"Zanidip": cov lus qhia rau kev siv, tiag tiag cov neeg mob thiab cov kws kho mob counterparts. "Zanidip-Rekordati": phau ntawv no, xyuas, analogs

Raws li statistics, hais txog 26% ntawm cov neeg laus nyob rau hauv lub ntiaj teb no raug kev txom nyem los ntawm cov ntshav siab tsis tu ncua. Feem ntau cov feem ntau tus kab mob no yog txuam nrog ib tug kev tshuaj ntsuam genetic predisposition. Txawm li cas los, muaj lwm yam yog vim li cas rau nws tshwm sim. Cov no muaj xws rog, haus luam yeeb, ntev li ntawm tsawg ntawm cov ntsev, tsis muaj ib txoj lw ntsiab thiab vitamins nyob rau hauv lub cev, dej caw, kev nyuaj siab, tsis muaj lub cev ua si, thiab lwm tus neeg.

Nws yuav tsum tau muab sau tseg tias cov kev loj hlob ntawm tawg nyob ntawm tus neeg lub hnub nyoog. Cov laus nws yog, qhov ntau dua qhov uas yuav muaj xws li ib tug pathological lub xeev. Thaum muaj hnub nyoog ntawm 40 xyoo, tus kab mob no yog yuav luag ib txwm tshwm sim ntawm sclerotic vascular txhab.

lus qhia dav dav

Feem ntau cov feem ntau, cov kws kho mob muab lawv cov neeg mob tus mob "tseem ceeb tawg". Yuav ua li cas yog nws? Nws yog ib tug kab mob thiab ib daim ntawv ntawm tawg. Nws tseem ceeb soj ntsuam cov tsos mob ua pheej thiab ntev nce ntawm cov ntshav siab.

Cov kev hloov nyob rau hauv xws tus kab mob tej zaum yuav txawv. Txawm li cas los, lawv feem ntau txheeb cov hlab ntsha thiab lub plawv.

Nyob rau hauv thiaj li yuav txhim kho tus neeg mob tus mob, cov kws kho mob pom zoo kom cov tshuaj no raws li "Zanidip". Xyuas ntawm cov neeg mob nyob rau hauv cov hauj lwm zoo ntawm cov tshuaj yuav tsum tau muab los sib tham nyob rau hauv cov ntaub ntawv ntawm qhov tsab xov xwm. Kuj muaj koj yuav nrhiav tau cov lus qhia txog yuav ua li cas tau txais hais tias cov tshuaj noj, yog hais tias nws muaj tej yam analogues thiab kev phiv.

Hauj lwm, muaj pes tsawg leeg, zoo lawm thiab ntim

Lub medicament "Zanidip" kev qhia yog muab cia rau hauv ib tug duab los qhia nras yog tawm nyob rau hauv daim ntawv ntawm cov ntsiav tshuaj teeb daj thiab puag ncig thiab biconvex ntaub ntawv ib lub cim rau ntawm ib lub sab. Lawv yog cov zaj duab xis-coated thiab muaj ib tug yellowish tint rau tus so.

Lub active ingredient ntawm cov tshuaj no ua lercanidipine hydrochloride. Tsis tas li ntawd, nws muaj xws li thiab koom haum pab Cheebtsam, uas yog sawv cev raws li povidone K30, lactose monohydrate, sodium carboxymethyl starch, microcrystalline cellulose thiab magnesium stearate.

Nrog kev xav txog zaj duab xis-txheej formulation, ces nws yog tsim los ntawm tshuaj xws li Opadry Daj, talc, hypromellose, titanium dioxide, hlau oxide daj zas thiab macrogol 6000.

Yuav "Zanidip" tshuaj nyob rau hauv sawv hlwv packs tej zaum yuav, uas yog muab tso rau hauv daim ntawv thawv.

Pharmacological yam ntxwv ntawm cov tshuaj

Koj puas paub hais tias yog ib tug yeeb tshuaj "Zanidip"? Cov lus qhia nyob rau hauv daim ntawv thov hais tias nws yog ib tug poov hlau channel blocker qeeb. Nws active ingredient yog ib tug racemic sib tov ntawm lub dextro-thiab levorotatory stereoisomers. Nws yuav tsum raug sau tseg hais tias nws yog ib tug derivative ntawm 1,4-dihydropyridine.

Qhov no medicament xyua thaiv cov hlab tam sim no ntawm calcium ions rau hauv mob hlwb, vascular hlwb thiab tus mob.

Lub hauv paus ntsiab lus ntawm pab antihypertensive nyhuv ntawm cov tshuaj yog vim muaj ib tug ncaj qha relaxant ntxim rau vascular tus mob hlwb.

Raws li cov lus qhia, tom qab tau txais ib tug kho nyhuv ntawm tus medicament yog tiav tom qab 5-7 teev. Lub caij ntawm nws validity yog khaws cia thoob plaws hauv lub hnub.

Vim lub high school lub selectivity ntawm cov tshuaj mus rau lub vascular tus mob hlwb, nws tsis muaj ib tug tsis zoo inotropic nyhuv.

Yog li ntawd yog dab tsi yog ib tug yeeb tshuaj "Zanidip-Rekordati"? Phau Ntawv Qhia hais tias nws yog metabolically nruab nrab kho uas tsis muaj ntau yam ntxwv nyob rau hauv cov ntsiab lus ntawm apolipoproteins thiab lipoproteins nyob rau hauv cov ntshav ntshiab, raws li zoo raws li tsis hloov lub profile ntawm lub rog nyob rau hauv cov neeg uas kub siab.

Lub kinetics ntawm cov tshuaj

Qhov twg absorbed tshuaj "Zanidip"? Cov lus qhia rau kev siv yuav tau qhia rau peb hais tias tom qab tau txais cov ntsiav tshuaj (10 los yog 20 mg) inwardly lercanidipine yuav luag tag absorbed los ntawm cov hnyuv ib ntsuj av. Tom qab 1.5-3 teev lub siab tshaj plaws concentration ntawm cov tshuaj nyob rau hauv cov ntshav ntshav nce mus txog ib tug nqi ntawm 3.3 ng / ml los yog 7,66 ng / ml feem.

Lub tsev ntawm cov tshuaj nyob rau hauv cov nqaij thiab kabmob yuav siv sij hawm qhov chaw sai heev. Kev sib txuas lus nrog ntshav cov nqaijrog tshaj 98%. Ua koob tshuaj ntsiav tshuaj ntawm lawv txuam nrog yog cai.

Cov metabolism ntawm cov tshuaj yog nqa tawm thaum lub sij hawm thawj pass los ntawm lub siab. Qhov no tshwm sim los ntawm biotransformation CYP3A4. Qhov no ua ib tug xov tooj ntawm metabolites uas tsis muaj kev pharmacological kev ua si.

Tso tawm cov tshuaj "Zanidip", xyuas uas yog hais me ntsis qis los ntawm cov hnyuv thiab ob lub raum. Muaj ob theem kev tshem tawm ntawm lercanidipine: thaum ntxov uas nws lub sij hawm yog 2-5 teev thiab tus kawg - 8-10 hom sij hawm.

Lub unchanged tshuaj no yog suab tsis kuaj nyob rau hauv cov quav thiab zis.

Cov neeg uas muaj siab los yog raum tus kab mob protein cov ntsiab lus ntawm cov ntshav yog significantly txo. Nyob rau hauv no hais txog, cov dawb feem ntawm lub active tshuaj ntawm lub medicament tej zaum yuav ntau heev muaj zog.

Indications yuav tau txais tshuaj

Vim li cas muaj peev xwm yuav muab tshuaj "Zanidip"? Xyuas ntawm cov kws kho mob tau qhia hais tias qhov no neeg sawv cev zoo exhibits nws tus kheej nyob rau hauv qhov tseem ceeb tawg thiab me ntsis heev.

Contraindications kom tau txais cov ntsiav tshuaj

Raws li cov lus qhia, cov tshuaj "Zanidip" yuav tsum tsis txhob coj raws li nram qab no:

• mob loj heev siab ua hauj lwm;
• mob hauv lub plawv tsis ua hauj lwm xwm (tshwj xeeb tshaj yog decompensation kauj ruam);
• impaired raum muaj nuj nqi;
• tsis ruaj tsis khov angina ;
• thaum lawv tseem nrog muaj zog inhibitors isoenzyme CYP3A4 (piv txwv li, "ketoconazole", "erythromycins", "itraconazole") thiab nrog "cyclosporin" thiab txiv kab ntxwv qaub kua txiv;
• thaum lub sij hawm cev xeeb tub;
• rhuav txhua ntawm cov hlab ntsha uas los ntawm sab laug ventricle ntawm lub siab los;
• lactose intolerance, lactase nqhis thiab malabsorption syndrome galactose / piam thaj;
• thaum lub sij hawm pub niam mis;
• tsis ntev los no los ntawm myocardial infarction (thaum lub sij hawm lub sij hawm ntawm ib lub hlis);
• Cov poj niam uas nyuam muaj hnub nyoog uas tsis siv txhim khu kev qha txhais tau tias ntawm pov;
• nyob rau hauv lub hnub nyoog (miv nyuas siv zug thiab kev nyab xeeb tsis tau tsim);
• npau taws me ntsis rau lercanidipine thiab lwm yam dihydropyridine derivatives los yog tej yam ntawm cov tshuaj.

Ceev faj kev tshuaj

Lub medicament "Zanidip-Rekordati" ceev faj yog pom zoo kom noj cov neeg uas muaj impaired siab muaj nuj nqi (ntsis thiab me me), mob hauv lub plawv nedostatochnostyusindromom qhov ntswg, sab laug ventricular tsis ua hauj lwm thiab coronary artery kab mob, thiab nrog simultaneous txais tos "Digoxin" beta-blockers.

Ntsiav tshuaj "Zanidip": cov lus qhia rau kev siv

Nyob rau hauv view ntawm lub loj tus naj npawb ntawm cov nyom txheej xwm xam tau tias yog tshuaj yuav tsum tau muab los ntawm tej tus neeg. Feem ntau, lub active tshuaj yog pom zoo kom noj nyob rau hauv ib tug npaum li ntawm 10 mg ib zaug ib hnub twg.

Ntsiav tshuaj yuav tsum tau nqa tawm nyob rau hauv thaum sawv ntxov, rau ¼ teev ua ntej noj tshais.

Nyob rau hauv lub kho nyhuv ntawm cov tshuaj ntawm cov tshuaj nyob rau hauv kev saib xyuas muaj peev xwm yuav ob npaug, i.e. mus txog 20 mg. Ua koob tshuaj medicament yuav tsum tshwm sim maj. Yog hais tias yuav tsum tau, lub nce nyob rau tus nqi ntawm cov medicament nqa tawm tom qab ob lub lis piam tom qab pib ntawm txoj kev kho.

Yuav ua li cas kuv yuav tsum tau coj "Zanidip-Rekordati"? Tsis txhob zom cov ntsiav tshuaj. Lawv feem ntau nqos thiab ntxuav nrog ib tug txaus tus nqi ntawm cov kua.

Nyob rau hauv cov neeg laus Tsis ntau npaum hloov yog yuav tsum tau. Tab sis thaum noj tshuaj rau lawv tus mob yuav tsum saib xyuas.

Nyob rau hauv lub xub ntiag ntawm hepatic los yog lub raum tsis ua hauj lwm los yog mob loj tsawv heev npaum kho yog tsis yuav tsum tau. Nyob rau hauv thawj ob peb hnub ntawm kev siv yeeb tshuaj muab nyob rau hauv ib tug npaum li ntawm 10 mg, thiab ces nrog ceev faj ua cov tshuaj mus rau 20 mg ib hnub twg.

Yog hais tias lub antihypertensive cov nyhuv yog xav qhia, cov kev cai tswjhwm ntau npaum yuav txo.

phiv

Yuav ua pliaj tshua "Zanidip-Rekordati"? Consumer xyuas qhia tau hais tias qhov tsawg ntawm cov no txhais tau tias lawv feem ntau tshwm phiv. Yuav ua li cas raws nraim, peb xav txog txoj cai tam sim no:

• Immune system: npau taws me ntsis.
• Plawv system: tachycardia, angina, palpitations, tsaus muag, kais rau lub ntsej muag daim tawv nqaij, mob hauv siab, cim yuav txo tau nyob rau hauv cov ntshav siab, lub plawv yuav nres.
• Lub paj hlwb: somnolence, mob taub hau, kiv taub hau.
• Hnyuv: ntuav, dyspepsia, xeev siab, reversible nce nyob rau hauv daim siab enzymes, raws plab thiab mob plab.
• Daim tawv nqaij pob.
• Licas: myalgia.
• Mob txeeb: polyuria.
• Lwm yam: peripheral edema, qaug zog, gingival hyperplasia, qaug zog.

Cov tsos mob ntawm overdose

Yuav ua li cas los yuav ua raws li, Yog hais tias koj noj ntau dua koob tshuaj ntawm cov tshuaj "Zanidip"? Phau Ntawv Qhia teev cov nram qab no cov tsos mob ntawm overdose: myocardial infarction, reflex tachycardia, peripheral vasodilation nrog cim txo nyob rau hauv cov ntshav siab, ib qho kev nce nyob rau hauv lub caij thiab zaus ntawm angina sib cem.

Yuav kom tshem tawm tej lub xeev symptomatic kev kho mob.

tshuaj cov kev sib tshuam

Yog nws tau mus ua ke nrog lwm yam tshuaj tshuaj "Zanidip"? Cov lus qhia rau kev siv ntawd hais tias lub cuab tam yog txwv tsis pub muab nrog xws li inhibitors CYP3A4 (cytochrome P450 ntawm lub siab), raws li "Itraconazole" "ketoconazole" thiab "erythromycin". Qhov no yog vim lub fact tias tag nrho cov tshuaj ua rau kom lub concentration ntawm lercanidipine nyob rau hauv cov ntshav, raws li zoo raws li ua rau lub antihypertensive nyhuv.

Tib mus txais tos qhia txhais tau hais tias "cyclosporin" yog txhob, raws li nws tej zaum yuav ua rau ib qho kev nce nyob rau hauv cov ntsiab lus ntawm tag nrho ob qho tshuaj nyob rau hauv ib tug neeg mob cov ntshav.

Lercanidipine yog txwv tsis pub yuav muab coj los ua ke nrog txiv kab ntxwv qaub kua txiv. No thaum lawv tseem yuav ua nyob rau hauv potentiation ntawm lub antihypertensive nyhuv ntawm lercanidipine thiab inhibition ntawm metabolism.

Nws yuav tsum ib ce muaj zog huab ceev faj thaum uas tau txais "Zanidipa" nrog xws li cov tshuaj raws li "Astemizole", "Terfenadine" thiab "quinidine", thiab kuj antiarrhythmics ntawm peb cov chav kawm ntawv (e.g., "Amiodarone").

Lub ua ke ntawm qhov suav hais tias medicament nrog anticonvulsant tshuaj ( "phenytoin," Carbamazepine ") thiab" rifamycins "tej zaum yuav ua rau kom txo nyob rau hauv cov ntshav ntau ntau cov lercanidipine, uas ua rau txo ntawm lub antihypertensive nyhuv ntawm lercanidipine.

Thaum cov tshuaj thaum lawv tseem nrog "Digoxin" yuav tsum tsis tu ncua saib xyuas tej yam tshwm sim ntawm intoxication.

Tib mus kho mob nrog rau cov medicament "midazolam" nyob rau hauv adulthood yuav ua rau kom cov absorbability ntawm lercanidipine thiab txo nws haum tus nqi.

Kws txawj hais tias "metoprolol" muaj peev xwm sawv ntawm kev txo bioavailability ntawm lercanidipine 50%. Nyob rau hauv cov ntaub ntawv no, lub bioavailability ntawm "Metoprolol" tseem unchanged. Cov nyhuv no tshwm sim los ntawm cov txo nyob rau hauv hepatic ntshav txaus tshwm sim los ntawm beta-blockers.

Kev npaj "Cimetidine" nyob rau hauv ib tug ntau npaum ntawm 800 mg ib hnub twg tsis raug nyob rau hauv tseem ceeb kev hloov nyob rau hauv cov ntshav concentration ntawm lercanidipine. Tab sis, thaum nws txais tos yuav tsum tau tshwj xeeb ceev faj, txij li thaum siab koob tshuaj tej zaum yuav ua rau kom lub bioavailability ntawm lercanidipine thiab thiaj li ua rau kom nws antihypertensive nyhuv.

Nrog ua ke nrog ntawm "Zanidipa" nrog "Simvastatin" thawj tshuaj yuav tsum tau noj nyob rau hauv thaum sawv ntxov, thiab lub thib ob - nyob rau hauv rau yav tsaus ntuj.

Lub medicament "fluoxetine" muaj tsis ntxim rau cov kinetics ntawm lercanidipine.

Tib mus txais tos "Zanidipa" nrog "warfarin" tsis muaj feem xyuam rau cov tshuaj ntawm lub yav tas.

Ntawm cov nyiaj yuav muab tag nrho nrog diuretics, beta-blockers thiab ACE inhibitors.

Peb kuj yuav tsum nco ntsoov tias ethanol tej lub antihypertensive nyhuv lekarnidipina.

tej tswv yim pom zoo

Tshuaj "Zanidip", analogues ntawm uas muaj li nram no, yuav tsum tau nrog huab ceev faj nyob rau hauv cov neeg uas muaj kev zoo raum muaj nuj nqi thiab coronary artery kab mob, raws li nyob rau hauv cov ntaub ntawv no, muaj ib tug zoo uas yuav muaj uas muaj zog zaus ntawm angina sib cem.

Ua ntej yuav tau txais cov tshuaj yuav tsum tau compensated lub plawv tsis ua hauj lwm ib tug mob xwm.

Kev ceev faj yuav tsum tau cai nyob rau hauv thaum pib ntawm txoj kev kho, tshwj xeeb tshaj yog nyob rau hauv cov neeg mob uas muaj mob loj tsawv thiab me me degree ntawm hepatic insufficiency.

Thaum lub sij hawm kev kho mob, nws yog ntshaw kom ua tib zoo nqa tawm kev ua hauj lwm uas yuav tsum tau tshwj xeeb xim, xws li nyob rau hauv txoj kev tswj. Qhov no yog vim lub fact tias nyob rau hauv thaum pib ntawm txoj kev kho thiab nyob rau hauv excess koob tshuaj muaj ib tug uas yuav muaj tshwm sim ntawm mob taub hau, nkees nkees thiab kiv taub hau.

cia tej yam kev mob, lub txee lub neej ntawm cov kev npaj thiab muag khoom

Kuv yuav yuav tshuaj "Zanidip-Rekordati"? Analogs ntawm cov nyiaj rau nws tus kheej noj tshuaj muag nyob rau hauv tej lub tsev muag tshuaj. Txawm li cas los, lawv yuav tsum tau yuav tsuas yog nyob rau hauv tus kws kho mob tshuaj.

Khaws yam tshuaj no tawm ntawm ncav cuag txaus rau cov me nyuam yaus qhov twg qhov kub thiab txias tsis pub tshaj 30 degrees.

Lub txee lub neej ntawm cov tshuaj nyob rau hauv saib xyuas yog peb lub xyoos. Tom qab no lub sij hawm, noj tshuaj txwv tsis pub.

tshuaj analogues

Yog koj paub txog dab tsi koj yuav hloov kev noj tshuaj "Zanidip"? Analogues ntawm qhov cuab tam yog heev yooj yim mus nrhiav tau. Kws txawj hais tias zoo xws li cov zog thiab muaj nuj nqi xws li npaj muaj raws li "Lerkamen" thiab "Lercanidipine". Noj cov tshuaj no yuav tsum tsuas yog rau kev kho mob.

Tshuaj "Zanidip": xyuas ntawm cov neeg mob thiab cov tub txawg

Nws yog ib heev zoo antihypertensive neeg sawv cev. Tias qhov no saib yog qhia los ntawm ntau cov kws kho mob. Peb pom zoo nrog lawv, thiab yuav luag tag nrho cov neeg mob uas noj tshuaj "Zanidip". Lawv hais tias tom qab noj cov tshuaj lawv tus mob markedly zoo tuaj. Tej yam tshwm sim ntawm qhov tseem ceeb tawg yog me me thiab loj tsawv heev tawm yuav luag tam sim ntawd.

Lub tsuas drawback ntawm cov tshuaj no yog hais tias noj nws heev feem ntau ua rau muaj kev phiv, tshwj xeeb tshaj yog nyob rau ib feem ntawm cov hnyuv thiab cov hlab plawv system.

Nws yuav tsum raug sau tseg hais tias muaj ntau cov neeg tsis txaus siab txog cov nqi ntawm cov tshuaj yog siab dhau heev lawm. Qhov no tshuaj yog nyob rau hauv tus nqi ntawm 28 ntsiav tshuaj yuav yuav rau 450-500 rubles. Nws yuav tsum tau muab sau tseg tias analogues ntawm hais tias medicament nyob rau hauv daim ntawv ntawm "Lerkamena" thiab "lercanidipine" tsis cheaper. Lawv yuav tsum tau muas rau lub nqe tib.

Kws txawj hais tias cov nqi ntawm "Zanidip" antihypertensive tshuaj tag nrho raws li nws zoo. Nws qhia tau hais tias yuav luag tag nrho cov ntawm nws ntev kev nyob rau hauv daim ntawv thov.