Nalidixic acid: Daim ntawv thov nyob rau hauv cov tshuaj

Nws yog lub npe hu hais tias cov kab mob no yog cov feem ntau heev pathogens ntawm inflammatory kab mob thiab kab mob. Yuav kom tshem lub cev ntawm lawv, siv ntau tshuaj tua kab mob. Muaj ntau ntau pab pawg ntawm cov tshuaj, uas nws txiav txim yog hais tiv thaiv cov kab mob no. Ib tug xws li txhais tau tias yog nalidixic acid. Nws yog lub active ingredient ntawm ntau antibacterial tshuaj. Ib tug piv txwv - ib tug ntsiav tshuaj "nevigramon". Qhov no tshuaj yog quinolones, pharmacological pab pawg neeg - antiinfectives. Ua ntej koj yuav pib kho mob, koj yuav tsum xeem dhau kev ntsuam xyuas kom paub tias lub pathogen thiab ntsuam xyuas nws rhiab heev rau lub medicament.

Nalidixic acid - yog dab tsi?

Muaj tseeb txhua leej txhua tus yog me ntsis txog cov kev npaj uas muaj nalidixic acid. Qhov no cov ntaub ntawv uas yog twb siv rau xyoo nyob rau hauv cov tshuaj raws li ib tug anti-microbial thiab anti-cab nrog. Nalidixic acid, raws li sau tseg saum toj no, hais txog cov pab pawg neeg ntawm quinolones. Kev kho mob qhov chaw hais txog cov tshuaj uas muaj antibacterial tshuaj. Nalidixic acid yog ib tug hluavtaws tshuaj uas yog tsim nyob rau hauv cov kev kuaj. Nws yog ib lub teeb daj hmoov, uas muaj peev xwm tsis yaj nyob rau hauv dej. Lub ntsiab rau daim ntawv thov ntawm acid - ib tug tshuaj. Nws yog ib tug tswv cuab ntawm ib co tshuaj tua kab mob.

Action nalidixic acid

Nyob rau hauv thiaj li yuav paub nyob rau hauv dab tsi tej yam kev mob thov nalidixic acid, nws yog tsim nyog los kawm txog cov mechanism ntawm qhov kev txiav txim. Lub ntsiab los ntawm cov tshuaj - yog cov hluav ntawm txoj kev loj hlob ntawm cov kab mob thiab lawv cov kev puas tsuaj. Nws mechanism ntawm qhov kev txiav txim yog cai DNA synthesis los ntawm kab mob polymerization. nalidixic acid tshuaj ua xyua rau Gram (-) cov kab mob. Lawv yog cov zoo tiv thaiv kab mob ntawm lub genus Proteus, Escherichia coli. Yog li ntawd, suppressing inflammatory kab mob, uas yog tshwm sim los ntawm cov kab mob.

Qhov kev txiav txim ntawm cov tshuaj nyob rau hauv nws cov concentration nyob rau hauv lub cev. Nyob rau hauv me me koob tshuaj, nws muaj ib tug bacteriostatic nyhuv, piv txwv li, nws cheeb DNA replication. Loj ntau ntawm cov tshuaj muaj feem xyuam rau ntawm lub protein synthesis thiab RNA. Yog li ntawd, ntev-lub sij hawm siv los yog koom haum saib xyuas ntawm cov ntsiav tshuaj nyob rau hauv loj koob tshuaj ua rau bactericidal kev txiav txim. Nws yuav tsum tau nco ntsoov tias Gram (+) kab mob thiab anaerobes yog insensitive rau nalidixic acid. Yog li ntawd, ua ntej koj muab rau nws, koj yuav tsum tau ua bacteriological xeem kev lom khoom (zis, ntshav) thiab siv antibiotikogrammy.

Indications rau kev siv ntawm nalidixic acid

Muaj ib tug ntau yam ntawm inflammatory kab mob nyob rau hauv uas lub thov nalidixic acid. Cov lus qhia nyob rau hauv lub pob nrog cov khoom, rau ib tug neeg ntawm cov ntsiab lus nyob rau hauv uas nws twb raug xa mus rau lub active tshuaj ntawm kab mob. Cuaj kaum, nws yuav tsum tau dais nyob rau hauv lub siab hais tias cov kab mob no tsis yog ib tshwm sim los ntawm Gram (-) muaj. Yog li ntawd, thaum lub ineffectiveness ntawm yeeb tshuaj yuav tsum tau hloov nrog rau lwm cov tshuaj nyob rau hauv 3 hnub. Mob raum o - ib tug tseem ceeb spectrum ntawm cov kab mob nyob rau hauv uas muab nalidixic acid. Cov kev siv ntawm cov khoom uas muaj no yeeb tshuaj, nws yog ib qho tsis tau tsuas yog nyob rau hauv Nephrology, tab sis kuj nyob rau hauv lwm yam liaj teb ntawm cov tshuaj. Lub ntsiab indications - yog:

1. Cystitis. O ntawm lub zais zis yog feem ntau tshwm sim los ntawm Escherichia coli thiab Proteus, txawm li cas los prescribers quinolone muaj ib tug siab miv nyuas siv zug tiv thaiv cov kab mob.
2. Pyelonephritis. O ntawm lub raum tubules heev teb zoo rau kev kho mob nrog rau cov tshuaj nalidixic acid, tshwj xeeb tshaj yog nyob rau hauv lub mob theem.
3. Mob ntawm mob txeeb zig. Nyob rau hauv cov ntaub ntawv no, cov tshuaj yog tshuaj rau urological manipulations thiab ua hauj lwm.
4. Mob otitis media.
5. Cholecystitis.
6. Inflammatory loj thiab me me hnyuv kab mob (enterocolitis).
7. Urethritis thiab prostatitis.

Tsis tas li ntawd, nalidixic acid yuav muab nrog lwm yam kab mob tshwm sim los ntawm gram (-) microorganisms.

Yuav ua li cas cov tshuaj muaj nalidixic acid?

Muaj ntau ntau cov khoom uas muaj nalidixic acid. Lawv tag nrho cov muaj tib lub kev txiav txim thiab indications rau siv. Nyob rau hauv tej rooj plaub, sib txawv ntau npaum ntawm lub ntsiab active tshuaj. Txawv npe thiab tus nqi ntawm cov tshuaj nyob rau hauv lub teb chaws ntawm siv thiab ua thiab lub tuam txhab uas ua tau tej yam tshuaj. Lub nto moo tshaj plaws tus neeg sawv cev yog cov tshuaj "nevigramon". Qhov no tshuaj muaj ntau yam analogues. Cov cov tshuaj, "Negroes", "Nalid", "Tsistidin", "Vintomilon", "Urogram" thiab lwm tus neeg. Tag nrho cov tshuaj muaj ib tug zoo li cov nyhuv ntawm lub cev.

Nalidixic acid: cov lus qhia rau kev siv ntawm lub medicament

Npaj muaj nalidixic acid, yuav tsum tau noj nyob rau hauv ib tug ntau npaum ntawm 500 mg 3-4 lub sij hawm ib hnub twg. Nyob rau hauv Feem ntau, qhov no tus nqi ntawm active ingredient muaj nyob rau hauv ib ntsiav tshuaj los yog cov tshuaj ntsiav. Rau hauv loj heev inflammations yuav coj 1000 mg plaub zaug ib hnub twg. Nyob rau hauv cov me nyuam, cov tshuaj yuav tsum tau muab los xam (60 mg / kg lub cev hnyav).

Contraindications thiab kev phiv

Zoo li feem ntau antimicrobials, nalidixic acid yog ua rau cov poj niam nyob rau hauv thawj peb lub hlis uas cev xeeb tub thiab pub niam mis. Tsis tas li ntawd, cov tshuaj yuav siv tsis tau rau cov me nyuam mus txog 2 xyoos. Cov lwm contraindications cais hlaus thiab hepatic insufficiency.

Cov nyom zoo xws li hnyuv ua txhaum kev ua hauj lwm (flatulence, xeev siab, ntuav), kiv taub hau, thiab tsis haum. Ceev faj yuav tsum raug siv nalidixic acid neeg kev txom nyem los ntawm neurological pathologies (Parkinson tus kab mob, qaug dab peg, mob stroke).