Zoledronic acid: pharmacological nyhuv thiab analogues

Nws yog lub npe hu hais tias bisphosphonates yuav inhibit qhov kev loj hlob ntawm cov pob txha metastasis thiab tiv thaiv kom txhob cov pob txha tsis. Ib tug ntawm qhov zoo tshaj plaws tshuaj teej tug mus rau qhov no pab pawg neeg - zoledronic acid. Tsis tas li ntawd, muaj pov thawj hais tias cov tshuaj no muaj angioneogenesis inhibition, mob ntxeem tau, adhesion ntawm lub qog hlwb nyob rau hauv cov pob txha ntaub so ntswg, induces kev puas ntsoog, thiab muaj yog synergy nrog cov kws khomob.

Formulation 1 vial

Zoledronic acid monohydrate - 4,26 mg cam - Sodium citrate, D-mannitol.

pharmacology

Ib inhibitor ntawm cov pob txha resorption. Zoledronic acid belongs rau ib tug tshiab hauv chav kawm ntawv ntawm siab hauv chav kawm ntawv ntawm bisphosphonates. Nws muaj ib tug xim ntxim rau cov pob txha. Reduces cov kev ua ntawm osteoclasts, tsis tas yuav ua ib tug tsis ntxim rau cov tsim thiab lwm yam qualities ntawm cov pob txha cov ntaub so ntswg. Tej yam uas bisphosphonates rau cov pob txha yog raws li nyob rau hauv ib tug siab zoo sib thooj mus mineralized pob txha, tab sis leej mechanism ntawm molecules uas muab inhibiting cov kev ua ntawm osteoclasts, rau hnub no tseem tsis tau kawm txog. Tsis tas li ntawd nws muaj ib tug ncaj qha anti-mob zog, kom ntseeg tau efficiency nyob rau hauv cov pob txha metastasis.

Nyob rau hauv vitro pom tias zoledronic acid, induces kev puas ntsoog thiab inhibiting loj hlob ntawm lub hlwb muaj ib tug antitumor nyhuv ncaj qha rau ntawm myeloma, raws li zoo raws li nyob rau kev mob hlwb ntawm lub mis, thaum uas txo txoj kev pheej hmoo ntawm metastasis. Tsis tas li ntawd, zoledronic acid muaj ib tug ntawm koj kom txhob muaj lub calcium concentration nyob rau hauv cov ntshiab hypercalcemia, uas yog tshwm sim los ntawm ib tug nqaij hlav.

indications

• Osteolytic txhab nyob rau hauv ntau yam myeloma foci.
• Osteoblastic, osteolytic mixed pob txha metastasis ntawm loj hlav.
• Hypercalcemia, uas yog tshwm sim los ntawm malignancy.

Contraindications

• Cev xeeb tub thiab pub niam mis.
• Raum insufficiency.
• Cov me nyuam thiab cov tub ntxhais hluas (daim ntawv thov kev ruaj ntseg tsis tau tsim).
• Npau taws me ntsis rau bisphosphonates thiab zoledronic acid.
• Ceev faj: raum tsis ua hauj lwm, bronchial hawb pob, hepatic tsis ua hauj lwm.

phiv

Ntshav Puas Txaus, thrombocytopenia, mob taub hau, kiv taub hau, conjunctivitis, xeev siab, anorexia, ntuav, raws plab, mob pob txha, arthralgia, hypophosphatemia, hypocalcemia, kub taub hau, mob npaws syndrome, qaug zog, koj qhov hnyav nce. Nyob rau hauv cov kev kho mob ntawm cov neeg mob nrog zoledronic acid yog tej zaum cai txoj kev loj hlob ntawm osteonecrosis ntawm lub puab tsaig (feem ntau yog tom qab kev kho hniav phais pab).

dosing

Tso dej txia, thiab tsis pub dhau 15 feeb, tab sis tsis muaj tsawg dua. Metastases ntawm ntau yam myeloma pom zoo koob tshuaj 4 mg ib zaug ib lub hlis. Thaum hypercalcemia, uas yog tshwm sim los ntawm ib tug kab mob qog hlav, txhaj ib koob tshuaj 4 mg ib hnub ib zaug.

ceev faj

Thaum cov tshuaj muab, nws yog tsim nyog los tswj cov concentration ntawm magnesium, phosphorus, creatinine thiab calcium nyob rau hauv cov ntshav ntshiab. Yog hais tias ua tau, nws yog pom zoo kom tsis txhob kho hniav phais.

Zoledronic acid. analogs

Tshuaj "Actonel", "Aneldronat", "Areda lyophilisate", "Bonviva", "Bondronat", "Bonefos", "Klobir", "ksidifon", "Lindron", "Ostalon", "Ostealen", "Osterepar" "Pamidronate", "Pomegara", "Rizendros", "Strongos", "Tevanat", "Foroza" "Fosamax", "Fosfoteh", "Rizarteva".

Zoledronic acid. nqi

Feem ntau, cov chaw muab kev koom tes nyob rau hauv lub tsev ntawm cov tshuaj nyob rau hauv lub txoj cai, qhia tus nqi rau lawv cov khoom. Tab sis, oddly txaus, tus nqi ntawm zoledronic acid yog feem ntau qhia kwv yees li. Tab sis kwv nws tus nqi nce mus txog txog 14 txhiab rubles ib lam fwj. Muag rau hauv pharmacies los ntawm cov tshuaj xwb.

Qhov saum toj no cov lus qhia no yog npaj rau paub noj qab haus huv neeg ua hauj lwm. Qhov tsab xov xwm yog hais txog zoledronic acid yuav hloov tsis tau tsim nyog tswv yim ntawm ib tug kws kho mob, thiab yuav muab tsis tau ib tug guarantee ntawm ib tug zoo ntxim los ntawm kev siv ntawm cov tshuaj.