Buserelin depot - piav qhia thiab daim ntawv thov nta

Qhov kev xaiv ntawm ib tug hormonal tshuaj yuav tsum tau raws li nyob rau hauv ib tug faj txoj kev tshawb no ntawm cov tsos mob thiab ib tug faj qhia kom paub txog cov kev pheej hmoo ntawm kev phiv.

Kev npaj "Buserelin Depot" piv favorably nrog lwm yam ntawm nws cov high efficiency thiab tsawg yuav qhov muaj tseeb ntawm kev phiv cov tsos mob. Nws yog ib tug tswv cuab ntawm hormonal anticancer agents.

Lub pharmacological kev txiav txim ntawm cov tshuaj

Qhov kev txiav txim muaj buserelin antigonadotropnym, anti-androgenic, anti-tshuaj, anti-mob los. Drug tshuaj "Buserelin Depot" los ntawm kev sib tw khi rau receptors ntawm hlwb secreting gonadotropin-tso tau (lawv yog nyob rau hauv tus qauv ntawm lub anterior lobe ntawm lub pituitary caj pas).

Nyob rau hauv thawj theem cov tshuaj tswv yim yog pom nraum nce nyob rau hauv lub concentration ntawm LH thiab FSH (gonadotropic hormone), faib los ntawm lub pituitary, uas ua rau yus muaj zog qhov chaw mos Gomonov cov ntsiab lus. Tom qab 14 - 21 hnub thaiv cov hlab txhais tau tias gonadotropic muaj nuj nqi los ntawm tsis zoo feedbacks, uas ua rau yus ib tug tseem ceeb yuav txo tau ntawm LH thiab FSH, thiab, raws li ib tug tshwm sim, thiab ib tug txo nyob rau hauv cov poj niam txiv neej cov tshuaj hormones. Yog li, cov txiv neej testosterone concentration decreases, nws nce mus txog ib theem uas yog tsim tom qab orchiectomy (kev kho mob castration). Cov poj niam cov tshuaj nyhuv "Buserelin Depot" yog nws txo qis mus rau theem ntawm ntau lawm estradioda uas twb muaj lawm nyob rau hauv posklimaktericheskom lub sij hawm.

Kev siv lub tshuaj "Buserelin Depot"

Nws yog siv nyob rau hauv cov kev kho mob ntawm prostate cancer, nyob rau hauv tej rooj plaub, siv mus suppress testosterone ntau lawm nyob rau hauv lub noob qes. Kuj siv nyob rau hauv cov kev kho mob cancer ntawm lub mis (hormone-dependent cov kab mob, uas yog yus muaj los ntawm siab zus tau tej cov estrogens los yog zoo nkaus li nyob rau hauv endometriosis). Lwm yam kab mob, kho "buserelina Depot": uterine fibroids, endometrial hyperplasia, kev cov IVF cov kev pab cuam nyob rau hauv kev kho ntxiv lawm tshob.

Contraindications thiab tshwj xeeb tswv yim pom zoo

Npau taws me ntsis, orchiectomy, cev xeeb tub, lactation. Ceev faj noj cov tshuaj nyob rau hauv lub pathology ntawm lub mob txeeb zig nyob rau theem ntawm vertebral metastasis, kub siab, ntshav qab zib, thiab kev nyuaj siab. Buserelin depot thiab cev xeeb tub - incompatible tswv yim.

phiv

Tus neeg mob tej zaum yuav tsis txaus siab ntawm malaise nyob rau ib feem ntawm lub hauv paus poob siab system nyob rau hauv daim ntawv ntawm cov mob taub hau, nervousness, insomnia, amnesia, tsis concentration, kiv taub hau, kev xav tsis khov, thiab tej zaum kuj nyuaj siab. Nws yuav muaj tinnitus los yog siab rau lub ceev ceev, qhov muag plooj tsis pom kev lossis tsis hnov lus. Nws muaj peev xwm feem ntau yuav "kub flashes." Nyob rau hauv thawj lub lim tiam ntawm kev kho mob nyob rau hauv cov poj niam cai psevdomenstruatsiya, ces teem caij rau lub paum dryness, tau pob txha demineralization, tsis libido. Nyob rau hauv cov txiv neej, cov kab mob tej zaum yuav exacerbated nyob rau hauv thawj 2 - 3 lub lis piam, los yog tshwm sim gynecomastia, txo potency. Pes tsawg tib zaum yuav tshwm sim: anorexia, dyspeptic ntshawv siab. Buserelin depot thiab haus dej haus cawv yog incompatible. Nyob rau hauv cov neeg mob uas kub siab tej zaum yuav ua rau kom siab, lub plawv dhia. Los ntawm kev tsis haum tshuaj tshwm sim: khaus, tawm pob, bronchospasm, anaphylactic poob siab. Hloov kuaj ntsuas: dyslipidemia, hyperglycemia, nce nyob rau hauv transaminases thiab bilirubin, thrombocytopenia thiab leukopenia.

Lub hauv paus ntsiab lus ntawm cov tshuaj

Intramuscular thawj coj: muab tam sim ntawd tom qab kev npaj ntawm qhov kev ncua.

- thaum prostate mob txhua txhua 4 lub lis piam tom 4.2 mg.

- Endometriosis - yog tswvcuab hauv 4 lub hlis.

- nrog uterine myoma -3 lub hlis.

- ntxiv lawm tshob - 4.2 mg.

Intranasal thawj coj:

- rau cov kev kho mob ntawm cov poj niam cov kab mob piav saum toj no - muab rau tus ntswg kab noj hniav 900 mg / hnub (ib koob tshuaj, 3 lub sij hawm ib hnub twg), los ntawm 1 - 2 hnub ntawm lub cev ntas.

- ntxiv lawm tshob 600 mg / hnub, 1 koob tshuaj nyob rau hauv lub qhov ntswg kab noj hniav plaub zaug ib hnub twg. Yog hais tias xav qhia blockade ntawm lub tsev me nyuam, lub koob tshuaj yog txo mus rau 2 lub sij hawm.

Ib txhia sau ntawv:

- kev kho mob ntawm prostate cancer yog nqa thoob plaws lub neej;

- anti-androgen tshuaj muab rau 2 lub lis piam. thiab rau 2 lub lis piam. ntawm kev kho mob nrog buserelin, tiv thaiv cov teeb meem uas yuav tshwm sim thaum lub sij hawm thawj lub lim piam ntawm kev kho mob;

- nyob rau hauv thawj lub sij hawm ntawm kev kho mob nyob rau hauv cov poj niam tej zaum yuav tshwm sim ntawm zes qe menyuam cyst;

- yuav tsum tiv thaiv kom txhob muaj menyuam thiab contraceptive tau txais tshuaj los kho buserelin, tab sis thawj 2 lub hlis yog tsim nyog los siv uas tsis yog-hormonal txoj kev ntawm kev tiv thaiv;

- ib tug paaj ntxim rau cov tshuaj kho mob ntawm endometriosis surgically los ntawm kev txo lub zaus ntawm rov.

Sis nrog lwm yam tshuaj

Buserelin thiaj li cov nyhuv ntawm hypoglycemic tshuaj. Nws yuav ua rau ntawm zes qe menyuam hyperstimulation, yog siv ua ke nrog tshuaj muaj nrog txiv neej pw cov tshuaj hormones.