"Sumatriptan": cov lus qhia rau kev siv, xyuas. Drug analogues "Sumatriptan"

Dab tsi yog meant tshuaj "Sumatriptan"? Cov lus qhia rau kev siv ntawm cov tshuaj, nws pharmacological txiav txim, thiab rau hauv daim ntawv ntawm cov muaj pes tsawg leeg yuav tsum tau nthuav tawm ib me ntsis ntxiv. Tsis tas li ntawd, nyob rau hauv no tsab xov xwm peb yuav qhia rau koj hais txog dab tsi lub contra-indications thiab tshwm sim los ntawm cov tshuaj no muaj, nws txoj kev ntawm daim ntawv thov thiab ntau npaum, yog hais tias nws muaj tej yam analogues thiab li ntawd.

Muaj pes tsawg leeg ntawm cov tshuaj thiab nws pes tsawg leeg

Tam sim no, tsuas yog tshuaj muaj nyob rau hauv cov chaw muag tshuaj thiab qhov ntswg tsuag "Sumatriptan". Cov lus qhia rau kev siv ntawm no lub cuab tam muaj tiav ntaub ntawv nyob rau hauv nyob tus yeees ntawm cov tshuaj. Paub nrog nws koj yuav tau mus tam sim no.

Ib tug zaj duab xis loj ntsiav tshuaj muaj lub active tshuaj xws li sumatriptan succinate. Nrog kev xav txog cov koom haum pab hais, no muaj xws li cov nram qab no: calcium hydrogen phosphate dihydrate, microcrystalline cellulose, giproloza (Klutsel los yog hydroxypropylcellulose LF), magnesium stearate, mannitol (los yog mannitol), croscarmellose sodium (los yog primelloza).

Lub active ingredient qhov ntswg tsuag "Sumatriptan" kuj ua hauj lwm pab sumatriptan. Raws li rau lub koom haum pab Cheebtsam, lawv yuav tsum tau hloov raws rau cov duab ntawm lub medicament tso tawm. Nws yuav tsum tau muab sau tseg tias cov tshuaj tsuag yog siv los kho deb tsis tshua muaj heev tshaj ntsiav tshuaj. Txawm li cas los, lawv muaj lawv tus kheej tau txais kev pab. Raws li ib tug txoj cai, cov no yog cov neeg mob uas tsis xis noj cov tshuaj hais lus.

Lub pharmacological cov yam ntxwv ntawm cov tshuaj

Yuav ua li cas nta yog "Sumatriptan" ntsiav tshuaj, uas xyuas peb saib ntxiv?

Hais tias kev npaj yog ib tug protivomigrenoznoe txhais tau tias. Nws yog ib tug meej thiab xim agonist ntawm 5-HT1-serotonin receptors, uas yog ib ncig nyob rau hauv cov ntshav hlab ntsha ntawm lub paj hlwb. Nws yuav tsum tau muab sau tseg tias cov tshuaj muaj tsis muaj cov nyhuv rau lwm subtypes ntawm 5-HT-serotonin receptors.

Tom qab noj cov tshuaj nws ua vasoconstriction teej tug carotid arterial txaj. Yog li, lub medicament "sumatriptan" (ntsiav tshuaj) khoom siv ntshav intracranial thiab extracranial ntaub so ntswg. Nws yuav tsum tau muab sau tseg tias nws meningeal vasodilatation, thiab lawv o thiab yog ua rau migraine nyob rau hauv tib neeg.

Peb tsis tau hais tias tom qab tus me nyuam ntawm no lub cuab tam muaj tsis muaj teeb meem loj ntxim (tsis zoo) rau cerebral ntshav txaus. Ntsiav tshuaj tsuas inhibit receptor kev ua ntawm afferent fibers (lawv txoj) ntawm lub trigeminal paj, uas yog nyob rau hauv lub Dura. Qhov no tshwm sim vim cov txo piav thoob hlo neuropeptide tso tawm.

Nws yuav tsum raug hais tias cov tshuaj "Sumatriptan" thiab "Sumatriptan Teva" kiag li tshem tawm photophobia thiab xeev siab, uas yog ncaj qha mus txuas rau migraine tawm tsam.

Cov hauj lwm zoo ntawm cov tshuaj

Yuav ua li cas sai sai los lub zoo ntxim tom qab tus me nyuam ntawm cov "Sumatriptan" tshuaj? Testimonials ntawm no medicament muaj cov ntaub ntawv uas cov tshuaj pib ua tsuas yog tom qab 30 feeb. Yog li tus neeg mob yuav tsum tau txhaj ib koob tshuaj 100 mg. Incidentally, nyob rau hauv 50-70% ntawm cov neeg mob yog sai sai tshem tawm migraine tawm tsam tom qab siv 25-100 mg ntawm cov tshuaj. Thaum lub sij hawm hnub ntawm 1/3 cov neeg mob relapse, uas yuav tsum tau tus ua siv ntawm cov tshuaj.

tshuaj

tshuaj "Sumatriptan" ntev npaum li cas yog absorbed? Lo lus teb rau lo lus nug no kuj muaj nyob hauv cov lus qhia rau kev siv ntawm cov nyiaj. Tom qab tau txais cov tshuaj sab hauv, nws yuav luag tam sim ntawd absorbed nyob rau hauv lub digestive ib ntsuj av. Tom qab hais txog 45 feeb lub concentration ntawm cov tshuaj nyob rau hauv lub ntshav ntshiab nce mus txog li 70%.

Vim tsis tiav haum thiab thawj-pass metabolism, lub meej bioavailability ntawm cov tshuaj thaum muab nyob rau nruab nrab 14%. Raws li hais losis tswvyim dabtsi rau cov ntshav ntshav cov nqaijrog, nws yog heev tsawg (txog 15-21%). Lub ib nrab-lub neej lub sij hawm yog hais txog 2 sij hawm. Kev npaj muab feem ntau los ntawm ob lub raum.

Absorbability ntawm cov tshuaj nyob rau hauv ib cov kev soj ntsuam lub sijhawm

Raws li cov kos duab, migraine tawm tsam tsis ho muaj kev cuam tshuam cov absorbability ntawm lub active neeg sawv cev sumatriptan (los ntawm haus los yog intranasal thawj coj).

Yog hais tias tus neeg mob yog ntxhov siab muaj nuj nqi, ces tom qab siv cov tshuaj nws yuav muaj kev ib tug nce qib ntawm active muaj nyob rau hauv cov ntshav. Qhov no tshwm sim raws li ib tug tshwm sim ntawm kev txo cov thawj-pass clearance.

Indications rau ntawm kev noj tshuaj

Nyob rau hauv tej rooj plaub, prescribers "Sumatriptan"? Cov lus qhia rau kev siv ntawm cov tshuaj hais tias nws yuav tsum tau noj xwb nrog ces migraine (tsis muaj aura los yog nws).

Contraindications rau kev siv ntawm

Yog hais tias muaj yog hloov nws yog nruj me ntsis txwv tsis pub noj tshuaj "Sumatriptan" analogs ntawm cov tshuaj no? Kuv xav los hais kom nyob rau hauv no hais txog nyob rau hauv cov lus qhia muaj ib tug loj npaum li cas ntawm cov ntaub ntawv. Uas yog vim li cas ua ntej yuav noj cov tshuaj nrog nws, yuav tsum tau nyeem.

Yog li ntawd dab tsi yog qhov contra-indications tau qhia cov tshuaj? Xav txog hauv daim ntawv teev txoj cai tam sim no:

• nce rhiab heev ntawm tus neeg mob mus rau lub ntsiab ntawm lub formulation;
• Cov laus cov neeg mob (tshaj 65 xyoo);
• basilar, los yog oftalmoplegicheskaya daim ntawv hemiplegic migraine;
• simultaneous txais tos ntawm ib tug medicament nrog medicaments uas muaj ergotamine thiab nws cov ntau derivatives, raws li zoo raws li Mao inhibitors (txwv tsis pub txais txhais tau tias ua ntej 14 hnub tom qab tshem ntawm hais tias cov tshuaj);
• coronary mob plawv, thiab xav tias nws;
• tub hluas ntxhais hluas thiab cov me nyuam lub hnub nyoog (18 xyoo);
• angina, xws li Prinzmetal angina ;
• cev xeeb tub thiab pub niam mis;
• myocardial infarction, xws li ntws nyob rau hauv keeb kwm;
• tawg (uncontrolled hom);
• tawg (tswj hom);
• occlusive peripheral leeg kab mob;
• qaug dab peg, xws li tej pathological tej yam kev mob txuam nrog cov uas tsis muaj epileptic pib;
• raum los yog hepatic tsis ua hauj lwm;
• stroke los yog nraum lub xeev ntawm cerebral ntshav txaus, xws li khiav keeb kwm.

Raws li hais saum toj no, cov tshuaj "Sumatriptan" yuav tsum tsis txhob muab siv thaum lub sij hawm cev xeeb tub. Tab sis, yog hais tias qhov uas yuav kom cov me nyuam hauv plab yog tsawg tshaj li cov kev pab rau cov niam, nws yog tseem muab rau cov poj niam nyob rau hauv lub xeev thiab niam. Txawm li cas los, ua li no yog tsuas yog ib txog tej tus kws khomob tshwjxeeb (cov tshuaj yog coj nruj me ntsis nyob rau hauv nws saib xyuas). Los ntawm txoj kev, nws yog tsis pom zoo kom pub koj tus me nyuam mis nyob rau hauv ib hnub tom qab tau txais hais tias cov ntsiav tshuaj.

Tshuaj "Sumatriptan": cov lus qhia rau kev siv

Qhov no tshuaj yog coj hais lus, tsis hais kev noj kev haus kom tsawg. Ntau npaum nyob rau hauv cov ntaub ntawv no yuav tsum muaj sib npaug zos rau 50 mg (yog tias yuav tsum tau - 100 mg).

Yog hais tias koj txiav txim siab mus ua ntawv thov lub qhov ntswg medicament "Sumatriptan" (tshuaj tsuag), nws koob tshuaj yog 20 mg nyob rau hauv txhua nostril. Ua thawj coj ntawm cov tshuaj yog tau tso cai tsis ntxov tshaj li tom qab 2 hr.

Qhov siab tshaj plaws txhua txhua hnub ntau npaum rau qhov ncauj thawj coj yog 300 mg. Thaum uas siv cov intranasal formulation, nws yog sib npaug zos rau ob koob tshuaj ntawm 20 mg.

nta tshuaj

Tam sim no uas koj paub yuav ua li cas los yeej muaj migraine. "Sumatriptan" (ntsiav tshuaj thiab tshuaj tsuag) copes zoo nrog neeg ua hauj lwm. Txawm li cas los, nws yuav tsum tau muab sau tseg tias medicament yog tsis npaj rau cov prophylaxis ntawm hais tias sib txawv.

Siv cov tshuaj yog tau tsuas yog nyob rau hauv lub rooj plaub uas tus mob yog nyob rau hauv tsis ntseeg. Ua ntej lub sij hawm teem ntawm cov tshuaj "Sumatriptan" cov neeg mob uas atypical thiab tsis yav tas los kuaj nrog migraine, tus kws kho mob yuav tsum nco ntsoov txoj cai tawm lwm neurological tej yam kev mob tej. Nws yuav tsum raug borne nyob rau hauv lub siab hais tias cov neeg mob uas muaj tus mob tom qab tus me nyuam ntawm cov hais tias cov ntsiav tshuaj tej zaum yuav tsim cerebrovascular ntshawv siab.

Lub xub ntiag ntawm kev txawv txav nyob rau hauv lub plawv system (nyob rau hauv cov txiv neej laus tshaj 40 xyoo thiab postmenopausal cov poj niam) yuav tsum tau ib yam ua ntej kev xeem nyob rau hauv thiaj li yuav cais kev txawv txav ntawm lub plawv thiab cov hlab ntsha.

Tam sim no muaj cov lus qhia txog qhov tshwm sim ntawm kev ua txhaum ntawm kev sib koom tes, tsis muaj zog thiab hyperreflexia tom qab noj cov tshuaj, "Sumatriptan" thiab lwm yam tshuaj los ntawm cov pab pawg neeg ntawm cov xim inhibitors.

Ua ntej thiab thaum lub sij hawm kev kho mob nrog rau cov tshuaj hais yuav tsum tau tas li khoom noj khoom haus kom tsawg, raws li zoo raws li kev ua raws li ib tug nruj kev noj haus. Yog li, tus neeg mob yuav tsum tau tshem tawm los ntawm koj cov zaub mov khoom noj uas muaj tyramine tshuaj (chocolate, citrus, cocoa, kav zaub, ceev, cheese, taum, thiab txiv lws suav). Nyob rau hauv tas li ntawd, nws yog tsim nyog los tso tseg noj nqos tau cov dej haus cawv, xws li liab, sparkling thiab qhuav cawv, champagne, npias.

Ce thiab tswj ib tug noj qab nyob zoo txoj kev ua neej nyob rau hauv kev (taug kev, ua luam dej, skiing), raws li zoo raws li lub xub ntiag ntawm tej hobby pab mus rau rov tshwm sim ntawm zoo cwj pwm txawv, uas tiv thaiv cov kev loj hlob ntawm ib tug tib neeg tus neeg mob ntawm migraine tawm tsam.

Cov lus qhia nyob rau kev siv ntawm ib tug ntswg tsuag

Trade lub npe ntawm cov tshuaj tsuag nrog cov active tshuaj sumatriptan suab zoo li "Imigran". Qhov no tshuaj muaj nram qab no:

• clamp ntiv tes;
• ib ntsis;
• xiav ib lub pob.

Nws yuav tsum tau muab sau tseg tias xiav khawm yog tshuab txais sai sai heev thiab tsuas yog ib zaug. Nyob rau hauv no kev twb kev txuas nws yog pom zoo kom tsis txhob nias rau ntawm nws kom txog thaum lub ntsis yog nkag mus rau hauv lub qhov ntswg tso cai. Txwv tsis pub, rau tag nrho cov koob tshuaj yuav ploj mus nyob rau hauv vain.

Yuav kom siv tau cov qhov ntswg tshuaj tsuag, tus neeg mob yuav tsum tau coj ib tug xis txoj hauj lwm, pw, sawv los yog zaum. Los ntawm txoj kev, tom qab tus neeg mob lub qhov ntswg kab noj hniav yog pom zoo kom yuav ntxuav nrog paj rwb swabs.

Tshem cov sawv hlwv pob thiab tshem tawm cov tshuaj rau qhov ntswg siv, cov tshuaj yuav tsum tau nkag mus rau hauv ib tug nostril. Raws li rau lwm yam zaj hauv qhov ntswg, nws yuav tsum tau nias ib tug ntiv tes mus rau lub qhov ntswg septum. Nyob rau hauv cov ntaub ntawv no, tus neeg mob yuav tsum ua pa ntawm qhov ncauj.

Ntxig rau lub ntsis mus rau hauv lub nostril qhov ntswg formulation yuav tsum yog 1 centimeter. Lub taub hau ntawm tus neeg mob yuav tsum tau khaws ncaj, tsis txhob muab pov rov qab rov qab. Tom qab ntawd, tus neeg mob yuav tsum kaw nws lub qhov ncauj thiab ua ib tug nyob ntsiag to thiab qeeb ua pa ntawm qhov ntswg, nrog ib tug simultaneous siab mus nias rau qhov xiav khawm nrog koj tus ntiv tes xoo. Nyob rau hauv cov ntaub ntawv no, ib tug neeg tej zaum yuav zoo li ntawd lub khawm yog heev ceev. Tab sis qhov no tsis yog cov ntaub. Thaum lub sij hawm txhaj tshuaj ntawm cov tshuaj rau hauv lub qhov ntswg kab noj hniav ntawm tus neeg mob yuav tsum tau hnov ib tug faint clicking suab. Qhov no txhais tau tias lub khawm tau ntse ua hauj lwm.

Tom qab txoj kev ua no, tus neeg mob yuav tsum tau qhib nws lub qhov ncauj thiab ua pa maj mam los ntawm nws. Lub taub hau yuav tsum kom ncaj. Tom ntej no, tus neeg mob yuav tsum tau ua ib tug nyob ntsiag to tsis taus pa los ntawm cov qhov ntswg kab noj hniav, thiab rau ces tshuab pa - los ntawm lub qhov ncauj (rau 10-20 vib nas this). Nws yog pom zoo kom tsis txhob ua pa heev heev.

Thaum cov txheej txheem tiav txhaj tshuaj ntawm cov tshuaj, ib tug neeg yuav xav tias hauv lub xub ntiag ntawm dej nyob rau hauv lub qhov ntswg, thiab neeg pluag saj. Cov ncus yog tsis txaus ntshai rau kev noj qab nyob thiab ceev heev dhau nthawv. Tom qab ib tug tib daim ntawv thov ntawm cov dispenser yuav tsum muab pov tseg.

Hais kom ceev faj thaum siv

Tshuaj "Sumatriptan Teva", xyuas uas yog zoo rau ib tug ntau dua li, nws yuav tsum tau noj nrog huab ceev faj rau cov neeg tsav tsheb ntawm cov tsheb, raws li zoo raws li cov neeg uas koom nyob rau hauv tej kev ua ub no uas yuav tsum tau nce cov nqi ntawm cov tshuaj tiv thaiv thiab saib xyuas.

phiv

Yuav ntxias tshwm sim los ntawm cov tshuaj "Sumatriptan"? Npaj ntawm no zoo yuav ua rau kom txoj kev loj hlob ntawm ib tug ncaj loj tus naj npawb ntawm tsis zoo tshwm sim. Cia peb xav txog lawv nyob rau hauv ntau yam:

• tib neeg circulatory system. Nyob rau hauv ib feem ntawm lub cev nyob rau hauv ib tug neeg mob uas tsis muaj ntshav siab kuj yuav muaj cai, heart attack myocardial infarction, ib ntus ntshav siab (feem ntau yog tom qab haus), tachycardia, bradycardia, tachycardia, thiab nyob rau hauv tej rooj plaub, arrhythmia, chua ntawm lub coronary hlab ntsha, nraum ECG hloov Raynaud lub syndrome.
• Lub paj hlwb thiab kev nkag siab kabmob. Tom qab noj cov tshuaj ib tug neeg tej zaum yuav muaj kev qaug zog, kiv taub hau, tsis muaj zog thiab nkees nkees. Nyob rau hauv tej rooj plaub, cov tshuaj ua rau diplopia, qaug dab peg, qhov tshwm sim ntawm flicker yoov ua ntej nws lub qhov muag, nystagmus, tsis pom tau qhov sib pom tseeb tseeb, scotoma thiab ib nrab nraum tsis pom.
• Lub digestive ib ntsuj av. Los ntawm cov kev zom nyob rau hauv tus neeg mob feem ntau pom ntuav, dysphagia, xeev siab, thiab ua (me) ua si ntawm daim siab enzymes, mob plab tsis xis nyob thiab ischemic mob plab.
• Kev tsis haum tshuaj. Tom qab noj cov tshuaj, ib co neeg mob qhia cov tsos ntawm pruritus, tawm pob, urticaria thiab erythema. Tsis tas li ntawd, muaj yog anaphylaxis, ib tug zoo nkaus li thaum tshav kub kub, tingling thiab mob nyob rau hauv lub taub hau, heaviness, siab, kais, thiab myalgia. Intranasal thawj coj ntawm cov tshuaj yuav tshwm sim nyob rau hauv daim ntawv ntawm lub zos tshua mob ntsws nraum voos los hlawv nov ntawm nqaij tawv nyob rau hauv lub caj pas thiab lub qhov ntswg kab noj hniav thiab qhov ntswg los ntshav.

Sis nrog lwm yam tshuaj

Yuav ua li cas ua lub lwm yam tshuaj rau cov hauj lwm zoo thiab tej yam uas cov "Sumatriptan" tshuaj? Cov lus qhia, cov lus los ntawm cov kws txawj nyob rau hauv cov ntawv no muaj cov nram qab no ntaub ntawv. Nrog rau cov simultaneous siv ntawm cov tshuaj nrog lub medicament "Ergotamine" thiab txhais tau tias ib tug neeg mob ergotaminsoderzhaschimi tau ntev vasospasm. Nyob rau hauv no hais txog, lub luv ntawm koob tshuaj ntawm cov tshuaj yuav tsum tau muaj yam tsawg 24 teev.

Raws li cov kev tshawb fawb, muaj ib tug kev sis raug zoo ntawm cov tshuaj "sumatriptan" thiab Mao inhibitors. Yog li lub metabolic tus nqi yog txo thawj, thiab nws cov concentration yuav tsub kom.

Nrog simultaneous siv hais tias anti-migraine tshuaj, thiab muaj xim serotonin reuptake inhibitors, tus neeg mob tej zaum yuav tsim tsis muaj zog, hyperreflexia thiab ntxhov kom sib haum ntawm taw.

Overdose ntawm cov tshuaj (cov tsos mob, kev kho mob)

Yuav ua li cas tshwm sim yog tias koj tsis ua raws li cov tshuaj pom zoo los ntawm koj tus kws kho mob? Thaum ntev siv cov kev npaj "sumatriptan" cov neeg mob tej zaum yuav ua rau kom saum toj no sab tshua. Nyob rau hauv no hais txog, lawv tus mob yuav tsum tau tshwj xeeb kev soj rau 10 xuab moos.

Yog hais tias tsim nyog, ib tug overdose neeg mob yog pab nyob rau hauv daim ntawv ntawm cov mob kev kho mob.

Tshuaj "Sumatriptan": analogues thiab cov tshuaj nqi

Tau lub cuab tam ntawm tej chaw muag tshuaj. Nws yuav tsum tau muab sau tseg tias tus nqi ntawm "Sumatriptan" ntawm cov tshuaj, piv rau lwm yam, kuj tsis tshua muaj. Yog li, tshaj 50 zaj duab xis loj ntsiav tshuaj nyob rau hauv uas koj yuav tau them xwb 170-200 Lavxias teb sab rubles. Raws li rau lub qhov ntswg txhais tau tias nws cov nqi yog hais txog cov tib yam.

seb counterparts muaj cov tshuaj "Sumatriptan"? "Amigrenin" - ib tug yeeb tshuaj uas yog feem ntau mas yuav kis tau los mus tshem tawm migraine tawm tsam yog hais tias tus saum toj no txhais tau tias tsis tuaj kawm ntawv los ntawm lub tsev muag tshuaj. Dhau li nws, analogues medicament "sumatriptan" ntawm active tshuaj yog cov nram no tshuaj: "Sumarin" "Imigran", "Sumitran", "Migrepam", "Sumatriptan-Teva", "sumatriptan succinate", "sumatriptan Pfizer", "sumatriptan Adifarm "" Sumamigren "," Trimigren "thiab thiaj on.

Tsis tas li ntawd, raws li ib tug zoo xws li cov ntswg decongestants, ib txhia kws pom zoo siv cov tshuaj tsuag "Imigran".

Cia tej yam kev mob thiab txee lub neej

Nthuav tshuaj yuav tsum tau muab cia rau xwb nyob rau hauv qhuav thiab kev tiv thaiv los ntawm tshav ntuj qhov chaw. Qhov kub nyob rau hauv lub chav tsev yuav tsum tsis txhob yuav ntau tshaj 25 degrees. Lub txee lub neej ntawm kev kho mob chaw yog 3 lub xyoo. Tom qab no lub sij hawm, cov tshuaj yuav tsum tsis txhob muab siv.