Cov tshuaj "Atokor": phau ntawv qhia, analogue thiab xyuas

High cholesterol theem nyob rau hauv cov ntshav muaj txhawb rau txoj kev loj hlob ntawm atherosclerosis thiab lub plawv tus kab mob txheej txheem.

Rau nqa lipid txos kev kho mob siv tshwj xeeb txhais tau tias, ib tug uas yog cov tshuaj "Atokor". Cov lus qhia nyob rau hauv yam tshuaj no piav qhia txog nws hypocholesterolemic thiab gipotriglitseridemicheskuyu luag hauj lwm nyob rau hauv txo lub concentration ntawm cov teeb meem cholesterol thiab lwm cov rog hauv tib neeg lub cev.

General yam ntxwv

Cov tshuaj hais txog inhibitors ntawm 3-methylglutaryl-3-hydroxy-CoA reductase. "Dr. Reddy lub chaw soj nstuam" yog ua los ntawm ib tug Indian lub tuam txhab.

Nyob rau hauv kev npaj "Atokor" ntau npaum tej zaum yuav 0,020 thiab 0,010 g

tso tawm daim ntawv

Ua neeg sawv cev nyob rau hauv cov ntsiav tshuaj daim ntawv coated nrog ib tug dawb zaj duab xis. Ntsiav tshuaj extruded nyob rau hauv ib tug daim duab peb sab zoo nrog biconvex chaw rau ib qho ntawm uas cov tsab ntawv "A" yog thov, thiab lwm yam yog xws li ib koob tshuaj "10" los yog "20".

qauv

Lub active ingredient ntawm cov tshuaj yog atorvastatin, uas yog sawv cev los ntawm micronized calcium trihydrate. Nyob rau hauv cov tshuaj "Atokor" ntau npaum thiab muaj pes tsawg leeg ntawm ntau yam kom nquag plias khoom sib ua zaub mov txawv me ntsis. Txhua 0,01084 los yog 0,02168 g ntawm atorvastatin calcium trihydrate sib npaug rau 0.01 los yog 0,02 g ntawm ntshiab atorvastatin.

Mis qab zib, calcium carbonate, croscarmellose sodium, polysorbate 80, hydroxypropyl cellulose, lactose DT, magnesium stearate cov ntsiav tshuaj tsim qauv.

Lub casing zaj duab xis tsim los ntawm hypromellose 15 CPS, propylene glycol, purified talc, titanium dioxide.

Cov tib yam rau ob leeg koob tshuaj txhais tau tias "Atokor" muaj pes tsawg leeg, thiab coj lawv tag nrho.

Ntsiav tshuaj ntawm 0.01 los yog 0,02 g ntawm 10 pieces uas manufactured nyob rau hauv ib tug sawv hlwv fej nyob rau hauv ib tug cardboard lub thawv.

mechanism ntawm qhov kev txiav txim

Tshuaj kev qhia ntawv nyob hauv daim ntawv thov koom rau cov xim, kev sib tw retarders 3-methylglutaryl-3-hydroxy-kofermentaA reductase. Nws yog ib qho tseem ceeb enzyme rau lub hloov dua siab tshiab ntawm ib tug compound 3-hydroxy-3-metilglyutarilkoenzima A rau mevalonic acid uas precedes styrenes thiab roj uas txhaws taus.

Yog hais tias cov neeg mob ntawm hypercholesterolemia, homozygous heterozygous familial thiab uas tsis yog-familial hom, thiab mixed dyslipidemia, cov tshuaj kom tsawg "Atokor" yuav pab txo tag nrho cov roj uas txhaws, cholesterol hais nyob rau hauv lub lipoproteins ntawm tsawg thiab tsis tshua muaj heev ceev, triglycerides thiab apolipoprotein B.

Medicament "Atokor" piav qhia txog cov tshuaj qhia ib tug muaj peev xwm rau tsis ruaj tsis khov ntsiav tshuaj pab ua rau kom cov theem ntawm sterol nyob rau hauv lipoproteins nrog kev kub ceev.

Nyob rau hauv mob hlwb, thiab triglycerides holesterolovye molecules ua ib feem ntawm lub lipoprotein tshuaj muaj zog uas tsis muaj kev ceev. Lawv raug txib mus cov ntshav, uas txeem mus rau hauv lub peripheral cov ntaub so ntswg. Ntawm cov tebchaw tsim lipoprotein tsawg saturation tau tshwmsim cov tshuaj tiv thaiv uas muaj affinity receptor hom formations. Tag nrho cov ntawm cov tshuaj yuav txhim khu kev loj hlob ntawm atherosclerotic kab mob.

Action Atorvastatin yog yus muaj los ntawm ib tug ntaus cim thiab pheej nce nyob rau hauv lub efficiency ntawm lub LDL-receptor ceg, kom txhob muaj teeb meem cholesterol ntau ntawm kom hypercholesterolemia ntawm homozygous raws roj ntsha yam.

Txhais tau hais tias "Atokor" qhia hais nws muaj peev xwm txo ntshav cholesterol ntau ntau thiab lipoprotein los ntawm inhibiting HMG-CoA reductase enzyme. Nws slows cia lub tsim ntawm roj uas txhaws taus nyob rau hauv lub mob hlwb, tsub kom lub xov tooj ntawm receptor formations ntawm lipoproteins nrog tsawg saturation nyob rau hauv lub cell week. Qhov no pab tau capture thiab catabolism roj uas txhaws taus los ntawm cov lipoprotein molecules ntawm tsawg concentration.

Yuav ua li cas yog siv

Medicament "Atokor" Neeg Daim Ntawv Thov tswv yim noj cov ntsiav tshuaj ntawm thawj cim uas muaj zog cholesterolemia heterozygous hom, hauv zos thiab uas tsis yog-lub zos ua cholesterol concentration, mixed geterlipidemii, nce tus nqi ntawm ntshav triglyceride molecules.

Lawv muab nyob rau hauv ua ke nrog nrog kev noj haus qhia rau txos siab cholesterol theem nyob rau hauv lub lipoproteins nrog tsawg saturation, apolipoprotein B thiab triglyceride tebchaw.

Ntsiav tshuaj txo cov ntshav concentration ntawm cholesterol nyob rau hauv LDL cholesterolemia ntawm tsa homozygous familial hom, thaum lub kev noj haus cov zaub mov thiab lwm yam uas tsis yog-pharmacological txoj kev tawg paj txi txiv.

Yuav ua li cas mus noj

Medicament "Atokor" cov lus qhia rau kev siv xav haus tsuas yog tom qab lub sij hawm teem ntawm tus txheem hypocholesterolemic noj cov zaub mov neeg mob, uas yuav tsum tau siv thaum lub sij hawm txoj kev kho. Dosing yog teem nyias rau txhua tus neeg mob, uas yog xam rau cov thawj theem ntawm cov roj uas txhaws nyob rau hauv lipoproteins nrog tsawg saturation. Nws yog ib qho tseem ceeb coj mus rau hauv tus account lub npaj siv, cov hauj lwm zoo ntawm txoj kev kho nrog "Atokor 'zaj lus tim khawv.

Feem ntau, thawj zaug ntau npaum yog sib npaug 0.010 g ntawm ib lub sij hawm ib hnub twg. Cov kev siv ntawm cov ntsiav tshuaj tsis yog nyob rau lub sij hawm ntawm ib hnub thiab zaub mov noj.

Cov tshuaj txhua hnub txhais tau hais tias ntawm 0,010 mus 0,080 g yog xaiv los ntawm cov thawj accounting ntsuas ntawm teeb meem cholesterol, lub hom phiaj thaj chaw thiab tus kheej hauj lwm zoo. Nyob rau hauv thawj zaug rau theem ntawm daim ntawv thov thiab los ntawm nce lub concentration ntawm cov tshuaj yuav tsum tau ib nrab ib lub hlis mus saib cov theem ntawm ntshav muaj roj, thiab kho cov koob tshuaj raws li tsim nyog.

Primary hypercholesterolemia thiab ua ke hyperlipidemia cim kho txhua txhua hnub ntau npaum nyob rau hauv 0,010 g

Therapeutic ua si tshwm sim tsis pub dhau 14 hnub, thiab lub siab tshaj plaws efficiency yog sai tau tom qab ib lub hlis. Heev siv ua rau nws ua tau rau kom muaj kho nyhuv.

Cov tshuaj "Atokor" nyob rau hauv Lavxias teb sab txhais tes muaj cov lus qhia rau terapiigiperholesterinemii ntawm homozygous familial hom. Feem ntau, cov tshuaj txhua txhua hnub ntau npaum nyob rau hauv 0.080 g Nyob rau hauv no siv yog ib tug txo nyob rau hauv LDL roj uas txhaws taus qhov tseem ceeb txog li 40%.

Nta ntawm kev kho mob

Cov ntsiav tshuaj "Atokor cov lus qhia rau kev siv yog xav pom zoo kom ua ntej pib siv cov tshuaj yuav tsum nrhiav qhov ua rau ntawm ib theem nce ntawm cov roj uas txhaws qhov tseem ceeb. Tej yam zoo xws li mob ntshav qab zib, cov neeg pluag kev kho mob ntawm cov ntshav qab zib, hypothyroidism, nephrotic txheej txheem disproteinemicheskih hloov, obstructive mob siab. Qhov no yuav muaj xws li ntxiv kev kho mob nrog rau lwm cov tshuaj thiab haus dej haus cawv yees. Tsuas yog tom qab tau txais tshem ntawm lub saum toj no yog vim li cas, koj yog npaj los siv cov ntsiav tshuaj "Atokor".

Txawm tias ua ntej txoj kev kho yog ua kev txiav txim ntawm lipid nqi koj tshuav ntawm lub tag nrho cov roj uas txhaws, LDL roj uas txhaws taus nyob rau hauv nyob rau hauv roj HDL thiab triglycerides.

Yog tsis muaj cov ntaub ntawv nyob rau kev siv ntawm cov tshuaj nyob rau hauv tus xyuas pejxeem, yog li no cov ntsiav tshuaj yog tsis qhia rau cov me nyuam.

Nyob rau hauv cov kev kho mob ntawm cov neeg laus cov neeg mob, uas nws muaj hnub nyoog yog tshaj 60 xyoo, yog ib qho kev nce rau hauv ntshav theem ntawm lub active neeg sawv cev ib feem rau 40%.

Nyob rau hauv cov ntaub ntawv ntawm ua txhaum ntawm lub raum hauj lwm yog tsis tsim nyog yuav tau kho cov koob tshuaj, raws li tus mob no tsis cuam tshuam rau atorvastatinovoe cov ntsiab lus nyob rau hauv cov hlab ntsha thiab cov hauj lwm zoo ntawm tej cov cholesterol.

Muaj pov thawj hais tias cov kev siv ntawm cov hoob kawm no ntawm tshuaj ua txoj kev loj hlob rabdomioliznoy myopathy thiab txaus los khi lub raum muaj nuj nqi nyob rau hauv ib tug mob daim ntawv. Nyob rau hauv cov kab mob los ntawm tshuaj yuav tsum tau muab pov tseg thaum lub sij hawm.

Npaj rau lub hauv paus ntawm atorvastatin yuav tsum tau coj kom zoo rau cov neeg uas tsim txom lawv haus dej haus cawv los yog tau muaj daim siab tus kab mob nyob rau hauv lub dhau los lawm.

Qhov kev txiav txim ntawm inhibitors ntawm HMG-CoA reductase enzyme tej zaum yuav hloov nyob rau hauv biochemical kev ntsuas ntawm lub siab muaj nuj nqi. Rau raws sij hawm installation ntawm xws ua txhaum yuav tsum ua kev luj xyuas ntawm hepatic kev ua si, thiab ces 3 lub hlis tom qab noj cov tshuaj nqa tawm ib daim tshev ua ntej rau kev kho mob.

Tshuaj "Atokor" rau Lavxias teb sab kev qhia ntawv muaj cov ntaub ntawv hais txog ib tug ntaus cim nce nyob rau hauv ntshav tseem ceeb ntawm cov active muaj nyob rau hauv cov neeg mob uas ua daim siab mob, uas raug kev txom nyem los ntawm alcoholism. Ib ntus los yog tiav tsis ua hauj lwm ntawm txoj kev kho rov siab transaminase kev ua si nyob rau hauv tus thawj ncej. Muaj ntau cov neeg mob tsis tshem cov kev siv ntawm cov tshuaj nyob rau hauv me me koob tshuaj, thiab tsis muaj kev phiv tshuaj muaj arisen.

Nyob rau hauv cov kev kho mob tej zaum yuav xav tias kiv taub hau, tsim nkees nkees, thiaj li thaum lub sij hawm ntawm daim ntawv thov ntawm cov ntsiav tshuaj cov neeg mob yuav txwv tsis pub mus tswj thauj thiab lwm yam kev seev.

Leej twg yuav tsum tsis txhob siv

Nyob rau medicament "Atokor" contraindications muaj xws li ib tug nce rhiab heev rau txhua tus muaj ntawm lub medicament.

Nws tsis tau coj cov ntaub ntawv ntawm mob siab tus kab mob thiab siab ua kom cov transaminase ntshiab enzymes thaum lawv cov kev ua yog 3 lub sij hawm ntau dua li cov sab sauv txwv ntawm ib txwm muaj nuj nqis.

Cov tshuaj no yog tshuaj rau cov poj niam deev muaj hnub nyoog uas tsis siv txaus pov. Contraindication yog ib tug mob ntawm nyuam thiab pub niam mis.

Tshuaj tsis kho cov me nyuam thiab cov tub ntxhais hluas nyob rau hauv 18 lub xyoos ntawm hnub nyoog.

Vim muaj cov mis nyuj nyob rau hauv nyob tus yeees ntawm cov ntsiav tshuaj 'Atokor "qab zib qhia ntawv nyob rau daim ntawv thov txwv tsis pub siv ntawm lawv nyob rau hauv ib tug raws roj ntsha los intolerance rau galactose molecules, nrog ib tug tsis muaj lactase thiab glucose-galactose malabsortsii.

analogs

Muaj ib tug loj tus naj npawb ntawm cov tshuaj nyob rau hauv lub hauv paus ntawm atorvastatin. Cholesterol-txos tshuaj lub luag hauj lwm rau "Atokor" phau ntawv qhia. Analogs kuj tau txo txog qib uas cov cholesterol nyob rau hauv cov ntshav.

Ib tug xws li tshuaj yog ib tug kho rau lub Slovenian "Atoris", uas yog ib tug chaw tsim tshuaj paus ntawm ob leeg Tshuag lub tuam txhab "Krka, Novo mesto." Nws yuav ua nyob rau hauv daim ntawv ntawm cov ntsiav tshuaj nrog ib tug active ingredient cov ntsiab lus ntawm 0.010 g, 0.020 g, 0.040 g

Cov tshuaj no yog npaj los mus tshem tawm ib tug hyperlipidemic mob, nyob rau lub tsis tsim nyog los txo tag nrho cov roj uas txhaws, lipoprotein cholesterol nyob rau hauv lub tebchaw nrog ib tug tsawg saturation, tus nqi ntawm cov apolipoprotein thiab molecules ntawm triglyceride nyob rau hauv cov hlab ntsha.

Tshuaj kho cov neeg uas muaj hypercholesterolemia polygenic heterozygous homozygous familial hom.

Nrog kev pab los ntawm "Atoris" tshuaj tsub kom lub concentration ntawm cov roj uas txhaws nyob rau hauv lipoproteins uas muaj saturation.

Lwm Slovene analogue xam tau tias yog tshuaj "Tulip," uas yog tsim los tam sim no "Lek Kws Company". Muaj peb noj tshuaj npaum cas zaj duab xis-coated ntsiav tshuaj: 0.01 g, 0,02 g thiab 0,04 g

Cov tshuaj no yog qhia rau cov tshem tawm ntawm cov thawj ntaub ntawv ntawm hypercholesterolemic thiab ua ke hyperlipidemic mob, rau cov kev kho mob ntawm kom cholesterol qhov tseem ceeb heterozygous thiab homozygous tsev neeg hom.

Ib yam li ntawd, cov txhais tau tias pom tau hais tias Indian tshuaj "Astin", uas yog ua los ntawm cov enterprise "Micro-piv Limited". Nws yog muaj nyob rau hauv ob noj tshuaj npaum cas: nyob hauv 0,010 g thiab 0,020 g ntawm atorvastatin.

Cov tshuaj no yog tshuaj nyob rau ntawm ib nce lipid cov ntsiab lus, thaum nws tsis yog cai zoo ntxim ntawm kev noj haus thiab lwm yam txheej xwm.

Indian raug ib tug medicament "Storvas" raws li lub calcium ntsev ntawm atorvastatin. Manufactured los ntawm "Ranbaxy Laboratories Limited" nyob rau hauv daim ntawv ntawm ib ntsiav tshuaj coated nrog ib tug sheath nyob rau hauv ob noj tshuaj npaum cas: nyob hauv 0,010 g thiab 0,020 g

Tshuaj "Storvas" txo lub siab cov ntsiab lus ntawm tag nrho cov roj uas txhaws taus, LDL roj uas txhaws taus molecules nyob rau hauv, thiab cov concentration ntawm apolipoprotein triglyceride tebchaw nyob rau hauv cov thawj, thiab nonmarried heterozygous familial hypercholesterolemic mob, raws li tau zoo raws li mixed hyperlipidemic kab mob.

Tshuaj thiaj li tau myocardial infarction myocardial stunning lub xeev ntawm cov nqaij, cwj nrag thiab kev hloov nyob rau hauv cerebral ntshav txaus. Ntsiav tshuaj rau kom lub kev vam meej ntawm coronary atherosclerotic mob.

American counterpart yog cov tshuaj "Lipitor" yog ua los ntawm "Pfizer". Nws yuav ua nyob rau hauv daim ntawv ntawm cov ntsiav tshuaj coated nrog ib tug plhaub nyob rau hauv peb noj tshuaj npaum cas: nyob hauv 0.010 g, 0.020 g, 0.040 g Cov tshuaj no kuj siv los mus tshem tawm cov hypercholesterolemic lub xeev ntawm ntau hom ntawm keeb kwm.

Xyuas

Tshuaj "Atokor" Neeg Daim Ntawv Thov piav raws li txhais tau tias muaj pov thawj miv nyuas siv zug. Muaj ntau cov neeg mob uas kom ntshav ntau ntawm cov teeb meem cholesterol, tom qab ib tug thaum kawg ntawm qhov kev siv yog tau zoo. Qhov tseem ceeb ntawm tag nrho cov roj uas txhaws taus thiab LDL roj uas txhaws taus yuav txo tau kom zoo npaum li, uas thiaj li lub sij hawm ntawm kev tsim atherosclerosis, thiab ischemic tej yam kev mob.

Cov tshuaj belongs rau hauv xov xwm nrog zoo tolerability, tab sis nyob rau hauv ib co neeg mob tej zaum nws yuav ua rau ncua sij hawm quav, tsam plab, mob nyob rau hauv lub plab mog, xeev siab, kem plab. Muaj mob taub hau, pw tsis tsaugzog. Tej zaum tsim jerky, asthenic thiab myalgic mob.

Nyob rau hauv tsawg zaus, sab los yog manifested myositis, myopathy, paresthesia, peripheral neuropathy, pancreatitis, kab mob siab, cholestatic daj ntseg.

Ntsiav tshuaj yuav ua rau anorexia, ntuav, hepatotoxicity ces, alopecia, pruritic ces ua pob ua xyua, impotence, cataracts, hyper- los yog hypoglycemia.