Cov lus qhia rau kev siv - ampicillin

Heev ib pliag dhau los, nws los ua lub npe hu hais tias lub ntsiab mechanism ntawm adaptability ntawm ntau hom ntawm tus kab mob rau tshuaj tua kab mob yog cov β-lactamase thiab lawv cov khoom. Lawv yog cov zoo heev nyob rau hauv pab rau txoj kev puas tsuaj ntawm cov kev tiv thaiv rings tshuaj tua kab mob thiab zoo nullify lawv kho nyhuv. Yuav kom kov yeej no yam tsis zoo zoo, nws tau tsim thiab suab npaj tshuaj tebchaw uas inactivate β-lactamase yog feem ntau clavulanic acid formulations sulbactam thiab tazobactam.

Cov tebchaw xws li raws li hais ntawm lub thiaj li hu ua penicillin ingibitorozaschischonnyh - ua ke yeeb tshuaj, uas muaj xws li penicillin tshuaj tua kab mob. Lug paub piv txwv ntawm tej kev npaj los mus yog ampicillin-sulbactam, amoxicillin, ticarcillin thiab lwm leej lwm tus constituting cov pab pawg neeg ntawm penicillins. Lawv siv yog zoo kuj vim hais tias lawv tau khiav lag luam raws li ib feem ntawm ib tug ntau yam ntawm ob peb ua ke ntawm lub cephalosporin ntawm III tiam, thaum cov hauj lwm zoo ntawm lub active ingredient nyob qis qis ntawm ib theem siab.

Thaum lub sij hawm ntau ob peb ua ke, yog siv nyob rau hauv ntau niaj hnub tshuaj muaj ib tug muaj pes tsawg leeg tshuaj tua kab mob thiab inhibitors ntawm β-lactamase, muaj yog ib tug thawj kev ua si lwm penicillins thiab lawv yuav luag tag zoo tu qab tso lawv kho miv nyuas siv zug nyob rau hauv combating feem ntau ntawm cov paub txog staphylococci hnub no anaerobes thiab Gram cov kab mob. Nyob rau hauv tas li ntawd, nyob rau hauv xws formulations yog expanding lawv antimicrobial spectrum. Tej tshuaj belongs rau ampicillin / sulbactam, uas nyob ntawm lub chaw tsim tshuaj paus yuav tseem yuav ua nyob rau hauv lub npe los yog unazin Sulatsillin.

Cov tshuaj no muaj xws li ampicillin thiab sulbactam, uas yog tam sim no nyob rau hauv ib qho ratio ntawm 2: 1. Raws li qhia los ntawm phau ntawv qhia, ampicillin thiab sulbactam nyob rau hauv kev npaj no tsuas yog ua tau thaiv cov hlab β-lactamases muaj ib tug ncaj pronounced ua si tiv thaiv Neisserial thiab atsinetobakterov.

Feem ntau rau hauv tshuaj tau txais muab sultamicillin, muaj li ntawm sulbactam thiab ampicillin. Ntsiav tshuaj thaum tau txais absorbed rau hauv lub cev. Ces cov tshuaj tiv thaiv ntawm hydrolysis thiab lub neej coj nyhuv muaj cov tshuaj ampicillin thiab sulbactam, uas yuav pab tau lub bioavailability ntawm ampicillin txawm ntau dua theem uas yog attained thaum tau txais vaj huam sib luag koob tshuaj tsoos ampicillin.

Kuj muaj ntau spectrum ntawm kev ua si, thiab cov tshuaj no. Yog li ntawd, cov kev siv ntawm feem ntau cov tshuaj no yog muaj nyob rau hauv kab mob ntawm cov kab mob hauv paus chiv keeb TTP, sinusitis ntau daim thiab etiology. Cov tshuaj yog tshuaj nyob rau hauv cov kab mob ntawm lub sab ua pa ib ntsuj av tau: mob bronchitis, mob ntsws.

Raws li cov lus qhia rau kev siv, ampicillin nrog sulbactam cov ntsiab lus yog zoo nyob rau hauv cov kev kho mob ntawm ntau yam ntaub ntawv ntawm intraabdominal thiab pelvic kab mob, xws li nqaij mos, cov pob txha thiab ob leeg mob, Septicemia.

Qhov npaj ntawm ampicillin nrog sulbactam ho zoo tshaj yog muab piv rau amoxicillin / clavulanate nyob rau hauv cov kev kho mob ntawm tus kab mob uas yog pib atsinetobakterom.

Cov tshuaj ntawm cov tshuaj txiav txim cov lus qhia rau kev siv. Ampicillin yog tshuaj hais lus, lub koob tshuaj rau cov neeg laus yog 0,375-0,75 grams hais txog ntawm cov pluas noj ob lub sij hawm thaum lub sij hawm hnub, yog hais tias tus kab mob no yog ib qho yooj yim ua cim. Nyob rau hauv loj dua ntaub ntawv ntawm cov tshuaj siv los ntawm 1.5-3.0 grams thoob plaws hauv lub hnub thaum lub heev yog nce, ntau npaum yuav muab ntau zog rau 6.0 grams.

Cov me nyuam mos tshuaj muab nyob rau hauv koob tshuaj xam txog 50 micrograms ib hnub rau ib ib kilogram ntawm qhov ceeb thawj ntawm tus me nyuam. Nkag yog nqa tawm ob zaug.

Tso daim ntawv thiab ntau npaum ntawm cov tshuaj qhia txog nyob rau hauv kom meej cov lus qhia rau kev siv. Ampicillin kuj yuav coj tsuas yog lub ntsiav tshuaj nyob rau hauv daim ntawv ntawm cov hmoov siv los npaj tshwj xeeb ncua kev kawm ntawv (thaum hais ntawm ncauj muab). Thiab muab cov kev siv ntawm cov tshuaj los ntawm kev txhaj tshuaj, qhov no yog ua nyob rau hauv cov hmoov daim ntawv no. Cov kuab nkag nrog cov tshuaj nyob rau hauv ib lub pob.