Omealoks".

Tsis tas li ntawd, cov tshuaj "Proksium" txhais tau tias muaj tshuaj-txhais "Kontrolok", "Pantazi", "Panzol", "Panum", "Nolpaza", "Penta", "Pantex", "Pultset", "Ultera".

Xyuas ntawm medicament

Zoo tag nrho cov kev xyuas txog cov tshuaj no yog zoo. Cov neeg mob hais tias cov tshuaj "Proksium" txhawb sai kho ntawm erosions thiab ulcers, raws li zoo raws li tiv thaiv tau qhov kev loj hlob ntawm relapse.

Raws li kev phiv, feem ntau manifested neeg mob muaj xws li xeev siab thiab teeb meem nrog ib lub rooj zaum.