"Azathioprine": phau ntawv qhia, xyuas, piav qhia, analogs

Uas hu rau cov tshuaj "Azathioprine"? Cov lus qhia nyob rau hauv daim ntawv thov xa los ntawm cov neeg ua hauj yuav tau piav nyob rau hauv no tsab xov xwm. Peb kuj qhia koj seb puas muaj contraindications thiab analogues muaj cov tshuaj no, yog dab tsi nws nqi, yuav ua li cas nyob rau hauv cov ntaub ntawv ntawm ib tug overdose, thiab hais txog. D.

Muaj pes tsawg leeg, ntim, zoo, hauj lwm medicament

Nyob rau hauv dab tsi daim ntawv no yog muaj tshuaj "Azathioprine"? Cov lus qhia rau kev siv qhia hais tias qhov no tshuaj yog muaj nyob rau hauv cov ntsiav tshuaj daim ntawv. Lawv active ingredient ua raws li azathioprine. Tsis tas li ntawd nyob rau hauv cov tshuaj thiab muaj xws li ntxiv cov khoom xyaw rau hauv daim ntawv ntawm qos starch, gelatin, lactose, thiab calcium stearate.

Nyob rau hauv ib lub pob muag cov tshuaj "Azathioprine"? Cov lus qhia rau kev siv ntawm cov tshuaj yog muab ntim rau hauv ib lub cardboard lub thawv, uas muab tso rau daj ntseg daj Valium tshuaj nyob rau hauv sawv hlwv packs ntawm 50 daim.

Pharmacological yam ntxwv ntawm lub medicament

Yuav ua li cas yog cov tshuaj raws li "Azathioprine"? Cov lus qhia rau kev siv, tiag tiag txog tej tub txawg qhia tias cov tshuaj nyob rau hauv lo lus nug yog ib qho analog "hypoxanthine", "Adenine" thiab "guanine", muaj nyob rau hauv cov qauv ntawm cov nucleic acids thiab muaj ib tug thaiv cov hlab cov nyhuv hauv relation mus rau cov ntaub so ntswg loj hlob thiab cell division.

"Azathioprine" - immunosuppressive neeg sawv cev. Nws txiav txim yog aimed ntawm cellular cytotoxicity.

Xam tias yog ib tug yeeb tshuaj muaj peev xwm mus inhibit qhov tshuaj tiv thaiv ntawm cov ntaub so ntswg incompatibility thiab muaj feem xyuam rau cov replication ntawm cov tshuaj, tiam sis tsuas yog rau ib tug me me qhov twg. Piv nrog rau "mercaptopurine" active tshuaj exhibits ib tug ntau pronounced.

Pharmacokinetic tshuaj

Tom qab qhov ncauj tshuaj no yog zoo yaim los ntawm lub hnyuv ib ntsuj av. Nws muaj ib tug uas tsis muaj daim ntawv cog lus nrog ntshav cov nqaijrog (kwv yees li 30%).

Lub biotransformation ntawm cov tshuaj tso tawm muaj tshwm sim nrog tioinozinovoy acid thiab mercaptopurine (i.e., active metabolite). Cov me me ntawm cov tshuaj mus rau hauv cov ntaub so ntswg. Nyob rau hauv cov ntaub ntawv no, ib tug me me concentration ntawm cov tshuaj nyob rau hauv lub hlwb.

Lub ib nrab-lub neej ntawm azathioprine, thiab nws active metabolites yog hais txog 6 sij hawm. Qhov siab tshaj plaws concentration ntawm cov tshuaj nyob rau hauv cov ntshav cai tom qab 70-110 feeb.

Cov tshuaj no yog yuav luag tag tawm ua ke nrog cov kua tsib, thiab tsuas yog 1-2% - los ntawm ob lub raum.

indications ntsiav tshuaj

Yuav ua li cas prescribers "Azathioprine" (cov lus qhia rau kev siv ntawm cov tshuaj, analogs, xyuas yuav tsum tau nthuav tawm tom qab)? Tej kev npaj no manifests nws tus kheej zoo thaum lub nram qab no txawv txav:

• psoriasis;
• mob caj dab rheumatoid;
• liab mauj lupus erythematosus ;
• ulcerative mob plab;
• dermatomyositis;
• myasthenia Heavy kev;
• Pemphigus hais lus phem;
• periarteritis nodosa;
• Crohn tus kab mob ;
• glomerulonephritis, autoimmune;
• mob active kab mob siab;
• Reiter lub syndrome ;
• purpura idiopathic thrombocytopenic.

Nws yuav tsum raug sau tseg hais tias qhov no tshuaj yog feem ntau kws kho rau cov kev tiv thaiv ntawm hloov rejection. Tab sis nyob rau hauv cov ntaub ntawv no nws yog tshwm sim nyob rau thaum lawv tseem nrog lwm yam tshuaj.

Contraindications rau kev siv ntawm cov tshuaj

Cov lus qhia rau kev siv ntawm cov tshuaj "Azathioprine" qhia cov neeg mob txog cov nram no contraindications:

• hepatic tsis ua hauj lwm ;
• npau taws me ntsis rau active los yog koom haum pab Cheebtsam noj tshuaj;
• thaum lub sij hawm cev xeeb tub;
• cov mob ntawm lub oppressed hematopoiesis;
• cov me nyuam muaj hnub nyoog;
• pub niam mis.

Medicament "Azathioprine": ntau npaum thiab tswj

Siv "azathioprine" ntsiav tshuaj yuav tsum tsuas yog siv hais lus. Nyob rau hauv txhua rooj plaub, lub koob tshuaj ntawm cov tshuaj yog txiav txim ib lub zuj zus, nyob ntawm seb cov muaj pov thawj, thiab raws li tus heev ntawm tus kab mob thiab concomitant txoj kev kho.

Rau kev tiv thaiv ntawm graft rejection tshuaj nyob rau hauv ua ke nrog nrog "cyclosporin" thiab corticosteroids. Thaum pib ntawm kev noj tshuaj kho nyob rau hauv ib tug loading koob tshuaj uas yog 5 mg ib kg (ntau tshaj li ob lub hlis). Tom qab noj tshuaj nyob rau hauv cov txij nkawm koob tshuaj (1-4 mg ib kg nyob rau hauv 3 koob tshuaj). Feem ntau, xws kev kho mob yog txuas ntxiv rau ib ntev lub sij hawm. Yog hais tias koj rho txoj kev kho koob tshuaj yog txo qis maj.

Thaum tshwm sim ntawm thawj cov cim qhia ntawm rejection ntawm transplanted khoom hauv nrog cev yuav tsum tau ua rau kom cov hnub ntau npaum ntawm medicament dua mus rau 4 mg ib kg.

Rau cov kev kho mob ntawm lwm yam kab mob medicament nquag muab nyob rau hauv ib tug txhua txhua hnub koob tshuaj 1.5-2 mg ib kg mus rau 4 faib koob tshuaj. Yog hais tias tsim nyog, lub teev nqi ntawm cov tshuaj yuav tau nce mus 200-250 mg (muab faib mus rau hauv 4 koob tshuaj). Lub caij ntawm kev kho mob nrog rau qhov no cuab tam yog teem ib lub zuj zus, ib tug uas tshwj xeeb.

Yuav ua li cas siv "Azathioprine" (ntsiav tshuaj) nyob rau hauv kev mob caj dab rheumatoid? Cov lus qhia rau kev siv, kev (piav kev npaj twb hais saum toj no) hais tias rau cov kev kho mob ntawm cov kab mob xws tshuaj 1-2.5 mg ib kg ib hnub twg (muab faib mus rau hauv 2 koob tshuaj). Duration ntawm kev kho yuav tsum tau muaj yam tsawg 3 lub hlis. Raws li kev pab txhawb rau tus neeg mob yog muab ib tug koob tshuaj 0.5 mg ib kg (tib koob tshuaj).

Rau cov kev kho mob ntawm tus kab mob siab B (active) muab ib tug txhua txhua hnub koob tshuaj 1-1.5 mg ib kg.

Mob ntawm tshuaj overdose

Yuav ua li cas yog cov tsos mob ntawm overdose tshwm sim nyob rau qhov tsis ncaj ncees txais tos "Azathioprine" tshuaj? Cov lus qhia rau kev siv, tiag tiag txog tej kws kho mob qhia hais tias lub siab koob tshuaj ntawm cov tshuaj yuav ua rau ntau yam dyspeptic lub xeev, pancytopenia, mob ntawm daim siab zog thiab kho kom zoo rau lwm tshwm sim los ntawm cov tshuaj.

Raws li kev kho mob ntawm xws phenomena siv symptomatic txoj kev kho. Yog hais tias tsim nyog, hemodialysis. Txawm li cas los, yuav tsum paub hais tias txoj kev ua no tsis tau lees tias tag nrho tshem tawm ntawm lub active tshuaj los ntawm lub cev.

tshuaj cov kev sib tshuam

Ib yam li lwm cov tshuaj muaj feem xyuam rau cov tshuaj "Azathioprine"? Cov lus qhia rau kev siv hais tias pa roj carbon monoxide-thawj coj ntawm tus neeg saib xyuas nrog "Allopurinol" yuav txhim khu cov tshuaj lom los ntawm tus thawj, thiab nyob rau hauv ua ke nrog lub "co-trimoxazole" feem ntau ua rau muaj zog myelotoxic los.

Tib mus kho mob nrog ACE inhibitors tsub kom qhov uas yuav mob leukopenia.

Nyob rau hauv ua ke nrog nrog rau lwm cov immunosuppressants (e.g., "Cyclosporins", glucocorticoids, anti-CD3 tshuaj) heev feem ntau muaj ib tug ntau yam ntawm neoplasms thiab kab mob.

Saib npaj exhibits antagonistic cov nyhuv rau nedepolyarizuyushim nqaij hnaiv.

Nws yuav tsum tau muab sau tseg tias txhaj tshuaj tiv thaiv thaum lub sij hawm kev kho mob "azathioprine" yuav yooj yim heev ua rau cov hluav ntawm zus tau tej cov tshuaj (nyob rau hauv cov ntaub ntawv kev mob cov tshuaj tiv thaiv), raws li zoo raws li kom tus kab mob replication (nrog rau cov kev taw qhia ntawm nyob cov tshuaj tiv thaiv).

tej tswv yim pom zoo

Tej yam uas yuav paub ua ntej koj muab tshuaj "Azathioprine"? Cov lus qhia rau kev siv, tiag tiag (analogues tshuaj uas muaj npe hauv qab no) lub xeev uas thaum lub sij hawm thawj ob lub hlis ntawm txoj kev kho yog yuav tsum tau txhua lub lim tiam mus soj ntsuam cov qauv ntawm cov peripheral cov ntshav. Tom qab lub sij hawm no, txoj kev tshawb qhia tau hais tias lub Cheebtsam nrog ib zaus ntawm 1 txhua txhua 30 hnub.

Nws tseem yog tsim nyog los saib xyuas cov theem ntawm bilirubin, alkaline phosphatase thiab siab enzymes.

Nyob rau hauv lub xub ntiag ntawm kev txawv txav ntawm lub raum lossis daim siab, raws li tau zoo raws li ib tug sib koom txais tos nrog "Allopurinol" medicament ntau npaum nyob rau hauv saib xyuas yuav tsum raug txo kom 1/4 ib feem.

"Azathioprine" nrog huab ceev faj muab rau cov neeg cov neeg mob nyob rau hauv uas muaj yog herpes zoster, chickenpox, xanthine oxidase tsis muaj peev xwm, thiab thaum lub sij hawm tawg los yog cytotoxic txoj kev kho.

Analogues thiab cov tshuaj nqi

Yuav ua li cas yuav hloov tau "Azathioprine"? Cov lus qhia rau kev siv (tus nqi ntawm cov tshuaj uas muaj npe hauv qab no) lub xeev uas tau pom tias cov tshuaj muaj ob peb tus phooj ywg. Qhov tseem zoo xws li cov nyob rau hauv tej yam muaj xws li cov nram qab no cov tshuaj:

• "Alpha-fetoprotein."
• "Alfetin".
• "Stemokin".
• "Profetal".
• "Revlimid".

Raws li rau tus nqi, ces cov khoom no yog tsis heev. 50 ntsiav tshuaj "azathioprine" nyob rau nruab nrab yog hais txog 230 Lavxias teb sab rubles.

Xyuas ntawm medicament

Ib tug ob peb xyuas ntawm cov tshuaj "Azathioprine" txhais tau tias mixed. Ib txhia neeg noj cov tshuaj vim hais tias ntawm ib tug kab mob autoimmune, yog txaus siab nrog nws cov zoo raug thiab tsis mob sab los. Lwm tus, txawm li cas los, cov neeg mob yuav tsis muaj los ntawm tej yam tshwm sim, thiab yog li ntawd lawv txiav txim siab los muab lawv nyiam mus rau lwm cov txhais tau tias.

Nws yuav tsum tau muab sau tseg tias tag nrho cov indications rau kev siv ntawm cov tshuaj "Azathioprine" xa mus rau ib tug es loj cov kab mob uas txaus txoj kev kho tsuas yog ib qho kev paub txog kev. Nyob rau hauv no hais txog, nyob rau hauv cov ntaub ntawv ntawm lub sijhawm twg los ntawm lub xub ntiag ntawm tej yam kab mob los ntawm cov saum toj no daim ntawv teev, koj yuav tsum yauv mus ua ib tug kev kho mob soj ntsuam, tsis rau nws tus kheej-medicate.