Tshuaj "cefotaxime": cov lus qhia rau kev siv, indications, nqe. Xyuas ntawm kev npaj

Nws yog tsis muaj daim card uas semisynthetic tshuaj tua kab mob muaj ib tug broad spectrum ntawm kev txiav txim. Tej formulations yog siv los kho ntau yam inflammatory thiab kis kab mob. Txawm li cas los, ua ntej koj muab ib tug yeeb tshuaj, tus kws kho mob yuav tsum qhia rau tus neeg mob rau undergo ib tug kev xeem. Tib txoj kev kom paub tseeb uas cov tshuaj tua kab yuav tsum zoo mus rau manifest nws tus kheej nyob rau hauv cov kev kho mob ntawm ib tug kab mob.

tshuaj "cefotaxime" nquag siv rau cov kev kho mob ntawm urogenital system, raws li zoo raws li lub ua pa ib ntsuj av. Nta ntawm cov khoom no, nws contra-indications, ntau npaum thiab lawv cov koom haum saib xyuas peb saib ib tug me ntsis ntxiv.

Muaj pes tsawg leeg, hauj lwm, daim ntawv thiab ntim ntawm tshuaj

Yuav ua li cas cov khoom xyaw muaj ib tug yeeb tshuaj "cefotaxime"? Tshuaj (cov me nyuam ntau npaum ntawm no neeg sawv cev yog teem ib lub zuj zus) muaj xws li xws li ib active tshuaj, xws li cefotaxime (sodium ntsev).

Kev npaj nws tus kheej yog ib tug dawb los yog yellowish hmoov, uas yog siv rau qhov kev npaj ntawm ib qho kev daws npaj tso dej raws leeg los yog intramuscular txhaj tshuaj.

Cov tshuaj no muaj nyob rau hauv lub khob vials, fej nyob rau hauv cartons.

pharmacological

Koj puas paub hais tias yog ib tug yeeb tshuaj "cefotaxime"? Cov lus qhia rau kev siv (tshuaj rau cov me nyuam - lub xeem yog tsis yooj yim, tab sis yog dab tsi yog hais tias xws yuav tsum tau mus siav) hais tias cov tub ntxhais cov neeg mob tshuaj no yog tshuaj nrog huab ceev faj, vim hais tias nws yog ib tug semi-hluavtaws tshuaj tua kab mob. Nws active tshuaj belongs rau lub thib peb tiam cephalosporins.

Tshuaj siv parenterally. Nws yog active tiv thaiv kab-zoo thiab gram-tsis zoo kab mob uas muaj ib tug siab kam mus rau lub aminoglycosides, sulfonamides thiab penicillin.

Lub hauv paus ntsiab lus ntawm lub antimicrobial kev txiav txim ntawm cov tshuaj no yog raws li nyob rau hauv nws muaj peev xwm inhibit qhov kev ua si ntawm transpeptidase. Qhov no tshwm sim vim thaiv cov hlab peptidoglycan.

Kinetics ntawm yeeb tshuaj

Yuav ua li cas absorbed "cefotaxime"? Abstract (tshuaj - nws yog ib lub xwb daim ntawv ntawm hais tias yeeb tshuaj) qhia tau hais tias, tom qab intramuscular thawj coj lub siab tshaj plaws concentration ntawm cov tshuaj nyob rau hauv cov ntshav cai tom qab 35 feeb. Kwv yees li 27-40% ntawm active ingredient yog bound rau ntshav proteins.

Bactericidal nyhuv ntawm cov tshuaj kav rau 12 xuab moos. Cov tshuaj no yog muaj nyob rau hauv lub tsib lub zais zis, myocardium, cov pob txha thiab cov nqaij mos.

Peb tsis tau hais tias lub active tivthaiv ntawm cov tshuaj no muaj peev xwm yuav hla lub tsho me nyuam thiab yuav tsum tau txiav txim nyob rau hauv lub pleural, peritoneal, synovial, hlwb txha nqaj qaum thiab pericardial kua.

Cov zis tso zis rau txog 90% ntawm cov tshuaj.

Intramuscular thawj coj ntawm cov tshuaj ib nrab-lub neej yog 60-90 feeb, thaum tso dej tshuaj - 1 hr. Part ntawm lub active ingredient yog tas ua ke nrog bile. Cumulation ntawm cov tshuaj yog cai.

indications

Uas cov kab mob yuav tsum siv cov tshuaj tua kab mob "cefotaxime"? Cov lus qhia rau kev siv (tshuaj, cov nqi ntawm uas muaj npe teev hauv qab no yuav tsum tsuas yog siv tus kws kho mob) nyeem hais tias cov medicament yog qhia rau lub xub ntiag ntawm kis kab mob.

Nws yog heev feem ntau siv nyob rau hauv cov nram no pathologies ntawm lub pa system:

• mob ntsws muaj dej;
• pleurisy;
• paug;
• ntsws.

Nws kuj xam tau tias yog ib tug txhais tau tias zoo nyob rau hauv:

• kab mob meningitis;
• endocarditis;
• postoperative teeb meem;
• Septicemia;
• nqaij mos thiab pob txha;
• Lyme kab mob;
• cov kab mob ntawm lub mob txeeb zig, caj pas, pob ntseg, qhov ntswg, mob raum;
• kab mob ntawm cov pob qij txha thiab cov pob txha;
• mob plab kab mob;
• kab mob tshwm sim tiv thaiv lub keeb kwm ntawm immunodeficiency.

Peb kuj yuav tsum nco ntsoov tias cov kev txhaj tshuaj "cefotaxime" feem ntau cov tshuaj los mus tiv thaiv kab mob uas tsim tom qab phais (xws li urology, Obstetrics thiab Gynecology, hnyuv kabmob, thiab hais txog. D.).

Contraindications rau kev siv ntawm cov tshuaj

Rau cov lus qhia yuav ua li cas rau yaj txhaj tshuaj "Cefotaxime," peb yuav qhia rau hauv qab no. Nws yuav tsum tau muab sau tseg hais tias qhov no lub cuab tam tsis yog ib tug ntev heev daim ntawv teev cov contraindications. Raws li cov lus qhia, cov tshuaj no yog tshuaj rau:

• los ntshav;
• cev xeeb tub;
• ib tug neeg npau taws me ntsis rau lub active tivthaiv;
• enterocolitis (xws li keeb kwm).

Yog nws tau los ua kom paub ib tug tov ntawm tus me nyuam "cefotaxime"? Tshuaj cov me nyuam (cov tswv yim rau cov hauj lwm zoo ntawm cov hais tias cov tshuaj yuav tsum tau muab nthuav rau ntawm qhov kawg ntawm tsab xov xwm) yog tau tso cai kom ua li ntawd tsuas yog thaum ncav lub hnub nyoog ntawm tus neeg mob 2.5 xyoo (rau cov / m).

Nrog huab ceev faj tshuaj me nyuam mos liab thaum lub sij hawm pub niam mis (raws li cov tshuaj nyob rau hauv me me tas nyob rau hauv niam cov kua mis), raws li zoo raws li lub xub ntiag ntawm mob raum tus kab mob thiab ulcerative mob plab (xws li keeb kwm).

Nyob rau hauv lub pathology ntawm lub raum thiab hepatic systems, tus neeg mob yuav tsum tau yauv mus ua ib tug ntxiv kev xeem nyob rau hauv thiaj li yuav tau cov lus xaus hais txog tus uas tsis muaj contraindications rau kev kho mob nrog tshuaj tua kab mob.

Tshuaj "cefotaxime": cov lus qhia rau kev siv (tshuaj)

Yuav ua li cas mus cog hmoov txoj cai? Yuav kom teb tau lo lus nug no, peb tig mus rau lub uas xa tuaj nrog cov lus qhia. Nws qhia txog cov ncauj lus kom ntxaws txoj kev npaj tshuaj daws teeb meem.

Yog li, rau tso dej thawj coj (txhaj) 1 g ntawm hmoov npaj diluted 4 ml ntawm dej rau tshuaj (muaj menyuam tsis taus). Npaj cov tshuaj txhaj maj mam 4-7 feeb.

Tso dej raws leeg Txoj kev lis ntshav 1-2 g ntawm hmoov yog diluted 50 los yog 100 ml ntawm cov kuab. Raws li nws yog siv 0.9% sodium chloride los yog 5% glucose (dextrose). Lub caij ntawm xws thawj coj - 55-65 feeb.

Rau intramuscular thawj coj ntawm cov tshuaj hmoov twb yaj 1 g ntawm 4 ml kuab. Raws li nws yog siv nrog dej rau txhaj los yog ib tug 1% lidocaine tshuaj.

Yog li, yog qhov kev siv yeeb tshuaj muaj peev xwm yuav muab intravenously los yog dav hlau, raws li zoo raws li intramuscularly.

Tshuaj feem ntau tus kws kho rau cov neeg laus thiab cov me nyuam hluas dua 12 xyoo uas ntau tshaj 50 kg. Nyob rau hauv lub mob xav tau rau nws siv nyob rau hauv cov kev kho mob ntawm cov tub ntxhais me nyuam.

Cov tshuaj ntawm cov tshuaj

Tam sim no koj paub tias dab tsi yuav diluted tshuaj "cefotaxime". Tab sis li cas yog lawv ntau npaum? Nws nyob ntawm tus hais thiab tus heev ntawm tus kab mob no.

Rau kab mob ntawm lub urogenital huam, raws li zoo raws li nyob rau hauv uncomplicated kab mob kev npaj yog tsim los siv intravenously los yog intramuscularly nyob rau hauv 1 g txhua txhua 9-12 teev.

Thaum ntsis kab mob - 1-2 g txhua txhua 12 teev.

Nyob rau hauv uncomplicated mob gonorrhea medicament yog muab intramuscularly nyob rau hauv ib tug ntau npaum ntawm 1 g (ib zaug).

Rau hauv loj heev kab mob (e.g., meningitis) npaj siv intravenously ntawm 2 g txhua txhua 6-9 teev. Qhov siab tshaj plaws tshuaj ib hnub twg yog 12 g Duration ntawm kev kho mob teem ib lub zuj zus.

Rau kev tiv thaiv ntawm cov kab mob ua ntej phais neeg thaum lub sij hawm induction ntawm tshuaj loog yog xeem ib zaug "cefotaxime" nyob rau hauv ib koob tshuaj 1 g Yog hais tias yuav tsum tau, txhaj tshuaj dua tom qab 6-12 teev.

Thaum caesarean seem thaum lub sij hawm clamps overlay txoj hlab leeg npaj muab intravenously nyob rau hauv ib tug npaum li ntawm 1 ntxiv 6-12 teev ua ntxiv txhaj tshuaj ntawm lub tib lub koob tshuaj.

Cov lus qhia rau cov me nyuam

Yog hais tias tsim nyog tshuaj "Cefotaxime" me nyuam mos thiab cov me nyuam ntxov ntxov nyob rau hauv lub hnub nyoog ntawm ib lub lim tiam muab intravenously nyob rau hauv ib tug npaum li ntawm 50 mg rau ib kg ntawm lub cev hnyav txhua txhua 12 teev. Thaum muaj hnub nyoog ntawm 1-4 lub lim piam ntawm kev siv yeeb tshuaj yog muab nyob rau tib lub koob tshuaj, tiam sis txhua txhua 9 teev.

2.5 lub xyoo laus cov me nyuam mos uas tsawg tshaj li 50 kg medicament muab intramuscularly los yog intravenously nyob rau hauv ib tug npaum li ntawm 50-180 mg rau ib kg lub cev qhov ceeb thawj (4 los yog 6 administrations).

Rau hauv loj heev kab mob, xws li meningitis, txhua hnub ntau npaum ntawm cov tshuaj yog nce rau 100-200 mg ib kg. Thaum zoo li no txhaj yog nqa tawm intravenously los yog intramuscularly nyob rau hauv ib tug npaum li ntawm 4-6 lub sij hawm ib hnub. Qhov siab tshaj plaws tshuaj ib hnub twg yog 12 g

phiv

Tawm tsam tom qab ntawm "cefotaxime" tshuaj nyob rau hauv cov neeg mob tej zaum yuav tsim xws zos tshua, xws li:

• mob ntawm intramuscular txhaj;
• phlebitis, paced los ntawm tso dej Txoj kev lis ntshav.

Nws kuj muaj xws li cov nram qab no phiv los:

• cholestatic daj ntseg, pseudomembranous mob plab;
• kab mob siab, xeev siab, hypoprothrombinemia;
• nce ALT, AST, hemolytic anemia;
• raws plab syndrome, tsis platelet suav;
• ntuav, neutropenia.

Nyob rau hauv tsawg tus neeg mob, tsis haum cov lus teb (kom nyob rau hauv lub xov tooj ntawm eosinophils, angioedema thiab khaus), thiab interstitial nephritis thiab Candidiasis.

Thaum tsom kwm lwm yam tsis zoo los yuav tsum tau kev kho mob, thiab nws tus kheej cov tshuaj tshem tawm.

Nqe thiab analogues ntawm lub tshuaj tua kab mob

Tus nqi ntawm cov tshuaj nyob rau hauv kev saib xyuas nyob rau hauv lub network margins thiab muag khoom hauv cheeb tsam. Nyob rau nruab nrab, ampoules, vials (5 pcs 1 g) yuav yuav rau 160-170 rubles.

Yog hais tias qhov kev kawm active medicament yog tso cai los hloov cov tib xws li lub "Claforan", "Tsefabol" thiab "Tsefosin".

Txawm li cas los, nws yuav tsum tam sim ntawd yuav muab sau tseg tias kev siv ntawm cov tshuaj no yuav ua tau tsuas yog tom qab kev sib tham nrog tus kws kho mob.

Xyuas ntawm tshuaj tua kab mob cov neeg ua hauj

Nyob rau hauv xyuas cov neeg mob cov tshuaj no feem ntau yog tshuaj raws li ib tug antimicrobial neeg sawv cev. Feem ntau, qhov no yog ua nyob rau hauv tus neeg mob thaum lwm tshuaj tua kab mob tsis muab ib tug zoo kho nyhuv.

Consumer xyuas ntawm tshuaj "cefotaxime" yog ntau tshaj li positive. tus neeg mob cov ntawv qhia paub meej tias nws cov high antimicrobial miv nyuas siv zug. Txawm li cas los, koj yuav nrhiav tau xws li cov lus teb, uas tshaj tawm hais txog lub xub ntiag ntawm ib tug loj tus naj npawb ntawm cov nyom tshua cai tom qab kev kho mob (tsam plab, goiter, Colic, thiab lwm yam).