"Relpaks": cov lus qhia rau kev siv, xyuas. tshuaj analogues

Yastes yastaw, tab sis yog tsis yog lub neej txoj sia tib neeg kev txom nyem, tab sis nyob rau tib lub sij hawm ho thiaj li muaj lub neej zoo. Nyob rau hauv lub xyoo, cov kws kev lag luam yog ua hauj lwm rau tsim ib cov khoom uas yuav tsis tsuas tshem tawm cov mob cov tsos mob ntawm tus kab mob no, tab sis kuj yuav feem xyuam rau txoj kev uas ua rau lub migraine. Tom qab tag nrho, kom txhob muaj tus mob yuav muaj zog painkillers. Tab sis lwm yam kev mob ntawm migraine xws li xeev siab, teeb rhiab heev thiab intolerance rau suab, nws yuav tsis yooj yim tshem tawm. Cov tshuaj rau migraine "Relpaks" nyob rau hauv no hais txog, kws txawj hais ib tug ntawm qhov zoo tshaj. Yuav ua li cas yog cov tshuaj no? Yuav ua li cas yuav nws thiab dab tsi cov nws counterparts muaj? Tag nrho cov no koj yuav tau nyeem rau.

formulation hauj lwm

Lub ntsiab active tshuaj "Relpaks" npaj - nyob rau hauv daim ntawv ntawm cov eletriptan hydrobromide yog muaj nyob rau hauv cov ntsiav tshuaj ntawm 20 mg. Muaj kuj yog ib tug ntau npaum ntawm 40 mg. Koom Haum kheev siv nyob rau hauv kev lag luam kws lactose monohydrate, magnesium stearate, croscarmellose sodium thiab MCC. Cov tebchaw tsis muaj feem xyuam rau cov muaj peev xwm ntawm cov tshuaj mus rau lub plab zom mov, thiab tsis cuam tshuam rau lub cev raws li ib tug tag nrho. Ntsiav tshuaj ntawm migraine "Relpaks" coated membrane plhaub txiv kab ntxwv, uas muaj titanium dioxide, colorants, lactose monohydrate, hypromellose thiab triacetin.

Txhua ntsiav tshuaj yog tsim nyob rau hauv ib puag ncig biconvex zoo. Nyob rau ib sab nws yog engraved «rep 20» los yog «rep 40 '(nyob ntawm seb tus nqi uas muaj nyob hauv cov ntsiav tshuaj ntawm active ingredient) thiab« Pfizer »- mus rau lwm lub. Nyob rau hauv ib hlwv fits 2, 3, 4, 6 los yog 10 ntsiav tshuaj, uas, nyob rau hauv lem, tau ntim rau hauv cov duab los qhia thawv 1, 2, 3, 4, 5, 6 los yog 10 daim.

Tshuaj thiab pharmacodynamics

Tshuaj "Relpaks" mus sai sai thiab zoo absorbed tom qab qhov ncauj cov thawj coj, tshwj xeeb yog nyob rau hauv ua ke nrog nrog fatty khoom noj khoom haus. Haum eletriptan feem 81%, thiab lub thiaj li hu ua bioavailability - 50%. Qhov siab tshaj plaws cov ntsiab lus ntawm cov active tshuaj nyob rau hauv cov ntshav ntshav yog twb yog ib thiab ib nrab teev tom qab noj cov tshuaj.

Lub ntsiab active tshuaj "Relpaks" npaj muaj ib tug zoo kev ua tau zoo rau kev twb kev txuas nrog ntshav cov nqaijrog (txog 85%). Primary eletriptan metabolism tshwm sim nyob rau hauv lub siab lub hlwb. Yog li tsim ob circulating metabolite, ib tug (tsim los ntawm N-oxidation) twb tsis muaj kev ua si. Qhov thib ob (tsim nyob rau hauv lub N-demethylation) muaj ntau heev rau tib lub zog li cov thawj cov ntaub ntawv uas, tab sis nws nyob rau hauv concentration ntshav tsuas yog 10-20% ntawm cov concentration ntawm eletriptan. Vim tus nquag metabolite twb tsis muaj appreciable kho nyhuv.

Ntsiav tshuaj migraine "Relpaks" cov lus teb ntawm cov kws txawj uas yog feem ntau zoo, zoo hais txog ntawm tus txiv neej pw ntawm tus neeg mob. Feem ntawm cov tshuaj metabolites yog ua li cas rau ib tug ntau dua raws li los ntawm ob lub raum (kwv yees li 90%), thiab los ntawm cov hnyuv.

Kev tshawb fawb tau paub tseeb hais tias cov tsis muaj cov nyhuv ntawm habituation mus rau lub ntsiab active khoom sib ua zaub mov ntawm cov tshuaj, yog li niaj hnub no muaj tsis muaj kev txwv nyob rau hauv lub caij ntawm txoj kev kho ntawm migraine mob los ntawm kev siv cov tshuaj "Relpaks".

Kuj pharmacodynamic tshuaj "Relpaks" Neeg daim ntawv thov hais qhov tseeb hais tias nws cov ntsiab active tshuaj teej tug mus rau cov pab pawg neeg ntawm cov xim serotonin vascular thiab neuronal receptors, niamntiav los nyob rau lwm lub hom ntawm lawv. Yog li selectivity yog manifested mus rau ib tug ntau dua raws li tus txheeb ze mus rau lub receptors nyob rau hauv lub carotid cov hlab ntsha. Protivomengrinoznuyu ua si eletriptan txiav txim tsis tau tsuas yog nws muaj peev xwm narrowing ntawm cov hlab ntsha nyob rau hauv lub cranium, tab sis kuj yog ib tug zoo ntxim rau cov xwm ntawm neurogenic o. Nyob rau hauv cov ntaub ntawv no, lub active tshuaj muaj suab tsis ntxim rau cov receptors ntawm lub femoral thiab coronary hlab ntsha.

zaj lus tim khawv

Tshuaj "Relpaks" cov lus qhia rau kev siv yog pom zoo nyob rau hauv lub ob hom migraine:

1. Nrog lub aura thaum ntxiv rau lub loj heev mob cov tsos mob xws li qhov muag pom, tactile, lub cev muaj zog, olfactory thiab hnov mob.
2. Tsis muaj aura, thaum nyob rau hauv tas li ntawd mus rau lub taub hau neeg mob kev txhawj xeeb xeev siab, ntuav, rhiab heev rau lub teeb thiab suab.

Yog hais tias muaj lwm yam ntaub ntawv ntawm tus kab mob ntawm kev siv ntawm cov tshuaj tsis tau tsuas yog muaj ib tug zoo ua hauj lwm, tiam sis tej zaum kuj ua rau ob peb teeb meem. Yog li ntawd, ua ntej koj siv yam tshuaj no los mus tshem tawm cov mob taub hau, migraine, koj yuav tsum sab laj nrog ib tug kws thiab mus ua ncauj lus kom ntxaws xeem. Qhov no yuav pab tsis tau tsuas yog rau muab txaus kho mob, tab sis kuj yuav tshem tawm tam sim ntawd uas muaj feem yuav mus rau lub noj qab haus huv ntawm tus neeg mob.

Contraindications

Xav txog daim ntawv teev cov contraindications rau kev siv "Relpaks" tshuaj. Ntsiav tshuaj, raws li hais saum toj no, muaj eletriptan uas muaj peev xwm ntawm muaj quag los rau tus kab mob thiab influences ntau dab. Nyob rau hauv tej rooj plaub, siv cov khoom tsis tsim nyog los yog undesirable:

• nyob rau hauv lub xub ntiag ntawm ib kom rhiab heev ntawm tus neeg mob rau tag nrho cov tshuaj txoj kev ib feem ntawm cov tshuaj;
• nyob rau hauv mob ntawm daim siab thiab ob lub raum, raws li metabolism thiab feem ntawm lub ntsiab active khoom sib ua zaub mov no tshwm sim nyob rau hauv lawv;
• nrog uncontrolled tawg;
• nrog latent los yog tshiab khiv ported cov kab mob ntawm lub plawv, nrog rau lub plawv nres, angina, coronary artery kab mob;
• nyob rau hauv lub muaj inklyuzionnyh peripheral vascular kab mob;
• thaum kis los yog twb muaj lawm thaum lub caij ntawm nraum ischemic nres, raws li zoo raws li tej kev yuam cai ntawm cerebral ncig.

Tshuaj "Relpaks" categorically tsis pom zoo rau cov neeg uas nws muaj hnub nyoog yog tsawg tshaj li 18 xyoo. Tsis tas li ntawd, cov tshuaj yuav siv tsis tau rau nyem ntawm qhov mob txuam nrog mob taub hau xws migraine hom raws li basilar, ophthalmic thiab hemiplegic.

Siv lub sij hawm uas cev xeeb tub thiab lactation

Kev siv lub tshuaj "Relpaks" thaum lub sij hawm cev xeeb tub tau insufficiently kawm. Txawm li cas los, kuaj kev tshawb fawb nyob rau hauv cov tsiaj qhia cov nyhuv ntawm eletriptan txog cov me nyuam hauv plab. Firstly, ib tug me me muaj pes tsawg tus ntawm mutated noob (raws li lub hauv paus ntsiab lus ntawm polyploidy) twb ntes tau nyob rau hauv lub embryo. Ob txhais, ib tug tag nrho-lub sij hawm yug me nyuam yuag twb ho qis tshaj nyob rau hauv cov tsiaj uas tsis tau txais thaum lub sij hawm hnub eletriptan. Yog vim li cas cov kws txawj nyob rau hauv nws lub sij hawm ua txoj cai, uas yog hais tias cov kev tsim pab rau cov niam ntau tshaj zaum yav tom ntej txaus ntshai rau lub fetus. Nws yuav tsum tau muab sau tseg hais tias eletriptan, ib feem ntawm cov tshuaj nyob rau hauv tib neeg cov mis nyuj, txawm tom qab hnub tom qab txais tos. Yog li ntawd, cov kev siv ntawm cov tshuaj los ntawm niam no tsuas tau nyob rau hauv cov ntaub ntawv ntawm tsis ua hauj lwm pub niam mis rau tsawg kawg ib hnub twg.

Sab los txuam nrog yeeb tshuaj siv "Relpaks"

Portability "Relpaks" tshuaj xyuas tshwj xeeb muab cov lus qhia txog tsis muaj zog heev ntawm sab teebmeem, uas nyob ib leeg yog nyob rau hauv ib tug raug luv luv lub sij hawm ntawm lub sij hawm. Nws tsis yog dab tsi koob (20 mg los yog 40) tau txais los ntawm tus neeg mob. Feem ntau cov tsos mob tej thaum peb noj lub tshuaj yog:

• o ntawm lub qhov ntswg kab noj hniav thiab lub caj pas (pharyngitis, thiab txhaws ntswg);
• piav thoob hlo teeb xws li tingling, "gus ua pob";
• nkees nkees;
• kiv taub hau los yog mob taub hau;
• myasthenia Heavy kev los yog hypoesthesia;
• hypertonicity ntawm cov nqaij fibers;
• mob los yog xav tias kaw ntom nti ua nyob rau hauv lub rov qab thiab lub hauv siab;
• mob arrhythmias, nyob rau hauv particular tachycardia;
• dyspeptic mob xws li mob los yog tsis xis nyob nyob rau hauv lub plab mog, qhov ncauj qhuav , thiab xeev siab;
• nce nyob rau tawm hws;
• kub flushes los yog ua daus no mus fim.

Noj rau hauv tus account lub tshuaj nyob tus yeees ntawm "Relpaks", kws txawj tsis cais txoj kev loj hlob ntawm kev tsis haum tshuaj rau Cheebtsam ntawm yeeb tshuaj, uas tej zaum yuav qhia nyob rau hauv cov tsos ntawm cov pob khaus, khaus khaus los yog liab. Nyob rau hauv tas li ntawd, nyob rau hauv uas tsis tshua muaj mob, cov neeg mob tej zaum yuav muaj kev txhawj xeeb txog xws phenomena li:

• anorexia;
• lymphadenopathy;
• tsis meej pem, zoo siab los yog kev nyuaj siab, insomnia thiab kev xav lability;
• photophobia, mob nyob rau hauv lub ceev ceev, conjunctivitis, txo los yog nce lacrimation;
• saj kawg;
• ringing nyob rau hauv lub pob ntseg, los yog hnov mob;
• ntshav siab;
• muaj mob hawb pob;
• hloov nyob rau hauv lub suab hais lus;
• o nyob rau hauv lub qhov ncauj kab noj hniav;
• cem quav los yog raws plab;
• mob caj dab los yog arthrosis;
• myalgia los yog myopathy;
• polyuria ntau zaus los tso zis;
• menstrual mob;
• ischemic mob plab.

Noj rau hauv tus account lub saum toj no-hais phiv, cov kev siv ntawm ib tug txhais tau tias ntawm migraine "Relpaks" yog pom zoo kom nqa tawm nyob rau hauv saib xyuas ntawm cov kws txawj, thiab tsuas yog tom qab lub tsim nyog kev tshawb fawb rau cov uas twb muaj cov kab mob yuav tsum nqa tawm, uas muaj peev xwm nyom kho mob.

sis

Xav txog cov kev sis raug zoo nrog ib co tshuaj antimigraine agents "Relpaks". Tshuaj qhia uas muaj nws kim heev cov lus qhia txog nws cov compatibility nrog lwm yam tshuaj yuav tsum tsis txhob noj ua ke nrog rau cov tsim nyog noj tshuaj nram qab no pab pawg:

• isozyme inhibitors, uas muaj xws li "erythromycin", "ketoconazole" "clarithromycin" thiab "Itraconazole";
• protease inhibitors, xws li "nelfinavir" thiab "Indinavir".

Kws txawj tseem nco ntsoov qhov tseeb hais tias lub simultaneous txais tos "Relpaks" tshuaj tshuaj "Propanolol" thiab "Verapamil" tsuas ntxias ib tug tseem ceeb nce nyob rau hauv cov ntshav siab, tab sis kuj txhim khu cov kev pheej hmoo ntawm lwm cov kev phiv. Nce cov ntshav siab kuj yuav muaj tau leej twg nyob rau hauv cov ntaub ntawv ntawm kev sib koom siv cov tshuaj nrog caffeine tshuaj. Yog vim li cas cov kws txawj pom zoo kom hais tias ib tug txhua txhua hnub luv ntawm receptions ntawm xws cov tshuaj raws li "Relpaks" (analogues kuj poob nyob rau hauv lub ntsiab txhais no) thiab ergotaminopodobnyh tshuaj.

Clinically, nws yog muaj pov thawj hais tias cov txhais tau tias ntawm migraine nyob rau hauv lo lus nug nyob rau hauv no tsab xov xwm tsis hnov mob nrog tshuaj muaj feem xyuam rau beta-blockers, estrogensoderjath hormone hloov los yog qhov ncauj contraceptives, tab sis kuj mus rau lub tricyclic antidepressants.

overdose

Yog hais tias koj ntau tshaj qhov pom zoo tus kws kho mob tus nqi ntawm cov tshuaj "Relpaks" phau ntawv qhia ceeb toom ntawm overdose, uas tej zaum yuav ua rau pheej nce nyob rau hauv cov ntshav siab thiab lwm yam mob ntawm cov hlab plawv system. Thaum lawv tshwm sim thiab symptomatic kev kho mob yog pom zoo yog tias tsim nyog pais plab lavage.

dosing

Tshuaj "Relpaks" kws txawj pom zoo kom noj thaum pib ntawm migraine tawm tsam. Yog hais tias tus mob taub hau thiab lwm yam ailments conjugate nws thab tus neeg mob rau ob peb teev, raws li cov tshuaj khaws nws cov hauj lwm zoo. Nws yuav tsum tau muab sau tseg uas txais tos ntawm cov tshuaj raws li ib tug tiv thaiv kev neeg sawv cev rau migraine yog inexpedient, txij li thaum nws yog muaj pov thawj hais tias nyob rau hauv cov ntaub ntawv no nws tsis muaj cov yam nyhuv. Nyob rau tib lub sij hawm thaum nce lub aura (cov neeg mob, ntev-lub sij hawm migraine sufferers yuav paub tus mob no) noj cov tshuaj tsis tau tsuas yog thiaj li muaj cov mob uas raws li cov aura, tab sis kuj relieves cov tsos mob xws li xeev siab, nkees nkees thiab photosensitivity. Qhov no tshwm sim tsis tau ib zaug, tab sis tsuas yog tom qab qhov pib ntawm mob taub hau. Yog li ntawd, migraine sufferers yuav tsum tsis txhob Rush mus haus dej haus ib ntsiav tshuaj txhua lub sij hawm ib tug ailments.

Tus koob tshuaj rau cov neeg mob 18-65 xyoo ntawm lub hnub nyoog yog 40 mg. Tom qab lub nyem ntawm migraine mob yuav resumed. Nyob rau hauv cov ntaub ntawv no, phau ntawv no xav noj cov tshuaj dua nyob rau tib lub npaum, tab sis tsis ntxov tshaj li 2 teev tom qab thawj zaug kev txais tos. Nyob rau hauv cov ntaub ntawv ntawm tsis ua hauj lwm ntawm cov tshuaj thaum mob taub hau unabated thaum lub sij hawm 2 teev tom qab cov tshuaj cov thawj coj, rov-kev tsis pom zoo koob. Qhov tshwj xeeb taw tes kom paub tias tom ntej no nres ntawm migraine nyob rau hauv tib neeg mob yuav tsum docked thawj zaug koob tshuaj "Relpaks" tshuaj. Consumer xyuas rau lub sij hawm no kuj muaj xws li cov ntaub ntawv.

Qhov siab tshaj plaws koob tshuaj medicament tau txais tsis pub dhau ib hnub yuav tsum tsis pub tshaj 160 mg. Haus cov ntsiav tshuaj yuav tsum tau tag nrho, tsis muaj kev zom khoom, haus kom ntau.

ceev faj

Txoj kev siv "Relpaks 'kev npaj yog tau tsuas yog tom qab lub qhia txog cov mob ntawm" migraine ". Qhov no yog vim lub fact tias thaum atypical mob taub hau, uas kuj yuav tshwm sim los ntawm tus mob stroke, aneurysm rupture thiab lwm yam kab mob, nws lub sij hawm yuav ua rau muaj mob ntau yam teeb meem. Tsis tas li ntawd, nws yog ib undesirable siv cov tshuaj no rau tshem tawm mob heev nyob rau hauv migraine amid kab mob plawv thiab mob ntawm lub raum thiab lub siab, raws li qhov no yuav ua rau ntshav siab rau ib tug tseem ceeb npaum li. Tib yam siv rau cov neeg mob nyob rau hauv uas kev pheej hmoo ntawm kev tsim kab mob yog high school. Uas yog vim li cas ua ntej muab tshuaj cov tshuaj "Relpaks" tus neeg mob yuav tsum yauv mus ua ib tug tag nrho cov kev xeem. Cov neeg mob thaum lub sij hawm siv tshaj 65 xyoo ntawm cov tshuaj yuav tsum tau nyob rau hauv lub saib xyuas ntawm cov kws txawj, vim nws yog lawv feem ntau nquag cai nce nyob rau hauv cov ntshav siab.

Ceeb toom! Hais txog cov kev txais tos ntawm cov tshuaj "Relpaks" phau ntawv qhia no muaj cov neeg ua tim khawv rau tej kev tshwm sim raws li kiv taub hau thiab nkees nkees, thiaj li koj yuav tsum tau tshwj xeeb tshaj yog ceev faj thaum tsav tsheb thiab cov tsheb thiab nyob rau hauv kev tswj txoj technology.

Analogs "Relpaks" tshuaj nqi

Feem ntau ntawm cov tshuaj los ntawm kws tuam txhab uas muag nyob rau hauv lub sab hnub poob, muaj domestic counterparts. Peb yuav tham txog thiab tawm tsam Pfizer - tsim "Relpaks" tshuaj. Txawm li cas los, txij li thaum nws tau sau npe nyuam qhuav xwb, rau hnub tim muaj cov tsis muaj cov tshuaj uas yuav muaj tib lub zog li lub tshuaj "Relpaks". Analogs ntsiab active ingredient eletriptan kuj paub, los ntawm uas nws yuav xaus lus tias cov kev npaj tshwj xeeb. nws nqi nyob rau hauv Russia yog los ntawm 380 mus 1200 rubles. Txoj nqi nyob rau hauv lub xov tooj ntawm cov ntsiav tshuaj nyob rau hauv lub hnab thiab yog dab tsi lawv npaum li cas.

Los ntawm cov qauv ntawm cov feem nyob rau lub hlwb hlab ntsha nyob rau hauv cov ntsiav tshuaj "Relpaks" muaj ntau ntau counterparts, uas tsis tsuas yog tsis txawv npaum li cas los ntawm nws nyob rau hauv tus nqi, tab sis yog feem ntau npaum li cas kim kim. Piv txwv li, tus kho rau migraine "Zomig" yuav tsum tau muas ntawm ib tug nqi ntawm ib ncig ntawm 400 rubles rau peb tshuaj. Tshuaj "Imigran" thiab "Sumatriptan" kuj zoo ib yam li "Relpaksom" muaj cov nyhuv ntawm thiab tus nqi. Lub tsuas tshuaj, uas raug nqi npaum li cas tsawg tshaj "Relpaks" ntsiav tshuaj - ib tug "Kofetamin". Lawv cov nqi tsis pub tshaj 75 rubles ib pob.

Xyuas ntawm kev npaj

Yog li ntawd, nyob rau lub tseem ceeb tshaj plaws lo lus nug. Dab tsi ua lawv xav hais tias txog lub lam khoom "Relpaks" txais kev pab thiab lawv tus kws kho mob? Yuav ua li cas yog cov pros thiab cons tau cov tshuaj no? Tus thawj uas lawv hais txog 80% ntawm cov neeg - yog lub high efficiency cov ntsiav tshuaj "Relpaks" txawm loj migraine nres. Tswv yim los ntawm cov neeg mob, tom qab noj ib tug ntsiav tshuaj rau qhov mob mus deb tom qab 30-40 feeb. Hais txog 8% ntawm cov neeg surveyed qhia hais tias tom qab siv tus thawj koob tshuaj ntawm 40 mg tau nyob tsos mob xws li co ntawm cov ceg ntoo thiab tingling nyob rau hauv lub ntsej muag thiab ob txhais tes. Txawm li cas los, cov tsis kaj siab cov txheej xwm coj qhov chaw rau ob teev uas tsis muaj ntxiv kev txiav txim.

Tsawg dua 1% ntawm cov neeg mob uas tau muab ib tug yeeb tshuaj "Relpaks", tus thawj txais tos yog tsis muaj nyob rau tag nrho ntawm nws cov nyhuv. Ib feem peb ntawm lawv thaum rov-haum ntawm cov tshuaj tau muaj nws cov nyhuv, thiab lwm tus raug yuam kom nrhiav tau ib tug hloov.

Kws txawj nco ntsoov cov qhov zoo ntawm qhov kev npaj ntawm nws cov me ntsis ntxim rau cov hlab ntsha ntawm lub taub hau. Txawm li cas los, lawv nco ntsoov hais tias cov tsos ntawm txawm lub feem ntau me sab los tus neeg mob yuav tsum cia li pw tsaug zog. Qhov no yuav ua tau txaus rau tag nrho cov tsis kaj siab tshwm sim ntawm yav dhau los. Kws txawj tseem nco ntsoov cov nram no: nyob rau hauv sib piv rau zoo xws li cov tshuaj, uas yog tsis ib feem ntawm eletriptan tshuaj "Relpaks" ntau npaum li cas yooj yim zam lub txim rau migraine neeg.