Ntshav-hlwb barrier

Tam sim no, ib tug tseem ceeb kev faib ua feem ntawm tag nrho cov qhov txhab ntawm poob siab system ntawm ib tug neeg yog koom kev raug mob. Thiab tsuas yog ib feem me me ntawm lub qhov txhab ncaj qha ua rau central lub paj hlwb cov kab mob.

Nyob rau hauv view ntawm ib co ntawm nws cov nta lub paj hlwb yog heev nthuav los ntawm lub scientific point of view. Qhov no yog hais tias lub cev ntawm lub hauv paus poob siab system yog heev kom to taub. Roos nws lub hauv paus paj fibers muaj lawv tus kheej, sib txawv los ntawm lwm cov tib neeg ntaub so ntswg, qauv.

Ib tug ntawm cov yam ntxwv tseem ceeb ntawm neural cov ntaub so ntswg yog heev tsawg muaj peev xwm mus tsim dua tshiab. Nws tsis yog hais tias puas qab haus huv tsis tsim dua tshiab, tab sis lawv rov qab yog qeeb heev thiab yuav tsum tau tej yam tej yam kev mob.

Lwm feature ntawm poob siab system nyob rau hauv Feem ntau, thiab nyob rau hauv particular lub Cns yog cov ntshav-hlwb barrier (BBB).

Nws yog tsis muaj daim card uas lub hlwb thiab tus txha caj qaum yog tshwj xeeb kua zoo xws li cov nyob rau hauv muaj pes tsawg leeg rau ib physiological saline daws, tab sis nws txawv ntawm cov ntsiab lus ntawm cov ntau yam zauv feem ntawm cov nqaijrog thiab micronutrients. Hlwb txha nqaj qaum (los yog hlwb txha nqaj qaum) kua yog tsim los ntawm cov ntshav thiab lymph nyob rau hauv tshwj xeeb "lim", uas ua lub luag hauj lwm ntawm cov ntshav-hlwb barrier.

Tshwj xeeb hlwb mezhendotelialnymi hu tiv thaiv lub nkag mus ntawm cov ntshav hlwb nyob rau hauv cov kua. Niaj hnub no, zaum tau tsis qoos figured tawm yuav ua li cas cov kev cai ntawm lub pom barrier muaj peev xwm, tab sis nws yog lub npe hu hais tias lub peev xwm ntawm nws muaj peev xwm hloov nrog lub metabolic kev ua si ntawm lub paj hlwb. Nyob rau hauv tas li ntawd, cov ntshav-hlwb barrier muaj sib txawv nyob rau hauv sib txawv thaj tsam ntawm lub hlwb, uas ua rau ua nws muaj peev xwm rau filtering kua (ntshav thiab lymph).

Kev tshawb fawb tau qhia tias ib txhia tshuaj txeem tau cov BBB feem ntau ntawm cov hlab ntsha, lawv lwm tus ib feem - ntawm lub hlab ntsha ntawm lub lymphatic system, thiab lwm tus yuav tuaj los ntawm ob xov xwm nyob rau tib lub ceev. En, thiab ib tug tshwj xeeb system ntawm nws tus kheej unexplored kom txog thaum lub muaj pes tsawg leeg muab tus me nyuam ntawm hlwb txha nqaj qaum kua tshuaj nyob rau hauv ib tug npaum li uas yog tsim nyog rau lub hauv paus poob siab system. Qhov no tshwm sim nrog cov kev cai ntawm qhov ntim ntawm cov kua feem, tus nqi thiab muaj pes tsawg leeg protein ntau, raws li zoo raws li nyob tus yeees ntawm cov ions (tus tom kawg sawv cev poov tshuaj thiab sodium).

Vim li cas peb yuav tsum tau rau cov ntshav-hlwb barrier?

Feem ntau qhov kev txiav txim ncaj qha mus rau ib tug raug rho tawm tej kev sib hwm mus rau lub central lub paj hlwb, tab sis kuj nws ua ib tug tiv nuj nqi, tiv thaiv allergic rau hauv lub CSF cov kab mob thiab cov kab mob los ntawm cov hlab ntsha los yog qog. Nws yog ib qho tseem ceeb kom to taub tias nyob rau hauv cov kev tshwm sim ntawm irregularities nyob rau hauv hauj lwm ntawm lub BBB zoo yuav loj heev. Yog li, cov kab mob penetrated rau hauv lub hlwb txha nqaj qaum kua ua rau daim npog hlwb, encephalitis, thiab lwm yam mob hauv lub meninges thiab lub hlwb ntaub so ntswg.

Ob peb cov kev tshawb fawb ua los ntawm cov neeg ua hauj lwm, ua tau los txhawb lub bandwidth ntawm cov ntshav hlwb barrier ntau yam npaj. Sib nrug los ntawm hais tias, cov tshuaj siv los mus taw qhia yav tas los pib no feature. Niaj hnub no, cov kws kho mob yog zoo dua lub npe hu li cas cov tshuaj thiab yuav ua li cas lawv muaj kev cuam tshuam cov BBB. Ntxiv mus, peb tau kawm siv cov thaj chaw rau cov kev pab ntawm tus txiv neej.

Yog li, cov ntshav-hlwb barrier muaj ib tug xov tooj ntawm tseem ceeb heev functions uas txhawb qhov kev pom mob ntawm lub sab hauv lub nruab nrog cev chelvoechesokgo. Txawm li cas los, nws yuav tsum tau to taub hais tias tej nta ntawm lub barrier kom nws rhiab heev rau ob leeg qhov kev raug mob thiab ntau yam pathological tej yam kev mob, uas yog vim li cas nws yog li ntawd ib qho tseem ceeb kom nkag siab txog thiab xav txog cov yam nyob rau hauv cov kev tiv thaiv thiab kev kho mob ntawm cov kab mob.