Uric acid: nws tus nqi nyob rau hauv lub cev

Ib qhov tseem ceeb hais yog purine bases uas yog ib feem ntawm tib neeg DNA thiab RNA (ribonucleic acid thiab deoxyribonucleic paub los ntawm lub tsev kawm ntawv) rau lub qub hauj lwm ntawm lub cev. Tam sim no peb yuav tsis mus rau hauv lub tsev kawm ntawv cov ntaub ntawv kawm thiab piav qhia txog txhua yam khoom uas - ib nplooj yog tsis txaus, peb yuav piav me me tias cov complex organic acids ua lub hloov lwm lub tsev ntawm lub caj code thiab muab kev koom tes nyob rau hauv protein synthesis.

Qhov no yog txaus kom to taub qhov tseem ceeb ntawm kev ua hauj lwm ntawm cov organic tebchaw - tsis muaj lub hav zoov ntawm purines yog tsis yooj yim sua xav txog tej yam lub neej ntawm cov haiv neeg raws li ib tug lom pejxeem. Lub decomposition thiab lub synthesis ntawm cov substrates - qhov biochemical kev tig cev uas tshwm sim nyob rau hauv lub cev ntawm txhua tus neeg nyob rau hauv lub ntiaj teb. Nyob rau hauv peb lub siab no tshwm sim tsis tseg purine metabolism, thiab cov khoom ntawm cov dab yog uric acid. Cov cai ntawm lub acid yog hom twg los ntawm 0.35 hli.

Qhov no tshuaj yog thawj sab nyob rau hauv lub lom kua, yog li ntawd nws tau txais nws lub npe. Tom qab lub raum uric acid tas los rau ntawm lub cev, relieving nws dhau heev lawm nitrogen uas yog muaj nyob rau hauv ntau cov kabmob: lub plawv, lub siab, thiab lub hlwb. Nyob rau hauv ntshav no acid yog daim nyob rau hauv daim ntawv ntawm sodium urate, nws nyob ntawm lub concentration theem ntawm cov microcell. Thaum tus nqi ntawm cov sodium urate nyob rau hauv cov ntshav uric acid ntxiv ntsig txog. Cov cai ntawm nws txheem, raws li qhov no yuav tsum tsis txhob ntau tshaj 0.35 mmol (ib liter ntawm cov ntshav).

Yog hais tias qhov no parameter yog nce, muaj yog deposition ntawm crystallized urate nyob rau hauv cov ntaub so ntswg ntawm lub cev. Nyob rau hauv qhov tseeb lub theem ntawm no acid concentration nyob rau hauv cov ntshav tsis deb ntawm nws cov crystallization chaw pib, yog li nce nws slightest tshwm sim ntxias cov khoom precipitate - nws tom qab tso rau hauv peb lub cev.

Muaj ntau ntau txawv yam uas ua rau muaj zog cov ntsiab lus ntawm urate, nws yuav ua tau ib tug noj cov zaub mov nplua nuj nyob rau hauv cov organic bases, ntshav, mob raum, lub plawv thiab mob cancer thiab tsis haum dab, thiab txawm ib tug muaj zog thaum sawv ntxov kev mob kev nkeeg thaum lub sij hawm cev xeeb tub. Feem ntau cov feem ntau lub ntsiab ua rau urate deposition ntawm uric acid tseem yog cov kev tsim txom ntawm dej cawv haus. Muaju peev xwm yuav tsim nyob rau hauv tag nrho cov hauv nruab nrog cev, tab sis feem ntau lawv yog tso nyob rau hauv cov pob qij txha. Lawv tsim feem ntau tau nyob rau hauv xws kab mob raws li gout.

Thaum diagnosing ib tug neeg muaj gout nyob rau hauv thawj qhov chaw yog teem qhov tseeb ua kom tus kab mob. Qhov no yuav tsis tau tsuas yog tso cai rau kom tsim nyog kev kho mob, tab sis kuj yuav nrhiav tau tawm lub xub ntiag ntawm lwm yam kab mob, uas tej zaum yuav pab raws li ib tug txhais rau qhov tshwm sim ntawm gout. Nyob rau hauv thawj gout tej yam tshwm sim qhia tias cov nram qab no: qhov kev nce rau ntawm uric acid synthesis los yog feem nws txog.

Secondary gout thiaj paub tias yog los ntawm muaj lwm mob - tus nqi ntawm uric acid nyob rau hauv cov ntshav ntawm tag nrho cov hom ntawm tus kab mob yuav nce. Kho, nws yog thawj tsim nyog xwb tsis cov pob qij txha, raws li zoo raws li lub homphiaj ntawm o - gout tom qab zoo txoj kev kho yuav ploj nyob rau hauv lawv tus kheej. Tab sis nyob rau hauv tas li ntawd mus gout yuav tshwm sim urolithiasis, uas tshwm sim nyob rau hauv lub rooj plaub thaum lub cev uric acid concentrates. Norma urate ntshav sharply tsub kom thiab ua rau tus kab mob no.

Nyob rau tib lub sij hawm nyob rau hauv lub zais zis los yog raum zoo li tus khoom los nag, feem ntau ua rau mob txeeb tuav tseg. Cov concretions tej zaum yuav ib tug ua ntawm inflammatory teeb meem thiab tej zaum yuav txawm puas nto ntawm hauv nruab nrog cev nyob rau hauv uas lawv muaj nyob rau. Lub diagnostic tus nqi yog tseem tsis uric acid. nws tus nqi yuav tsum tsis txhob yuav hauv qab no 0.15 hli.

Qhov tsawg concentration ntawm uric acid yuav qhia lub xub ntiag ntawm mas yuav kis tau los yog pub cov kab mob. Thaum kuaj nyob rau hauv cov ntshav uas tsis yog raws kev cai nqi ntawm uric acid yuav tsum, ua ntej ntawm tag nrho cov, mus saib xyuas kev noj haus, tsis suav kas fes, dej cawv, chocolate, thiab kom muaj xws li nyob rau hauv cov zaub mov ntawm tshiab zaub (spinach, radishes, asparagus).