Fibrinogen - cai thiab pathology

Nyob rau hauv txoj kev tshawb no ntawm cov ntshav txhaws system, qhov no Performance index yog txiav txim tas. Nws yog ib qho tseem ceeb rau tej yam. Ua ntej lub lag luam, nyob rau hauv kev npaj rau kev yug menyuam, kab thiab inflammatory kab mob ntawm cov ntshav yeej ib txwm txiav txim fibrinogen. Norma yog tsis tau tib yam rau cov neeg laus thiab cov me nyuam mos. Rau cev xeeb tub cov poj niam, cov sab sauv txwv ntawm nws ntau dua. Tab sis siab rau cov qauv ib tug me ntsis rau yav tom ntej. Ua ntej, peb tham txog dab tsi yog feem ntau sawv cev rau fibrinogen.

Raws li lawv cov tshuaj qauv, nws yog - lub protein. Nws tseem hu ua ntau txhaws yam I. Nws yog muab kev koom tes nyob rau hauv lub kawg theem ntawm cov ntshav txhaws, namely - nyob rau hauv lub tsim ntawm cov ntshav los khov rau ntawd. Nyob rau hauv ib tug noj qab nyob zoo human fibrinogen nyob rau hauv cov ntshav yog tam sim no nyob rau hauv lub neej hauv lub xeev.

Nyob rau hauv cov ntaub ntawv ntawm kom ntawm lub coagulation system nyob rau hauv nws thawj theem nyob rau hauv qhov kev txiav txim ntawm lwm txhaws yam tsim thrombin.

Nyob rau hauv lub thib ob theem nyob rau hauv tus ntawm txhaws fibrinogen thiab thrombin cleaved hloov dua siab tshiab rau hauv insoluble fibrin, uas tas lub hauv paus ntawm ib tug ntshav los khov rau ntawd, ib tug thrombus. Nws yuav siv ceev xwmphem los ntshav. Li no nws yuav ntshiab lub ntsiab lus hais tias lub cev muaj fibrinogen. Cov cai ntawm no substance rau ib tug neeg laus noj qab nyob zoo tus neeg sau raws nkaus Ii 2-4 g / l. Nyob rau hauv tus me nyuam mos cov me nyuam mos, tus nqi yog tsawg - 1,25-3 g / l. Tab sis nws nce thaum lub sij hawm cev xeeb tub rau 6 g / l. Qhov no yog to taub. Tom qab tag nrho, ib tug poj niam lub cev npaj rau me nyuam, uas yog ib txwm txuam nrog los ntshav. Yog li, nws puv tawm, tus nqi ntawm fibrinogen nyob rau hauv cov ntshav yog tsis tau tib yam rau tag nrho cov. nws yog ntau ntau rau cev xeeb tub cov poj niam.

"Yog, tab sis qhov twg puas tau nws los qhovtwg los?" - koj nug. Nws hloov tawm hais tias qhov no txhaws qhov zoo tshaj yog ua nyob rau hauv daim siab thiab lub hlwb ntawm lub reticuloendothelial system. Yog li ntawd, nyob rau hauv cov kab mob ntawm lub siab, xws li tus kab mob siab los yog mob npuas paug hnyav fibrinogen uas nws cai - tsis tsawg tshaj li 2 g / l, tej zaum txo kom heev me me xov tooj. Qhov no yuav ua tau kom ib tug ntau yam ntawm los ntshav, los ntshav nyob rau hauv daim tawv nqaij thiab qog ua kua week. Noj yam tshuaj (androgens, anabolic steroids) kuj txo cov theem. Nyob rau hauv tej rooj plaub, muaj inborn uas tsis ntawm kev kawm ntawv zoo tshaj I. Qhov no yog hu ua afibrinogenemia los yog hypofibrinogenemia.

Tus ntse txo ntawm fibrinogen yog cai nyob rau hauv lub thib ob thiab thib peb theem dessiminirovannogo intravascular coagulation syndrome. Qhov no hnyav pathological mob, feem ntau xaus nrog copious hemorrhage vim tus tsim ntawm me me hlab ntsha tawg khiav ri niab fibrin txhaws. Lawv yog li ntawd ntau npaum li cas uas fibrinogen depleting stocks. Mob fibrinolysis, tus txheej txheem uas yog txuam nrog rau cov strengthening ntawm lub xaus ntawm fibrin, kuj nrog los ntawm ib tug txo ntawm fibrinogen. Nws txo nrog mob myeloid leukemia, nrog ib tug tsis muaj peev xwm ntawm vitamin B12 nyob rau hauv lub cev thiab S.

Nyob rau hauv ib co kab mob, nyob rau hauv tsis tooj, muaj ib tug muaj zog fibrinogen. Cai coob tus nqi ntawm coagulating zoo tshaj yuav yog sib npaug zos rau 4 g / l. Tab sis rheumatic, kis kab mob, inflammatory dab, mob cancer, thrombosis thiab infarctions tau kuv theem yuav muab ntau zog los ntawm 1.5-2.5 lub sij hawm. Fibrinogen tseem hu ua mob theem protein, txij li thaum nws nce yog nrog los ntawm mob inflammatory kab mob. Cov theem ntawm no protein nrog kev raug mob, kev siv ntawm qhov ncauj contraceptives thiab cov tshuaj no tom qab phais.

Muaj pov thawj hais tias kom fibrinogen theem yuav ua ntej cov tsos ntawm tus cwj nrag thiab lub plawv tuaj. ib tug ntshiab kev sib raug zoo ntawm cov kab mob thiab nws yav dhau los txhawb theem twb pom nyob rau hauv kev tshawb fawb.

Yuav kom txiav txim seb qhov theem ntawm fibrinogen, koj yuav tsum xeem dhau ib qho kev npliag plab ntshav los ntawm ib tug hlab ntsha. Cov ntshav yog coj mus rau ib tug xeem raj nrog lub anticoagulant.