Cov tshuaj "Leykostim": cov lus qhia rau kev siv, tiag tiag counterparts

Yuav ua li cas yog cov tshuaj "Leykostim"? Cov lus qhia, tso tawm daim ntawv no, indications thiab contraindications rau cov tshuaj no yuav tsum tau piav rau hauv qab no. Peb kuj qhia koj hais txog dab tsi analogs yog muaj nyob rau qhov cuab tam yog muaj nyob rau hauv nws cov muaj pes tsawg leeg, thiab hais txog.

Tus duab, ntim, ib feem ntawm cov tshuaj

Yuav ua li cas daim ntawv tsis tshuaj "Leykostim"? Cov lus qhia rau kev siv qhia tias active medicament yog manufactured raws li ib tug tshuaj rau subcutaneous los yog tso dej raws leeg thawj coj.

Lub active feem ntawm cov neeg uas sawv cev filgrastim. Nws yog ib tug kev siv granulocyte colony-stimulating tau. 1 ml ntawm cov tshuaj tov tej zaum yuav muaj 300 mg (30 lab. IU), 600 mg (60 lab. IU) los yog 150 micrograms (15 lab. I.U.) filgrastim.

Raws li rau lub cam, ces lawv siv raws li mannitol, sodium acetate trihydrate, dextran, acetic acid, polysorbate, thiab dej rau txhaj tshuaj.

Nyob rau hauv ib lub ntim tshuaj muag "Leykostim"? Cov lus qhia rau kev siv kos nyob rau hauv ib cardboard lub thawv ua ke nrog ib tug los yog tsib vials ntawm cov tshuaj.

Lub zog ntawm cov tshuaj

Yuav ua li cas yog lub mechanism ntawm qhov kev txiav txim ntawm cov tshuaj nyob rau hauv "Leykostim"? Cov lus qhia rau kev siv, cov kws kho mob xyuas hais tias nws yog ib tug yeeb tshuaj-immunomodulator. Nws yog ib tug heev lim uas tsis yog-glycosylated protein uas muaj ib tug ntxawg cawv rau txoj kev loj hlob thiab lub zog (los ntawm cov pob txha mus rau hauv cov ntshav) haumxeeb qe.

Tom qab cov kev taw qhia ntawm cov tshuaj ho tsub kom tus xov tooj qe nyob rau hauv cov ntshav thiab tsuas yog me ntsis - monocytes. Qhov no tshwm sim tsis pub dhau 24 teev.

Qhov nce nyob rau hauv cov ntshav qe yog koob tshuaj-dependent. Cim ntawm biologically active protein, i.e. filgrastim, uas normalizes lub loj hlob thiab ntau yam ntawm lub hlwb nqa los ntawm kab mob los ntawm cov kab mob Escherichia coli. Incidentally, lub yav tas, vim lub peevxwm ntawm niaj hnub tshuaj ntsuam genetic engineering, complemented los ntawm noob granulocyte colony stimulating tib neeg tau.

Raws li nws tus hauv paus ntsiab lus los ntawm cov lub cev cov tshuaj yog zoo li tus granulocyte colony-stimulating tau, uas yog ntawm tej yam ntuj tso keeb kwm. Lub tsuas txawv yog qhov tseeb hais tias "Leykostim" (tshuaj) yog tsis glycosylated, thiab muaj N-davhlau ya nyob twg amino acid residue ntawm methionine.

Nta ntawm cov tshuaj

Yuav ua li cas nta muaj cov tshuaj "Leykostim"? Cov lus qhia rau Siv hais tias nws yuav tsum tau siv nyob rau hauv qhov mob ntawm neutropenia nyob rau hauv cov neeg uas yauv kws khomob. Tsis tas li ntawd, qhov no tshuaj yog zoo heev rau mob neutropenia. Qhov no yog vim lub fact tias nws muaj peev xwm mus muab lub pom tooj qe nyob rau hauv tib neeg lub cev.

Siv cov formulation rau kev tiv thaiv, tus neeg mob yuav txo tau cov xwm txheej ntawm neutropenia, raws li zoo raws li txo tau cov complexity ntawm lub txaus thiab lub caij lub sij hawm ntawm tus kab mob. Tej raug tiv thaiv kab mob, txo tus neeg mob ntev ntawm lub tsev kho mob nyob twj ywm, tso cai cov kws khomob tsis muaj departing los ntawm cov nqe lus uas tau raug tsim general tswvyim ntawm kev kho mob.

Raws li tib neeg lub cev ua "Leykostim"? Cov lus qhia rau kev siv ntawd hais tias cov kev siv ntawm cov tshuaj txhawb rau cov kev taw qhia nyob rau hauv peripheral ntshav ua ntej hematopoiesis, uas yog sau los ntawm cytapheresis (i.e., separating lub ntshav mus rau hauv cellular tivthaiv nrog cov xim tshem tawm) thiab muab rau ib tug neeg mob tom qab ib tug thaum kawg ntawm high-koob tshuaj kws khomob.

Nyob rau hauv lem, tus txhaj hlwb (kav) muaj hematopoietic muaj nuj nqi, txo tiv thaiv kab mob thiab hematopoietic system, raws li zoo raws li tau kom tsis txhob kis tau mob thiab heev ntawm kab thiab hemorrhagic teeb meem.

tshuaj muaj kev ruaj ntseg

Nws yog muaj kev ruaj ntseg rau cov neeg tshuaj "Leykostim"? Phau ntawv hais tias cov tshuaj no yuav siv tau rau cov menyuam yaus thiab cov neeg laus. Nws yog Attendance zoo rau tag nrho cov neeg uas tau txais cytotoxic cov kws khomob.

Cov neeg mob uas immunodeficiency virus daim ntawv thov tshuaj muab lub zoo theem qe thiab muab lub sij hawm los mus ua raws li tag nrho cov pom zoo noj tshuaj npaum cas ntawm antiretroviral los yog myelosuppressive txoj kev kho.

Thaum uas siv cov khoom no ntawm tus kab mob HIV replication muaj cai.

tshuaj

Yuav ua li cas pharmacokinetic tshuaj muaj "Leykostim"? Instruction ntawd hais tias cov concentration ntawm lub active ingredient ntawm no neeg uas sawv cev ncaj qha nyob rau hauv lub xeem koob tshuaj.

Tom qab subcutaneous cov thawj coj, tus loj tshaj npaum li cas ntawm cov tshuaj nyob rau hauv cov ntshav cai tom qab kwv yees li 8-15 teev.

Lub ib nrab-lub neej "Leykostima" active khoom yog peb mus rau plaub teev. Filgrastim metabolized los peptides. Hais txog 1% ntawm cov active tivthaiv zoo nkaus li unchanged nyob rau hauv cov zis.

Filgrastim txuam nyob rau hauv tib neeg lub cev tsis tshwm sim txawm tom qab heev siv ntawm cov tshuaj (thaum txoj kev kho tshaj lub hli). Nyob rau hauv no lub sij hawm ntawm nws ib nrab-lub neej yog tib yam.

indications

"Leykostim" Cov tshuaj yog tshuaj rau cov nram qab no:

• kev txo lub caij ntawm neutropenia txaus kauj ruam 2-4, thiab kuj yuav txo cov xwm txheej ntawm febrile neutropenia nyob rau hauv tib neeg nrog hlav nemieloproliferativnymi tom qab cov kws khomob nrog cytostatic tshuaj mas siv;
• los txo kev muaj teeb meem uas tshwm sim thaum neutropenia, raws li zoo raws li rau txo lub sij hawm kawg ntawm tus kab mob nyob rau hauv tib neeg niaj myeloablative cov kws khomob nrog pob txha hloov yuav tsum;
• cell destinations ua ntej hematopoiesis nyob rau hauv lub peripheral cov ntshav rau lub hom phiaj ntawm nkauj nraug thiab hloov lawv tom qab myelosuppressive cov kws khomob;
• rau cov kev kho mob ntawm neutropenia nyob rau hauv cov neeg uas muaj kab mob HIV (xws li cov nyob rau hauv lub theem) nyob rau hauv thiaj li yuav txo txoj kev pheej hmoo ntawm kis kab mob ntawm cov kab mob hauv paus chiv keeb;
• rau cov kev kho mob ntawm tus kab mob neutropenia;
• cell chaw ua ntej hematopoiesis, nyob rau hauv lub peripheral ntshav noj qab nyob zoo hloov yuav tsum tau transplanted thiab cais lawv muaj mob.

Contraindications

Yuav ua li cas yog cov contraindications tshuaj muaj "Leykostim"? Xyuas cov tub txawg qhia cov nram qab no txwv:

• nce ib tug neeg rhiab heev ntawm tus neeg mob mus rau lub active thiab lwm yam khoom xyaw rau hauv nyob tus yeees ntawm cov tshuaj;
• congenital neutropenia, mob ntws nyob rau hauv nrog cytogenetic mob (Kostmann syndrome);
• neonatal lub sij hawm (tshwj xeeb tshaj yog cov thawj lub hlis ntawm lub neej).

Tshuaj "Leykostim": kev qhia thiab daim ntawv thov

Saib cov tshuaj yuav muab nyob rau hauv ob txoj kev:

• intravenously;
• subcutaneously.

Ntau npaum thiab tus qauv ntawm koom haum saib xyuas "Leykostima" yuav tsum tau txiav txim los ntawm cov kws txawj, nyob ntawm seb tus soj ntsuam qhov teeb meem no, tus neeg yam ntxwv ntawm tus neeg mob thiab cov kab mob. Txawm li cas los, nws yuav tsum tau muab sau tseg tias kev kho mob xyaum nws yog najnpawb subcutaneous thawj coj ntawm cov tshuaj.

Tso dej raws leeg active medicament yog rho los ntawm cov vial los ntawm tus xiaslias, thiab ces nws tau ntxiv rau ib tug minyuam lam fwj tshuaj ntawm 5% dextrose. Cov uas ua cov tshuaj yog muab rau ib tug neeg mob rau ib nrab ib teev.

Yuav ua li cas mus thov "Leykostim"? Cov lus qhia (analogues cov tshuaj no yuav tsum tau tham hauv qab no) hais tias cov tshuaj yuav tsum tau siv tsis muaj ntxov tshaj lub hnub tom qab qhov kawg ntawm cov kws khomob.

Cov tshuaj tov twb muab nyob rau hauv tus neeg mob hnyav. Cov koob tshuaj yog hom twg ntawm 5-12 mg ib 1 kg ceeb thawj. Tshuaj yog ua txhua hnub nrog ib zaus ntawm ib zaug ib hnub twg.

Therapy yog suav tias yog cov tshuaj yuav tsum tau nqa tawm raws li ntev raws li tus xov tooj ntawm qe nyob rau hauv cov ntshav tsis tau ib txwm theem. Feem ntau, cov kev kho mob ntev yog ob lub lis piam.

Thaum lub sij hawm thawj coj tshwj xeeb yuav tsum tau tsis tu ncua txiav txim seb tus naj npawb ntawm cov leukocytes nyob rau hauv cov ntshav. Yog hais tias lub xov tooj yog ntau tshaj 50,000 / microliter, cov tshuaj ntxeev.

Thaum lub sij hawm txoj kev kho, tus neeg mob tej zaum yuav tsim thrombocytopenia. Nyob rau hauv rooj plaub nyob rau hauv rov seev lub platelet count tus nqi yog khaws cia rau hauv qab no 100,000 / microliter, ces tshuaj xyuas qhov ib ntus tshem tawm ntawm cov tshuaj los yog txo nws npaum li cas.

phiv

Raws li statistics, cov tshuaj "Leykostim" tsis tshua muaj ua rau kev phiv tshuaj. Txawm li cas los, nws yeej tseem ua rau kom lub rov tshwm sim ntawm tej teebmeem raws li:

• dysuria;
• mob nyob rau hauv cov pob txha los yog cov nqaij ntshiv;
• alopecia;
• hepatomegaly, splenomegaly;
• hypotension (nraum);
• nce theem ntawm uric acid thiab alkaline phosphatase;
• tsis muaj zog, mob taub hau thiab nkees;
• kev tsis haum tshuaj nyob rau hauv thaum pib ntawm cov kev kho mob, uas feem ntau tshwm sim tom qab tso dej thawj coj ntawm cov tshuaj.

Nws yuav tsum tau muab sau tseg tias thaum ib tug tsis yog txhaj yuav cuam tshuam tus neeg mob tsis xis nyob ntawm lub qhov koob.

tshuaj cov kev sib tshuam

Ua ntej siv cov tshuaj no, koj yuav tsum tau xyuas seb yuav ua li cas koom tau nrog lwm cov tshuaj "Leykostim". Cov lus qhia (INN ntawm cov tshuaj suab zoo li "filgrastim") muaj cov tiav ntaub ntawv los ntawm:

• Medicament "5-FU" yuav ntxiv zog rau neutropenia.
• Vim hais tias loj hlob myeloid hlwb yog cov tsis tshua nkag siab cytotoxic agents, kom taw "Leykostim" yuav tsum muaj ib hnub ua ntej los yog tom qab siv cov tshuaj.
• Saib medicament incompatible nrog sodium tshuaj dawb.
• Thaum uas siv cov tshuaj rau cov kev taw qhia ntawm progenitor hlwb nram qab no cov kws khomob yuav tsum tau xav hais tias lub efficiency txo thaum lub luag hauj lwm mobilization daim ntawv thov "carmustine" "Melphalan" thiab "carboplatin".

tej tswv yim pom zoo

Nws tsis pom zoo kom muab "Leykostim" cov neeg uas muaj kev zoo siab muaj nuj nqi thiab lub raum, raws li filgrastim kev nyab xeeb thiab ua tau nyob rau hauv cov neeg mob no twb tsis tau kawm txog.

Cov neeg mob uas txha thiab lwm yam pob txha kab mob, uas siv cov tshuaj tsis tu ncua rau rau lub hlis, koj yuav tsum ua tus tswj ntawm tus pob txha ceev.

Cov hauj lwm zoo ntawm cov tshuaj nyob rau hauv cov neeg uas muaj ib tug me me npaum li cas ntawm myeloid progenitor hlwb twb tsis tau kawm txog. Txawm li cas los, cov kws txawj hais lus cam uas nyob rau hauv xws cov neeg mob cov neeg kawm ntawv ntawm kev nce rau hauv tus naj npawb ntawm qe yuav ua tau ho qis.

Miv nyuas siv zug thiab kev nyab xeeb ntawm "Leykostima" nyob rau hauv cov neeg uas muaj mob myeloid leukemia thiab myelodysplastic syndrome tsis tau tsim muaj. Nyob rau hauv no kev twb kev txuas, nyob rau hauv xws kab mob yog tsis muaj.

Monotherapy xam tau tias yog tsis siv yeeb tshuaj tiv thaiv anemia thiab thrombocytopenia, uas yog tshwm sim los ntawm myelosuppressive cov kws khomob. Nws yuav tsum tau los mus txiav txim tus naj npawb ntawm platelets thiab hematocrit. Kev ceev faj yuav tsum tau siv thaum siv ib zaug xwb-tivthaiv los yog thaum lawv tseem chemotherapeutic kiag, yog lub npe hu rau lawv muaj peev xwm yuav ua tau kom mob loj heev thrombocytopenia.

Ua ntej yuav pib kev kho mob, "Leykostimom" tsim nyog los ua ib tug ncauj lus kom ntxaws tsom xam ntawm cov ntshav nrog ib tug tej tus nqi ntawm platelet thiab leukocyte suav, thiab tshawb karyotype thiab hlwb pob txha daim duab.

Thaum lub sij hawm lub sij hawm ntawm kev kho mob yuav tsum tau tsis tu ncua saib xyuas cov zis thiab qhov luaj li cas ntawm tus po.

Tshuaj "Leykostim": analogs thiab tus nqi

Analogues tshuaj suav hais tias yog raws li nram no tshuaj: "Filergim", "Grasalva", "Granogen", "Neupogen," "leucite", "Neypomaks", "Mielastra", "Neyrostim".

Raws li rau tus nqi, ces "Leykostima" no heev. Yuav cov tshuaj no nyob rau hauv pharmacies nyob rau hauv Moscow thiab lwm yam Lavxias teb sab lub zos yuav ua tau ntawm 2500-4500 rubles. Tus nqi ntawm cov tshuaj no nyob rau qhov luaj li cas thiab tus naj npawb ntawm ampoules ib pob.

Tshuaj Xyuas

Tu siab, txheeb xyuas ntawm cov neeg mob uas noj cov tshuaj no, heev me ntsis. Raws li qhov tseeb hais tias muaj, cov tshuaj feem ntau kws kho rau lub cev, raws li zoo raws li cyclic neutropenia nyob rau hauv cov me nyuam. Cov nyhuv ntawm cov tshuaj nyob rau hauv xws loj cov kab mob yog luv luv.

Nws yuav tsum raug sau tseg hais tias muaj neeg mob testimonials rau tus soj ntsuam kev siv ntawm "Leykostima" nyob rau hauv cov me nyuam thiab cov laus uas neutropenia txuam nrog rau mob cancer cov kws khomob. Kev npaj muab cov me nyuam mos nyob rau hauv ib tug ntau npaum ntawm 5 mg / kg ib hnub twg, es zoo taus.

Ib txhia neeg xav nyob rau hauv cov nqe lus nug txog dab tsi zoo ntawm cov tshuaj yog zoo dua: "Leykostim" los yog "Neupogen". Raws li ib tug tshwm sim ntawm kev soj ntsuam tej kev txom nyem uas tau nqa tawm kom paub tias cov tolerability thiab miv nyuas siv zug ntawm cov kab mob, lub nram qab no cov lus xaus tau mus txog: hnub kawg rau tus kho lus ntawm neutropenia tom qab siv cov tshuaj hais yog tsis distinguished. Ntxiv mus, lawv muaj raws nraim tib yam kev ntsuas ntawm miv nyuas siv zug thiab tolerability.