"Capecitabine": cov lus qhia rau kev siv, tiag tiag counterparts, tso tawm daim ntawv no, lub chaw tsim tshuaj paus. "Capecitabine-TL": daim ntawv qhia

Capecitabine (Latin Capecitabinum.) - ib yam khoom uas yog ib tug fluoropyrimidine carbamate derivative. Nws belongs rau cov pab pawg neeg ntawm antimetabolites - tej tebchaw tau inhibit qhov kev loj hlob ntawm phem hlav. Lub paj nyob rau hauv xws tshuaj originated nyob rau hauv 1960 g. Thawj zoo tau raug muab los ntawm cov kev tshawb fawb nyob rau hauv nas. Tej lub sij hawm tom qab ntawd, nws raug sab nws cov hauj lwm zoo nyob rau hauv cov kev kho mob ntawm tej yam cancer kab mob nyob rau hauv tib neeg.

Niaj hnub no, muaj ntau yam anticancer tshuaj uas muaj lub active tshuaj capecitabine. Xyuas ntawm ntau cov neeg mob hais txog txoj kev vam meej ntawm daim ntawv thov ntawm xws cuab yeej nyob rau hauv anticancer txoj kev kho.

Therapeutic thiab cov khoom

Formula capecitabine - 5'-deoxy-5-Fluoro-N - [(pentyloxy) carbonyl] cytidine. Antimetabolites tshuaj pab pawg neeg yog sawv cev los ntawm ib tug xov tooj ntawm tej yam uas yog zoo xws li cov nyob rau hauv qhov mus rau hauv cov khoom ntawm metabolism (metabolism) tib neeg. Lawv yog cov tau mus koom rau hauv metabolic tshua, thiab kho lawv kom qeeb ib co ntawm cov biochemical dab. Yog li muaj ib tug malfunction nyob rau hauv tseem ceeb heev mob hlwb thiab inhibition ntawm lawv txoj kev loj hlob thaum uas siv cov npaj raws li tej yam khoom uas capecitabine. Xyuas ntawm cov neeg uas sib tham txog kom txhob muaj cov loj ntawm hlav. Qhov no mechanism ntawm qhov kev txiav txim yog hu ua cytostatic.

Cov zog tso cai rau cov kev siv cov tshuaj antimetabolitnyh lawv nyob rau hauv anticancer txoj kev kho. lawv cov pov thawj miv nyuas siv zug tiv thaiv phem hlav ntawm tus mob huam thiab mammary qog. Nyob rau hauv cov ntaub ntawv no, ib tug zoo tshwm sim muab ob lub monotherapy thiab ua ke nrog nrog rau lwm cov tshuaj mas siv. Rau hnub tim, rau lub hauv paus ntawm anti-metabolites tsim ntau tshaj 800 cov khoom, tab sis tseem tseem mus nrhiav tshiab pawg ntawm cov tebchaw.

mechanism ntawm qhov kev txiav txim

Capecitabine kom tshwm sim nyob rau hauv cov ntaub so ntswg ntawm lub qog, tom qab uas nws pib pheev nws lom ntxim rau cov hlwb (cytotoxic mechanism). Qhov no tshuaj yog muab kev koom tes nyob rau hauv lub metabolism ntawm cov tshuaj tiv thaiv thiab ua rau lub fact tias cov noj qab nyob zoo thiab lub qog hlwb yog hloov dua siab tshiab rau hauv cytotoxic analogs. Yog li muaj ib tug ua txhaum generating tshuaj tsim nyog rau DNA synthesis thiab, thiaj li, tus faib cov txheej txheem.

Txij li thaum lub hlwb nres tsis ua kom lawv tus xov tooj. Nyob rau hauv lwm scenario, muaj yog ib tug "hloov" ib leeg yeeb tshuaj, uas muaj protein ntau synthesis yog disturbed thaum noj tshuaj raws li capecitabine compound. Phau Ntawv Qhia piav nyob rau hauv kom meej tus txheej txheem no.

Lub mechanism ntawm no transformation minimizes tau ntawm kev puas tsuaj rau kev noj qab nyob hlwb. Capecitabine yog ntau concentrated nyob rau hauv lub qog nws tus kheej, dua li nyob rau hauv lub surrounding ntaub so ntswg. Xws li ib tug feature yog tsawg teeb meem rau lub cev thaum ib tug neeg yog raug kho rau ib tug yeeb tshuaj raws li nyob rau hauv lub tshuaj capecitabine. Cov lus qhia rau kev siv xav tau txais cov nyiaj nyob rau hauv nruj me ntsis txhais koob tshuaj uas txiav txim los ntawm lub mus kawm tus kws kho mob.

Nyob twj ywm tshuaj nyob rau hauv lub cev

Thaum tau txais capecitabine yog nws ceev ceev haum nyob rau hauv txoj hnyuv ib ntsuj av. Yog hais tias koj noj lub sij hawm no, cov txheej txheem yuav qeeb. Yog li ntawd, raws li nyob rau hauv lub txais tos antimetabolite tshuaj yog nqa tawm tom qab haus. Ntxiv transformation tshwm sim nyob rau hauv lub siab yeeb tshuaj, ib qhov nqi ntawm capecitabine thiab nws cov metabolites khi rau cov nqaijrog (e.g., albumin). Lub ncov ntshiab theem attained tom qab 1.5 -3 teev tom qab cov tshuaj daim ntawv thov. Qhov no hais lus rau cov tshuaj "Capecitabine" kev qhia ntawv. Analogs muaj zoo xws li cov tshuaj.

Feem ntau ntawm cov tshuaj yeeb dej caw yog tas nyob hauv cov zis, qis - nrog rau cov quav. Ntxiv mus, tsis tsuas yoojyim lub cev capecitabine unchanged (txog 3%), tab sis nws derivatives. Ib txhia ntawm lawv yog metabolized tsawg lub tebchaw. Lub chaw nyob thiab tus transformation ntawm capecitabine nyob rau hauv lub cev yog tsis cuam tshuam los ntawm cov tub los ntxhais, hnub nyoog, haiv neeg.

Thaum muab?

Capecitabine rau hauv ntau yam formulations los siv rau cov neeg mob uas muaj mob cancer mis, xws li metastatic theem. Nyob rau hauv cov ntaub ntawv no, cov ntaub ntawv uas siv nyob rau hauv lub moj khaum nyob ib leeg, los yog ua ke kev kho mob nrog contraindications los yog tsis muaj miv nyuas siv zug ntawm cov kws khomob. Feem ntau cov feem ntau, capecitabine ua ke nrog docetaxel.

Nws kuj tshuaj rau cov neeg mob nrog rau mob cancer ntawm cov nyuv, hlab pas, plab, pancreas, colorectal cancer, ob qho tib si nyob rau hauv lub zos kis ntawm cov theem, thiab thaum lub sij hawm metastasis. Nyob rau hauv cov kev kho mob ntawm cov nyuv mob cancer yog tseem muab "capecitabine". Cov lus qhia rau kev siv ua tib zoo ua raws li cov pom zoo npaum thiab ua raws li lub tswv yim ntawm cov kws kho mob.

Sis nrog lwm yam tshuaj

Yog hais tias cov kws khomob muaj pov thawj tsis zoo, ib tug Oncology specialist yuav muab ib tug ua ke kev kho mob, uas yuav tsum tau siv "capecitabine". Cov lus qhia rau kev siv muab ib daim ntawv teev kev pab, uas yog ua tau rau ntse sib tov.

Piv txwv li, nrog "docetaxel" - tshuaj cytotoxic txiav txim hom muaj ib tug zaub keeb kwm. Nws yog tau rau siab rau ib ntev lub sij hawm nyob rau hauv lub hlwb nyob rau hauv siab ntau. Txawm li cas los, xws li ib tug ua ke ntawm cov neeg ua hauj yog contraindicated rau cov neeg uas muaj cov xov tooj ntawm platelets thiab qe 100,000 / ul thiab 1500 / l, ntsig txog. Tsis tas li ntawd "Docetaxel" siv tsis tau rau cov neeg mob nrog rau kev tus nqi ntawm bilirubin. Nyob rau hauv cov ntaub ntawv no, cov tau tsis kaj siab txim. Yog hais tias "Docetaxel" rau ib txhia yog vim li cas "lub caij nplooj zeeg" ntawm cov kev kho mob regimen, ntxiv txoj kev kho "capecitabine", tab sis nyob rau txo koob tshuaj.

Nyob rau hauv cov kev tshwm sim ntawm npau taws me ntsis kev tshua kev kho mob "capecitabine" thiab "docetaxel" nres thiab tshem tawm cov tsos mob tshwm sim los. Scheme ua ke supplementation muaj oncologist txawj tus kws txawj txua. Qhov no tswvyim yog tom nyob rau hauv cov kev tshwm sim ntawm tshuaj lom los.

"Capecitabine" yog tsis tsa nyob rau tib lub sij hawm "Sorivudinom" - ib tug antiviral neeg sawv cev. No thaum lawv tseem yuav ua rau kom cov tshuaj muaj taug ntawm cov thawj tshuaj. Lub ua ke siv cov antiepileptic tshuaj "phenytoin" tsub kom lub concentration ntawm lub yav tas rau hauv cov ntshav ntshav. Nws yog tseem tau los ntshav teeb meem nyob rau hauv lub siv ntawm coumarin anticoagulants thiab txhais tau tias, qhov twg lub ntsiab tivthaiv - capecitabine. Cov lus qhia rau kev siv ceeb toom ntawm tus tau txim, yog li ntawd koj yuav tsum xub paub koj tus kheej nrog nws.

Leej twg yog txhob?

Yog vim li cas hais tias yog txhob los yog tas rau cov tshuaj tej zaum yuav:

• High rhiab heev (meem kev txhawj xeeb cov tshuaj tiv thaiv).
• Qhov muaj mob raum los yog hepatic insufficiency.
• Ntau theem ntawm cev xeeb tub (cov tshuaj muaj feem xyuam rau cov txiv hmab txiv ntoo), nrog rau cov kev zam ntawm tus neeg mob qhov twg leej niam lub neej yog muab tso rau hauv ua ntej;
• Pub me nyuam mos noj.

Tsis tas li ntawd tau txais capecitabine txwv rau cov neeg uas muaj mob plawv (CHD), thaum ib lub xeev uas muaj zog concentration ntawm bilirubin nyob rau hauv cov ntshav, daim siab mob metastatic rau koj ua txhaum ntawm nws yooj yim zog. tsis muaj kev npaj yog pom zoo rau cov menyuam yaus thiab cov neeg laus. Qhov no qhia cov tshuaj "Capecitabine" kev qhia ntawv. Testimonials hais txog ib tug ntau yam ntawm cov kev phiv thiab tshuaj lom los nyob rau hauv cov kev kho mob. Yog li ntawd, capecitabine txoj kev kho yuav siv sij hawm qhov chaw nyob rau hauv cov nruj kev saib xyuas ntawm ib tug kws oncologist.

Puas muaj tej kev phiv?

Tom qab noj cov tshuaj yuav ua tau ib tug mob taub hau, xeev nkees, nkees, tsis muaj zog. Insomnia zaum yuav tshwm sim, los yog vice versa - nkees nkees. Nyob rau hauv tsawg zaus - tsis sib haum thiab tshuav nyiaj li cas, tsis meej pem.

Sab los rau cov hlab plawv system yog anemia (anemia). Yuav kom ib tus twg lesser tej zaum nws yuav ua rau angina, myocardial ischemia, mob stroke, plawv tsis ua hauj lwm thiab lwm cov neeg. Yog hais tias tus txheej txheem ntawm lub pa kabmob uas yuav muab kev koom tes, tej zaum yuav muaj tsis taus pa, mob caj pas, hnoos. Heev tsis tshua - pulmonary embolism, mob ntsws chua.

Thaum siv nyob rau hauv muaj pes tsawg leeg nyob ib leeg los yog ua ke kho mob tau tsis zoo los rau tus licas. Nws manifests nws tus kheej nyob rau hauv kev mob nyob rau hauv lub ceg ntoo thiab lub duav rov sauv, tshwm sim hypertonus nqaij (myalgia), ob leeg mob (arthralgia).

Cov tawv nqaij tej zaum kuj yuav cuam tshuam. Tej zaum ua rau dermatitis, erythema, ntev dryness ntawm daim tawv nqaij, lossis puas liab liab, tingling, xws li loog loog, tshwv, khaus, nce pigmentation, kev puas tsuaj muaj feem xyuam rau cov rau tes. Nyob rau hauv tsawg zaum muaj yog daim tawv nqaij kab nrib pleb, npau taws me ntsis rau ultraviolet hluav taws xob, tshwv thiab muaj zog fragility ntawm tus ntsia thawv daim hlau.

Cov lwm phiv txheej xwm yuav tshwm sim kab dab vim txo lub cev defenses. Tom qab tshuaj kho ua ib tug txo nyob rau hauv cov ntshav platelets thiab qe ntshav dawb. Tej ces qhia txog ib tug medicament "Capecitabine" phau ntawv qhia. Analogues muab tib los.

cov tshuaj

"Capecitabine" haum tsuas yog rau hauv kev siv. Feem ntau nws yog ntxuav cia nrog dej tom qab ib nrab ib teev tom qab ib tug noj mov, tab sis tsis pub. Lub hnub koob tshuaj yog txiav txim los ntawm lub mus kawm oncologist, nyob ntawm seb qhov loj ntawm hlav, txoj kev loj hlob theem, thiab tag nrho cov lub cev deg hauv cheeb tsam. Nws yog ntshaw uas tus kws khomob tshwjxeeb uas twb txawj ntse los mus ua hauj lwm nrog cov tshuaj no. Cov feem ntau tus kws kho ob zaug-txhua hnub - thaum sawv ntxov thiab yav tsaus ntuj. Nyob rau hauv cov ntaub ntawv no, tag nrho cov hoob kawm kav ob lub lis piam, thiab ces - ib tug so rau xya hnub, ua raws li los ntawm ib tug rov kho mob.

Rau cov neeg mob raum insufficiency, txhua hnub koob tshuaj txo. By txo tus naj npawb ntawm leukocytes (leucopenia) thiab qe (neutropenia) nyob rau hauv cov ntshav ntxiv noj cov tshuaj. Yog li ntawd xav ib txoj kev "Capecitabine" phau ntawv qhia. Txhais los yog analogues xeem nyob rau cov teg num ntawm lub mus kawm tus kws kho mob.

toxicity

Muaj ntau ntau degrees, raws li uas tsim tshuaj lom los ntawm cov tshuaj "capecitabine" (Cov lus qhia rau Siv). Xyuas ntawm ntau cov neeg hais tias qhov no yog ib tug neeg txheej txheem.

Muaj ntau ntau degrees ntawm toxicity:

• 1 degree. Muaj ob peb phiv.
• 2 degree. Lub khaus raws plab (txog li 4 lub sij hawm ib hnub twg) raws li los ntawm povtseg o, lossis puas liab liab, kev ua teeb meem, ib tug ntse nce nyob rau hauv bilirubin. Rau ntawm no theem, cov txais tos cuam tshuam capecitabine kom txog rau thaum cov tsos mob ntawm tshuaj muaj taug ntawm theem 1.
• 3 degree. Zawv plab quickens mus txog 9 sij hawm ib hnub. Nws tshwm sim malabsorption (sprue). Thaum zoo li no muaj cai ib tug muaj zog tawv nqaij tshwv, lossis puas liab liab, hlwv thiab qhov ncauj tawm. Muaj ntse pains nyob rau hauv lub extremities, tsis kev ua tau zoo. Bilirubin yog nce los ntawm 3 lub sij hawm. Rau ntawm no theem ntawm kev kho mob lawm, thiab lub manifestation ntawm toxicity of 1 degree tseem tau txais txhais tau tias nyob rau hauv lub qis koob tshuaj.
• 4 degree. Ntau heev raws plab - txog li 10 lub sij hawm ib hnub. Quav nrog cov ntshav. Muaj yog ib tug yuav tsum tau rau cov kev taw qhia ntawm cov tshuaj, bypassing txoj hnyuv ib ntsuj av. Yog hais tias tej yam tshwm sim ntawm no degree ntawm kev kho mob yuav tsum tau tso tseg thiab yeej tsis resumed.

Yuav ua li cas kev ntsuas yuav tsum ua raws kev ruaj ntseg?

Hoob no ntawm kev kho mob yuav tsum muab qhov chaw nyob rau hauv ze kho mob saib xyuas. Tus kws khomob tshwjxeeb yuav tsum raws sij hawm ntes lom ces -. Seb xeev siab, raws plab, thiab lwm yam Thaum nrhiav kom tau ntawm cov nta, cov kev kho mob yog tom. Yog hais tias tsim nyog, tshem tawm cov tsos mob, txo lub hnub koob tshuaj, ua ib tug so. Kev kho mob yuav tsum tau mus ntxiv, yog tias tej yam tshwm sim ntawm toxicity tsis ua rau ib tug kev hem thawj rau lub neej.

Rau cov neeg uas muaj mob plawv keb soj ntsuam cov kws yuav tsum tau tshwj xeeb tshaj yog txhij txhua. Nyob rau hauv cov ntaub ntawv no, koj yuav tsum lub sij hawm los qhia cov tsis zoo rau cov hlab plawv system thiab nyob rau hauv lub sij hawm kom tus tsim nyog kev npaj rau.

Kws txawj refrain los ntawm kev siv cov tshuaj yeeb dej caw nyob rau hauv xyuas xyaum. Cov hauj lwm zoo ntawm nws siv tsis tau tsim rau cov me nyuam. Yog hais tias kev kho mob yog raug mus rau ib tug poj niam ntawm nyuam lub hnub nyoog, nws yuav tsum tau qhia rau tej yam uas capecitabine nyob rau fetus. Thaum lub sij hawm hauv chav kawm ntawm kev kho, nws yuav tsum tau siv txhim khu kev qha contraceptives.

Npaj thiab analogues

Muaj ntau cov khoom rau lub hauv paus ntawm capecitabine. Nyob rau hauv lub Lavxias teb sab kev ua lag luam muaj 7 luam lub npe ntawm cov tshuaj, ua los ntawm ob peb lub domestic thiab txawv teb chaws tuam txhab uas muag. Piv txwv li:

• "Capecitabine".
• "Capecitabine-TL".
• "Tutabin".
• "Xeloda".
• "Kabetsin".
• "Kapetsitover".
• "Kapametin FS".

Txij li thaum lub hauv paus ntawm tag nrho cov txhais tau tias ib tug thiab tib yam kom nquag plias khoom sib ua zaub mov - capecitabine, rau lawv cov kev qhia ntawv yuav tsum zoo sib xws. Feem ntau nws qhia tias ib lub rooj rau xam ntau npaum muab lub cev hnyav thiab cov kev kho mob kho Circuit Court thaum ib tug kos npe rau ntawm zaubmov toxicity.

Nws yog ib qho tseem ceeb kom nkag siab txog hais tias cov thawj zaug uas tau nyeem, thaum nws tau raug tsa, rau piv txwv, "Capecitabine TL" - kev qhia ntawv. Cov ntaub ntawv muaj nyob rau ntawd yog tsis haum rau nws tus kheej-thawj coj cov cuab yeej! Tag nrho cov lus teb hais txog cov tshuaj thiab kev kho mob regimen, ua ib tug kws kho mob - oncologist nrog txaus txawj txaus nyob rau hauv cov teeb meem no. Self-thawj coj ntawm anticancer agents ua irreparable raug mob rau lub cev.

Cia peb xav txog ib co ntawm cov tshuaj.

Hauj lwm ntawm kev npaj

• "Capecitabine - TL" ua rau cov Lavxias teb sab lub tuam txhab OOO "Technology ntawm cov tshuaj." Ib tug tseem ceeb tivthaiv - capecitabine. Cov lus qhia rau kev siv, qhov kev tso tawm daim ntawv ntawm kev txaus siab rau ntau yam. Xav txog cov lus. Qhov no ntsiav tshuaj, zaj duab xis-coated. Cov ntsiab lus ntawm active tshuaj - 150 los yog 500 mg. Koom haum pab Cheebtsam: cellulose, lactose, croscarmellose sodium, hypromellose, magnesium stearate. Ib pob tej zaum yuav 60 xyoo los yog 120 cov ntsiav tshuaj, nyob ntawm seb ntau npaum ntawm cov tshuaj "Capecitabine - TL". Cov lus qhia yuav tsum muaj cov lus qhia hais txog kev siv ntawm cov nyiaj.
• "Capecitabine" - domestic khoom nrog rau cov tib yam kom nquag plias khoom sib ua zaub mov. Nws cov hauj lwm yog zoo li tus txhais tau tias teev saum toj no. Tso daim ntawv ntawm cov tshuaj "Capecitabine" - cov ntsiav tshuaj. Cov lus qhia rau kev siv kuj muab ntim rau hauv lub hnab.
• "Kabetsin" - anticancer neeg sawv cev ntawm Lavxias teb sab siv ( "Company" Deco "). Khoom daim ntawv - cov ntsiav tshuaj zaj duab xis coated nrog 150 los yog 500 mg ntawm active tshuaj. Secondary khoom xyaw: microcrystalline cellulose, crospovidone, starch, magnesium stearate. Cia los ntawm cov chaw muag tshuaj xwb los tshuaj.
• "Kapetsitover" - ib tug khoom ntawm Lavxias teb sab lub tuam txhab OJSC "Veropharm". Qhov no anticancer neeg sawv cev muaj nyob rau hauv cov ntsiav tshuaj ntawm 150 los yog 500 mg ntawm 60 - 120 tej daim. Dhau li capecitabine, nyob rau hauv cov kev npaj muaj xws li lactose, cellulose, croscarmellose sodium, sodium stearate, thiab hypromellose.
• "Kapametin FS" - ua los ntawm Lavxias teb sab lub tuam txhab "Nativ" - ib tug active koom tes nyob rau hauv qhov kev pab cuam ntawm lwm lub teb chaws muab los ntawm cov tshuaj. "Kapametin FS" tso ib tug ntau npaum ntawm 150 - 500 mg active neeg sawv cev - capecitabine. Cov lus qhia rau kev siv (kuj tsim muab nyob rau hauv nws) yuav qhia rau koj ntau npaum li cas cov ntsiav tshuaj ib pob - 60 los yog 120.
• "Tutabin" - teb chaws cov khoom nyob rau hauv lub hauv paus ntawm capecitabine. Nws ua ib tug Argentine lub tuam txhab Laboratorio VARIFARMA SA, uas yog tseem lub npe neeg saib xyuas. "Tutabin" yog ua nyob rau hauv daim ntawv ntawm cov ntsiav tshuaj nrog ib tug active ingredient cov ntsiab lus ntawm 500 mg. Ntim - cardboard lub thawv nrog cov lus qhia nkag.
• "Xeloda" - ib tug antitumor neeg sawv cev. Ua nyob rau hauv Switzerland los ntawm "by F. Hoffman La Roche" thiab nws cov subsidiaries thiab tus neeg sawv cev chaw ua hauj lwm nyob rau hauv lwm lub teb chaws - Mexico thiab lub tebchaws United States. Nyob rau hauv lub Lavxias teb sab kev ua lag luam muaj cov 5 tshuaj nrog cov lag luam tawm lub npe. Khoom daim ntawv - cov ntsiav tshuaj (150 - 500 mg) nyob rau hauv 60 los yog 120 tej daim. nyob rau hauv ib lub pob.

Xyuas

Xyuas ntawm lub chaw ua hauj lwm nyob rau hauv lub hauv paus ntawm ib tug ntau yam ntawm cov tshuaj capecitabine. Feem ntau ntawm lawv yog zoo, tab sis tseem muaj tsis zoo xyuas. Txawm li cas los, qhov no tsis characterize cov nyiaj raws li qhov zoo los sis phem, vim hais tias koj yuav tsum nco ntsoov coj mus rau hauv tus account lub kheej ntawm lub cev ntawm txhua tus neeg. Tau txais tib yam txhais tau tias sib txawv ntawm cov neeg yeej tsis muab tus raug tib yam. Ntawm kuj zoo kawg tseem ceeb yog qhov tseeb uas lub cev twb ntaus neoplasm thiab ntev npaum li cas nws twb mus nyob rau hauv.

Cov neeg uas coj cov tshuaj, hais tias ib tug muaj zog tshuaj lom nyhuv tom qab ob peb hnub ntawm kev txais neeg kawm. Txawm li cas los, muaj ntau yam qhia tseem ceeb kev txhim kho nyob rau hauv lawv tus mob thiab txawm nkag mus rau hauv txoj kev zam txim. Ib qho tseem ceeb mob tias cov tshuaj yuav ua hauj lwm raws li tau zoo raws li ua tau rau ib tug tib neeg, ib tug noj kev haus oncologist thiab nruj kev ua raws li nws cov lus qhia txog kev kho mob.