"Disulfiram": kev xyuas. "Disulfiram": hauj lwm, nqi

Nyob rau hauv no tsab xov xwm, peb txiav txim siab los qhia rau koj hais tias qhov no yog ib tug yeeb tshuaj raws li "Disulfiram". Cov lus qhia rau siv, tawm tswv yim thiab indications ntawm cov nyiaj yuav kuj yuav piav hauv qab no. Nyob rau hauv tas li ntawd, koj yuav kawm tau hais tias dab tsi yog qhov nqi ntawm hais tias cov tshuaj, nws yog ua nyob rau hauv tej daim ntawv uas yog muaj nyob rau hauv nws cov muaj pes tsawg leeg, ua li ntawm. D.

Daim ntawv thiab muaj pes tsawg leeg ntawm ntim

Lub medicament "Disulfiram", cov lus qhia rau kev siv uas yog muab ntim rau hauv ib lub thawv uas ua los ntawm cov duab los qhia, yog marketed nyob rau hauv daim ntawv ntawm cov oily tshuaj thiab cov ntsiav tshuaj qhov ncauj saib xyuas thiab implantation.

Tus thawj daim ntawv no yog ua nyob rau hauv vials ntawm 20 ml, thiab lub thib ob thiab thib peb - nyob rau hauv lub khob hub ntawm 10 thiab 20 units feem.

Lub active ingredient ntawm lub medicament yog disulfiram. Dhau li nws, cov tshuaj muaj kuj ntxiv Cheebtsam (nyob ntawm seb qhov kev tso tawm ntaub ntawv): sodium chloride, mannitol, starch, sodium stearate, PEG-6000, MCC, calcium diphosphate, hydroxypropyl cellulose, stearic acid thiab polyoxyl 40.

pharmacological

Yuav ua li cas yog ua ntej peb tshuaj? Yuav ua li cas lawv hais txog nws cov kev kho mob xyuas? "Disulfiram" muaj ib tug qhia tau anti-cawv nyhuv.

Thaum koj tau txais qhov cuab tam yog muab sau rau nws ho ua rau dej cawv metabolism. Raws li ib tug tshwm sim, kev ruaj ntseg metabolites yog tsim, uas ua rau kom tus concentration ntawm tej yam tshuaj lom xws li acetaldehyde. Nws yog nws leej twg txiav txim seb tus miv nyuas siv zug ntawm cov tshuaj.

Nrog tso dej thawj coj ntawm ib tug medicament, raws li zoo raws li nws cov qhov ncauj cov neeg mob yuav luag tam sim ntawd pib xav tias kub flushes, mob dyspepsia, tachycardia, asthenia muaj zog thiab txawm tuag hypotension. Nyob rau hauv tas li ntawd, cov tsos ntawm intoxication los ntawm acetaldehyde txhawb aversion rau haus dej haus cawv thiab tshem tawm ntawm tus neeg mob thrust rau dej cawv.

pharmacokinetic tsis

Yuav ua li cas saib xyuas muaj cov tshuaj kinetic tsis? Yuav ua li cas txog nws cov haum daim ntawv qhia txog kev xyuas? "Disulfiram" heev sai thiab yuav luag tag yaim los ntawm lub plab.

Thaum uas siv cov nws, muaj ib tug siab metabolism ntawm lub active tivthaiv, thaum lub sij hawm uas ob peb metabolites tsim. Derivation ntawm cov khoom yog nqa tawm los ntawm lub ntsws thiab ob lub raum.

indications

Tshuaj "Disulfiram", tus nqi ntawm uas yog qhia hauv qab no, yuav qhia rau:

• kev kho mob ntawm tus kab mob alcoholism;
• kev tiv thaiv ntawm relapse nyob rau hauv cov kev kho mob ntawm tus kab mob alcoholism.

Noj cov tshuaj no nyob rau hauv nws kev txiav txim undesirable. Nws yuav tsum tau taw kws kho mob.

Contraindications

Tshuaj "Disulfiram" intravenously thiab lus yog tsis pom zoo rau cov nram qab no cov kab mob:

• neuropsychiatric kab mob;
• qaug dab peg;
• mob ntshav qab zib.

Tsis tas li ntawd, qhov no tshuaj yog tsis qhia thaum lub sij hawm cev xeeb tub, qhov rhiab heev rau lub active tivthaiv thiab ib qho ntxiv tivthaiv, kev pub niam mis.

Peb kuj yuav tsum nco ntsoov tias nrog huab tsum ceev faj cov tshuaj no yog pom zoo kom noj nyob rau hauv tus neeg mob nrog impaired siab muaj nuj nqi, ua pa system thiab ob lub raum.

Tshuaj "Disulfiram": cov lus qhia rau kev siv

Kev siv tej yam uas daim ntawv ntawm cov nyiaj yog permissible tsuas yog nyob rau tus kws kho mob txiav txim. Tus kws kho mob yog yuam ua hauj lwm rau kev ib tug tag nrho kev soj ntsuam ntawm tus neeg mob, thiab ces xaiv ib tug neeg kho mob regimen thiab KOOB rau nws.

Raws li cov lus qhia, lub nruab nrab txhua hnub koob tshuaj ntawm cov tshuaj rau qhov ncauj thawj coj yog hais txog 125-500 mg.

Raws li rau lub txhaj thiab implantation ntawm cov tshuaj, ces cov txheej txheem yuav tsum tau ua los ntawm ib tug tej ti teg taw. Nyob rau hauv rooj plaub no tus pom zoo ntau npaum ntawm cov tshuaj nyob rau tus yam ntxwv ntawm cov neeg mob thiab cov heev ntawm uas twb muaj lawm tus kab mob.

phiv

tshwm sim los ntawm cov tshuaj nyob rau hauv lo lus nug Kuv yuav hu? Yuav ua li cas txog qhov no hais tias kev xyuas? "Disulfiram" tsis tshua ua ua txaus ntshai sab tshua. Thaum noj tej zaum nws yuav muaj ib co sib txawv nyob rau hauv cov hnyuv thiab muaj cov nws yog xim hlau saj thiab cov kev loj hlob ntawm tus kab mob siab.

Nyob rau hauv tas li ntawd, kev ua txhaum yuav tshwm sim nyob rau hauv lub paj hlwb zog. Tej undesirable tej yam kev mob xws li polyneuritis ntawm sab nqua, puas siab puas ntsws, nco tsis tau, tsis meej pem thiab mob taub hau.

Tsis tas li ntawd, tsis txhob cais txoj kev loj hlob ntawm ntau yam kev tsis haum tshuaj, uas raug txhais los ntawm cov cawv (e.g., cev qhuav dej, tus cwj nrag, mob arrhythmias, cerebral edema thiab myocardial infarction).

Cov tsos mob ntawm overdose

Kev npaj "Disulfiram" nyob rau high school koob tshuaj yuav ua rau los xws li lub cev qhuav dej, coma thiab txaus ntshai neurological tshua.

Yuav kom tshem tawm cov tsos mob yuav tsum siv symptomatic txoj kev kho nyob rau hauv lub tsev kho mob, uas yuav tsum tau muaj xws li detoxification kev ua ub no.

Antidotes medicament

Tshwj xeeb tau muaj pov thawj hais tias tus ua kom tiav neutralization ntawm cov tshuaj yuav tsis muab suav hais tias.

Yog hais tias tsim nyog, tso zis "Disulfiram" los ntawm lub cev tib neeg (e.g., nyob rau hauv kev mob loj tshua rau tshiab khiv saws koob tshuaj cawv) yog nqa tawm tej yam cov kev cai.

Raws li ib tug antidote rau no siv tshuaj ascorbic acid. Nws yog tsim los siv intravenously. Qhov no lub caij tsis pub haus dej haus cawv yuav tsum tau hloov mus rau hauv acetaldehyde, uas, nyob rau hauv qhov tseeb, ua rau tsis xis nyob.

Tej zaum lawv kuj yuav siv ephedrine thiab H1-blockers.

tshuaj cov kev sib tshuam

Yog nws tau mus rau siv lwm yam tshuaj ua ntej peb tshuaj? Yuav ua li cas hais txog kev siv yeeb tshuaj cov kev sib tshuam xyuas hais? "Disulfiram" nyob rau hauv thaum lawv tseem nrog anticoagulants tsub kom lawv txiav txim, thiab kuj yuav tsub qhov uas yuav los ntshav.

Tib mus kho mob nrog rau cov tshuaj siv yeeb tshuaj uas yog metabolized nyob rau hauv lub siab, muaj peev xwm ho thuam thaum lub sij hawm tus txheej txheem.

Combining Mao inhibitors, tricyclic antidepressants thiab phenothiazine derivatives nrog "Disulfiram" tej zaum yuav pab mus rau rov tshwm sim ntawm txoj sab tshua.

Lub ua ke ntawm no txhais tau tias nrog "buspirone" ua rau cov kev loj hlob ntawm delusions. Tej cov tshuaj raws li "Amitriptyline", feem ntau tej cov nyhuv ntawm "Disulfiram" thiab seb puas tsimnyog tau nws lom los rau hauv lub paj hlwb.

Saib medicament muaj peev xwm zuj zus concentration ntawm chlordiazepoxide thiab diazepam nyob rau hauv cov ntshav, txo cov kev siv ntawm tshuaj lom tshuaj thiab yuav ua tau rau kiv taub hau.

Nrog ua ke nrog ntawm "Disulfiram" nrog "Isoniazid" tej zaum yuav tsim kev nyuaj siab thiab kiv taub hau, "metronidazole" - tsis meej pem thiab mob psychosis, ib tug "Omeprazole" - lus nco qab, thiab muaj caffeine - txo nws feem ntawm lub cev.

"Chlorzoxazone" tsub kom lub concentration ntawm anti-cawv thiab tshuaj yaj yeeb nyob rau hauv cov ntshav, thiab "Chlorpromazine" amplifies hypotension.

Tshuaj "Disulfiram": xyuas, nqi thiab analogues

Zoo ib yam li los muaj tshuaj xws li "Ekzorran", "Radotera", "Aspen", "Krotenal", "Tetlong", "Refuzal", "Stoptil", "Antietil", "Kontrapot", "Tetradin", "Antietan" "Dizetil", "Alkofobin", "Aversan", "Anticoli", "Antabuse", "Esperal", "Lidevin", "Abstinil".

Yuav ua li cas npaum li cas yog ib tug tshuaj "Disulfiram"? Tus nqi ntawm cov tshuaj no nyob rau hauv cov ntsiav tshuaj yog hom twg 200-1000 rubles (nyob ntawm seb lub chaw tsim tshuaj paus). Nrog kev xav txog cov cog zoo lawm, raws li tau zoo raws li oily tshuaj, lawv yuav tsum tau muas 600-2400 rubles.

Feem ntau cov kev xyuas txog rau tam sim no formulation zoo. Nws yog noteworthy tias qhov no tshuaj yog feem ntau siv rau daim card kev kho mob ntawm cov neeg uas muaj alcoholism. Kws txawj tsis pom zoo muab lub tsev no tsis muaj tus neeg mob txoj kev paub.

Raws li lub tswv yim ntawm cov uas siv cov tshuaj xam tau tias yog nws zoo heev fights along mus coj ib tug tshiab koob tshuaj haus dej cawv. Feem ntau, tom qab tau txais cov tshuaj nyob rau hauv tus neeg mob tshwm sim aversion rau dej cawv. Yog hais tias ib tug dej cawv twb dhau tom qab siv cov tshuaj, nws ua rau mob dyspepsia, yaug kais dej, mob asthenia, tachycardia, thiab txawm tuag hypotension.