Cov tshuaj "Daraprim": phau ntawv qhia, xyuas, muaj pes tsawg leeg, analogs thiab xyuas

Malaria yog ib pab pawg neeg ntawm kab vector kab mob, uas yog kis tau rau tib neeg thaum yoov tshaj cum ntawm lub genus Anopheles tom. Rau xws li ib tug pathological mob yus kub taub hau, ua daus no, splenomegaly, hepatomegaly thiab anemia.

Thaum untimely thiab kev kho mob ntawm malaria tuag no tshwm sim (nyob rau hauv feem ntau tus neeg mob).

Cov feem ntau rau cov kev kho mob ntawm cov kab mob xws siv tshuaj "Daraprim". Cov lus qhia rau kev siv, xyuas, nqi thiab analogues cov tshuaj no yuav tsum tau muab nthuav hauv qab no.

Muaj pes tsawg leeg, zoo lawm, thiab ntim qhov kev piav qhia ntawm cov kev npaj

Cov tshuaj "Daraprim" qhia uas yog muaj nyob rau hauv ib lub thawv uas ua los ntawm cov duab los qhia, yog muag nyob rau hauv cov ntsiav tshuaj daim ntawv opaque dawb xim. Lub active tshuaj yog suav tias yog txhais tau tias pyrimethamine.

Yuav cov tshuaj no tej zaum yuav nyob rau hauv lub contour hlwb uas muab tso rau hauv cov nkev ntawv thawv.

Nta ntawm cov tshuaj

Yuav ua li cas yog tus kho "Daraprim"? Cov lus qhia rau kev siv qhia tau tias qhov kev ua los tiv thaiv cov tshuaj. Nws muaj antitoksoplazmoidnoe thiab antimalarial los, thiab tseem muaj txhawb rau thaiv cov hlab folatreduktazy transforming folic acid folinic.

Cov tshuaj no yog zoo tiv thaiv cov plasmodium yav thiab toxoplasmosis. Nws kuj muaj shizontotsidnoe kev txiav txim.

Nyob rau hauv tib neeg, cov tshuaj nyob rau hauv lo lus nug tsis cuam tshuam rau lub cev (sib deev) Plasmodium falciparum, vim nws yog devoid gamontotsidnoy kev ua si. Txawm li cas los, qhov no txhais tau tias yog tau inhibit fertilization txheej txheem gamont cab kuj cev (i.e., muaj gamontostaticheskoe txiav txim).

Indications rau kev txais neeg kawm lekrstva

Tshuaj "Daraprim", uas cov kev qhia ntawv yuav tsum hais hauv qab no, yog npaj rau cov kev kho mob thiab kev tiv thaiv ntawm malaria. Tsis tas li ntawd, nws yog kws kho rau toxoplasmosis (congenital thiab mas yuav kis tau) thiab uveitis (toxoplasmosis los yog tsis paub hais tias keeb kwm).

Contraindications tshuaj

Nyob rau hauv dab tsi tej yam kev mob yuav tsum tsis txhob muab ib yam tshuaj "Daraprim"? Phau Ntawv Qhia neeg pab leg ntaubntawv nws txhais tau hais tias txhob nrog npau taws me ntsis thiab megaloblastic B12-deficiency anemia, uas yog txuam nrog ib tug tsis muaj folic acid.

C huab ceev faj suav tshuaj kws kho rau folate-deficient tej yam kev mob thiab hepatic los yog lub raum tsis ua hauj lwm.

Medicament "Daraprim": cov lus qhia rau kev siv

Analogues cov tshuaj no yuav tsum tau teev tseg hauv qab no.

Noj xws tshuaj yuav tsum tsuas yog sab hauv. Lawv ntau npaum nyob rau hauv lub pov thawj.

Rau kev tiv thaiv ntawm malaria tshuaj 1 ntsiav tshuaj ib hnub ib zaug. Cov me nyuam hnub nyoog li 5-10 xyoo yog pom zoo kom noj cov tshuaj ntawm ib nrab koob tshuaj.

Prophylaxis yuav tsum tau pib ua ntej los yog sai li sai tau tom qab koj mus txog hauv lub cheeb tsam nyob qhov twg muaj ib tug siab ntau yam ntawm kev cog lus malaria. Nyob rau hauv cov ntaub ntawv no, lub koob tshuaj ntawm cov tshuaj nyob rau hauv no koob tshuaj yuav tsum tshaj lub hlis tom ntej.

Raws li rau cov kev kho mob ntawm malaria rau nqa mus rau hauv lub tshuaj "Daraprim"? Phau Ntawv Qhia tau qhia hais tias kev kho mob ntawm xws li ib tug kab mob no yog nqa tawm comprehensively. Tshuaj ua ke nrog "sulfadoxine" los yog "sulfalena". Nws yog muab nyob rau hauv ib tug npaum li ntawm 1 mus rau 3 ntsiav tshuaj kev txais tos. Cov me nyuam hnub nyoog 9-14 xyoo muab 2 ntsiav tshuaj pirimetrina thiab 4-8 xyoo - ib tug.

Rau cov kev kho mob ntawm toxoplasmosis cov me nyuam laus tshaj 6 lub xyoo thiab laus yog pom zoo kom siv li 2 "Daraprima" ntsiav tshuaj ib hnub twg, thiab cov me nyuam 2-6 xyoo - ib tug.

Lub caij ntawm kev kho mob nrog rau qhov no neeg sawv cev yog 3-6 lub lis piam. Yog hais tias tsim nyog, cov kev yuav tau rov qab.

phiv

Tau txais antimalarial tshuaj tej zaum yuav ua rau ntau yam kev phiv tshuaj teev. Chim siab tshaj plaws feem ntau manifested:

• mob plab ntswj, mob taub hau, qhuav caj pas los qhov ncauj, tsis muaj zog, xeev siab;
• kiv taub hau, ntuav, dermatitis, raws plab (nyob rau hauv thaum pib ntawm kev kho mob), tawm pob, kev nyuaj siab;
• daim tawv nqaij heev, kub taub hau, anemia, leukopenia;
• plawv cev qhuav dej, thrombocytopenia, ulcerations nyob rau hauv lub qhov ncauj, fenilalaninemi, insomnia.

tshuaj cov kev sib tshuam

"Warfarin" thiab "quinidine" ua rau kom cov tshuaj muaj taug thiab miv nyuas siv zug ntawm cov tshuaj.

Toxic siab raug mob uas yuav muaj yog tshuam ntau zog los ua ke "Daraprima" nrog "lorazepam". Tsis tas li ntawd enhanced myelosuppression, uas yog tshwm sim los ntawm cytotoxic tshuaj (xws li "methotrexate").

Cov me nyuam nrog leukemia thiab Cns tom qab thawj coj ntawm "pyrimethamine" thiab "methotrexate" tsub kom qhov yuav mob chua leeg hlwb.

Nyob rau hauv cov neeg uas raug kev txom nyem los ntawm mob myeloid leukemia, uas tau txais "cytosine arabinoside," "Aunorubitsina" thiab pyrimethamine yuav ua rau hlwb pob txha aplasia.

Cov tswv yim rau cov uas tau txais antimalarial

Saib tshuaj nrog ceev faj rau cov neeg uas raum lossis daim siab tsis ua hauj lwm, thiab congenital tsis muaj peev xwm ntawm folic acid los yog vim malnutrition.

Nyob rau hauv cov kev kho mob ntawm toxoplasmosis nyob rau hauv thiaj li yuav txo txoj kev pheej hmoo ntawm hlwb pob txha hluav, uas yuav tsum tau coj txais tos calcium folinate los yog folic acid.

Thaum lub sij hawm tag nrho lub sij hawm ntawm kev kho mob yuav tsum tau nqa tawm txhua txhua lub lim tiam tus neeg mob cov ntshav tsom xam.

Analogs thiab nqi

Nqe qhia tus neeg saib xyuas yog hais txog 7-8 txhiab rubles. Lub Khoos Loos Tsev analogues ntawm kev npaj no tsis muaj. Txawm li cas los, ib txhia kws cam hais tias zoo xws li cov zog muaj xws li tshuaj raws li "Milife", "Zener" (hmoov), "Plaquenil" thiab "Lariam".

Xyuas

Tam sim no koj paub lub pharmacological thaj chaw ntawm cov tshuaj "Daraprim". Phau Ntawv Qhia nqi ntawm qhov cuab tam kuj tau nyob rau hauv no tsab xov xwm.

Nrhiav neeg xyuas ntawm no antimalarial tshuaj yog ib qhov nyuaj. Tom qab tag nrho, raws li koj paub, hais txog 85-90% ntawm cov neeg ntawm tus kab mob tus kab mob no tshwm sim nyob rau hauv qhov chaw ntawm teb chaws Africa. Raws li ib tug txoj cai, lawv kis tau kab mob rau cov me nyuam nyob rau hauv lub hnub nyoog ntawm tsib.

Kws txawj qhia tias kev tuag tus nqi los ntawm malaria tau poob ho tom qab siv cov tshuaj. Txawm li cas los, tsis yog txhua txhua tus neeg muaj lub sij hawm los mus ua ntawv thov lub tsev no thaum lub sij hawm kab mob.