"Glyurenorm": cov lus qhia rau kev siv, tiag tiag counterparts

Insulin nyob mob ntshav qab zib mellitus los yog mob ntshav qab zib ntawm lub thib ob hom yog hu ua ib tug kab mob metabolic. Nws yog yus muaj los ntawm mob hyperglycemia, uas muaj vim kev ntshawv siab nyob rau hauv insulin sis raug zoo nrog cov ntaub so ntswg hlwb.

Cov tsos mob ntawm tus kab mob no yog lub dryness thiab nqhis dej nyob rau hauv lub qhov ncauj, ntau tso zis, nqaij tsis muaj zog, cov tawv nqaij khaus, phem zazhivlyaemost txhab thiab rog. Rau cov kev kho mob ntawm hom 2 ntshav qab zib siv tshuaj "Glyurenorm". Cov lus qhia rau kev siv, analogs, lub zog thiab zoo ntawm hais tias cov tshuaj yog hais hauv qab no.

Muaj pes tsawg leeg ntawm yeeb tshuaj, nws cov hauj lwm, ntim, zoo

Nyob rau hauv dab tsi daim ntawv tsim cov tshuaj "Glyurenorm"? Cov lus qhia rau kev siv qhia tias lub tsev no yog muaj nyob rau hauv daim ntawv ntawm cov dawb ntsiav tshuaj thiab du hloov puab, nrog Valium thiab beveled npoo, thiab engraved "57C" thiab lub tuam txhab logo.

Lub ntsiab feem ntawm cov tshuaj no yog xam tias yog gliquidone. Tsis tas li ntawd nws muaj lub qhuav pob kws starch, lactose monohydrate, pob kws starch thiab cov soluble magnesium stearate (ntxiv tebchaw).

Nyob rau hauv lub qhov muag ntawm cov tshuaj "Glyurenorm" (ntsiav tshuaj) yog nkag nyob rau hauv sawv hlwv packs ntawm 10 daim, uas yog fej nyob rau hauv packs ntawm cardboard.

Cov tshuaj

Yuav ua li cas yog cov tshuaj "Glyurenorm"? Cov lus qhia rau kev siv ua dlejnum hais tias qhov no hypoglycemic neeg sawv cev, sulfonylurea (thib ob tiam). Nws yog npaj rau qhov ncauj thawj coj.

Xam tias yog ib tug yeeb tshuaj muaj vnepankreaticheskim thiab pancreatic los. Nws nkoos lub tso pa tawm ntawm insulin thiab potentiates glucose-kho hom haum xeeb pathway ntawm nws tsim.

Sim kawm rau laboratory tsiaj tau hais tias cov tshuaj "Glyurenorm" qhia uas yog muaj nyob rau hauv ib lub thawv uas ua los ntawm cov duab los qhia, muaj peev xwm ntawm kev txo insulin kuj nyob rau hauv adipose cov ntaub so ntswg thiab tus neeg mob lub siab. Qhov no tshwm sim los ntawm stimulation postreceptor mechanism uas yog kho hom haum xeeb los ntawm cov kua dej los, raws li zoo raws li ntau zog receptor thereto.

Hypoglycemic nyhuv tom qab dosing muaj tom qab 65-95 feeb. Nrog kev xav txog cov nyiaj pab ntau tshaj cov nyhuv ntawm yeeb tshuaj, nws tshwm sim tom qab txog 2-3 teev thiab kav rau txog 8-10 hom sij hawm.

kev tig tau zog

Pab "Glyurenorma" qhia hais tias kev siv ntawm ib koob tshuaj ntawm cov tshuaj (15-30 mg) muaj txhawb rau nws ceev ceev thiab ua kom tiav haum los ntawm tus mob huam (txog 80-95%). Ncov nws concentration tom qab nws nce mus txog ib tug 2 teev.

Active muaj ib tug medicament muaj ib tug high affinity rau ntshav proteins.

Tsis muaj ntaub ntawv nyob rau hauv qhov tshwm sim ntawm dua gliquidone los yog nws cov derivatives ntawm lub tsho me nyuam los yog cov ntshav-hlwb barrier muaj. Tsis tas li ntawd, muaj yog tsis muaj cov lus qhia txog lub allergic gliquidone nyob rau hauv leej niam cov kua mis.

Nyob qhov twg lub metabolism "Glyurenorm" tshuaj? Cov lus qhia rau kev siv hais tias ntshai neeg sawv cev yog metabolized nyob rau hauv lub siab los ntawm demethylation thiab hydroxylation.

Lub ntsiab yog ib feem gliquidone derivatives muab los ntawm cov hnyuv. Lub ib nrab-lub neej sij hawm ntawm cov tshuaj yog 1-2 xuab moos.

Nyob rau hauv cov neeg laus thiab nruab nrab-hnub nyoog cov neeg mob kinetic tsis "Glyurenorma" zoo sib xws.

Raws li cov kws txawj, qhov no txhais tau tias cov metabolism yog tsis tau hloov nyob rau hauv cov neeg mob uas hepatic insufficiency. Nws yuav tsum tau muab sau tseg tias cov neeg nrog impaired raum muaj nuj nqi tshuaj tsis accumulate.

zaj lus tim khawv

Nyob rau hauv dab tsi tej yam kev mob qhov zoo tshaj tshuaj behaves "Glyurenorm"? Cov lus qhia rau kev siv, xyuas hais tias cov hais rau nws siv yog mob ntshav qab zib ntshav qab zib ntawm lub thib ob yam nyob rau hauv cov neeg laus thiab nruab nrab-hnub nyoog (nrog rau cov ineffectiveness ntawm noj cov zaub mov).

Txwv tau txais tshuaj

Nyob rau hauv uas tus neeg mob yog txhob muab tshuaj "Glyurenorm"? Cov lus qhia rau kev siv qhia cov nram qab no contraindications ntawm cov tshuaj:

• sib quas ntus porphyria mob;
• ntshav qab zib mellitus thawj hom;
• hepatic tsis ua hauj lwm, mob;
• ntshav qab zib acidosis, precoma, ketoacidosis thiab coma;
• lub sij hawm tom qab resection ntawm pancreatic mob cancer;
• Tej tsawg raws roj ntsha xwm ntawm tus kab mob raws li galactosemia, lactose intolerance, tsis muaj lactase thiab glucose-galactose malabsorption;
• mob mob ntawm tus neeg mob (e.g., loj phais cov txheej txheem, mob kab mob);
• thaum lub sij hawm cev xeeb tub;
• me muaj hnub nyoog (vim tsis muaj cov ntaub ntawv nyob rau hauv kev ruaj ntseg thiab miv nyuas siv zug ntawm cov tshuaj nyob rau hauv lub hnub nyoog no pawg);
• kev pub niam mis;
• npau taws me ntsis rau sulfonamides.

Ceev faj npaj txais tos

Nrog ceev faj saib xyuas medicament kws kho rau:

• feverish syndrome;
• tsis muaj glucose-6-phosphate dehydrogenase;
• cov kab mob ntawm lub qog caj pas (nyob rau hauv ua txhaum ntawm nws functions);
• alcoholism.

Tshuaj "Glyurenorm": cov lus qhia rau kev siv

"Glyurenorm" tshuaj kho tsuas sab hauv. Thaum lawv txais tos nws yog tsim nyog los ua raws li nrog tag nrho cov tswv yim pom zoo ntawm tus kws kho mob txog cov tshuaj thiab cov tshuaj noj cov khoom noj. Nws yog txwv tsis pub kom txhob noj cov tshuaj tsis muaj thawj noj kev haus nrog ib tug tshwj xeeb.

Initial koob qhia txhais tau tias yog 0.5 ntsiav tshuaj (i.e., 15 mg) thaum lub sij hawm thawj noj tshais. Cov tshuaj yuav tsum tau noj thaum pib ntawm lub noj mov. Tom qab nws siv yog txwv tsis pub hla pluas noj.

Yog hais tias koj siv 1/2 ntsiav tshuaj tsis ua txoj kev txhim kho, tom qab kev sib tham nrog ib tug kws kho mob ua rau kom cov tshuaj maj. Thaum ib tug txhua txhua hnub koob tshuaj "Glyurenorma" tsis muaj ntau tshaj li 2 ntsiav tshuaj, nws yuav tsum noj ib zaug thaum lub sij hawm noj tshais.

Yog hais tias tus kws kho mob prescribes ib tug ntau dua ntau npaum ntawm cov tshuaj, ces rau qhov zoo tshaj plaws cov nyhuv lawv yuav tsum tau muab faib ua 2 los yog 3 koob tshuaj.

Ntau dua koob tshuaj mus txog rau 4 ntsiav tshuaj ib hnub twg yog feem ntau tsis ua rau kom lawv ua hauj lwm zoo. Yog li ntawd, noj cov tshuaj "Glyurenorm" ntau dua li tus nqi no yog tsis pom zoo.

Nyob rau hauv cov neeg uas muaj impaired raum muaj nuj nqi ntau npaum hloov yog yuav tsum tau.

Noj cov tshuaj ntau tshaj li 75 mg nyob rau hauv cov neeg mob uas impaired siab muaj nuj nqi yuav tsum xyuas los ntawm cov kws kho mob.

ua ke nrog "Glyurenormom" neeg mob tej zaum yuav ua ntxiv thiab muab "Metformin" Nrog tsis txaus kho nyhuv.

tus neeg mob ntawm overdose

Txais tos ntawm siab koob tshuaj sulfonylurea derivatives feem ntau ua rau hypoglycemia. Nyob rau hauv tas li ntawd, ib tug overdose ntawm no lub cuab tam yuav ua rau cov nram qab no cov tsos mob: tawm hws, tachycardia, txob taus, kev tshaib kev nqhis, mob taub hau, palpitations, co, insomnia, nyob tsis tswm, qhov muag plooj tsis pom kev thiab hais lus, tsis nco qab.

Yog hais tias tej yam tshwm sim ntawm hypoglycemia yuav tsum tau zib los yog zaub mov nplua nuj nyob rau hauv carbohydrates.

phiv

Tam sim no, koj paub, los ntawm dab tsi yog tshuaj xws li ib tug yeeb tshuaj raws li "Glyurenorm". Cov lus qhia rau kev siv ntawm cov tshuaj lawm kuj tau los sib tham saum toj no.

Raws li cov nqe lus ntawm cov neeg mob, thaum ib tug txais tos ntawm cov nyiaj yuav ua tau:

• thrombocytopenia, angina, agranulocytosis;
• paresthesia, hypoglycemia, kiv taub hau;
• leukopenia, mob taub hau, neeg ntaus, nkees nkees;
• kev pab cuam tshuam, kev qaug zog, hypotension;
• plawv tsis ua hauj lwm, qhov ncauj qhuav, Stevens-Johnson syndrome;
• tsis qab los noj mov, photosensitivity cov tshuaj tiv thaiv, xeev siab, tawm pob;
• ua xua, ntuav, mob hauv siab, cholestasis;
• cem quav, khaus, raws plab, tsis xis nyob rau hauv lub plab mog.

tshuaj cov kev sib tshuam

Thaum concomitantly nrog gliquidone "Allopurinol", ACE inhibitors, antifungals, analgesics, coumarin derivatives, narcotics yuav muab thiab lwm yam hypoglycemic nyhuv yuav amplified thawj.

"Rifampicin" barbiturates thiab "Phenytoin" qis hypoglycemic nyhuv "Glyurenorma".

tej tswv yim pom zoo

Hypoglycemic agents rau qhov ncauj thawj coj yuav tsum tsis txhob hloov kho mob noj.

Cov neeg uas muaj mob ntshav qab zib tag nrho cov kws kho mob pom zoo yuav tsum tau nruj me ntsis cai.

Yog hais tias tej yam tshwm sim ntawm hypoglycemia yuav tsum tam sim ntawd muab cov zaub mov uas muaj qab zib.

Lub cev ce yuav txhim khu lub hypoglycemic nyhuv ntawm cov tshuaj.

Muab hais tias lub raum feem gliquidone los ntawm me ntsis, saib medicament yuav xyuam xim siv nyob rau hauv cov neeg mob uas raum tsis ua haujlwm zoo thiab nephropathy ntawm ntshav qab zib.

Thaum lub sij hawm soj ntsuam cov kev tshawb fawb nws pom hais tias kev siv ntawm cov tshuaj nyob rau hauv kev saib xyuas yog tsis pab ua rau kom cov neeg mob lub cev qhov ceeb thawj rau 30 lub hlis. Ntxiv mus, tus neeg mob tau sau tseg txo lub cev hnyav los ntawm 1-2 kg.

Analogs thiab xyuas

Los ntawm analogues ntawm cov tshuaj "Glyurenorm" muaj xws li cov nram qab no txhais tau tias: "Gliklada", "Amiks", "Glianov", "Glayri", "Glibetik".

Xyuas ntawm lub tam sim no cov tshuaj ua tau raws li cov feem ntau sib txawv. Raws li rau cov kev tau txais kev pab, cov tshuaj no yog zoo heev thiab yoojyim rau txhua leej txhua tus. Txawm li cas los, nws yuav tsum tau muab sau tseg hais tias muaj ntau cov neeg mob heev kev txhawj xeeb txog daim ntawv teev cov kev phiv ntawm no neeg sawv cev. Txawm tias cov kws kho mob hais tias lawv tshwm sim heev tsis tshua muaj thiab tsuas yog nyob rau hauv tej yam tshwm sim.