Cov tshuaj "Sulpiride": xyuas, indications, analogs

Psychosis ntawm qhov ntau heev nrog tib neeg puas tau. Nyob ntau centuries nws twb ntseeg tau tias muaj los ntawm dab ntxwg nyoog nyob rau hauv ib tug neeg mob, thiab yog li ntawd "kho" qhov teeb meem no tau tsim nyog. Ua ntej mus rau lub creation ntawm neuroleptic tshuaj nyem ntawm hlwb kev ntshawv siab ua herbal kho mob tsim rau lub hauv paus ntawm belladonna, henbane, opiates. Xyaum raws li kev kho mob uas muaj calcium (tso dej) thiab immersing tus neeg mob nyob rau hauv ib tug pw tsaug zog tshuaj.

Cov thawj heev antipsychotic chlorpromazine yuav yog hu ua, uas yog muaj kev koom siv rau cov kev kho mob ntawm cov neeg mob nrog kev puas hlwb noj qab haus huv tej teeb meem txij thaum 1953. Tam sim no, daim ntawv teev cov antipsychotic tshuaj, antipsychotics ho txhab. Ib tug ntawm lug siv tshuaj ntawm no pab pawg neeg yog "Sulpiride". Testimonials piav nws raws li ib tug heev atypical antipsychotic.

pharmacodynamics ntawm cov tshuaj

Neuroleptic nyhuv "sulpiride" antidofaminergicheskim txuam nrog qhov kev txiav txim, m. E. Nyob rau hauv lub central tshee system tshuaj blocks mas dopaminergic receptors. Dopamine yog ib qho tseem ceeb feem ntawm cov "nqi zog system" ntawm lub paj hlwb - nkoos lub Library nov ntawm nqaij tawv, satisfying tshaj, nyob rau hauv lem, muaj feem xyuam rau txoj kev kawm thiab motivational dab. Nyob rau hauv high txaus koob, ua nyob rau hauv tus txheej txheem ntawm tej zoo kev (nyob rau subjective tswv yim ntawm ib tug neeg) - txais tos ntawm cov zaub mov qab, nrog txiv neej pw, tsis muaj qab ntxiag cev ncus. Nrog nce nqi ntawm dopamine nyob rau hauv lub central tshee system yog zoo puas siab puas ntsws kev nplij siab, nrog ib tug txo - tsim cov tsos mob ntawm kev nyuaj siab.

Action "sulpiride" nyob rau hauv ib koob tshuaj tshaj 600 mg (txhua hnub ntau npaum li cas ntawm cov tshuaj) yog ib qho antipsychotic xwm. Yog hais tias lub noj tshuaj npaum cas tsawg tshaj li 600 mg - ntau tus nais khu hom thiab antidepressant teebmeem. Txawm li cas los serotonicheskie, histamine, adrenergic receptors tshuaj muaj me ntsis cov nyhuv.

Cov tshuaj - analogues

Lub medicament "Sulpiride" - atypical neuroleptic, teej tug mus rau cov pab pawg neeg ntawm pawg benzamides - muaj ib tug txaus loj tus naj npawb ntawm cov tshuaj uas zoo sib xws nyob rau hauv muaj pes tsawg leeg thiab muaj ib cov nyhuv. Muaj cov tshuaj uas phim rau lub code ATC 4 theem. Cov no yog cov "Betamax", "tiaprid", "Eglonil". Sib nrug ntawm no, ib tug broad neeg thov "Prosulpin", "Eglek" "restful" "Vero Sulpiride", "Sulpiride Belupo." Xyuas ntawm tag nrho cov tshuaj los ntawm cov kev pab yuav muaj ob qho tag nrho zoo kev taw qhia thiab tsis zoo. Nws tag nrho cov nyob rau hauv lub heev ntawm tus neeg mob lub xeev kev kho mob, nws rhiab heev rau lub ntsiab active khoom sib ua zaub mov - sulpiride, thiab ntau npaum lub ntawm cov tshuaj muab yuav tau txais ib tus kws kho mob.

Indications yuav tau txais tshuaj

Sam neuroleptic "Sulpiride", nws analogs muaj ib tug ncaj sab kheej ntawm cawv thiab yuav tau muab txais ib tug txaus loj cov kab mob. Coj nws nyob rau hauv lub xub ntiag ntawm schizophrenia nyob rau hauv lub mob theem, thiab thaum twg nws yog mob. Sulpiridsoderzhaschih kev txaus cai siv ntawm antipsychotics thaum lub sij hawm mob theem ntawm kev loj hlob ntawm fem (puas siab puas ntsws tsis meej ntawm qhov, nrog los ntawm ib tug disturbance ntawm nco qab xws li los ntawm kiv taub hau thiab txawm coma). Heev feem ntau cov tshuaj yog tshuaj rau ntau yam neurotic mob thiab kev nyuaj siab, tsis hais ntawm lawv cov keeb kwm.

Thaum Kiv tauv hau ntawm txawv keeb kwm xav noj "Sulpiride" phau ntawv qhia. Xyuas ntawm cov neeg mob thiab kev kho mob cov neeg ua zoo yus medicament nyob rau hauv kev kho vestibular neuritis, thaum tsis ua hauj lwm vertebrobasilar-basilar yam uas otitis media thiab cranial traumas, nrog Meniere tus kab mob (nce volume ntawm dej nyob rau hauv lub inner pob ntseg kab noj hniav, uas txo nws hwj siab rau lub hlwb lub luag hauj lwm rau kev tswj equilibrium lub cev thiab nws cov orientation rau hauv qhov chaw).

Raws li ib tug "Sulpiride" ib feem ntawm ib tug kev kho yuav siv tau nyob rau hauv kho kev ua ub no rau peptic rwj kab mob thiab chim siab plob tsis so tswj syndrome.

Leej twg yuav tsum caiv txhob noj antipsychotic tshuaj rau lub hauv paus ntawm sulpiride?

Neuroleptics "Sulpiride" tshuaj analogues ntawm lub ntsiab active khoom sib ua zaub mov muaj ib tug meej daim ntawv teev cov contraindications. Tsis txhob coj nws mus rau cov neeg uas muaj hypersensitivity rau sulpiridu thiab kev txom nyem los ntawm hyperprolactinemia (ho tsa theem ntawm cov hormone prolactin nyob rau hauv cov ntshav). Raws li, cov tshuaj no yog tsis muab nrog prolactin-dependent hlav (cancer ntawm lub mis, prolactinoma pituitary caj pas , thiab lwm yam).

Ntxiv mus, "Sulpiride" (indications piav saum toj no) txwv tsis pub muaj kev qhia ntawv nyob rau hauv pheochromocytoma (hormonally active chromaffin cell hlav), manic psychosis thiab ntau yam affective mob nrog tus cwj pwm aggression qaug dab peg. Tsis txhob siv cov tshuaj no sulpiridsoderzhaschih tawm tsam lub backdrop ntawm mob cawv qaug cawv, lom nrog hypnotic lam tshuaj thiab narcotic analgesics.

Tsis qhia yog siv cov neuroleptic "Sulpiride" cov neeg mob muaj hnub nyoog qis dua 18 xyoo thiab cov poj niam thaum lub sij hawm lactation.

Tau tshwm sim los ntawm

Phiv tshua rau neuroleptic nws tus kheej thiab analogues "sulpiride" neeg mob testimonials thiab noj qab haus huv cov tub txawg tuab li sufficiently loj, ho ntsuas tus mob ntawm tus neeg mob. Muaj ib tug tau ntawm hyperprolactinemia nyob rau hauv ib tug ntau yam ntawm ntaub ntawv (gynecomastia, dysmenorrhea, frigidity, txo potency, galactorrhea, nce nyob rau hauv lub cev hnyav).

Ntxiv tau qhov tseeb ntawm tus extrapyramidal syndrome, uas yog manifested los ntawm pathological mob ntawm kom muaj nuj nqis thiab zoo tshaj ntawm txawj zog ua los ntawm skeletal leeg, hloov nyob rau hauv cov nqaij laus. Txawm li cas los, tuag tes tuag taw yog tsis muaj cov tsos mob uas qhia qhov tseeb ntawm extrapyramidal syndrome.

Raws li sab tshua mus "Sulpiride" analogs neuroleptic, tej zaum yuav tshwm sim co, akathisia (tsis muaj peev xwm yuav nyob rau hauv so), dyskinesia, insomnia, nkees nkees, ntxhov siab vim siab excitability, irritability. Yuav manifest cov tsos mob ntawm neuroleptic phem syndrome, yus muaj los ntawm autonomic txawv txav, daj daim tawv nqaij, hyperthermia.

Sab los ntawm tus mob huam tej zaum yuav ua tau ib tug nov ntawm nqaij tawv ntawm dryness nyob rau hauv lub qhov ncauj, txoj kev loj hlob ntawm kub siab, xeev siab tsos, retching, cem quav. Tau ua kom cov hepatic transaminases thiab alkaline phosphatase.

Plawv system daim ntawv thov "sulpiride" yuav teb ib qho kev nce rau hauv cov ntshav siab (tsis tshua muaj - ib tug txo nyob rau hauv cov ntshav siab, kiv taub hau), muaj zog lub plawv dhia, nce QT-luv. Heev tsis tshua, tab sis koj yuav hnov tias nyob rau hauv "Sulpiride" tshuaj lus teb los ntawm cov kws kho mob qhia tias cov kev loj hlob torsadedepointes hom arrhythmia.

Cov kev tsis haum ces xws li daim tawv nqaij sawv pob, pruritus, eczematous txhab. Tej zaum koj yuav hnov txog cov kev yuam cai ntawm nrig txog kev pom pom tseeb tseeb.

dosing thiab daim ntawv thov Circuit Court hom

Raws li cov lus qhia rau kev siv ntawm lub medicament, feem ntau cov laus cov neeg mob nyob ntawm tus kab mob tshuaj txhaj koob tshuaj ntawm 100-300 mg ib hnub twg (muab faib mus rau hauv 2-3 koob tshuaj). Ncauj tshuaj muab nyob rau hauv txawv ntau npaum: 100-800 mg ib hnub twg rau intramuscular thawj coj (ua ntej yuav siv tas co). Qhov siab tshaj plaws taus koob tshuaj rau ib tug neeg laus yog 1.6 g

Yog hais tias nws yuav tsim nyog muab "sulpiride" rau cov me nyuam nyob rau hauv 18 lub xyoos ntawm hnub nyoog, ntau npaum yuav tsum tau xam noj mus rau hauv tus account lub nyhav rau lub hauv paus ntawm 5 mg ib kilogram ntawm lub cev hnyav.

Yog hais tias tus neeg mob muaj ib tug mob ntawm psychosis nyob rau hauv lub mob los yog mob ntev, txoj kev kho feem ntau yog pib nrog intramuscular thawj coj (400-800 mg ib hnub). Nyob rau hauv Feem ntau, lub sij hawm ntawm kev kho mob yog tsawg kawg yog 2 lub lis piam. Sai li sai tau raws li cov kev kho mob ntawm tus neeg mob, los ntawm intramuscular txhaj pauv mus rau lub txais tos "sulpiride" hauv ib ntsiav tshuaj. Neuroleptic "Sulpiride" neeg mob xyuas piav raws li ib tug zoo tshuaj. Duration ntawm lub chav kawm ntawm kev kho yuav tsum tau txiav txim thiab hloov los ntawm cov chaw tus kws kho mob.

Ntev li koob tshuaj

Tej yam tsos mob qhia tias qhov tseeb ntawm tau siab tshaj lub siab tshaj plaws permissible koob tshuaj saum toj no, tsis muaj. Feem ntau nyob rau hauv cov teeb meem, muaj yog nce ntshav siab, qhov muag plooj tsis pom kev. Tej zaum qhov kev loj hlob ntawm kev ua kom loog (hluav nco qab provoked los ntawm cov tshuaj, mos nyhuv, thaum dua zaug - hypnotic). Nyob rau hauv feem ntau tus neeg mob, cov teebmeem ntawm cov tshuaj "Sulpiride" neeg mob testimonials qhia cov tsos ntawm xeev siab, qhov ncauj qhuav, muaj zog tawm hws, ntuav. Nyob rau hauv tsawg tus neeg mob tsim extrapyramidal cov tsos mob, gynecomastia yuav tshwm sim yog txiv neej (mis o). Heev tsis tshua txawj hais lus ntawm pronounced parkinsonism, coma.

Raws li xim antidote rau "sulpiride" offline, symptomatic kev kho mob yog pom zoo, nyob ntawm seb tus mob ntawm tus neeg mob. Nyob rau hauv tej rooj plaub, thov holinoblokatory central kev txiav txim.

Nyob rau dab tsi them sai sai mus?

Kiag li tag nrho cov khoom antipsychotic pab pawg neeg (xws li sulpiridsoderzhatsie "Betamax", "Vero Sulpiride", "Prosulpin", "Sulperid Belupo", "Eglonil", "Sulpiride") xyuas tshwj xeeb thiab kev khiav hauj lwm cov lus qhia thiab txwv tsis pub rau tom qab haus dej cawv haus. Rau cov neeg mob uas tau qaug dab peg yog pom zoo rau kev soj ntsuam thiab electrophysiological kev tshawb fawb tau tau sulpiride nws lowers tus Harbor rau qaug dab peg kev ua si. Yog hais tias cov tshuaj yog siv concomitantly nrog tshuaj uas ua rau kom txoj kev pheej hmoo ntawm ventricular arrhythmias, xws cov neeg mob yuav tsum xyuas ntawm lub electrocardiogram. Nce QT-luv nyob rau hauv lub koob.

Yog hais tias thaum lub sij hawm kev kho mob, "sulpiride" yog cov tsos mob ntawm hyperthermia (a fact tias cov ntsiab lus rau txoj kev loj hlob ntawm neuroleptic phem syndrome), los ntawm kev siv ntawm cov tshuaj yuav tsum tau txiav.

Sudden cessation ntawm txoj kev kho "sulpiride" yuav ntxias ntsoos ntsoos cov tsos mob. Maltitol yog tam sim no nyob rau hauv cov tshuaj ua rau nws tsis yooj yim sua rau siv los ntawm cov neeg kev txom nyem los ntawm fructose intolerance.

Thaum lub sij hawm tag nrho kev kho mob lub sij hawm yuav tsum tau ceev faj txog tsav tsheb thiab cov kev siv ntawm kev tswj ua hauj lwm uas yuav tsum tau sai teb psychomotor thiab siab concentration.

Sulpiridsoderzhaschie tshuaj thiab cev xeeb tub

Cov poj niam thaum lub sij hawm cev xeeb tub "Sulpiride 'xyuas nyob rau hauv lub feem ntau zoo kev taw qhia. Maximum pub koob tshuaj rau cov pojniam xeebtub yog 200 mg ib hnub twg tsis ntxias teratogenic los (deflection ntawm embryonic txoj kev loj hlob). Cov kuj loj koob tshuaj ntawm cov tshuaj rau cev xeeb tub cov poj niam tsis ntaub ntawv muaj nyob. Tsis tas li ntawd, muaj yog tsis muaj cov ntaub ntawv nyob rau hauv tej yam ntawm cov tshuaj-antipsychotics rau lub hlwb txoj kev loj hlob ntawm tus me nyuam.

Nyob rau hauv kev, noj qab haus huv neeg ua hauj lwm xav tsis siv "Sulpiride" rau cov kev kho mob ntawm cev xeeb tub cov poj niam, tsuas yog nyob rau hauv tus neeg mob qhov twg ib tug zoo ntxim rau cov poj niam prevails tshaj tej zaum yuav raug mus rau lub fetus. Nyob rau hauv xws li mob, "Sulpiride" qhia (xyuas paramedics paub tseeb hais tias) xav muab nyob rau hauv tus nqi qis tshaj tau koob tshuaj thiab yog ua tau kom txo tau lub sij hawm ntawm kev kho mob.

Nyob rau hauv cov me nyuam yug los rau poj niam noj thaum lub sij hawm cev xeeb tub sulpiridsoderzhaschie tshuaj puav cai hnyuv cov tsos mob (tsam plab, thiab hais txog. N.) txuam atropinopodobnye tus ntawm neuroleptics. Tej zaum koj yuav hnov txog extrapyramidal syndrome. Thaum lub sij hawm pub niam mis Zoo siab txais tos "sulpiride" txhob.

Tswv yim ntawm cov neeg mob "sulpiride"

Lub ib thooj ntawm cov neeg mob nyob rau hauv cov tshuaj "Sulpiride" xyuas yoojyim ib tug zoo kev taw qhia. Neuroleptic sufficiently zoo thiab pov thawj rau cov tshaj tawm hais tias cov yam ntxwv. Cov neeg noj "Sulpiride" los yog nws analogues rau kev puas hlwb cov tsos mob thaum lub sij hawm pais plab rwj los yog duodenal rwj, qhia ib tug txo nyob rau hauv cov kev siv ntawm mob plab thiab kev txhim kho nyob rau hauv cov kev mob.

Me tagnrho cov medicament (50 mus rau 300 mg ib hnub twg) yog feem ntau tus kws kho rau cov neeg mob uas tau txais thaum kev tsis txaus siab ntawm heev kiv taub hau sawv rau ntau yam yog vim li cas. Lub ib thooj ntawm cov neeg mob no yog txaus siab rau qhov kev tshwm sim ntawm kev kho mob.

Loj koob tshuaj "sulpiride" (ntau tshaj 600 mg ib hnub twg), nyob rau hauv lub tswv yim ntawm kev kho mob neeg ua hauj lwm los muab zoo antipsychotic ntxim rau cov neeg mob. Koob tsawg tshaj li 600 mg, thiab nyob rau hauv lub tswv yim ntawm cov kws kho mob thiab cov neeg mob, nqa stimulating thiab antidepressant nyhuv.

Muaj yog ib pab pawg neeg ntawm cov neeg mob uas tawm hauv lub "sulpiride" nyob rau hauv ib tug txoj kev tsis zoo. Tsis neeg tsim xeev siab, kev zoo siab, giddiness. Tsis zoo cov tsos mob zoo tom qab discontinuation ntawm lub "sulpiride".