"Lorista" (ntsiav tshuaj): cov lus qhia rau kev siv, tiag tiag counterparts

Cov kws ua lag luam no yog nplua nuj nrog tshuaj kom txo tau cov ntshav siab. Ntawm lawv yog cov lub enzyme angiotensin receptor antagonists.

zoo ntawm cov tshuaj

Tshuaj "Lorista" muaj nyob rau hauv ob peb cov ntaub ntawv: ib tug ib-feem npaj "Lorista" ua ke ntaub ntawv "Lorista H" thiab "Lorista ND" uas txawv ntau npaum active tshuaj. Bicomponent daim ntawv ntawm kev npaj muaj antihypertensive kev ua si thiab muaj diuretic nyhuv.

qauv

Ntsiav tshuaj "Lorista" monocomponent formulation yog muaj nyob rau hauv peb noj tshuaj npaum cas ntawm cov ntsiab lus ntawm active tshuaj losartan poov tshuaj 12.5 mg, 25 mg, 50 mg. Raws li koom haum pab Cheebtsam siv thiab pregelatinized pob kws starch, microcrystalline cellulose, ib tug sib tov ntawm lactose thiab cellulose, aerosil, magnesium stearate. Zaj duab xis txheej noj tshuaj npaum cas ntawm 25 mg los sis 50 mg ntawm losartan poov tshuaj muaj hypromellose, talc, propylene glycol, titanium dioxide, thiab 12.5 mg rau cov tshuaj siv txawm quinoline daj zas xim.

Ntsiav tshuaj preparations "Lorista H" thiab "Lorista ND" muaj ib tug tub ntxhais thiab ib tug plhaub. Cov tub ntxhais muaj ob active Cheebtsam: Losartan poov tshuaj 50 mg (rau cov H daim ntawv no) thiab 100 mg (rau ND ntaub ntawv) thiab hydrochlorothiazide 12.5 mg (rau "N" daim ntawv no) thiab 25 mg (rau "ND" zoo). Yuav kom tsim rau cov tub ntxhais siv ntxiv Cheebtsam li pregelatinized starch, microcrystalline cellulose, lactose, magnesium stearate.

Ntsiav tshuaj "Lorista H" thiab "Lorista ND" zaj duab xis txheej uas muaj hypromellose, macrogol 4000, quinoline daj zas, titanium dioxide thiab talc.

Raws li siv yeeb tshuaj ua

Ua ke antihypertensive neeg sawv cev ( "Lorista" npaj) rau phau ntawv qhia txog cov pharmacological kev txiav txim ntawm txhua yam kom nquag plias tivthaiv.

Ib tug ntawm cov active cov khoom xyaw yog losartan, kuj yog ib xim antagonist ntawm angiotensin enzyme hom 2 receptors nonprotein qauv.

Kev tshawb fawb ua nyob rau hauv vitro thiab nyob rau hauv cov tsiaj, pom tias cov nyhuv ntawm losartan thiab nws carboxyl metabolite yog aimed ntawm thaiv cov hlab cov teebmeem ntawm angiotensin rau angiotensin hom 1 receptors. Qhov no activates lub renin nyob rau hauv cov ntshav ntshav thiab ua rau ib tug txo nyob rau hauv aldosterone concentration tam sim no nyob rau hauv cov ntshav ntshiab.

Ua kom theem ntawm angiotensin hom 2 receptors losartan activates no enzyme, nyob rau tib lub sij hawm tsis hloov lub lag luam ntawm lub enzyme hom 2 kininazy muab kev koom tes nyob rau hauv lub metabolism ntawm bradykinin.

Qhov kev txiav txim ntawm lub active ingredient ntawm cov kev npaj "Lorista" aimed ntawm txo tag nrho cov peripheral kuj ntawm lub vascular txaj, lub siab nyob rau hauv cov hlab ntsha ntawm lub pulmonary kev, afterload, rau kev ntawm ib tug diuretic nyhuv.

Losartan tiv thaiv tus sawv ntawm pathological nce nyob rau hauv lub plawv mob, tsub kom kuj rau lub cev ua hauj lwm ntawm tib neeg lub cev, nyob rau hauv uas muaj yog mob hauv lub plawv tsis ua hauj lwm.

Txhua hnub daim ntawv thov ntawm ib tug tib koob tshuaj losartan ua ib tug neeg twg poob rau hauv lub Upper (systolic) thiab sab (diastolic) cov ntshav siab. Thoob plaws hauv lub hnub nyob rau hauv tus ntawm cov tshuaj yog nqa tawm niaj hnub tswj ntawm cov ntshav siab thiab antihypertensive nyhuv coincides nrog lub ntuj circadian atherosclerosis. Txo lub siab thaum lub sij hawm ntawm kaw haujlwm ntau npaum losartan tshwm sim nyob rau 80% piv nrog rau lub ncov kev ua si ntawm lub active ingredient. Nyob rau hauv cov kev kho mob lub medicament yog tsis cuam tshuam rau lub plawv dhia, thiab nyob rau txiav ntawm lub txais tos yog tsis tsim tej yam tshwm sim ntawm tshem ntawm cov tshuaj. Cov hauj lwm zoo losartan thov rau cov txiv neej thiab poj niam lub cev ntawm tag nrho cov muaj hnub nyoog.

Lub ib feem ntawm lub neej coj txhais tau tias ntawm qhov kev txiav txim ntawm hydrochlorothiazide raws li ib tug diuretic, ib tug thiazide txuam nrog impaired haum ntawm cov tshuaj ions, sodium, magnesium, poov tshuaj, thiab dej nyob rau hauv cov thawj zis rov qab mus rau hauv cov ntshav ntshav ntawm lub raum distal nephron. Cov tshuaj yeeb dej caw tej tuav calcium ion thiab uric acid. Hydrochlorothiazide muaj antihypertensive zog vim yog lub expansion ntawm lub arterioles. Diuretic nyhuv pib tom qab 60-120 feeb thiab lub siab tshaj plaws diuretic nyhuv kav los ntawm 6 mus rau 12 teev. Pom antihypertensive nyhuv ntawm cov tshuaj kho mob tshwm sim tsis pub dhau 1 lub hli.

Yog vim li cas thov

Tshuaj "Lorista" ntsiav tshuaj, phau ntawv qhia kom:

• rau cov kev kho mob ntawm kub siab, nyob rau hauv uas lub neej coj kev kho mob yog pom tias;
• los txo cov kev yuav ua rau muaj kab mob ntawm cov hlab plawv system thiab tus naj npawb ntawm cov neeg tuag nyob rau hauv tawg thiab pathological kev hloov nyob rau hauv rau sab laug ventricle.

dosing

Qhov no tshuaj yog npaj rau qhov ncauj thawj coj. Noj cov zaub mov muaj tsis ntxim rau cov kev txiav txim ntawm cov tshuaj. Ntsiav tshuaj "Lorista" siab tej zaum yuav ua ke nrog antihypertensives. Noj cov zaub mov muaj tsis ntxim rau cov kev txiav txim ntawm cov tshuaj.

Nyob rau hauv kev npaj "Lorista" (ntsiav tshuaj) cov lus qhia rau kev siv yog ib tug hluas-tivthaiv dosing tswv yim zoo lawm, "H" thiab "ND" ob peb ua ke. Rau tag nrho ntau ntau yam medicament thawj zaug thiab txij nkawm koob thaum txhawb siab raws li lub 1 1 ntsiav tshuaj ib hnub ib zaug. Qhov siab tshaj plaws cov nyhuv ntawm siab txo yog cai tom qab 3 lub lim piam ntawm kev kho mob. Mus cuag ib tug tseem ceeb ua hauj lwm, tau tso cai rau kom lub hnub koob tshuaj "Lorista H" rau 2 ntsiav tshuaj ib 1 txais tos. Qhov siab tshaj plaws pes tsawg tus ntawm cov sij hawm ntau npaum cov ntsiav tshuaj 50 / 12.5 mg ntawm 2 daim.

Yog hais tias ib tug txaus kho nyhuv ntawm kev noj cov medicament "Lorista H" yog tsis tuaj kawm ntawv, cov prescribers "Lorista ND" ntsiav tshuaj. rau lub cuab tam daim ntawv qhia muaj cov ntaub ntawv hais txog lub siab tshaj plaws pes tsawg tus loj npaum (100/25 mg) ib hnub twg, uas yog tsis ntau tshaj 1 ntsiav tshuaj.

Los ntawm kev txo qhov ntim ntawm cov ntshav circulating nyob rau hauv cov hlab ntsha thaum lub sij hawm kev kho mob uas muaj koob diuretics thawj zaug txhua hnub koob tshuaj losartan 25mg siv tau nyob rau ib lub sij hawm. Yog li ntawd, xws li ib tug txoj kev kho antihypertensives tsuas yog sai tau tom qab diuretics thiab normalization ntawm cov ntshav ntim cais.

Nyob rau hauv kev npaj "Lorista" (ntsiav tshuaj) qhia tsis muaj cov lus qhia txog qhov yuav tsum tau mus kho cov koob tshuaj rau cov neeg laus cov neeg mob thiab cov neeg niaj hemodialysis, los yog muaj lub raum tsis ua hauj lwm nrog ib tug creatinine clearance ntawm 30 mus rau 50 ml ib feeb.

Yuav kom txo tau txoj kev pheej hmoo ntawm cardio-leeg tshav system thiab tus naj npawb ntawm cov neeg tuag nyob rau hauv cov neeg mob uas arterial tawg thiab pathological kev hloov nyob rau hauv rau sab laug ventricle ntawm tus txheej txheem pib koob tshuaj losartan hnub xeem nyob rau 50 mg rau ib zaug xwb koob tshuaj. Yog hais tias qhov kev tshwm sim twb tsis tau tiav los ntawm txos cov ntshav siab nyob rau thawj zaug ntau npaum yuav tsum tau nce mus 100 mg losartan, uas yog tau thaum siv 2 "H Lorista" kev npaj ntawm cov ntsiav tshuaj los yog tshuaj 1 "Lorista ND" ib hnub twg nyob rau hauv ib feem.

phiv

ib co Cov neeg mob tau hais tias undesirable los ntawm kev kho mob raws li hypotensive neeg sawv cev. Thaum uas siv cov "Lorista" npaj (ntsiav tshuaj) siv kev qhia ntawv muaj xws li ib daim ntawv teev phiv nrog qhov sib txawv systems ntawm tus kab mob.

Los rau lub hauv paus poob siab system manifested los ntawm mob taub hau, mauj thiab uas tsis yog-mauj kiv taub hau, insomnia, qaug zog, migraine.

Thaum muaj tej yam nyob rau hauv cov hlab plawv system ntawm cov tshuaj ua rau ib koob tshuaj txog orthostatic hypotension, palpitations, tachycardia, vascular o.

Action on lub pa system zoo nkaus li hnoos, ib tug kab mob nyob rau hauv lub Upper pa ib ntsuj av tau, pharyngitis, o ntawm lub qhov ntswg mucosa.

Lub digestive system yog poob nyob rau hauv daim ntawv ntawm kev zawv plab, dyspepsia, xeev siab, ntuav, mob plab, kab mob siab, kev txawv txav siab ua hauj lwm, thaum twg hloov cov kev ua ntawm daim siab enzymes thiab bilirubin.

Nyob rau licas ntawm qhov kev txiav txim manifested myalgia, mob nyob rau hauv lub rov qab, arthralgia.

Nyob rau hauv cov ntshav-sib sau ua kabmob feem xyuam rau txoj manifested anemia thiab purpura.

Hloov thiab kuaj tsis, yus los hyperkalemia, nce theem ntawm hemoglobin, creatinine, hematocrit, urea nyob rau hauv cov ntshav ntshav.

Qhov kev txiav txim yuav tsum tau nrog los ntawm kev tsis haum tshuaj, manifested urticaria, pruritus, anaphylactic poob siab, angioneurotic edema ntawm lub ntsej muag, caj dab, lub cev thiab lub seem ntawm lub peripheral kabmob.

Contraindications

Tsis yog txhua tus yuav kho tau los ntawm cov tshuaj "Lorista". Cov lus qhia rau kev siv yog tsis qhia mus thov lub cuab tam ntawm anuria qhia tib neeg raum thaum creatinine clearance tsawg tshaj li 30 mL ib feeb.

Contraindications txais tos nrog hyperkalemia refractory hypokalemia tackle dej tshuav nyiaj li cas nyob rau hauv lub cev thaum lub sij hawm txoj kev kho uas muaj koob diuretics qhia tib neeg lub siab, txhawb siab, tsis muaj peev xwm ntawm cov lactase enzyme, intolerance rau piam thaj thiab galactose, cev xeeb tub, mis-pub cov me nyuam thiab cov tub ntxhais hluas nyob rau hauv 18 lub xyoos ntawm hnub nyoog .

Kev kho mob nrog "Lorista" (ntsiav tshuaj) qhia txwv tsis pub meem kev txhawj xeeb rau sulfonamide sib txuas ntawm cov series, rau ib yam khoom losartan, hydrochlorothiazide los yog koom haum pab Cheebtsam medicament.

ceev faj yuav tsum tau thaum siv nyob rau hauv cov neeg mob uas impaired dej-ntsha tshuav nyiaj li cas nyob rau hauv cov ntshav thaum muaj tej yam tshwm sim hypochloremic alkalosis, tsis tshua muaj cov ntsiab lus ntawm sodium ions, poov tshuaj, magnesium thiab END ntawm calcium ions nyob rau hauv tib neeg lub cev.

Ob sab sib dho constriction ntawm lub raum leeg los yog narrowing ntawm leeg mus rau ib tug ib lub raum, mob ntshav qab zib, kom ntau ntau cov uric acid nyob rau hauv cov ntshav ntshav, deposition ntawm urate nyob rau hauv cov pob qij txha, lub nyob rau hauv lub yav dhau los tsis haum tshuaj loj rau cov tshuaj uas inhibit angiotensin converting enzyme, bronchial hawb pob, cov ntshav system kab mob yog ib tug ua kom ceev faj siv antihypertensive tshuaj.

Nta ntawm daim ntawv thov

Thaum lub sij hawm kev kho mob "Lorista" (ntsiav tshuaj) cov lus qhia rau kev siv ntxiv pub noj lwm yam antihypertensives. Rau cov laus dua cov neeg uas tsis yog ib tug tshwj xeeb kev xaiv ntawm thawj zaug ntau npaum yuav tsum tau.

Ntawm cov tshuaj tej zaum yuav ua rau muaj zog ntau ntawm creatinine thiab urea nyob rau hauv cov ntshav ntshiab ntawm cov neeg mob uas tau muaj ib tug ob sab sib dho stenosis ntawm lub raum leeg los yog stenosis ntawm leeg ntawm ib lub raum.

Nyob rau hauv tus ntawm hydrochlorothiazide amplifies hypotension, ntxhov ntsha tshuav nyiaj li cas, uas yog yus muaj los ntawm ib tug txo nyob rau hauv ntshav ntim, hyponatremia, gipohloremichesky alkalosis, hypomagnesemia, hypokalemia. Nyhuv ntawm diuretic yog raws kev coj kom ua lub concentration ntawm cov roj cholesterol thiab triglycerides, variation siab tev taus ntawm tus kab mob rau piam thaj molecules, tsis feem ntawm calcium nyob rau hauv cov zis, uas ua rau lawv nce nyob rau hauv cov ntshiab. Hydrochlorothiazide yuav ua hyperuricemia thiab gout.

Nyob rau hauv nyob tus yeees ntawm lub neej coj kev npaj muaj lactose, uas yog ua rau cov neeg mob kev txom nyem los ntawm tsis muaj lub enzyme lactase muaj galactosemia los yog piam thaj intolerance syndrome thiab galactose.

Nyob rau hauv thawj zaug rau theem ntawm kev kho mob ntawm antihypertensive tshuaj tej zaum yuav txo tau lub siab thiab kiv taub hau no, uas tau ua txhaum cov psycho-lub cev ua si ntawm lub cev. Yog li ntawd, cov neeg mob uas nws ua hauj lwm yog kev cob cog rua nrog nce xim nyob rau hauv cov kev tswj ntawm txoj kev los yog txoj mechanisms, yuav tsum txiav txim seb lawv tus mob ua ntej koj sim ua lawv txoj hauj lwm.

analogs

AO "KRKA, dd, Novo mesto" yog lub chaw tsim tshuaj paus ntawm antihypertensive tshuaj "Lorista" (ntsiav tshuaj). Analogs ntawm lub cuab tam nyob rau hauv cov qauv muaj active tshuaj losartan poov tshuaj. Rau chav ntaub ntawv uas zoo sib xws medicaments comprise ob active Cheebtsam: losartan poov tshuaj thiab hydrochlorothiazide.

Rau kev npaj "Lorista" analog yuav muaj tib lub antihypertensive nyhuv thiab kev phiv zoo sib xws. Ib tug xws li txhais tau tias yog ib tug medicament "Cozaar" ntsiav tshuaj ntawm 50 mg los yog 100 lozertana poov tshuaj. Cov chaw tsim tshuaj paus yog lub phiaj los nqis tes "Merck Ntse & Dohme BV" nyob rau hauv lub Netherlands.

Rau chav ntaub ntawv ntawm analogue yog "Gizaar" thiab "Gizaar forte." Cov chaw tsim tshuaj paus yog cov "Merck Ntse & Dohme BV" nyob rau hauv lub Netherlands. Ntsiav tshuaj coated medicament ntawm ib tug ntau npaum daj plhaub oval cim nrog "717" rau ib qhov ntawm cov chaw thiab cov kev txaus ntshai rau cov division nyob rau lwm yam sab, thiab kheej li qe ntsiav tshuaj ntau dua ntau npaum coated dawb zaj duab xis-coated nrog cov los "745" rau ntawm ib sab.

Muaj pes tsawg leeg ntawm lub medicament "Gizaar forte" yog losartan poov tshuaj nyob rau hauv ib tug npaum li ntawm 100 mg, thiab hydrochlorothiazide, uas muaj 12.5 mg. Cov kev npaj "Gizaar" yog losartan poov tshuaj nyob rau hauv ib tug npaum li ntawm 50 mg, thiab hydrochlorothiazide, uas muaj 12.5 mg.

Tsis zoo li cov tshuaj "Lorista ND" medicament "Gizaar forte" muaj ib nrab ntawm hydrochlorothiazide thiab poov tshuaj lozertana point. Ob tshuaj muaj antihypertensive diuretic kev txiav txim nrog me ntsis cov nyhuv.

Lwm analog yog ib tug neej coj tshuaj "Lozap plus" lawm "Zentiva AS", Czech koom pheej. Nws yuav ua nyob rau hauv daim ntawv ntawm cov oblong ntsiav tshuaj nrog Valium rau ob chaw coated nrog ib lub teeb daj zaj duab xis. Muaj pes tsawg leeg ntawm lub medicament muaj losartan poov tshuaj nyob rau hauv ib tug npaum li ntawm 50 mg, thiab hydrochlorothiazide, uas muaj 12.5 mg.

Ib yam li ntawd tshuaj rau "Lorista H" yog ib tug yeeb tshuaj "Vazotenz H" lawm "Aktavis pawg ib tug ib tug", Iceland. Muaj nyob rau hauv ob noj tshuaj npaum cas. Nyob rau hauv cov ntsiav tshuaj, cov me koob tshuaj muaj 50 mg losartan poov tshuaj thiab hydrochlorothiazide 12.5 mg, thiab cov ntsiav tshuaj nrog ntau dua cov tshuaj muaj 100 mg ntawm losartan poov tshuaj thiab 25 mg hydrochlorothiazide.

Xyuas

Tshuaj "Lorista" tau txais ntau yam kev xyuas. Ib txhia neeg pom txoj kev txhim kho nyob rau hauv thawj zaug rau theem ntawm kev kho mob, thaum lub cai decreases nyob rau hauv cov ntshav siab. Lwm tus nco ntsoov ib qho kev nce rau hauv cov ntshav siab nyob rau hauv lub yav tsaus ntuj los yog ib tug surge ntawm kev tig tau. Nyob rau hauv xws li ib tug cov ntaub ntawv nws yog tsim nyog los tshem tawm kev kho mob tshuaj "Lorista" (ntsiav tshuaj). Cov lus qhia Testimonials combines "phiv" seem, uas qhia tau hais tias tag nrho cov tau phiv cov txheej xwm uas tau sau tseg rau hauv txoj kev siv cov antihypertensive neeg sawv cev.

Tshuaj "Lorista" coj txhua txhua hnub, siv ib tug tsawg kawg nkaus npaum uas tsub kom lub sij hawm vim lub habituation ntawm tus kab mob mus rau lub active tshuaj. Cov kev kho mob nyhuv yog tsis tam sim ntawd, tab sis tsub zuj zuj ntawm cov tshuaj nyob rau hauv lub cev.