"Celecoxib": cov lus qhia rau kev siv, xyuas. tshuaj analogues

Kev kho mob ntawm cov kab mob txuam nrog kev puas tsuaj rau lub licas, xav tau los ntawm tus kws ua lag luam tsim tshuaj tshiab muaj tsawg phiv thiab ntau dua efficiency. Zaum muaj sab thiab tsim ib tug tshiab tiam ntawm uas tsis yog-tshuaj anti-inflammatory siv tshuaj rau lub hauv paus ntawm celecoxib. Cov tshuaj txo toxicity thiab zoo zam los ntawm lub cev.

Hauj lwm ntawm "Celecoxib" tshuaj

Substance celecoxib muaj ib tug daj ntseg daj xim thiab hais txog cov pab pawg neeg coxibs uas muaj xim inhibition ntawm cyclooxygenase thib ob hom. Medicaments raws li nyob rau hauv lub tebchaw rau tam sim no muaj cov lus hais anti-inflammatory thiab analgesic zog. Tus thawj cov tshuaj nyob rau hauv lub hauv paus ntawm celecoxib yog pom tias yuav tau tsim los ntawm lub American lub tuam txhab "Pfizer" tshuaj "Celebrex". nws yog tshawb nrhiav thiab tshawb xyuas cov pharmacodynamic yam ntxwv ntawm toxicity rau tib neeg lub cev.

Tus lwm yam medicaments muaj cov active tshuaj celecoxib yog generic, xws li tshuaj "celecoxib".

ntau npaum ntaub ntawv

Qhov tshuaj nyob rau hauv ib qho nyuaj gelatin tsiav tshuaj thaum ib tug ntau npaum ntawm active ingredient, 100 mg thiab 200 mg. Tsis zoo li lwm yam uas tsis yog-steroid anti-inflammatory kab mob, muaj tsis muaj ntau npaum daim ntawv raws li ib tug tshuaj pleev, gel, injectable kev daws teeb meem los yog kev rho tawm. Muaj ib co neeg mob mistakenly hu ua tso tawm daim ntawv "Celecoxib" tshuaj - ntsiav tshuaj, txawm tias peb yuav tau tham txog lub tsiav tshuaj.

qauv

Lub active ingredient yog celecoxib tshuaj nyob rau hauv ib tug npaum li ntawm 100 mg thiab 200 mg. Muaj pes tsawg leeg ntawm tsiav tshuaj muaj xws li koom haum pab Cheebtsam uas muab qhov chaw filling, lub flowability thiab stability ntawm lub granulated sib tov. Cov no muaj xws lactose, sodium lauryl sulfate, polyvinylpyrrolidone (K30), sodium croscarmellose, magnesium stearate.

Txuas mus rau lub tshuaj "celecoxib" phau ntawv qhia comprises cov muaj pes tsawg leeg thiab yam ntxwv cov tsos ntawm ib tug gelatin capsule plhaub. Raws li qhov kev piav qhia, nws zoo nkaus li npub, muaj yuav luag dawb nyob rau hauv cov xim thiab cov cim nrog tej yam tshwm sim "100" los yog "200", nyob rau lub xiav los yog daj band, ntsig txog. Qhov no tso cai rau kom paub qhov txawv tsiav tshuaj uas txawv noj tshuaj npaum cas. Muaj pes tsawg leeg ntawm daj thiab xiav inks kuj pleev xim rau kom meej qhia dyes txawm mus kab.

zoo xws li cov tshuaj

Lam khoom "Celecoxib", analogues ntawm uas tseem muaj cov active tshuaj celecoxib, yuav muaj tib lub kho nyhuv on osteoarthritis ntawm tus tib neeg cev pob txha.

Tus thawj tshuaj "Celebrex" thiab nws cov generic "Celecoxib", "Artoksib", "Zitsel", "Revmoksib", "Ranseleks" yog xam tau tias yog interchangeable tshuaj. Txawm li cas los, cov thawj nqe qeb yuav raug nqi ib qho kev txiav txim ntawm qhov ntau ntau kim tshaj lawv cov counterparts.

Nyob rau hauv kev npaj "Celebrex" muaj celecoxib ntawm ib tug ntau npaum ntawm 100 thiab 200 mg raws li ib tug medicament "celecoxib". Koom haum pab Cheebtsam ntawm lub tshuaj ntsiav thiab nws lub hnab ntawv tej zaum yuav txawv ob leeg nyob rau qhov zoo thiab ntau pes tsawg leeg uas tsis muaj feem xyuam rau lawv lub zog. Hais txog hauv daim ntawv ntawm qhov kev tso tawm ntawm generic "Celecoxib" tshuaj analogues yog ua xwb nyob rau hauv ib qho nyuaj gelatin tsiav tshuaj rau hauv kev siv.

Muaj tshuaj anti-inflammatory kab mob, cyclooxygenase Attendance muaj feem xyuam rau lub thib ob hom tab sis muaj sib txawv nyob rau hauv nyob tus yeees ntawm cov active tivthaiv, cov pharmacokinetic thiab pharmacodynamic yam ntxwv. Cov muaj xws li cov sulfonamide compound nimesulide uas nyob rau hauv ib tug txhua txhua hnub ntau npaum ntawm 200 mg zoo ua zoo rau cov tsos mob ntawm osteoarthritis thiab rheumatoid mob caj dab. Formulations raws li nyob rau hauv nws cov anti-inflammatory thiab analgesic nyhuv los ntawm inhibiting lub cyclooxygenase thib ob thiab mus rau ib tug tsawg raws li - ntawm cov thawj hom, kev cuam tshuam rau ib tug ntau yam ntawm kev sib kho ntawm kev mob thiab o.

Raws li nimesulide, celecoxib yog tus neeg sawv cev ntawm lub sulfonamide chav kawm ntawv ntawm tshuaj, thiab kuj nyob rau hauv ib tug txhua txhua hnub ntau npaum ntawm 200 mg eliminates cov tsos mob ntawm osteoarthritis. Nws tsis inhibit qhov kev cyclooxygenase thawj hom thiab ua rau ib tug me me muaj pes tsawg tus ntawm kev sib kho ntawm kev mob thiab o.

Ib lwm kev kho mob coxibs qhov ncauj thawj coj yog injectable ntaub ntawv ntawm cov narcotics yuav muab. Ib tug ntawm lub ntsiab zoo ntawm "Celecoxib" khoom - tus nqi. Tshuaj (ampoules cov kev txhaj tshuaj) lwm yam uas tsis yog-tshuaj anti-inflammatory siv tshuaj raug nqi kim kim, tab sis xws txhaj efficiency yog nyob deb superior rau lub tshwm sim los ntawm txoj kev siv cov tshuaj nyob rau hauv cov khoom ntaub ntawv.

mechanism ntawm qhov kev txiav txim

Tshuaj "Celecoxib" - ib cov tshuaj uas nruab nrab yog ib tug tshiab tiam ntawm nonsteroidal anti-inflammatory kab mob, anti-inflammatory, analgesic, antipyretic kev ua si. Nws mechanism ntawm qhov kev txiav txim yog txuam nrog thaiv cov hlab qhov tsim ntawm inflammatory prostaglandins los ntawm kev txo cov kev ua ntawm COX-2.

Inflammatory tshua ua lub induction ntawm cyclooxygenase thib ob hom, nyob rau hauv lem accelerates tsub zuj zuj ntawm prostaglandin synthesis thiab tshuaj uas txhim khu o. State muaj o thiab mob.

Cyclooxygenase thawj hom tsis cuam tshuam rau kho koob "celecoxib" kev npaj. Cov lus qhia rau kev siv qhia txog cov inertia ntawm cov tshuaj txoj kev no enzyme txuam nrog cov kev ua ub ntawm muaj sia dab tshwm sim nyob rau hauv lub hlwb ntawm tus mob huam thiab platelet lug.

Tsis tas li ntawd, nyob rau hauv cov lus qhia muab cov ntaub ntawv nyob rau hauv tej yam ntawm cov tshuaj nyob rau hauv ob lub raum. Nyob rau hauv qhov kev txiav txim ntawm lub celecoxib yog tsawg tshaj li tso tawm nyob rau hauv cov zis muaj pes tsawg leeg prostaglandin E2 thiab F1 ntawm 6-keto-prostaglandin, tab sis tsis hloov cov kev faib nyiaj ntawm B2 11-dehydro-thromboxane, uas qhia cov xim nyhuv tshuaj.

Kev siv lub tshuaj "Celecoxib" tsis ua rau ib tug txo nyob rau hauv lub filtration rate nyob rau hauv lub raum glomeruli neeg laus thiab nyob rau hauv cov neeg mob uas raum insufficiency.

Indications rau kev siv

Raws li pharmacodynamic yam ntxwv ntawm cov kev npaj "celecoxib" daim ntawv thov nws yuav zoo rau cov kev kho mob ntawm rheumatoid thiab psoriatic mob caj dab, mob mob mob ntawm cov nqaj qaum thiab sacroiliac pob qij txha thiab osteoarthritis.

Vim nws analgesic zog siv rau mob nyob rau hauv licas mob tom qab lub phais kho mob, dysmenorrhea, uas yog nrog los ntawm mob ua poj niam. Cov anti-inflammatory nyhuv ntawm cov tshuaj yog aimed ntawm txo outgrowths thiab polyps nyob rau hauv cov nyuv thiab qhov quav nyob rau hauv lub mob ntawm "adenomatous polyposis".

Yuav ua li cas mus noj

Siv cov tshuaj "Celecoxib" cov lus qhia rau kev siv hauv xav tsis txuas nrog rau cov kev noj zaub mov. Lub tsiav tshuaj tsis txhob qhib thiab tsis chewed, thiab nqos tag nrho los ntawm kev haus dej kom ntau.

Qhov siab tshaj plaws nqi ntawm celecoxib, uas tej zaum yuav tsum tau noj ib hnub twg yog 0.4 g npaj no yog siv nyob rau hauv excess xwb nyob rau hauv uas tsis tshua muaj mob.

Plawv mob yuav ua rau siab koob tshuaj thiab lub caij nyoog kev kho mob nrog rau cov tshuaj "Celecoxib". Phau Ntawv Qhia no muaj cov ntaub ntawv nyob rau hauv me me noj tshuaj npaum cas rau lub symptomatic kev kho mob ntawm txhua nyeem ntawv. Muab tswv yim pom zoo nyob rau hauv luv luv siv.

Yuav kom tshem tawm cov tsos mob txuam nrog osteoarthritis, thiab ankylosing spondylitis, txhua hnub noj ib los yog ob lub sij hawm nrog rau 200 mg ntawm cov tshuaj.

Yuav kom tshem tawm cov tsos mob ntawm kev mob caj dab rheumatoid siv ib tug txhua txhua hnub koob tshuaj ntawm 200 los yog 400 mg, uas yog muab raws li ob zaug.

Mob thiab thawj dysmenorrhea yog kho nyob rau hauv thawj hnub lub siab koob tshuaj ntawm 400 mg, nrog rau cov tau txais tos ntawm ib tug ntxiv 200 mg toj ib hnub, siv 200 mg 2 lub sij hawm ib hnub twg.

Cov neeg laus, thiab cov neeg mob muaj mob me me degree tsis txaus siab los yog me ntsis hlaus insufficiency, tsis muaj recalculation ntawm koob tshuaj yog nqa tawm.

Tsis tshua muaj ceeb thawj (tsawg tshaj li 50 kg), qhov nruab nrab heev ntawm daim siab tsis ua hauj lwm - cov ntaub ntawv pawg rau cov neeg mob kho nrog tsawg koob tshuaj tshuaj.

Feem ntau, rau cov kev kho mob ntawm inflammatory dab nyob rau hauv cov pob qij txha siv kev kho mob systems raws li nyob rau kev siv ntawm ob peb tshuaj nyob rau hauv ntau yam ntau npaum cov ntaub ntawv. Muab "celecoxib" capsule, tshuaj pleev, los yog gel-hom sov "Apizatrona" los yog "finalgon. Tshuaj pleev siv ua rau ib tug ib ntus nyhuv, yog li ntawd lawv siv ua ke nrog tshuaj rau sab hauv tsev txais tos.

Qhov no txwv tsis pub siv cov

Tsis yog txhua txhua tus neeg mob nrog cov kab mob ntawm cov pob qij txha, koj muaj peev xwm coj cov tshuaj "Celecoxib". Cov lus qhia rau kev siv muaj ib daim ntawv teev ntawm cov kab mob thiab tej yam kev mob nyob rau hauv uas lub cuab tam yuav ntau ua mob ntau tshaj kev zoo. Cov muaj xws li:

• ua xua, mob hawb pob, allergic kev mob los ntawm qhov kev txiav txim ntawm tshuaj aspirin thiab lwm yam nonsteroidal anti-inflammatory siv tshuaj;
• rov qab lub lag luam txuam nrog coronary artery bypass grafting ;
• exacerbation ntawm peptic rwj;
• plab thiab cov hnyuv los ntshav;
• o ntawm lub mucosa nyob rau hauv cov hnyuv;
• lub plawv tsis ua hauj lwm;
• ischemic cov kab mob ntawm lub plawv mob;
• tsis peripheral hlab ntsha thiab cerebral vessels nrog impaired cerebral ntshav txaus;
• hepatic nedostatochnosttyazheloy zoo lawm;
• mob loj heev raum tsis ua hauj lwm;
• nyuam;
• pub niam mis rau tus me nyuam;
• nyob rau hauv lub hnub nyoog ntawm kaum yim xyoo;
• npau taws me ntsis rau cam;
• nce nyhav mus rau lub sulfonamide tivthaiv.

Nrog ceev faj siv ntawm cov tshuaj "Celecoxib" neeg ntawd yuav tsum nrog cov kab mob ntawm tus mob huam txuam nrog peptic rwj los ntshav nyob rau hauv lub dhau los lawm, kab mob ntawm lub qog ua kua kab mob ntawm lub genus Helicobacter pylori.

dej tuav nyob rau hauv lub cev thiab nqaij mos mos edema, mob ntawm lub siab theem nrab theem, lub plawv thiab leeg tshav kab mob, nyob rau hauv lub cev, nyob rau qhov kev nce rau hauv lub cholesterol theem nyob rau hauv cov ntshav ntshav cai lipid metabolism, mob ntshav qab zib, qab zib, Somatic kab mob nyob rau hauv loj thiab yog ib tug ua rau siab tshaj plaws ceev faj siv ntawm cov tshuaj "celecoxib" nyob rau hauv lub saib xyuas ntawm ib tug kws kho mob.

phiv

Txawm tias lub tshiab tau nyob rau hauv cov creation ntawm ib tug tshiab tiam ntawm coxibs, cov tshuaj thiab cov tshuaj raws li lawv yog cov tsis devoid ntawm sab los.

Cas cov tshuaj "Celecoxib" cov lus qhia rau kev siv, ua siab ntev testimonials thiab tshwj xeeb - cov chaw muaj ntaub ntawv hais txog cov ua tau phiv los uas tej zaum yuav tshwm sim nyob rau hauv lub siab ntsws tseem ceeb.

Cov tau tej yam tsis zoo nyob rau hauv lub digestive system yus NSAID-gastropathy, mob nyob rau hauv lub plab mog, xeev siab, ntuav, kub siab, txo qhov yuav tsum tau rau cov zaub mov kom tsawg thiab raws plab. Long-term siv siab koob tshuaj yuav ua rau ulceration thiab los ntshav nyob rau hauv lub qog ua kua membrane ntawm lub plab thiab cov hnyuv, los ntshav cov pos hniav, ntev li kom ntawm lub transferase siab.

Tshee ntshawv siab yog manifested excitement, mob taub hau, kiv taub hau, somnolence, insomnia, depressive lub xeev.

Cawv rau cov hlab plawv system vim nce siab nyob rau hauv cov hlab ntsha, thiab tachycardia.

Kev npaj "celecoxib" thiaj li tsis kam mus kis cov kab mob ntawm lub pa system, uas yuav tsum tau qhia nyob rau hauv txoj kev loj hlob ntawm sinusitis, rhinitis, pharyngitis, mob nyob rau hauv lub qhov ntswg thiab caj pas, hnoos, dyspnea, bronchospasm.

Tej yam ntawm cov tshuaj nyob rau hauv qhov txhia ua rau ib tug txo nyob rau hauv hnov xaav thiab cov tsos ntawm tinnitus.

Nyob rau urinary system muaj feem xyuam rau cov tshuaj "Celecoxib" yog li ntawd tej zaum koj yuav tau txais lub raum tsis ua hauj lwm nrog txoj kev loj hlob ntawm edema syndrome.

Nrog hais txog mus rau cov ntshav-sib sau ua kabmob, cov tshuaj yuav ua rau lub manifestation ntawm agranulocytosis, anemia, leucopenia, thrombocytopenia.

Daim tawv nqaij ua pob ua xyua tej zaum yuav tshwm sim nrog rau cov tsos ntawm kev tsis haum pruritus, urticaria, photosensitivity, angioedema nyob rau hauv lub ntsej muag thaj av ntawd, extremities, genitalia.

nta txais tos

Tshuaj "Celecoxib" xam qhovkev disadvantage txuam nrog rau kev raug mob ntawm cov nyom los ntawm cov hlab plawv system ua rau thrombosis, infarction ntawm myocardial stunning cov nqaij thiab mob stroke. Tshwj xeeb tshaj yog cov uas muaj feem yuav nce thaum lub sij hawm mob thawj coj ntawm cov tshuaj los ntawm cov neeg mob nyob rau hauv uas muaj cov kab mob plawv.

Yuav kom txo tau txoj kev pheej hmoo ntawm xws teeb meem nyob rau hauv cov neeg mob noj cov tshuaj "Celecoxib" muab tus nqi qis tshaj koob thaum feem ntau luv luv lub sij hawm ntawm kev kho mob. Tus neeg mob yuav tsum sib tham nrog koj tus kws kho mob tau tej yam tshwm sim ntawm tus kab mob thiab yuav tau txais cov tswv yim yuav ua li cas teb cov lus thaum lawv tshwm sim.

siv ib tug ua ke ntawm acetylsalicylic acid nyob rau hauv tsawg heev koob los tshuaj "celecoxib" Yuav kom txo tau cov kab mob. Xyuas ntawm cov kws kho mob qhia tias cov antiplatelet nyhuv ntawm cov tshuaj aspirin rau nyias cov ntshav thaum noj coxibs, uas tsis muaj xws li anti-thrombotic zog. Feem ntau, xws li ib tug ua ke no yog muaj nyob rau hauv cov neeg laus cov neeg mob uas mob ntawm lub licas thiab hlab plawv system, hnyuv toxicity yog nce thaum uas tsis yog-xim uas tsis yog-tshuaj anti-inflammatory siv tshuaj. Tab sis kev siv ntawm ib yam khoom celecoxib nrog rau lwm cov narcotics yuav muab yog tsis pom zoo.

Rau cov neeg mob kev txom nyem los ntawm ntshav siab, tus nruam xyuas ntawm no parameter thaum tau txais "Celecoxib" tshuaj.

Kev mloog yuav tsum tau muab rau saib xyuas qhov mob ntawm tus kab mob nyob rau hauv ua ke nrog nrog anticoagulant (warfarin) thiab antiplatelet tshuaj (acetylsalicylic acid, clopidogrel) siv xim inhibitors (citalopram, sertraline), inhibiting serotonin reuptake inhibitors ntawm CYP2C9 isozyme, ntsiav tshuaj ntaub ntawv glucocorticosteroids.

Cov tshuaj "celecoxib" txhawb zus tau tej cov prostaglandin tshuaj, uas retard lub kua nyob rau hauv lub cev thiab txhawb txoj kev loj hlob ntawm edema. Tshwj xeeb yog ceev faj nyob rau hauv cov kev kho mob ntawm cov tshuaj yuav tsum tau cov neeg uas raug kev txom nyem los ntawm lub plawv mob tsis ua hauj lwm thiab ntshav siab. yuav tsum tsis txhob noj "Celecoxib" tshuaj no yog tias muaj cov cim qhia ntawm o ntawm ntaub so ntswg.

Cov neeg mob uas raum mob kev kho mob coxibs yuav tsum tau nrog los ntawm kev saib xyuas ntawm lawv cov cim tseem ceeb.

Thaum lub cev qhuav dej noj cov tshuaj yog tau tsuas yog tom qab lub dej qab ntsev kawg cov dej qab ntsev.

Txais tos "celecoxib" antipyretic tshuaj vim mus ua hauj lwm ua rau mob lub diagnostic index, raws li kom kub thaum lub sij hawm txoj kev loj hlob ntawm cov kab mob.

Qhov kev txiav txim ntawm cov tshuaj yuav ua rau kev txawv txav nyob rau hauv daim siab muaj nuj nqi, tshwj xeeb tshaj yog nyob rau hauv cov neeg uas muaj pre-uas twb muaj lawm mob ntawm lub siab. Loj cov tsos mob txuam nrog fulminant kab mob siab, siab nekrozomtkaney. Tej yam kev mob tshwm sim tam sim ntawd, tab sis tsuas yog tom qab 30 hnub tom qab daim ntawv thov "celecoxib" kev npaj. Ces koj xav saib xyuas kev ua tau zoo nyob rau hauv cov kev kho mob ntawm daim siab lub tsev no, thiab nyob rau hauv cov ntaub ntawv ntawm hnyav xwb koj yuav tsum tau kom sai rho lub sij hawm.

Reviews for cov kev kho mob ntawm "Celecoxib"

Nonsteroidal anti-inflammatory siv tshuaj yog nqa tsuas yog nyob rau cov tshuaj. Cov kev tshwm sim ntawm txoj kev siv ntawm "Celecoxib" tshuaj xyuas ntawm qhov kev txiav txim yog mixed. Ib cov tshuaj yuav pab tau tiv nrog inflammatory dab nyob rau hauv cov pob qij txha, rau lwm tus neeg nws yog ices thiab ua rau ib tug xov tooj ntawm cov nyom txheej xwm.

Raws li ntau tus neeg mob soj ntsuam cov tshuaj "Celecoxib"? Xyuas qhia ib tug xov tooj ntawm cov teeb meem: kev mob nyob rau hauv lub plab, mob raum, coj khaub ntshawv siab. Tej cov neeg mob tus kws kho mob ua kev tshem medicament thiab assigns lwm kev kho mob.

Raws li cov kev xav ntawm cov neeg mob nyob rau hauv lub los ntawm cov tshuaj nyob rau hauv lub kub lug pob qij txha, nws muaj peev xwm yuav xaus lus tias nws yog zoo nyob rau hauv sib ntaus tawm tsam kev mob caj dab. Yuav kom tshem tawm cov kev mob tshwm tsos mob, o ntawm ntaub so ntswg nyob rau hauv lub cheeb tsam cov ntawm ib tug mob xwm, cov neeg mob yog nyob rau hauv lub Autumn thiab lub caij nplooj ntoos hlav nqi ntawm cov tshuaj kho "Celecoxib". Nws yog siv los ntawm ncaws pob nyob rau hauv kev poob plig thiab pob qij txha.

Tshwj xeeb tshaj yog medicament ua zoo nyob rau hauv ua ke nrog nrog sov ointments thiab tshuaj kua rau tshuaj pleev daim ntawv thov. Txawm li cas los, raws li cov tswv yim pom zoo uas muaj nyob rau hauv cov lus qhia rau kev siv muab NSAID siv luv luv hoob kawm, nyob rau hauv kev txiav txim kom tsis txhob muaj kev nyuaj siab nyob rau hauv ob lub raum, lub siab, lub plawv thiab plab. Txwv tsis pub tsis yuav tsum tsis txhob swb nyob rau hauv lub chaw ua hauj lwm ntawm cov lub cev.