Eradication - dab tsi yog qhov no? nta

Nws tau ntev tau xav hais tias lub plab ib puag ncig, kuj muaj menyuam tsis taus vaj tse nws microflora. Nyob rau hauv lub plab, nrog nws cov sab hauv cov ntsiab lus - acid, los yog tsuas yog tsis tau ciaj sia muaj ib zaug xwb kab mob. Nov ntawm Helicobacter pylori nyob rau hauv lub mob huam muaj revolutionized lub tswv yim ntawm qhov ntawm txoj hnyuv kab mob: gastritis, duodenitis, pais plab ulcers thiab duodenal ulcers, hnyuv mob cancer thiab lawv kho. Nyob rau hauv no tsab xov xwm peb xav txog nyob rau hauv kom meej li cas eradication. Nws yog ib txog kev txoj kev kho mob uas tau ua heev nrov nyob rau hauv xyoo tsis ntev los.

Excursion mus rau hauv lub keeb kwm ntawm Helicobacter pylori

Nyob rau hauv qhov tseeb, tus kab mob twb tshwm sim ib tug ntev lub sij hawm thiab tsis tau ib zaug. Rau cov thawj lub sij hawm no tau tshwm sim nyob rau thaum kawg ntawm lub xyoo pua xeem. Nws yog 1886. Jagiellonian University xib fwb V. Yavorsky ntes cov kab mob yam ntxwv kauv zoo nyob rau hauv lub pais plab khoom. Nws muab lub npe ntawm tus kab mob Vibrio rugula, thiab pom tias nws plays ib tug luag hauj lwm nyob rau hauv txoj kev loj hlob ntawm pais plab kab mob.

Txawm li cas los, vim xim tsis tau Yavorsky ua hauj lwm nyob rau hauv cov kev kho mob hauv zej zog. Xya xyoo tom qab, tus Italian paub txog D. Bidzodzero kos xws kab mob los ntawm cov hnyuv ntawm tus aub. Cov tom ntej no, uas sau tseg rau hauv lub xub ntiag ntawm cov kab mob nyob rau hauv lub plab lub hlwb los ntawm cov ua ulcerative neeg mob yog xibfwb Morozov Moscow. Nws yog twb qhov kawg ntawm lub 70s ntawm lub xeem caug xyoo.

Ntxiv me nyuam no yuav sov ua licas piav qhia txog, cais, kom loj hlob nyob rau hauv lub laboratory thiab xyuas anonymous kab mob tau raug pom zoo nyob rau hauv 1979 thiab 1981 Australians Marshall thiab Warren. Thiab lawv ua tau zoo. Marshall yog nyob vam meej kev ntawm yus tus kheej-kab mob ntawm Helicobacter pylori thiab zoo ntawm Helicobacter gastritis mas yuav kis tau los ntawm ib tug ob-lub lim tiam kawg ntawm kev kho mob nrog "metronidazole" thiab Bismuth ntsev.

Qhov no txoj kev ntaub ntawv lub hauv paus ntawm niaj hnub eradication ntawm Helicobacter pylori. Ib tug siab tawv explorers nyob rau hauv 2005 tau txais lub Nobel nqi zog nyob rau hauv cov tshuaj.

Lub npe ntawm Helicobacter pylori kab mob yog nyob rau hauv 1989, raws li tau zoo raws li ib tug tag nrho cov hauj lwm thiab kev faib. Muab Kauv kab mob tej vaj tse tau xaiv "gatekeeper" ntawm lub plab ( "pylori" - los ntawm Greek "gatekeeper") kis tag nrho qhov chaw ntawm lub duodenum thiab lub plab. Nyob rau hauv ib tug tseem ceeb feem pua ntawm cov tag nrho cov gastritis, duodenitis, plab hnyuv ulcers thiab duodenal ulcers kom txog rau thaum lawv cancer yog txhaum ntawm no microorganism.

Cov kev txaus ntshai ntawm tus kab mob Helicobacter pylori?

Helicobacter pylori, lub tsev nyob rau hauv lub mob huam ntawm tus txiv neej los yog tsiaj mus rau pores behaves kwv yees li. Thaum lub slightest tsis ua hauj lwm nyob rau hauv lub cev los yog los ntawm cumulative nyhuv ntawm malnutrition los yog tsis zoo cwj pwm tsis zoo tshuab txais kab mob yuav txhoj puab heev. Yuav ua li cas yog nws txaus ntshai? Nyob rau hauv lub txheej membrane ntawm cov hauv nruab nrog cev - plab thiab duodenum - pathogenic microorganism ua rau nws.

Pib nce kev tso tawm ntawm secrets, uas adversely muaj feem xyuam rau cov hnyuv cov ntaub so ntswg. Txheej lawv yuav xoob, tawg, muaj mas kub lug cheeb tsam uas muaj cov tsim ntawm ulcers. Mob gastritis tshwm sim los ntawm pathogenic microorganism Helicobacter pylori pab pawg neeg, tsis zoo li cov pa txhua yam gastritis, yog tsis amenable mus kho los ntawm cov pa txoj kev.

Helicobacter pylori penetrates tag nrho cov ntxaum khaubncaws sab nraud povtseg ntawm cov ntaub so ntswg, li no unaffected los ntawm feem ntau tshuaj tua kab mob (antibiotics yog tsis ruaj tsis khov rau acidity). Tej vandalnye nws kev ua ua irreversible dab nyob rau hauv lub mucosa, piv txwv li, ib tug precancerous mob, thiab, ncaj nraim, txoj kev loj hlob ntawm Oncology. Kom tsis txhob no, thov eradication ntawm Helicobacter.

Mob ntawm Helicobacter pylori nyob rau hauv lub mob huam

Yog hais tias tus neeg mob yws kev xeev siab thiab kem plab, kub siab, mob, muaj teeb meem nrog ib lub rooj zaum, ib tug mob tsis xis nyob rau hauv lub epigastric cheeb tsam - ib tug ncaj qha hais yuav tsum tau soj ntsuam kuaj rau lub xub ntiag ntawm tus kab mob Helicobacter pylori. Ntsuam nqi xauj tsev yog:

• ntshav, cov kev tsom xam ntawm ib tug antibody, xws li muaj cov H. pylori;
• quav tsom xam rau lub xub ntiag ntawm cov kab mob pov tseg;
• ua tsis taus pa xeem yog raws li nyob rau hauv kev txiav txim ntawm ammonia nyob rau hauv concentration exhalation;
• cytologic tsom xam.

Qhov tseem txhim khu kev qha txoj kev diagnosing kab mob yog ib tug cov ntaub so ntswg me ntawm lub pais plab mucosa thiab duodenal ulcers. Cov ntaub yog coj rau kev tsom xam los ntawm endoscopy.

indications eradication

Raws li twb hais saum toj no, lub eradication - yog ib tug txoj kev mus nrog cov pais plab kab mob.

Eradication nqa tawm cov neeg muaj mob nyob rau hauv xws pathologies:

• rwj cov tsos mob nyob rau hauv lub plab thiab duodenum;
• raws li txoj cai ncej resection (phais kom tshem tawm cancer);
• precancerous lub xeev nrog lub cev nqaij mos Atrophy;
• nqaij hlav.

Thaum uas muaj feem yuav yog cov neeg uas nws cov txheeb ze tau raug kev txom nyem cov qog nqaij hlav. Pom zoo eradication txoj kev kho thiab nyob rau hauv cov neeg mob uas Gastroesophageal reflux kab mob thiab tej dyspepsia.

eradication txoj kev

Eradication - yog kev puas tsuaj, eradication (English eradication.). Qhov kev ntsuas no, tsim los ua kom puas rau tus kab mob Helicobacter pylori hnyuv ib ntsuj av. Cov kev kho mob yog qhia nyob rau hauv cov neeg mob uas muaj mob loj pais plab rwj los yog duodenal rwj. Nws essence lies nyob rau hauv lub chav kawm kom tsawg ntawm cov tshuaj nyob rau hauv ib lub qauv.

Ua ntej qhov pib ntawm lub Hoob no yuav qhia ntxiv txoj kev tshawb no pais plab mucosal cov ntaub so ntswg rau lub xub ntiag ntawm phem hlwb.

Helicobacter pylori eradication muaj ob peb hom:

• mono, qhov uas siv tau nyob rau hauv cov kev kho mob ntawm tsuas yog ib qho tau txais txhais tau tias, feem ntau yog medicaments raws li nyob rau hauv lub Bismuth ntsev, los yog ib tug tshuaj tua kab mob;
• Duo, dual txoj kev kho (vismutosoderzhaschee tshuaj ntxiv tshuaj tua kab mob);
• triplet, raws li lub npe implies, qhov no kev kho mob nrog peb cov tshuaj (Bismuth, ib tug tshuaj tua kab mob thiab ib tug neeg sawv cev imidazole pab pawg neeg);
• kvadriplet, tsim ib tug plaub, nyob rau ib txoj triplet ntxiv PPI txoj kev kho (blockers ntawm hydrochloric acid).

Mono-eradication - qhov no yog yuav luag yeej tsis siv txoj kev kho mob vim hais tias ntawm nws cov ineffectiveness (hauv qab no 50%). Nws yog nyob rau hauv Vogue nyob rau kaj ntug ntawm cov lus qhib thiab cov thawj thwmsim helikobakterialnoy kho kab mob.

Eradication siv ob yam tshuaj muaj ib qho kev ua hauj lwm zoo ntawm pov tseg ntawm Helicobacter txog 60%, thiab heev me ntsis nyob rau hauv hnub no lub neej xyaum. Yuav ua li cas yog siv niaj hnub no eradication? Kev kho mob kiag yog siv.

Tripletoterapiya muaj xws li ib tug Bismuth compound, ib tug tshuaj tua kab mob (amoxicillin thiab nce siv klaritomitsin) thiab imidazoles (qhov no fungicides).

Hoob no ntawm plaub tshuaj - tag nrho cov saum toj no formulations ntxiv proton twj tso kua mis inhibitors (qhov no pab pawg neeg antiulcer tshuaj tswj kom txhob muaj pais plab acid ntau lawm). Txoj kev rau nws ua hauj lwm zoo yog kev kawm indices 90% thiab 95% feem. Ntawm no yog ib co zoo eradication ntawm Helicobacter yuav ua tau.

Cov tshuaj siv rau eradication

Vim hais tias cov acidic puag ncig nullifies cov teebmeem ntawm feem ntau tshuaj tua kab mob, ib daim ntawv teev cov tshuaj yuav tshem tau kabmob tag nrho luv luv:

• tshuaj tua kab mob;
• antiinfectives;
• vismutosoderzhaschie tshuaj;
• proton twj tso kua mis inhibitors;
• probiotics thiab prebiotics.

Tshuaj tua kab mob yog cov feem ntau siv nyob rau hauv txoj kev kho eradication

Yuav ua li cas mus pib eradication? Tshuaj tua kab mob yog cov nram qab no:

• "Amoxicillin" los yog "Flemoksin Soljutab" - penicillin pab pawg neeg, yog haum rau feem ntau cov neeg mob yog tsis pom zoo rau kev siv thaum lub sij hawm cev xeeb tub, lub raum tsis ua hauj lwm.

• "Amoxiclav" - ib tug ua ke ntawm amoxicillin thiab kavulonovoy acid, lub broadest spectrum tshuaj tua kab mob yog pom zoo ceev faj siv ntawm nws nyob rau hauv tus neeg mob lub raum pathologies, thaum lub sij hawm cev xeeb tub lub tshuaj tua kab mob ua rau muaj mob loj dysbiosis.
• "Clarithromycin" los yog "Klatsid" - uas tsis muaj tshuaj lom tshuaj tua kab mob erythromycin pab pawg neeg ntau hom ntawm cov feem ntau nrov rau lub eradication, yog ua rau cov me nyuam mos mus txog rau lub hlis, cev xeeb tub cov poj niam, siv cov kev ceev faj nyob rau hauv cov neeg mob uas raum los yog hepatic insufficiency.
• "Azithromycin" - ib tug lwm txoj rau "Klaritomitsinu" muaj tsawg heev phiv, txawm li cas los, nws yog tsis tshua zoo tiv thaiv Helicobacter pylori.

Tshuaj tua kab mob "tetracycline" thiab "Levofloxacin" yog siv tsawg feem ntau thiab nyob rau hauv cov mob uas lub saum toj no-hais cov tshuaj tsis muaj cov yam tshwm sim. Formulations tetracycline pab pawg neeg sau nruj kev txiav txim nyob rau hauv cov nqe lus ntawm cov kev phiv tom qab eradication ntawm Helicobacter, yog li ntawd tsis tshua muaj siv.

Antibacterial thiab anti-ua kab mob tshuaj rau eradication

"Metronidazole" - anti-ua kab mob chemotherapeutic neeg sawv cev nitromidazolovoy pab pawg neeg, heev tshuaj lom, nruj me ntsis incompatible nrog haus dej haus cawv thiab txwv tsis pub lub sij hawm uas cev xeeb tub.

"Makmiror" los yog "Nufuratel" - ib tug tua yeeb tshuaj, nws yog siv nyob rau hauv cov ntaub ntawv ntawm tsis ua hauj lwm ntawm "Metronidazole".

Vismutosoderzhaschie tshuaj

"De-Nol '- qhov no yog dab tsi tshuaj tau qhia lub siab tshaj plaws degree ntawm neutralizing raug Helicobacter. "De-Nol 'dissolves thiab nkag mus rau hauv cov kua tsib slime nyob rau hauv lub deepest khaubncaws sab nraud povtseg ntawm cov cuam tshuam los hloov khoom nruab nrog. Teeb meem tshwm sim muaj yuav luag tsis muaj, raws li zoo raws li contraindications (tshwj tsis yog, feeb, cev xeeb tub).

Tsawg zaus siv nyob rau hauv cov kev kho mob ntawm Helicobacter ntsev Bismuth tebchaw:

• Bismuth Subsalicylate;
• Bismuth subnitrate.

Npaj raws li nyob rau hauv cov Bismuth ntsev siv tau rau cov kev kho mob ntawm txoj hnyuv kab mob, ua ntej qhib ntawm Helicobacter pylori. Cov tebchaw no resistant mus rau lub acidic ib puag ncig ntawm lub plab. Bismuth tebchaw rau lub mucosa puas nto tsim tau ib cov kev tiv thaiv zaj duab xis los ntawm lub corrosive ib puag ncig, txo acidity thiab txhawb thaum ntxov cirrhosis ntawm cuam tshuam chaw.

Thaum koj qhib qhov Helicobacter pylori Bismuth tebchaw pom ib tug stunning ntxim rau cov hluav thiab kev puas tsuaj ntawm no xyov cov kab mob.

Formulations qhov pab pawg neeg siv rau lub eradication

proton twj tso kua mis inhibitors (PPIs) yog indispensable nyob rau hauv lub complex ntxim rau cov Helicobacter pylori. PPI tshuaj muaj ib yam ntawm cov antacid nyhuv, thiaj li muaj cov Aggressiveness ntawm lub acid ib puag ncig. Cov kab mob kev tshawb fawb pom tau hais tias tawm ntawm lub acidic puag ncig nws tuag. Li no, PPI tsim intolerable tej yam kev mob rau xis hav zoov ntawm cov kab mob nyob rau hauv ib tug complex nrog Bismuth, "metronidazole" thiab cov tshuaj tua kab mob yuav tsub kom qhov kev vam meej eradication ntawm Helicobacter pylori rau 95% thiab saum toj no. Cov tshuaj no muaj xws li:

• "Omez" ( "omeprazole");
• "Nolpaza";
• "Rabeprazole";
• "Pantoprazole" thiab li ntawd.

namely "Omez" muab ntau ntau. Blockers los yog proton twj tso kua mis PPI slows cia lub chaw ua hauj lwm ntawm lub tso pa tawm ntawm digestive qog.

Normalization ntawm cov hnyuv microflora tom qab eradication ntawm Helicobacter

Raug tshuaj tua kab mob nyob rau hauv Feem ntau, yog detrimental rau hauv cov hnyuv thiab plab. Yog li ntawd, tom qab eradication cov txheej txheem tsim nyog los txo cov kev puas tsuaj tshwm sim los rau lub cev. Ua li no, muaj cov khoom uas pab xws li probiotics los yog prebiotics, qhia nyob dysbacteriosis, flatulence, raws plab, thiab lwm yam Cov no muaj xws li .:

• "Laktoferon";
• "Linex";

• "Hilak Forte";
• "Bifidumbacterin";
• "Atsipol" thiab li ntawd.

Probiotics thiab Prebiotics - ib tug fundamentally sib txawv kab lis kev cai, sib haum xeeb complementing lwm tus txoj kev ua hauj lwm. Ob pab pawg muaj ib tug nyhuv lig rau tus kab mob los ntawm normalizing cov hnyuv muaj. Qhov txawv nruab nrab ntawm lawv yog tias probiotics - nyob kab lis kev cai ntawm pab microorganisms. Prebiotics tib yam - organic tshuaj tebchaw. Tus thawj yog ncaj qha mus "loj hlob" ib tug tuag microflora, lub thib ob - tsim dej siab tej yam kev mob rau qhov no. Lawv mas nws yeej tau mus noj tom qab eradication.

tiv thaiv kab mob

Helicobacter pylori latent cab kuj tej zaum yuav txhua. Lub microorganism nyob rau hauv lub plab, hnyuv thiab lub qhov ncauj kab noj hniav ntawm ib tug tib neeg los yog tsiaj ntau lub xyoo thiab tsis manifest nws tus kheej.

Kom ntawm cov kab mob no tshwm sim vim ib lub cev tsis ua hauj lwm nyob rau hauv kev nyuaj siab, teeb meem cwj pwm tsis zoo (dej cawv, haus luam yeeb), kauj noj cov zaub mov thiab epigastric mob manifests nws tus kheej. Ib txhia hom Helicobacter yuav cuam tshuam rau daim siab.

xaus

Kis los ntawm xov xwm kab mob tshwm sim los ntawm hu rau los yog los ntawm kev siv ntawm domestic khoom. Koj yuav tsum ua tib zoo ua raws li cov kev cai ntawm tus kheej kev tu cev, nyob rau hauv thiaj li yuav txo tau cov kab mob sib kis ntawm ib tug thib peb-tog. Ces nws tsis yuav tsum tau eradication ntawm Helicobacter pylori.