"Indomethacin" (ntsiav tshuaj): cov lus qhia rau kev siv, tiag tiag

Ib tug ntawm cov neeg sawv cev ntawm cov pab pawg neeg ntawm nonsteroidal anti-inflammatory siv tshuaj yog ib tug yeeb tshuaj "Indomethacin" (ntsiav tshuaj). Vim nws anti-inflammatory, analgesic thiab antipyretic los ntawm nws cov kev siv rau cov kev kho ntawm inflammatory kab mob, pab kev mob, kom tsis txhob o thiab los sib koom muaj.

Hauj lwm ntawm cov kev npaj

Lub ntsiab active ingredient ntawm cov tshuaj yog indomethacin, uas muaj feem rau indole acetic acid derivatives. Hauv ntim medicament "Indomethacin" piav qhia txog raws li cov ntsiav tshuaj daim ntawv qhia hais nrog ib tug tiv thaiv enteric txheej uas tso cai rau lub active neeg sawv cev yuav tsum tau tso tawm nyob rau hauv cov hnyuv, bypassing lub plab. Tus duab ntawm round ntsiav tshuaj, biconvex, rau sab saum toj them nrog ib lub teeb-xim av plhaub.

Ntsiav tshuaj muaj ntau noj tshuaj npaum cas: 25 mg, 50 mg thiab 100 mg ntawm indomethacin. Muaj nyob rau hauv 10 los yog 40 daim ib pob.

Tag nrho cov ntau npaum ntaub ntawv

Tsis tas li ntawd cov ntsiav tshuaj, muaj lwm yam ntaub ntawv ntawm cov "Indomethacin" kev npaj rau qhov ncauj siv, rau Piv txwv li ib pab tso tawm capsule ntau npaum ntawm 75 mg. Rau qhov quav thawj coj, suppositories yog siv nrog ib koob tshuaj 50 mg. Rau sab nraum zoov daim ntaub ntawv tsim tshuaj pleev 5% thiab 10% thiab 3% gel.

mechanism ntawm qhov kev txiav txim

Lub medicament yog ib tug nonsteroidal antiinflammatory neeg sawv cev mauj txiav txim, uas muaj antiinflammatory, decongestant, analgesic thiab antipyretic los. Txuas mus rau lub tshuaj "Indomethacin" (ntsiav tshuaj) daim ntawv qhia mechanism comprises ib piav txog ntawm nws lub lag luam lub active ingredient txuam nrog ib tug txo nyob rau hauv cyclooxygenase kev ua ntawm hom 1 thiab 2. Nyob rau hauv lem, qhov no enzyme muaj ib tug tsawg heev ntxim rau cov arachidonic acid uas thiaj li nws hloov dua siab tshiab rau prostaglandin. Cov tshuaj ua rau o thiab mob.

Indomethacin teev antiplatelet nyhuv, kom txhob muaj ntshav txhaws clumping ntawm ntshav. Substance attenuates mob nyob rau ob leeg mob nyob rau hauv ib tug twj ywm thiab mobile xeev, thiaj li sawv ntxov nruj thiab o, tsub kom ntau ntawm cov lus tsa suab. Action indomethacin tswj kom txhob muaj cov mob. Qhov siab tshaj plaws cov nyhuv yog muab rau lub xya hnub ntawm kev kho mob, cov tshuaj ntsiav tshuaj.

uas khoom

Raws li cov mechanism ntawm qhov kev txiav txim, "Indomethacin" ntsiav tshuaj phau ntawv qhia kom siv rau mauj kev kho mob ntawm:

• articular syndrome;
• inflammatory kab mob ntawm lub licas tshwm sim los ntawm rheumatoid, psoriatic, rheumatoid, hluas caj dab, khov xub pwg, ankylosing spondylitis, ob leeg tus kab mob nyob rau hauv deforming osteitis thiab uretrookulosinovialnom syndrome;
• degenerative cov kab mob ntawm lub licas tshwm sim los ntawm osteochondrosis nrog radicular syndrome, osteoarthrosis ntawm cov pob qij txha, tshwj tsis yog lub duav thiab intervertebral arthrosis;
• diffuse kab mob, yuav tsum vov lub connective cov ntaub so ntswg;
• rheumatism;
• suppurative inflammatory txhab ntawm periarticular hnab thiab tendons;
• mob cov tsos mob nyob rau hauv lub qis rov qab thiab lwm qhov chaw ntawm cov nqaj qaum thaum lub sciatic neuralgia thiab lwm yam qab haus huv, o ntawm cov nqaij ntshiv;
• puas o nyob rau hauv cov nqaij mos mos los yog pob qij txha.

Nws yuav pab tau koj mus rau tiv nrog mob taub hau, coj khaub, hniav, tuberculosis.

Raws li ib tug koom haum pab neeg sawv cev rau kab thiab inflammatory kab mob xws li pharyngitis, tonsillitis, otitis siv medicament "Indomethacin" (ntsiav tshuaj). Indications muaj xws li cov kev kho mob ntawm cystitis, adnexitis, prostatitis.

Cov tshuaj no yuav siv tau rau kev tshem tawm ntawm febrile syndrome muaj feem xyuam rau Hodgkin tus kab mob, nqaij hlav, metastatic hlav, thaum tsis sawv paracetamol thiab acetyl salicylic acid.

Yuav ua li cas mus noj

"Indomethacin" tshuaj nyob rau hauv cov ntsiav tshuaj yog muab rau ib tug neeg mob nyob rau hauv ib tug ntau npaum raws li cov neeg kawm ntawv ntawm tus kab mob. Feem ntau, cov neeg laus pib nrog tau txais ib koob tshuaj 25 mg peb lub sij hawm ib hnub tom qab noj mov.

Yog hais tias cov nyhuv ntawm kev kho mob yog tsis txaus pronounced ob ntau npaum li 50 mg 3 lub sij hawm ib hnub. Maximum pub koob tshuaj yuav tsum tsis txhob ntau tshaj 200 mg indomethacin. Tom qab ib tug tseem ceeb kev txhim kho tshwm sim los ntawm cov tshuaj txoj kev kho, kev kho mob yuav tsum tau tso tseg tsuas yog tom qab 4 lub lis piam siv yav dhau los lub sij hawm los yog ib tug txo koob tshuaj. Yog hais tias cov neeg mob noj tshuaj rau ib ntev lub sij hawm "Indomethacin" phau ntawv qhia kom ib koob tshuaj 75 mg ntawm active ingredient ib hnub twg.

kev kho mob ntawm cov me nyuam

Rau cov me nyuam txhua txhua hnub koob tshuaj muab xam 2.5 los yog 3 mg rau nws lub cev loj, nws yog noj rau 3-4 lub sij hawm. Rau txhua lub hnub nyoog pab pawg neeg muab kev siv ntawm ib tug thawj zaug txhua hnub koob tshuaj:

• cov me nyuam 3 mus rau 7 xyoo muab los ntawm 50 mg rau 75 mg, uas sib raug rau 2 los yog 3 ntsiav tshuaj;
• cov me nyuam 7 mus rau 12 xyoo: los ntawm 75 mg rau 100 mg, uas sib raug mus rau lub 3 los yog 4 ntsiav tshuaj;
• Cov me nyuam 12 xyoo muab los ntawm 100 mg rau 125 mg, uas sib raug mus rau 4 los yog 5 ntsiav tshuaj.

Nyob rau hauv thawj ob peb hnub, koj yuav tsum paub yuav ua li cas cov tshuaj rau tus me nyuam lub cev, ces siv ib tug me me koob tshuaj ntawm cov tshuaj. Lub caij ntawm txoj kev kho nrog "Indomethacin" (ntsiav tshuaj) qhia tsa raws li lub sij hawm los ntawm 6 mus rau 7 hnub.

nta txais tos

Nyob rau hauv no hais txog, muaj ib tug tau kev phiv los ntawm cov txais txhais tau tias "Indomethacin" nyob rau hauv cov ntsiav tshuaj, nws yog ib qhov zoo dua tsis siv rau cov kev kho mob ntawm mob rheumatic fever nyob rau hauv thaum yau. Tswv yim rau hauv niam cov kua mis, cov active ingredient tau txais mus rau hauv tus me nyuam cov ntshav, tsub kom lub physiological daj ntseg nyob rau hauv tus me nyuam mos thiab lub yeej ntawm lub siab lub hlwb. Kom tsis txhob no, rho pub niam mis.

Cov neeg laus, cov neeg mob uas mob siab, mob raum, cov hnyuv, dyspeptic cov tsos mob, kub siab, txhaws lub plawv tsis ua hauj lwm tom qab phais, Parkinson tus kab mob, qaug dab peg, cev xeeb tub nyob rau hauv kuv thiab II peb lub hlis thaum muab Indomethacin kev kho mob yuav tsum tau saib xyuas tus txheej xwm ntawm tus kab mob. Nws yog tsim nyog los tswj cov kev ua ntawm problematic kabmob, ib zaug txhua txhua 7 hnub los mus xyuas lub peripheral cov ntshav.

Yog hais tias nyob rau hauv lub yav dhau los yog tsis haum rau cov uas tsis tshuaj anti-inflammatory siv tshuaj, cov tshuaj "Indomethacin" (ntsiav tshuaj) yog tsa nyob rau hauv huab mob.

Peb tsis pom zoo ua tej hauj lwm nyob rau hauv cov kev kho mob, raws li cov disturbed mloog thiab psychomotor yam kev ua si.

Thaum twg koj tsis tau

Muaj cov kab mob nyob rau hauv uas cov tshuaj txhob "Indomethacin" (ntsiav tshuaj). Nws siv yog tsis tau:

• npau taws me ntsis rau indomethacin;
• nyob rau hauv lub xub ntiag ntawm erosive thiab ulcerative txhab ntawm lub digestive system nyob rau hauv lub mob theem;
• thaum "aspirin triad", yus muaj los ntawm intolerance rau acetylsalicylic acid, qhov ntswg polyps thiab bronchial hawb pob;
• ntawm hemodyscrasia;
• thaum pronounced kev hloov ntawm lub siab thiab ob lub raum;
• ntawm ncua sij hawm ntawm ntsev thiab kua nrog tau peripheral edema;
• nyob rau hauv kev mob loj mob tsis ua hauj lwm cim ntawm lub myocardium;
• ntawm kom siab;
• bronchial hawb pob;
• nyob rau hauv o ntawm lub pancreas;
• nyob rau hauv lub III peb lub hlis ntawm hnub ntawm tus me nyuam;
• Kev pub niam mis;
• nyob rau hauv cov me nyuam yau tshaj 3 xyoos.

phiv tshua

Cov tshuaj "Indomethacin" (ntsiav tshuaj) tej zaum yuav txuam nrog cov nyom txheej xwm tsis zoo rau cov mob ntawm tib neeg lub cev. Rau cov kev phiv tshuaj muaj xws li xeev siab, anorexia, mob nyob rau hauv lub plab mog, plab, quav tawv, kem plab.

Nyob rau hauv tsawg zaus, sab los yuav tshwm sim erosive thiab ulcerative txhab, los ntshav thiab perforation ntawm lub plab thiab cov hnyuv phab ntsa; applasticheskoy los yog hemolytic anemia, leukopenia, thrombocytopenia, agranulocytosis, tawm pob, cov plaub hau poob, daim tawv nqaij khaus, qaug dab peg, angioedema, bronchospasm.

Tej yam tshwm sim ntawm tshuaj lom epidermal necrolysis, heev tsis tshua cai anaphylactic poob siab, erythema nodosum.

Thaum lub sij hawm kev kho mob tej zaum yuav tsis tau lub lag luam los ntawm cov excretory raum thiab lub siab, uas tsub kom tus nqi ntawm cov bilirubin, hepatic transaminases.

Long-term siv cov tshuaj "Indomethacin" (ntsiav tshuaj) tsis cais kev phiv tshuaj txuam nrog pw tsaug zog teeb, kiv taub hau, peripheral neuropathy, mob taub hau, ntxhov siab, txob taus, qaug zog. Lawv tsiag ntawv los ntawm clouding ntawm lub cornea, conjunctivitis, lub rooj sib hais kev tsis taus, tinnitus, kub siab, edema.

Xyuas

Nws yog ib qho tseem ceeb ua raws li tag nrho cov kev cai ntawm cov tshuaj, cais tag nrho contraindications.

Yog tov nyob rau kev txais neeg kawm ntawm "Indomethacin" tshuaj xyuas. Ntsiav tshuaj muaj ntau sab los tshaj ntau npaum ntaub ntawv rau lwm siv. Tsis tas li ntawd, active tshuaj koom inhibitors ntawm cyclo-oxygenase 1 thiab 2, uas yog hais tias yuav tsis tshua zoo thiab ua ib tug xov tooj ntawm undesirable tshua ntawm lub gastro-plab hnyuv ib ntsuj av.

Rheumatologists thiab lawv cov neeg mob, cov neeg phais feem ntau muab newer cov tshuaj los ntawm cov pab pawg neeg ntawm oxicams. Lawv inhibit qhov kev cyclooxygenase hom 2 xwb, tsis muaj cuam tshuam rau lub enzyme hom 1, uas saib kuas zus tau tej cov prostaglandins uas tiv thaiv lub digestive system. Uas yog vim li cas oxicams ua tsawg dua li mob mus rau lub plab dua kho "Indomethacin" (ntsiav tshuaj). Cov lus qhia tsis zoo tswv yim muaj xws li ib tug piav qhia ntawm sab los, tab sis qhov no tsis txhais hais tias cov kev kho mob lawv yuav tsum tau qhia. Txhua yam nyob rau tus yam ntxwv ntawm tus kab mob.

Muaj ntau cov neeg mob, qhov no txhais tau hais tias txuag los ntawm rov qab mob, myalgia, intercostal neuralgia, thaum lwm yam tshuaj tsis pab. Ib tug tsis zoo los zoo tsis tshwm sim los ntawm cov kev kho mob ntawm "Indomethacin" tshuaj. Xyuas ntawm cov ntsiav tshuaj zoo tu qab tso cov neeg mob ua zoo. Txawm tias txoj kev pheej hmoo yog yeej ib txwm tam sim no, thiab tsuas yog tus kws kho mob yuav muab tshuaj rau hauv lub txais tos ntawm xws li ib tug loj heev tshuaj.

analogs

Ntsiav tshuaj nrog active tshuaj Indomethacin yog ua los ntawm ntau txawv teb chaws thiab domestic tuam txhab uas muag, xws li lub tuam txhab "Sopharma", "Ludwig Mekle" "Nycomed", "Farmahim", "Berlin Chemie Menarini," "Altfarm". Tsuas yog txhua tshuaj nws luam lub npe, nws muaj pes tsawg leeg koom haum pab Cheebtsam. Tag nrho cov tshuaj tib lub indications rau siv, phiv, contraindications.

Cov feem nrov tshuaj "Indomethacin Sofarma" (ntsiav tshuaj). Ua nyob rau hauv ib koob tshuaj ntawm 50 thiab 100 mg los ntawm "Sofarma" (Bulgaria). Nws yog hais txog ib tug uas tsis yog-tshuaj anti-inflammatory siv tshuaj.

Lwm khub ntawm tsis tsawg tshaj li tus paub analogues - tshuaj "Indomethacin 50 mg ntawm Berlin-Chemie" thiab "Indomethacin 100 mg ntawm Berlin-Chemie". Ua nyob rau hauv ob noj tshuaj npaum cas (50 thiab 100 mg) los ntawm cov Italian lub tuam txhab "Berlin-Chemie Menarini".

Nyob rau hauv kev npaj "Indomethacin" (ntsiav tshuaj) muaj analogues thiab Lavxias teb sab ntau lawm. Lawv yog cov muaj nyob rau hauv txawv ntau npaum cov ntaub ntawv. yog lub ntsiab counterparts:

• "Indomethacin-evkawj" Tshuaj-Kws tsob nroj JSC "Akrikhin";
• "Indomethacin-Altfarm", LLC "Altfarm";
• "Indomethacin-biosynthesis", JSC "biosynthesis";
• "Vero Indomethacin", OJSC "Veropharm".