Phospholipid syndrome: Ua thiab kuaj

Phospholipid syndrome - ib tug kuj ntau pathology ntawm autoimmune keeb kwm. Tawm tsam tom qab ntawm tus kab mob yog feem ntau pom vascular, raum, cov pob txha thiab lwm yam kabmob. Nyob rau hauv lub qhaj ntawv ntawm kev kho mob nkees yuav ua tau kom yus mob mus txog thaum tuag ntawm tus neeg mob. Ntxiv mus, tus kab mob yog feem ntau ntes tau nyob rau hauv cov poj niam thaum lub sij hawm cev xeeb tub, yuav ua rau cov kev kho mob ntawm cov leej niam thiab tus me nyuam.

Ntawm cov hoob kawm, muaj coob tus neeg tab tom nrhiav rau cov lus qhia ntxiv, nug cov lus nug hais txog cov ua ntawm tus kab mob. Yuav ua li cas cov tsos mob yuav tsum tau saib rau dabtsi? Puas muaj ib tug phospholipid syndrome tsom xam? Yuav cov tshuaj muab zoo txoj kev kho mob?

Phospholipid syndrome: yog dab tsi?

Rau cov thawj lub sij hawm tus kab mob no twb tau piav ntev los no. Lwm cov ntaub ntawv hais txog nws twb luam tawm nyob rau hauv lub 1980s. Txij li thaum ua hauj lwm nyob rau hauv txoj kev tshawb no ntawm lus Askiv rheumatologist Grem Hyuz, tus kab mob yog feem ntau xa mus rau raws li Hughes syndrome. Tseem muaj lwm cov npe - antiphospholipid syndrome, antiphospholipid antibody syndrome.

Phospholipid Syndrome - kab mob autoimmune nyob rau hauv uas lub cev pib ua tshuaj uas tua lub cev tus kheej phospholipids. Vim qhov no tshuaj muaj nyob rau hauv daim nyias nyias ntawm ntau ntawm phab ntsa, thiab cov lesion nyob rau hauv xws tseem ceeb mob:

• Cov tshuaj tua noj qab nyob zoo endothelial hlwb, txo txoj kev loj hlob yam tseem ceeb thiab synthesis ntawm prostacyclin, uas yog lub luag hauj lwm rau cov expansion ntawm cov hlab phab ntsa. Tawm tsam tom qab ntawm tus kab mob muaj yog ib tug ua txhaum ntawm platelet aggregation.
• Phospholipids kuj pom nyob rau hauv cov phab ntsa hauv lub platelets lawv tus kheej, uas ua rau yus muaj zog aggregation thiab ceev ceev kev puas tsuaj.
• Nyob rau hauv lub xub ntiag ntawm cov tshuaj yog cai nce nyob rau hauv cov ntshav txhaws thiab cov weakening ntawm heparin kev ua si.
• Tus txheej txheem ntawm kev puas tsuaj yog tsis bypassed thiab hlab ntsha hlwb.

Cov ntshav pib txawj tu nyob rau hauv cov hlab ntsha, txoj kev ua txhaws uas cuam tshuam cov ntshav txaus, thiab chaw pib rau cov kev ua ntawm ntau yam kabmob - yog li tsim ib tug phospholipid syndrome. Ua thiab cov tsos mob ntawm tus kab mob ntawm kev txaus siab rau ntau tus neeg. Tom qab tag nrho, lub ntxov tus kab mob no yog kuaj, cov uas tsis tshua mob yuav tsim nyob rau hauv tus neeg mob.

Lub ntsiab ua rau ntawm tus kab mob

Yog vim li cas tib neeg muaj kev phospholipid syndrome? Yog vim li cas tej zaum yuav txawv. Nws yog lub npe hu hais tias feem ntau heev rau tus neeg mob muaj ib tug kev tshuaj ntsuam genetic predisposition. Mob muaj yog ib tug malfunction ntawm lub cev, uas rau ib co yog vim li cas pib tsim tshuaj rau lub cev tus kheej hlwb. Nyob rau hauv txhua rooj plaub, tus kab mob yuav tsum tau ib yam dab tsi triggered. Rau hnub tim, zaum twb tau mus qhia ob peb yam tseem ceeb uas muaj feem yuav:

• Phospholipid syndrome feem ntau muaj nyob rau hauv lub xub ntiag ntawm microangiopathy, tshwj xeeb yog trobotsitopenii, hemolytic-uremic syndrome.
• Risk yam tseem ceeb muaj xws li lwm yam kab mob autoimmune xws li lupus erythematosus, vasculitis, scleroderma.
• Mob feem ntau muaj nyob rau hauv lub xub ntiag ntawm cancer nyob rau hauv tus neeg mob.
• Risk yam tseem ceeb muaj xws li kab mob. Ib qho txaus ntshai yog kis mononucleosis thiab AIDS.
• Tshuaj tej zaum yuav tshwm sim tom DIC.
• Nws yog lub npe hu hais tias tus kab mob no tej zaum yuav tsim nyob rau hauv cov neeg mob uas tau txais tej yam tshuaj, xws li hormonal contraceptives, psychotropics, "novokainamid" thiab t. D.

Lawm, nws yog ib qho tseem ceeb kom paub seb yog vim li cas tus neeg mob tau tsim ib tug phospholipid syndrome. Kuaj thiab kho mob yuav tsum qhia tau thiab yog hais tias tau tshem tawm hauv paus ua kom tus kab mob.

Lub swb ntawm cov hlab plawv system thaum phospholipid syndrome

Ntshav thiab cov hlab ntsha - cov thawj "lub hom phiaj" uas muaj feem xyuam rau cov phospholipid syndrome. Cov tsos mob ntawm nws nyob rau cov theem ntawm tus kab mob. Ntshav txhaws feem ntau tsim nyob rau hauv thawj povtseg ntawm me me hlab ntsha. Lawv zom cov hlab ntsha, uas yog nrog los ntawm cov ntaub so ntswg ischemia. Cov cov povtseg yog yeej ib txwm txias mus rau lub kov, daim tawv nqaij puv daj ntseg thiab cov nqaij ntshiv maj dig. Ntev malnutrition cov ntaub so ntswg ua rau necrosis thiab gangrene qab.

Sij hawm thiab sib sib zog nqus cov hlab ntsha thrombosis povtseg, uas yog nrog los ntawm o, mob, impaired ncig. Lub phospholipid syndrome yuav nyuab los ntawm thrombophlebitis (o ntawm lub vascular phab ntsa), uas yog nrog kub taub hau, ua daus no, daim tawv nqaij liab nyob rau hauv lub lesion thiab ntse, ntse mob.

lub tsim los ntawm cov ntshav txhaws nyob rau hauv loj cov hlab ntsha yuav ua rau txoj kev loj hlob ntawm cov hauv qab no pathologies:

• aortic syndrome (nrog los ntawm ib tug ntse nce nyob rau hauv siab nyob rau hauv cov hlab ntsha ntawm lub lub cev);
• syndrome, superior vena cava (rau ib tug muab kev mob yus muaj los ntawm edema, cyanosis ntawm daim tawv nqaij, los ntshav los ntawm lub qhov ntswg, lub raj cua thiab txoj hlab nqos mov);
• syndrome ntawm lub inferior vena cava (nrog los ntawm ib tug disturbance ntawm cov ntshav ncig nyob rau hauv lub qis ib feem ntawm lub cev, povtseg o, mob nyob rau hauv ob txhais ceg, pob tw, plab mog thiab puab tais).

Thrombosis muaj feem xyuam rau cov hauj lwm ntawm lub plawv. Feem ntau tus kab mob no yog los ntawm txoj kev loj hlob ntawm angina, pheej tawg, heart attack myocardial infarction.

kev puas tsuaj rau lub raum thiab lub ntsiab tsos mob

Thrombus tsim ua rau cov neeg pluag kev, tsis tsuas nyob rau hauv lub nqua - thiab raug kev txom nyem hauv nruab nrog cev, tshwj xeeb tshaj yog ob lub raum. Nrog ntev-lub sij hawm kev loj hlob ntawm phospholipid syndrome nws yog ua tau qhov thiaj li hu ua lub raum infarction. Qhov no mob yog nrog los ntawm kev mob nyob rau hauv lub qis rov qab, kom txhob muaj tus nqi ntawm cov zis thiab muaj cov ntshav nyob rau hauv nws ntawm impurities.

Lub los khov rau ntawd yuav thaiv lub raum leeg, uas yog nrog los ntawm ntse pains, xeev siab thiab ntuav. Qhov no yog ib tug txaus ntshai mob - yog tias tsis kho, tej zaum yuav tsim necrotic txheej txheem. Nyaum txim phospholipid syndrome muaj xws li mob raum microangiopathy nyob rau hauv uas me me ntshav txhaws yog tsim ncaj qha nyob rau hauv lub raum glomeruli. Xws li ib tug mob feem ntau ua rau cov kev loj hlob ntawm tus kab mob raum tsis ua hauj lwm.

Tej zaum kuj muaj yog neeg pluag kev nyob rau hauv lub adrenal qog, uas ua rau yus muaj kev cuam tshuam ntawm hormonal theem.

Yuav ua li cas lwm yam kabmob zaum yuav cuam tshuam?

Phospholipid syndrome - ib tug kab mob uas muaj feem xyuam rau ntau kabmob. Raws li hais, cov tshuaj muaj feem xyuam rau neuronal cell week, uas tsis tau tsis muaj txim. Muaj ntau cov neeg mob tsis txaus siab ntawm qhov muaj zog mob taub hau uas yog feem ntau nrog kiv taub hau, xeev siab thiab ntuav. Muaj ib tug tau ntawm txoj kev loj hlob ntawm ntau yam kev puas hlwb kev ntshawv siab.

Ib txhia neeg muaj txhaws nyob rau hauv cov hlab ntsha uas muab cov ntshav txaus rau lub optic analyzer. Heev tsis muaj oxygen thiab as-ham ua rau yus Atrophy ntawm lub optic paj. Tau thrombosis ntawm retinal vessels nrog tom ntej hemorrhage. Ib txhia ntawm ocular pathologies, hmoov tsis, irreversible: nrig txog kev pom kev tsis taus nyob twj ywm nrog tus neeg mob rau lub neej.

Nyob rau hauv lub pathological kev tej zaum yuav muab kev koom tes thiab cov pob txha. Cov neeg feem ntau thiaj paub hais tias reversible txha, uas yog nrog los ntawm deformation ntawm cov pob txha thiab nquag pob txha lov. Ntau txaus ntshai yog tus aseptic necrosis ntawm cov pob txha.

Rau mob thiab yog yus muaj los ntawm daim tawv nqaij qhov chaw mob. Feem ntau ntawm daim tawv nqaij ntawm lub Upper thiab qis extremities yog tsim kab laug sab leeg. Tej zaum koj yuav pom ib tug heev yam ntxwv pob, uas tsa ib tug me me, pinpoint hemorrhages. Ib txhia neeg tsim erythema rau lub qab xib taws ntawm tus taw thiab lub xib teg. Muaj yog ib tug heev subcutaneous hematoma tsim (tsis muaj khees ua) thiab los ntshav nyob rau hauv tus ntsia thawv phaj. Ntev disturbance ntawm lub trophic cov ntaub so ntswg entails tawm tias ntev kom zoo thiab yooj yim los kho.

Peb pom hais tias yog ib tug phospholipid syndrome. Ua thiab cov tsos mob ntawm tus kab mob - teeb meem tseem ceeb. Tom qab tag nrho ntawm tej yam yuav nyob ntawm seb tus xaiv tus kws kho mob kev kho mob regimen.

Phospholipid syndrome: mob

Ntawm cov hoob kawm, nyob rau hauv cov ntaub ntawv no yog tsis tshua muaj ib qho tseem ceeb lub sij hawm los xyuas txog cov muaj cov kab mob. Neeg phem phospholipid syndrome, koj tus kws kho mob yuav txawm thaum lub sij hawm anamnesis. Thawb nyob rau hauv no lub tswv yim yog hais tias tus neeg mob yog muaj peev xwm sawv ntawm thrombosis thiab venous ulcers, nquag ua kom nchuav menyuam, tej yam tshwm sim ntawm anemia. Ntawm cov hoob kawm, ntxiv ntsuam xyuas ntxiv.

Analysis ntawm lub phospholipid syndrome muaj nyob rau hauv kev txiav txim rau theem ntawm kev tshuaj rau phospholipids nyob rau hauv cov ntshav ntawm cov neeg mob. Nyob rau hauv kev, tsom xam ntawm cov ntshav muaj peev xwm pom ib tug txo nyob rau hauv platelet suav, nce erythrocyte sedimentation tus nqi, nce tus naj npawb ntawm leukocytes. Feem ntau cov syndrome yog nrog los ntawm hemolytic anemia, uas muaj peev xwm kuj yuav pom nyob rau hauv laboratory kev tshawb fawb.

Tsis tas li ntawd ua ntshav Science News for KIDS. Tus neeg mob muaj ib tug muaj zog npaum li cas ntawm gamma globulins. Yog hais tias lub keeb kwm yav dhau pathology twb puas siab, tsub kom tus nqi ntawm cov bilirubin nyob rau hauv cov ntshav, thiab alkaline phosphatase. Nyob rau hauv lub xub ntiag ntawm lub raum kab mob no yuav tsum muaj cai nce nyob rau hauv cov ntshiab creatinine thiab urea.

Ib txhia neeg thiab pom zoo kom tej immunological kev kuaj ntshav. Piv txwv li, kuaj kev tshawb fawb yuav tsum tau ua los mus txiav txim rheumatoid ceeb thiab lupus coagulant. Thaum phospholipid syndrome ntshav yuav ntes tus xub ntiag ntawm cov tshuaj rau cov ntshav liab, muaj zog lymphocytes. Yog hais tias muaj yog lub sijhawm twg los ntawm loj kev puas tsuaj rau lub siab, raum, cov pob txha, yuav muaj instrumental xeem, xws li X-ray, ultrasound imaging.

Yuav ua li cas yog qhov teeb meem ntawm tus kab mob yog txuam?

Yog hais tias tsis kho, lub phospholipid syndrome yuav ua tau kom tsis tshua muaj neeg txaus ntshai teeb meem. Tawm tsam tom qab ntawm tus kab mob nyob rau hauv cov hlab ntsha tsim txhaws, uas nyob rau hauv nws tus kheej yog txaus ntshai. Ntshav txhaws khaum cov hlab ntsha, cuam tshuam ib txwm ntshav - ntaub so ntswg thiab kabmob tsis tau txais txaus cov as-ham thiab oxygen.

Feem ntau tiv thaiv lub keeb kwm ntawm tus kab mob, cov neeg mob tsim stroke, thiab myocardial infarction. povtseg embolism yuav ua tau kom gangrene. Raws li hais saum toj no, cov neeg mob muaj cai kom malfunction ntawm ob lub raum thiab adrenal qog. Cov feem ntau txaus ntshai qhov yuav tau txais ntawm ib tug pulmonary embolism - qhov no pathology npaj acutely, thiab tsis nyob rau hauv tag nrho cov mob, ib tug neeg mob tsis xa rau lub sij hawm mus rau lub tsev kho mob.

Cev xeeb tub nyob rau hauv cov neeg mob uas phospholipid syndrome

Raws li twb tau hais, lub phospholipid syndrome thiaj paub tias yog thaum lub sij hawm cev xeeb tub. Yuav ua li cas txaus ntshai mob thiab yuav ua li cas nyob rau hauv xws li ib tug teeb meem no?

Vim phospholipid syndrome nyob rau hauv cov hlab ntsha tsim txhaws uas txhaws cov hlab ntsha nqa cov ntshav mus rau lub tsev me nyuam. Embryo tsis tau txais txaus cov pa thiab as-ham, nyob rau hauv 95% ntawm cov neeg no ua rau yus nchuav menyuam. Txawm hais tias lub cev xeeb tub yog tsis tu ncua, muaj ib tug uas yuav ntawm placental abruption thaum ntxov thiab lig kev loj hlob ntawm preeclampsia, uas yog heev txaus ntshai rau ob qho tag nrho leej niam thiab tus me nyuam.

Qhov tseeb tiag mas, ib tug poj niam yuav tsum mus kuaj nyob rau hauv cov kev npaj theem. Cuaj kaum phospholipid syndrome yog feem ntau thiaj paub hais tias thaum lub sij hawm cev xeeb tub. Nyob rau hauv xws li mob, nws yog ib qho tseem ceeb heev rau daim ntawv ceeb toom ntawm lub xub ntiag ntawm tus kab mob thiab nqa mus siv rau qhov tsim nyog ntsuas. Rau kev tiv thaiv ntawm yav tom ntej leej niam ntawm thrombosis yuav raug muab tso rau anticoagulation nyob rau hauv me me koob tshuaj. Nyob rau hauv tas li ntawd, cov poj niam yuav tsum tsis tu ncua saib xyuas kom cov kws kho mob yuav pib pom placental abruption. Txhua txhua ob peb lub hlis, tos leej niam uas raug kho uas muaj strengthening txoj kev kho, kev noj kev npaj muaj vitamins, minerals thiab antioxidants. Nrog rau txoj cai mus kom ze, cev xeeb tub feem ntau xaus yam xyuam xim.

Yuav ua li cas yog cov kev kho mob?

Yuav ua li cas yog tias ib tug neeg yog pom phospholipid syndrome? Kev kho mob nyob rau hauv cov ntaub ntawv no, thiab nws nyob rau hauv lub xub ntiag nyob rau ib tug neeg mob ntawm tej yam teeb meem. Raws li lub keeb kwm ntawm tus kab mob no daim ntawv txhaws, txoj kev kho yog feem ntau aimed ntawm thinning cov ntshav. Cov kev kho mob regimen feem ntau yuav siv li ntawm ob peb pab pawg ntawm cov tshuaj:

• Thawj tsa anticoagulants ntawm indirect txiav txim, thiab antiplatelet agents ( "aspirin", "warfarin").
• Therapy feem ntau muaj xws li xim uas tsis yog-tshuaj anti-inflammatory siv tshuaj los ntawm keeb kwm, nyob rau hauv kev lub "Nimesulide" los yog "Celecoxib".
• Yog hais tias tus kab mob no yog txuam nrog mauj lupus erythematosus thiab ib co lwm yam kab mob autoimmune, tus kws kho mob yuav muab tshuaj rau steroid kho mob (hormonal anti-inflammatory siv tshuaj). Nrog rau qhov no tej zaum yuav siv tau, immunosuppressive tshuaj uas suppress cov kev ua ntawm lub cev thiab kom txhob muaj cov ntau lawm ntawm tej tshuaj.
• Cev xeeb tub poj niam tej zaum intravenously muab immunoglobulin.
• Cov neeg mob yuav tsis tseg noj npaj muaj vitamins ntawm pab pawg neeg B.
• Txog cov kev noj qab haus huv, tiv thaiv cellular week thiab cov hlab ntsha siv tshuaj, antioxidants, thiab kuj npaj uas muaj ib tug complex ntawm polyunsaturated fatty acids ( "Omacor", "Mexicor").

Pab rau tus neeg mob tus mob muaj feem xyuam rau electrophoresis txoj kev. Thaum nws los txog rau theem nrab phospholipid syndrome, nws yog ib qho tseem ceeb los tswj cov thawj kab mob. Piv txwv li, cov neeg mob uas vasculitis thiab lupus yuav tsum tau txais txaus kev kho mob ntawm cov pathologies. Nws tseem yog ib qho tseem ceeb lub sij hawm los xyuas kis kab mob thiab nqa tawm lub tsim nyog txoj kev kho kom txog thaum ua tiav rov qab (yog tias ua tau).

Cov raug rau cov neeg mob

Yog hais tias phospholipid syndrome mob nyob rau hauv lub sij hawm thiab tus neeg mob tau txais qhov tsim nyog kho mob, cov raug yog heev paaj. Yog xav tau tshem ntawm cov kab mob no yog hmoov tsis tsis tau, tab sis muaj tshuaj yuav tswj tau nws cov aggravation thiab kev pab tiv thaiv kev kho mob ntawm thrombosis. Xam tias yog yus teeb meem no nyob rau hauv uas tus kab mob no yog txuam nrog thrombocytopenia thiab ntshav siab.

Nyob rau hauv txhua rooj plaub, nyob rau hauv lub saib xyuas ntawm ib tug rheumatologist yuav tsum nyob rau hauv tag nrho cov neeg mob uas muaj mob ntawm "phospholipid syndrome." Los ntawm rov tsom xam raws li yuav ua li cas feem ntau koj yuav tsum tau xeem kom dhau xeem nyob rau lwm lub kws kho mob yog dab tsi tshuaj yuav tsum tau muab raws li mus saib xyuas hauv lub xeev ntawm nws tus kheej lub cev - tag nrho cov no yuav qhia rau cov kws kho mob.