Immunoglobulin E thiab nws physiological tseem ceeb

Immunoglobulin E thiab nws physiological tseem ceeb - cov teeb meem uas yuav tsum tau saib xyuas. Tam sim no, muaj ntau ntau hom ntawm immunoglobulins (antibodies). Muaj ob peb hom tshuaj uas txawv nyob rau hauv qhov xwm ntawm kev txiav txim thiab lub mechanism ntawm anti-ua kab mob tiv thaiv. Tshuaj ntxias nag lossis daus thiab flocculation ntawm lub yaj kab mob khoom, agglomeration thiab agglutination corpuscular antigens (spirochetes, cov kab mob, protozoa thiab cov kab mob). Thaum lub cell daim nyias nyias vibrios trypanosomes thiab tsau spirochetes immunoglobulins tej ceg nrog complement, ua platelet adsorption. Feem ntau, cov kab mob ua hauj lawm yog muab khaws cia tseg nyob rau hauv lub lymphoid cov ntaub so ntswg. Lub immunoglobulins ntawm cov chav kawm ntawv G thiab M ua ke nrog complement yuav hydrolyze spirochetes, trypanosomes, cov kab mob thiab cov kab mob.

Nyhuv ntawm cov tshuaj nyob rau hauv lub pathogen yog tshem tawm thaum nws nkag mus rau hauv lub cell, thiab tsis tau hnov txog lub antigen rau lub cell nto. Immunoglobulins yuav ntxiv dag zog los yog tsis muaj zog lub cev kuj ntawm tus kab mob. Antigen-antibody complex uas muaj cov antigen dhau heev lawm, ua ib tug stimulating nyhuv, thiab cov complex nrog ib tug dhau heev lawm ntawm cov tshuaj ua rau lub opposite nyhuv. Feem ntau cov feem ntau, tus immunoglobulins yog qhov ua rau ntawm autoimmune thiab tsis haum teeb meem.

IgE yog tsim mas nyob rau hauv lub hlwb ntawm lub qog ua kua week ntawm lub pa, gastro-plab hnyuv ib ntsuj av tau, raws li tau zoo raws li nyob rau hauv lub regional lymph node. Rau cov thawj lub sij hawm, raws li ib tug nyias muaj nyias ib chav kawm ntawv ntawm immunoglobulin E yog tus uas pom nyob rau hauv 1966, thiab nyob rau hauv 1968, lub LEEJ TWG tau pom zoo raws li ywj siab IgE chav kawm ntawv ntawm immunoglobulins.

cov hoob kawm no ntawm cov nqaijrog nyob rau hauv tib neeg, liab thiab ib co kuaj cov tsiaj. Feem ntau ntawm cov E immunoglobulin molecules txuas rau daim tawv nqaij mast hlwb thiab basophils. Txij li thaum nyob rau hauv ib txwm tej yam kev mob immunoglobulin E ntau nyob rau hauv cov ntshav ntshiab ntawm ib tug ob peb nanograms ib milliliter, qhov yooj yim lub tswv yim ntawm cov qauv ntawm no molecule yog tau tsuas yog nyob rau lub hauv paus ntawm txoj kev tshawb no ntawm ob peb myeloid proteins. Heev tsawg theem ntawm immunoglobulin E nyob rau hauv cov ntshiab obviously tshwm sim los ntawm lub fact tias nws muaj peev xwm sawv ntawm "attracted" mus rau qhov chaw ntawm lub hlwb thiab khov kho khi rau mast hlwb thiab basophils.

Nws yog ntseeg hais tias Іg E yog lub loj hauv chav kawm ntawv ntawm immunoglobulins uas tsim mast hlwb thiab basophils mus koom nyob rau hauv kev tsis haum tshuaj loj. Cov theem ntawm no protein nyob rau hauv ntshav dej ntawm cov neeg mob uas koob tshuaj tiv thaiv nce thiab feem ntau tshaj 350-800 U / mg. Tag nrho cov IgE nws cai nyob rau hauv cov me nyuam nyob rau hauv lub hnub nyoog ntawm 12 lub hlis mus txog rau 15 U / ml. IgE plays ib qho tseem ceeb luag hauj lwm nyob rau hauv lub tshua tam sim ntawd npau taws me ntsis. Immunoglobulin E cai rau cov neeg laus kev ntsuas pib ntawm 0 mus rau 120 U / ml.

Raws li niaj hnub tswv yim, lub ntsiab muaj nuj nqi ntawm immunoglobulin E yog los tiv thaiv lub cev txheej week vim qhov ua kom ntawm lub zos yam ntawm cov ntshav ntshav thiab effector hlwb. Pathogens yog tau ua txhaum los ntawm kev tiv thaiv kab uas roos immunoglobulins ntawm cov chav kawm ntawv A. Tom qab ntawd cov kab mob los yog kab mob rau ntawm qhov chaw ntawm mast hlwb khi rau tej immunoglobulin E chav kawm ntawv, raws li ib tug ntawm xws li kev sis raug zoo mast hlwb tau txais ib lub teeb liab mus tso ntawm vasoactive amines thiab chemotactic yam, uas nyob rau hauv lem ua inflow ntawm circulating Ig chav kawm ntawv qhov G, complement, eosinophils thiab qe. Eosinophilic chemotactic tau, uas yog muab tso tawm los mast hlwb, yeej txhawb tsub zuj zuj ntawm eosinophils thiab kev puas tsuaj ntawm cua nab. Nws yog ntseeg hais tias cov IgE adsorbed rau ntawm qhov chaw ntawm tus kab mob, attracts macrophages ua tsaug rau Fc-receptors.