Alkaline phosphatase - ib tug tseem ceeb enzyme tib neeg lub cev

Rau hnub tim, lub complex mob ntawm ntau cov kab mob siv kuaj txoj kev xeem. Qhov no yuav ib tug biochemical tsom xam ntawm cov ntshav.

Alkaline phosphatase: general yam ntxwv ntawm cov enzyme

Alkaline phosphatase - ib qho ntawm feem tseem ceeb ntsuas. Qhov no compound yog ib qho enzyme uas exhibits phosphatase kev ua si. Nws yog tam sim no nyob rau hauv txhua tus tib neeg lub hlwb. Nws siab tshaj plaws ua si no yog muaj nyob rau hauv ib tug alkaline nruab nrab thiab yog txuam nrog cell week. Qhov siab tshaj plaws concentration ntawm no compound yog kaw nyob rau hauv osteoblasts (hlwb nyob rau hauv cov pob txha ntaub so ntswg), mob hlwb thiab lub raum tubules nyob rau hauv lub plab hnyuv mucosa, raws li zoo raws li lub tsev me nyuam. Alkaline phosphatase, uas yog muaj nyob rau hauv lub ntshiab, raws li ib tug txoj cai, muab los ntawm cov pob txha los yog hepatocytes. Nws siab kev ua si yog cai feem ntau nyob rau hauv daim siab kab mob uas tshwm sim nrog dab tsi thaiv ntawm cov kua tsib duct, raws li zoo raws li nyob rau hauv qhov txhab ntawm cov pob txha ho muaj pob txha kho.

Alkaline phosphatase theem siab. Yog vim li cas?

Muaj ntau ntau tus kab mob kas nyob rau hauv uas muaj zog alkaline phosphatase. Cov cai ntawm qhov ntsuas no yog nyob rau hauv lub hnub nyoog thiab pw ua ke, thiaj coj qhov no mus rau tus account thaum txhais ntshav biochemistry.

Ntawm cov etiological yam tseem ceeb uas tej zaum yuav cuam tshuam rau theem ntawm enzymes, xws li alkaline phosphatase, yuav tsum muaj xws li cov nram qab no:

• cev xeeb tub;

• Postmenopausal;

• tsis txaus kom tsawg ntawm kev noj haus calcium, thiab phosphates;

• tshaj ntawm ascorbic acid nyob rau hauv lub cev;

• kev siv ntawm ib pharmacological cov neeg ua hauj (e.g., contraceptives muaj estrogen thiab progesterone, raws li zoo raws li tshuaj tua kab mob).

Nyob rau hauv tas li ntawd, alkaline phosphatase yuav tau nce nyob rau hauv cov nram no cov kab mob:

• hyperparathyroidism;

• lub plawv yuav nres lub raum los yog mob ntsws cov ntaub so ntswg;

• ntau myeloma;

• kab mononucleosis;

• pob txha kab mob, xws li mob cancer ntawm qhov;

• Kab mob Hodgkin, uas muaj tshwm sim nrog kev puas tsuaj ntawm tus pob txha;

• rickets;

• phem lesion ntawm biliary ib ntsuj av tau;

• o ntawm lub kab xwm los yog mob npuas paug ntawm lub siab, nws yeej tuberculosis.

Etiology txo alkaline phosphatase

Muaj ib tug xov tooj ntawm pathologies nyob rau hauv uas, nyob rau hauv tsis tooj, alkaline phosphatase txo. Yog li, cov theem ntawm enzyme hauv qab no ib txwm nyob rau hauv hypothyroidism. Kev ua txhaum ntawm cov pob txha loj hlob, tsis muaj peev xwm ntawm zinc thiab magnesium, raws li zoo raws li anemia - etiological yam tseem ceeb uas tej zaum yuav cuam tshuam rau tus nqi ntawm cov alkaline phosphatase nyob rau hauv cov ntshav ntshiab. Noj tej yam tshuaj kuj hloov lub xeem. Tsis tas li ntawd, lub xub ntiag ntawm scurvy, uas muaj vim yog lub insufficiency ntawm ascorbic acid ua rau ib tug txo ntawm lub enzyme.

Nws yuav tsum tau muab sau tseg tias nyob rau hauv cev xeeb tub alkaline phosphatase yuav loj hlob los ntawm nce lub xov tooj ntawm placental isoenzyme. Qhov no yog raug ntawm cov theem kawg ntawm cev xeeb tub thiab yog txuam nrog lub siab tshaj plaws txoj kev loj hlob ntawm lub tsho me nyuam. Xws li ib tug qauv muaj tsis muaj diagnostic nqi, li ntawd, nws tsis yog muaj feem xyuam rau kev luj xyuas hauv lub xeev ntawm tus niam los yog me nyuam hauv plab. Nyob rau hauv tus neeg mob thaum ib tug poj niam thiaj paub tias yog placental insufficiency, lub concentration ntawm no compound yog txo enzyme.

Nta ntawm kev hloov ntawm cov theem ntawm alkaline phosphatase

Alkaline phosphatase yog nyob rau hauv daim ntawv ntawm ob peb isoenzymes. Lub degree ntawm kev nce rau hauv lub concentration ntawm cov compound yog correlated nrog active osteoblastic (pob txha tsim cov txheej txheem), yog li ntawd lub siab tshaj plaws qib ntawm cov pob txha isoenzyme cai nyob rau hauv Paget tus kab mob. Yog hais tias tus neeg mob muaj cov pathology nrog osteolytic kev ua si (xws li, ntau yam myeloma), lub alkaline phosphatase nce, tab sis tsuas yog me ntsis.

Thaum txhab ntawm lub hepatobiliary system tsub kom hepatic isoenzyme. Nyob rau hauv soj ntsuam kev xyaum, nws yog siv raws li ib tug marker ntawm cholestasis. Nyob rau hauv cov ntaub ntawv no, qhov ncaj tsis mob hlwb yuav siv sij hawm qhov chaw tiv thaiv lub keeb kwm ntawm ib txwm los yog txawm tsawg theem ntawm alkaline phosphatase. Qhov no txawv yog raug, raws li ib tug txoj cai, rau feem ntau cov kev soj ntsuam tus neeg mob, txawm hais tias nws tej zaum yuav tsis muaj cai nyob rau hauv ib tug neeg mob, txawm nrog kev puas tsuaj rau lub siab los yog biliary ib ntsuj av.

Nws yog ib nqi sau cia hais tias muaj zog alkaline phosphatase nyob rau hauv ib tug me nyuam - ib tug muaj sia tshwm sim, uas yog txuam nrog muaj zog txoj kev loj hlob. Yog li, cov theem ntawm no enzyme nyob rau hauv cov me nyuam tej zaum yuav mus txog ib theem uas tshaj lub cai rau ib tug neeg laus tib neeg yog 1.5-2 lub sij hawm (los ntawm 82 mus 341 U / L).

Tseem txiav txim rau cov theem ntawm alkaline phosphatase

Rau hnub tim, lub pom tej yam kev mob rau lub tsom xam rau qhov kev txiav txim ntawm lub concentration ntawm alkaline phosphatase yog sib txawv, vim hais tias txhua kuaj nws muaj nws tus kheej cov qauv. Muaj ntau ntau tshuaj ntsuam txoj kev uas nyob ntawm seb lub enzyme substrate thiab tus tsis system raws li zoo raws li lub ntsuas kub ntawm uas qhov kev kuaj no yog muaj nyob rau. Uniform ib thaj tsam qhia "alkaline phosphatase" tsis yog, ces nws yog tsis tsim nyog los sib piv qhov tseem ceeb ntawm cov enzyme, uas twb tau nyob rau hauv txawv laboratories. Qhov no yog tshwj xeeb tshaj yog muaj tseeb thaum nws tsis paub dab tsi uas kav cov chaw soj nstuam teem.

Rau kev tsom xam ntawm cov ntshav ntshiab yog siv. Nyob rau hauv feem ntau tus neeg mob, kev noj rau sab saum toj txheej, uas yog tsim nyob rau hauv lub separator raj. Nws yog ib nqi sau cia hais tias lub theem ntawm alkaline phosphatase tej zaum yuav erroneously ntau zog, yog cov ntshav zauv tourniquet nyob rau sab sauv povtseg tau yuam rau ntau tshaj 30 vib nas this. Nyob rau hauv tas li ntawd, cov kev ua ntawm no enzyme tej zaum yuav txawv me ntsis yog hais tias tus ntshav twb khaws cia nyob rau hauv chav tsev kub. Nyob rau hauv no nyob rau hauv vitro hemolysis tsis cuam tshuam rau kev xeem.

Yuav ua li cas thaum ib tug pathological theem ntawm alkaline phosphatase?

Thaum alkaline phosphatase ntau zog, cov kev kho mob yuav tsum muaj etiological kev taw qhia. Yog li, lub xub ntiag ntawm daim siab los yog biliary kab mob yuav tsum tau nrog ib tug gastroenterologist. Cholestasis, muaj pancreatitis, dej tus kab mob siab los yog mob npuas paug yuav tsum tau coj kev kho yeeb tshuaj uas ntim tsuas txiav txim los ntawm tus kws kho mob. Self nyob rau hauv cov ntaub ntawv no yuav ua rau ib tug aggravation ntawm cov thawj kab mob.

Hloov cov concentration ntawm enzymes, xws li alkaline phosphatase, tej zaum yuav muaj cai nyob rau hauv lub plawv tsis ua hauj lwm, mob cancer pathology thiab mob puas tsuaj mus rau lub ob lub raum, raws li tau zoo raws li nyob rau hauv cov ntshav qab zib, kom koj thiaj li yuav tsum tau nrog ib tug kws kho plawv, nephrologist los yog endocrinologist. Tus kws kho mob yuav txiav txim seb lub tshuaj tactics nyob rau hauv lub soj ntsuam daim duab.

Nyob rau hauv tshem cov etiological yam, alkaline phosphatase kev ua si rov los li qub. Nyob rau hauv lub sij hawm ntawm txoj kev kho yuav tsum tau coj mus rau hauv tus account tias, piv txwv li, ib tug muaj sia kev nce ntawm qhov ntsuas no yog tau nrog cov pob txha lov, active kev loj hlob ntawm lub skeletal system, nrog hnub. Nws tsis yuav tsum tau kev kho mob kev pab. Txhais lus ntawm cov kev tshwm sim ntawm laboratory kev ntsuam xyuas yuav tsum tau nqa tawm comprehensively, noj mus rau hauv tus account lwm biochemical tsis thiab tus neeg mob kev tsis txaus siab.