"Azathioprine": analogues, nqe, daim ntawv qhia thiab xyuas

Kab mob autoimmune - ib pab pawg neeg ntawm pathological tej yam kev mob nyob rau hauv uas muaj yog nce ua si ntawm lub cev tiv thaiv tsis tau nws tus kheej lub cev. Nyob rau hauv thiaj li yuav txo lub cev lo lus teb, muab cov tshuaj uas suppress lub cev. Qhov no pab pawg neeg ntawm cov tshuaj yog indispensable nyob rau hauv kev sib hloov los mus tiv thaiv graft rejection. Cia saib nyob rau hauv xws li ib tug yeeb tshuaj, raws li ib tug "Azathioprine" analogs ntawm cov tshuaj, thiab cov lus qhia rau kev siv ntawm nws cov nta.

pharmacological characterization

Nyob rau hauv nws ib feem ntawm cov tshuaj "Azathioprine" muaj cov active ingredient ntawm lub tib lub npe. Qhov no tshuaj compound yog ib tug derivative ntawm cov tshuaj tsim nyog rau cov synthesis ntawm DNA thiab RNA. Nyob rau hauv lub cev, azathioprine muab DNA synthesis thiab, thiaj li, cheeb cell division dab nyob rau hauv ntaub so ntswg. Txo cov kev ua ntawm lub cev tshwm sim los ntawm tus ntawm cov tshuaj "Azathioprine" nyob rau hauv lub lymphoid cov ntaub so ntswg.

Yog li muaj yog inhibition ntawm cell division dab thiab cellular tiv thaiv kab mob teb. Tom qab cov kev taw qhia ntawm "Azathioprine" npaj nyob rau hauv lub cev yog txawv txav yuav txo tau nyob rau hauv lub xov tooj ntawm phagocytes thiab txo immunoglobulin synthesis. Cia peb ntxiv tsom xam cov ntaub ntawv: dab tsi yog qhov yam ntxwv ntawm lub "Azathioprine" tshuaj analogues, nqe, cov lus qhia rau kev siv.

tshuaj

Cov tshuaj yog heev zoo absorbed rau hauv lub mauj kev, thiab nws cov nyiaj pab ntau tshaj concentration cai tom qab xwb 2 xuab moos tom qab qhov ncauj thawj coj. Cov tshuaj tsis yog tshwj xeeb ke rau ntshav cov nqaijrog: nws losis tswvyim dabtsi rau lawv li 30%. Rau azathioprine yam ntxwv ntxim thawj metabolic los yog thawj pass los ntawm lub siab.

Dhau los ntawm lub hepatocytes, cov tshuaj yog metabolized mus rau lub active compound - mercaptopurine, thiab cov uas muaj pharmacodynamic los. Formulation yuav luag tag tas nrog bile. Cov zis tas los ntawm tsis muaj ntau tshaj li 2% ntawm medicament.

indications

Kev npaj "Azathioprine" analogues nrog tib yam kom nquag plias yam khoom uas yog qhia rau kev siv nyob rau hauv kev sib hloov los mus tiv thaiv graft rejection cov tshuaj tiv thaiv.

Tsis tas li ntawd, cov tshuaj yog zoo siv nyob rau hauv rheumatological xyaum los kho mob caj dab rheumatoid thiab autoimmune kab mob xws li kab mob siab, mauj lupus erythematosus, psoriasis, thrombocytopenic purpura, pemphigus, thiab ntau lwm tus neeg.

Contraindications

Tshuaj "Azathioprine" yog ua rau cov neeg mob uas npau taws me ntsis mus rau yeeb tshuaj tivthaiv. Vim lub fact tias cov tshuaj cheeb tag nrho cov kab mob ntawm cov ntshav, "Azathioprine" yog ua rau cov kab mob ntawm cov ntshav (anemia leykotsito- thiab lymphopenia, thrombocytopenia), raws li zoo raws li cev xeeb tub thiab laus.

Siv lub sij hawm uas cev xeeb tub thiab pub niam mis

Lub active tshuaj kis mus rau hauv niam cov kua mis thiab los ntawm gematoplatsentarny barrier. Nyob rau hauv no hais txog, cov kev siv tsis pom zoo nyob rau hauv cev xeeb tub thiab pub niam mis. Yog hais tias tsim nyog, lub sij hawm ntawm cov tshuaj los yog nws analogues nyob rau hauv pawg no ntawm cov neeg uas yog tsim nyog rau kev ntsuam xyuas qhov uas yuav los ntawm kev siv ntawm qhov kev siv ntawm cov tshuaj thiab lub peev xwm ua mob rau tus niam thiab tus me nyuam hauv plab. Thaum muab cov tshuaj mas siv thaum lub sij hawm pub niam mis nyuam qhuav mus rho.

Nta ntawm daim ntawv thov

Cov tshuaj thiab nws analogs yuav tsum tau siv nrog ceev faj nyob rau hauv cov neeg mob kev txom nyem los ntawm chickenpox, thiab nyob rau hauv cov neeg mob uas tsis muaj peev xwm ntawm xanthine oxidase.

phiv

Lub ntsiab pab pawg neeg ntawm cov phiv nrog inhibition ntawm pob txha tsim muaj nuj nqi, lub luag hauj lwm rau zus tau tej cov ntshav liab. Nyob rau hauv thov analogs muaj azathioprine, ib qho kev nce nyob rau hauv lub loj ntawm lub hlwb nyob rau hauv cov ntshav, yuav txo tau ntawm leucocyte count, platelet suav, anemia.

Rau ib feem ntawm cov hnyuv feem ntau phiv muaj xws li: tsis qab los noj mov, quav mob, impaired hepatic muaj nuj nqi, ulcerative txhab ntawm tus mob huam. Tau tsis hepatocytes, ua raws li los ntawm ib qho kev nce nyob rau hauv bilirubin los yog lwm yam lub siab muaj nuj nqi kev ntsuam xyuas. Nyob rau hauv cov neeg mob niaj phais rau hloov hloov thiab cov ntaub so ntswg tej zaum yuav tsim pancreatitis, ulcerative txhab ntawm lub plab, hnyuv, kev loj hlob ntawm tshuaj lom kab mob siab.

Cov kev tsis haum tshwm sim heev tsis tshua thaum muab tshuaj "Azathioprine" analogs raws li nyob rau hauv nws (e.g., "Azathioprine"). Txoj kev ua tsis qhia, mas vim daim tawv nqaij sawv pob los yog feverish lub xeev.

Cov lwm sab los yuav tsum tau muab sau tseg txoj kev loj hlob ntawm ob kab dab nyob rau hauv lub cev, cov tsos ntawm npag thiab mob tej pob txha, mob raum haumxeeb insufficiency. Nyob rau hauv ib co loj heev zaum, cov tshuaj "Azathioprine" analogues nrog tib yam kom nquag plias yam khoom uas yuav ua rau hemolytic anemia, muab cov tsos mob los ntawm lub hauv paus poob siab system. Azathioprine raws li ib tug pharmaceutically active tshuaj, ib feem ntawm tib lub npe tshuaj thiab nws analogues, muaj ib tug qhia tau lub hwj lub fetus (teratogenic thiab mutagenic teebmeem) thiab muaj peev xwm ntawm provoking cov tsos ntawm mob dab thiab lawv tom ntej malignancy. Yog li, nws yog tsim nyog los xyuas lub sij hawm ntawm cov tshuaj "Azathioprine" (ntsiav tshuaj) xyuas, piav qhia, kev siv yeeb tshuaj analogues thiab xaiv txoj cai tactics. Nrhiav ntej, peb nco ntsoov hais tias raws li lub active ingredient azathioprine niamntiav lig los rau hauv chav kawm ntawm tus kab mob, raws li indications. Qhov no yog qhia tsis tau tsuas yog cov kws kho mob tab sis kuj cov neeg mob lawv tus kheej.

"Azathioprine" - txhais, analogs

Azathioprine - cim nyob rau hauv nws tus kheej txoj kev ib yam khoom uas muaj ib tug immunosuppressive kev txiav txim. Nyob rau hauv view ntawm tus kws ua lag luam yog tsis zoo heev sawv cev npaj muaj azathioprine. Analogs "azathioprine" yuav tsum tau nthuav tawm nyob rau hauv xws li ib tug yeeb tshuaj, raws li ib tug "Azathioprine".

Cov tshuaj no muaj nyob rau cov ntsiav tshuaj daim ntawv zoo li cov ntsiab lus azathioprine. Lub tsuas nuance yog tus nqi ntawm "Azathioprine" ntawm cov tshuaj, uas tau nyob rau hauv 4-5 lub sij hawm tus nqi ntawm "azathioprine" Lavxias teb sab ntau lawm.

Lom thiab overdose

Drug overdose "Azathioprine" thiab nws cov counterpart "Azathioprine" manifested mob ntawm tus mob huam, tsuj ntawm pob txha tsim muaj nuj nqi, raws li zoo raws li nce siab muaj nuj nqi kev ntsuam xyuas. lom kho mob raws li cov tshuaj rau nws tus kheej thiab nws cov analogues yog symptomatic, tswj lub hais tshem tawm ntawm cov tshuaj los ntawm lub cev. Tsis muaj ib yam tshuaj. Lim Ntshav Hauv Lub detoxification txoj kev yog zoo nyob rau hauv ib feem vim lub active tshuaj los ntawm lawv tas tsis tau kiag li.

ceev faj

Cov tshuaj thiab nws analogs yog tsis pom zoo rau long-term siv. Thaum pib ntawm cov kev kho mob yuav tsum tau tas li xyuas ntawm lub hlwb ntawm peripheral cov ntshav, raws li zoo li xyuas ntawm daim siab enzymes.

Nyob rau hauv lub neej yav tom ntej, txhua hnub tswj ntawm so, kev saib xyuas cov kev tshawb fawb ib zaug los yog ob zaug ib lub hlis.

xaus

Cov tshuaj thiab nws analogs yuav xaiv tsuas yog ib tug tej tus kws khomob tshwjxeeb. Ua ntej yuav noj cov txhais tau tias tsim nyog los yauv ib tug tag nrho cov kev soj ntsuam thiab tejzaum kev txij nkawm txoj kev kho. Yog xav paub ntxiv, ua kom lub sij hawm ntawm "Azathioprine" npaj cov lus qhia rau kev siv. Nqe, analogues ntawm no lub cuab tam li ib feem ntawm ib tug yoj ntawm cov neeg mob. Yog li, qhov tsawg kawg nkaus tus nqi ntawm 50 ntsiav tshuaj yog nyob rau hauv lub cheeb tsam ntawm 250-300 rubles, thiab txog analogues hais saum toj no. Ua ntej yuav noj koj yuav tsum luj qhov "pros" thiab "cons" thiab pib kho mob.