MMF (mycophenolate mofetil): hauj lwm, analogs

Mycophenolate mofetil (INN Mycophenolic acid) yog muaj nyob rau hauv cov pab pawg neeg ntawm immunosuppressants. Cia peb xav txog nyob rau hauv ntau yam cov neeg nyob rau hauv uas nws yog tsim nyog los siv yeeb tshuaj, dab tsi yog qhov contraindications rau nws siv thiab kev phiv.

Nyob rau hauv tas li ntawd, peb yuav nrhiav tau tawm yog hais tias muaj yog nyob rau hauv niaj hnub pharmacology zoo xws li cov txhais tau tias.

Ntsiab lus

mycophenolate mofetil yog muaj nyob rau hauv daim ntawv ntawm ib qho nyuaj gelatin tsiav tshuaj nyob rau hauv kaus ntxhw nrog dawb hmoov hauv.

Yuav cov tshuaj nyob rau hauv pharmacies yog hais tias koj muaj ib tug tshuaj los ntawm ib tug kws kho mob.

Txee lub neej yog ob lub xyoos txhais tau tias. Cia nws yuav tsum nyob ib kub txog li 25 degrees.

Nyob rau hauv thiaj li yuav muaj ib tug yeeb yam nkag siab txog ntawm yuav ua li cas peb xav zoo nkaus li cov tshuaj (mycophenolate mofetil), yees duab saum toj no ua piv txwv piv txwv li.

cov tshuaj

Ib cov tshuaj ntsiav txhais tau tias muaj 250 mg ntawm active compound (mycophenolate mofetil). Nyob rau hauv tas li ntawd, tam sim no thiab koom haum pab Cheebtsam, xws li croscarmellose sodium, microcrystalline cellulose, povidone thiab magnesium stearate.

tshuaj

Tom qab cov tshuaj yog nws ua kom tiav haum thiab ua kom tiav presystemic metabolism. Nyob rau hauv cov ntaub ntawv no, lub concentration ntawm active tshuaj nyob rau hauv ntshav yog cai vim nws sai transformation mus rau hauv active metabolites.

Txhais tau hais tias tas nrog zis thiab feces.

indications

Nyob rau hauv tej rooj plaub, siv mycophenolate mofetil? Cov lus qhia rau kev siv sai sai teb lo lus nug no.

Cov kws kho mob muab tshuaj rau noj cov tshuaj rau cov prophylaxis ntawm mob hloov rejection nyob rau hauv cov neeg mob tom qab lub raum hloov, daim siab los yog lub plawv.

Contraindications

Muaj tsis muaj ntau tus neeg mob qhov twg rau kev siv cov tshuaj no yog nruj me ntsis txwv tsis pub "Mycophenolate mofetil". Cov muaj xws li cov nyob ntawm tus neeg mob lub meem kev txhawj xeeb mus rau lub ntsiab active tshuaj los yog lwm yam ntawm tus neeg saib xyuas, raws li zoo raws li thaum lub sij hawm cev xeeb tub thiab lactation.

Cov miv nyuas siv zug thiab kev nyab xeeb ntawm cov tshuaj nyob rau hauv cov kev kho mob ntawm cov me nyuam tsis tau lawm tias, yog li ntawd tsis txhob siv nws nyob rau hauv Pediatrics.

phiv

Mycophenolate mofetil tau ntxias ib co mob tshwm sim. Nws siv nyob rau hauv ua ke nrog nrog cyclosporine thiab corticosteroids yuav ua rau raws plab, ntuav, leukopenia thiab sepsis. Nyob rau hauv tej rooj plaub, muaj ib txoj kev loj hlob ntawm nqaij hlav thiab lwm yam malignancies, tshwj xeeb yog ntawm daim tawv nqaij.

Nyob rau hauv tas li ntawd, tag nrho cov hloov cov neeg mob muaj teeb meem ntawm kis kab mob, uas tau provoked los ntawm opportunistic pathogens. Feem ntau ntawm lawv yog herpes, Candidiasis thiab cytomegalovirus.

Lwm yam kev phiv tshua yuav manifest lawv tus kheej nyob rau hauv daim ntawv ntawm cov shingles, mob txeeb zig, rhinopharyngitis, hyperthermia, txawv txav siab muaj nuj nqi, esophagitis, hnyuv los ntshav, mob ntawm lub Upper pa ib ntsuj av tau, hnoos, mob taub hau, Gastroenteritis, qaug zog, sinusitis, qhov ncauj Candidiasis , pancreatitis, pancytopenia, neutropenia, thiab hais txog.

Muaj cov kev hem thawj ntawm mob loj heev thiab nyob rau hauv tej rooj plaub txawm txaus ntshai tshwm sim xws li kab mob ntsws, kab mob endocarditis, atypical mycobacterial kab mob.

Dosing thiab Administration

Yuav ua li cas siv cov tshuaj "Mycophenolate mofetil"? Cov lus qhia uas txuas mus rau nws, muab cov ntaub ntawv.

Rau kev tiv thaiv ntawm lub raum rejection. Tus thawj koob tshuaj ntawm tus neeg saib xyuas yuav tsum tau nkag mus rau hauv lub cev tsis pub dhau 72 teev tom qab kev sib hloov ua. Tom qab, tus neeg mob yuav tsum tau noj 1 g ib hnub ob zaug txhais tau tias.

Yog li mycophenolate mofetil yog feem ntau muab nyob rau hauv ua ke nrog nrog corticosteroids thiab cyclosporin.

Rau kev tiv thaiv ntawm lub plawv tsis. Tus thawj zaug yuav tsum raug coj tsis pub dhau 5 hnub tom qab phais ua. Tom qab ib tug tsim nyog tus nqi ntawm cov khoom yog 1.5 g ib hnub ob zaug

overdose

Cov ntaub ntawv nyob rau hauv cov tshuaj overdose, "mycophenolate mofetil," yog tsis muaj.

Nws txhais tau tias nws yog tsis yooj yim sua rau deduce los ntawm lub cev los ntawm hemodialysis. Tshuaj uas khi cov kua tsib acids (cholestyramine) tej zaum yuav pab txhawb kev tshem tawm ntawm lub IFC kab mob, nce nws feem.

Nta ntawm daim ntawv thov

Thaum nrhiav kom tau ntawm ib tug neeg mob neutropenia yuav tsum raug txo koob thiab zoo saib xyuas tus neeg mob lub noj qab haus huv raws li txoj cai los yog cuam tshuam tej kev kho mob mycophenolate mofetil.

Nyob rau hauv lub xub ntiag ntawm mob loj heev mob raum tsis ua hauj lwm yuav tsum soj ntsuam lub xeev kev kho mob thiab tsis pub tshaj ib tug tshaj plaws tshuaj txhais tau tias, uas nyob rau hauv cov ntaub ntawv no muaj nqi mus rau 2 g ib hnub twg.

Cov laus cov neeg mob (65 xyoo) pom zoo rau kev siv ntawm 1 g ntawm yeeb tshuaj, 2 lub sij hawm ib hnub twg.

Ntaub ntawv hais txog cov hauj lwm zoo ntawm cov kab mob nyob rau hauv cov kev kho mob ntawm cov neeg mob raum tsis ua hauj lwm uas underwent ib siab hloov los yog lub plawv, yog uas ploj lawm. Tsis tas li ntawd, muaj yog tsis muaj cov lus qhia txog yuav ua li cas cov tshuaj yog zoo rau cov neeg mob nrog siab txhab uas underwent lub plawv hloov tau ua.

precautionary ntsuas

Nyob rau hauv txhua rooj plaub yuav tsis qhib qhov capsule nyob rau hauv kev npaj. Yuav tsum tsis txhob kov nrog rau cov hmoov: nws nqus tau pa, kev sib cuag nrog cov tawv nqaij los yog qog ua kua week. Yog hais tias, txawm li cas los, nws tshwm sim, yuav tsum tam sim ntawd ntxuav lub cheeb tsam cov nrog xab npum thiab dej.

analogues ntawm cov nyiaj

Puas muaj cov tshuaj uas yuav hloov tau cov khoom "Mycophenolate mofetil"? Analogs, ntawm chav kawm, tsis muaj. Lawv muaj tib lub INN (International Nonproprietary lub npe), los yog ATC code. Yuav tsuas yuav txawv me ntsis spectrum ntawm kev ua si thiab cov nyiaj ntsuab nqi.

Lub nto moo tshaj plaws yog cov nram qab no tshuaj:

• "Baksmun". Siv nyob rau hauv ua ke nrog nrog cyclosporine thiab corticosteroids rau kev tiv thaiv ntawm rejection ntawm lub plawv, siab los yog ob lub raum tom qab kev sib hloov.
• "Zenapax." Nws yog siv los mus tiv thaiv rejection ntawm ib lub raum hloov nyob rau hauv ua ke nrog nrog cyclosporine GCS.
• "Imusporin". Siv rau kev tiv thaiv thiab kev kho mob ntawm transplanted nruab nrog cev thiab hloov hlwb pob txha zoo li raws li nyob rau hauv rheumatoid mob caj dab, endogenous uveitis, Behcet tus kab mob, mauj lupus erythematosus, thiab lwm yam kab mob.
• "Imufet". Raws li zoo raws li lub ntsiab yeeb tshuaj, tus neeg saib xyuas muab nyob rau hauv ua ke nrog nrog corticosteroids thiab cyclosporin rau kev tiv thaiv tsis muaj ib tug transplanted raum lossis daim siab.
• "Layfmun". Tool muaj ib tug dav spectrum ntawm kev txiav txim. Nws yuav siv tau rau kev tiv thaiv thiab kev kho mob ntawm rejection ntawm transplanted kabmob ntawm lub cev thiab pob txha, raws li zoo raws li kev mob caj dab, nephrotic syndrome, active ntaub ntawv ntawm muaj quag lupus erythematosus, Behcet tus kab mob, endogenous uveitis thiab lwm yam kab mob.
• "Mifenaks". Indications rau kev siv yog tib yam li hais tias ntawm lub ntsiab txhais tau tias.
• "Mifortik". Tsim los tiv thaiv kom txhob rejection ntawm lub transplanted raum.
• "Mofilet". Indications thiab pab zoo sib xws nrog mycophenolate mofetil.
• "Panimun". Siv nyob rau hauv kev sib hloov ntawm lub ntsws, lub plawv, lub raum, cov pob txha hlwb, pancreas, raws li zoo raws li nyob rau hauv tej yam kab mob.
• "CellCept." Nws muaj peev xwm raug muab tso thaum ib tug hloov raum.
• "Sertikan". Nws yog qhia rau raum los yog lub plawv cov neeg mob uas muaj mob loj tsawv los yog tsawg immunological uas muaj feem yuav.
• "Tsikloral". Siv nyob rau hauv nrog lwm yam tshuaj nyob rau hauv nruab nrog cev hloov.
• "Ekvoral". Nws yog siv nyob rau hauv kev sib hloov ntawm parenchymal kabmob, raws li zoo raws li rau kev tiv thaiv ntawm rejection tom qab kev sib hloov.

Txawm tias muaj tseeb hais tias tag nrho lawv muaj ib tug zoo li hom ntawm kev txiav txim, ua ntej hloov lub ntsiab tshuaj mus rau lwm yam, koj yuav tsum xub sab laj, thiab tham nrog koj tus kws kho mob.