"Korvitol": analogues, xyuas, cov lus qhia rau kev siv. Yuav ua li cas yuav hloov tau "Korvitol 50" thiab "100 Korvitol"?

Kab mob plawv yog cov feem ntau. Nyob rau hauv thiaj li yuav sai tau kom tsis txhob siab, kom tsis txhob plawv dhia, alleviate tus mob ntawm angina pectoris, migraine, tshuaj noj "Korvitol". Analogs kuj tau xaiv feem ntau yog ib tug vim los yog lwm tus. Cov tshuaj muaj contraindications, yog li ntawd ua ntej yuav siv, nrog koj tus kws kho mob.

Tso daim ntawv thiab muaj pes tsawg leeg ntawm cov tshuaj

Cov tshuaj belongs rau lub beta-blocker. Nws yuav ua nyob rau hauv daim ntawv ntawm cov dawb ntsiav tshuaj uas muaj ib tug yeej spigot, thiab tug-ib tog chamfer uas muaj feem yuav. Muaj nyob rau hauv ob noj tshuaj npaum cas:

• "Korvitol 100". Nws muaj 100 mg ntawm active ingredient metoprolol tartrate.
• "Korvitol 50". Nws muaj ib tug muaj pes tsawg leeg ntawm 50 mg ntawm lub active ingredient metoprolol tartrate.

Ntxiv cov khoom xyaw rau ob qho tib si ntaub ntawv ntawm qhov teeb meem qub thiab hais lactose monohydrate, magnesium stearate, povidone K30, croscarmellose sodium, silicon dioxide, colloidal talc.

Cov ntsiav tshuaj fej nyob rau hauv txhuas hlwv ntawm 10 daim. Cov pob yuav tsum yog los ntawm 3 mus rau 10 hlwv. Yuav kom cov tshuaj nkag phau ntawv qhia.

Pharmacology thiab pharmacodynamics

"Korvitol" yog ib tug cardioselective beta-blocker, uas qhia tau hais tias tsis muaj sympathomimetic kev ua si thiab tsis muaj daim nyias nyias stabilizing zog. Nws possesses antihypertensive, antiarrhythmic, antianginal zog.

Cheeb nyob rau hauv ib tug me me npaum li cas β1-adrenergic receptors ntawm lub plawv thiab thiaj li tsim ntawm catecholamines tshuab txais camp los ntawm ATP, thiaj li intracellular calcium ion tam sim no. Adversely BATM, chrono-, Drome thiab inotropic cawv.

TPR thaum pib ntawm txoj kev siv ntawm beta-blockers nce, thiab tom qab ib tug ob peb hnub siv cov tshuaj rov qab mus rau tus thawj theem, thaum ntev-lub sij hawm siv yog txo.

Antihypertensive vaj tse tshwm sim los ntawm cov txo nyob rau hauv mob cov zis thiab synthesis ntawm ib tug renin inhibition ntawm cov renin-angiotensin thiab central tshee systems, baroreceptor rhiab heev kho tshiab ntawm lub aortic koov thiab nws thiaj li txo tau peripheral sympathetic influences. Nws txo cov ntshav siab nyob rau hauv tas thiab thaum lub sij hawm lub cev neuropsychic load.

Lub hypotensive cov nyhuv yog tiav nyob rau hauv feeb. Yog li, lub systolic ntshav siab uas nws txo qis tom qab kaum tsib feeb tom qab ib tug tshaj plaws ntawm ob teev. Cov nyhuv tiav kav rau lub sij hawm. Diastolic ntshav siab yog hloov maj mam. Stabilization yuav ua tau tiav xwb tom qab ob peb lub lim piam ntawm kev kho mob.

Antiangialnye zoo tshaj ntawm cov tshuaj txiav txim ib tug txo nyob rau hauv myocardial oxygen thov vim lub txo nyob rau hauv lub plawv dhia. Txo nyhav rau cov teebmeem ntawm myocardial sympathetic innervation, tus naj npawb thiab heev ntawm angina sib cem. Tsub kom lub cev endurance.

Antiarrhythmic khoom no manifested thaum tshem arrhythmogenic ces txo excitation thiab ectopic qhov ntswg atherosclerosis, thiab inhibition ntawm AV-conduction. Thaum ces supraventricular tachycardia, atrial fibrillation tshwm sim thiab nrhiav kom tau ntawm qhov ntswg tachycardia txuam nrog kab mob plawv thiab hyperthyroidism, cov tshuaj thiaj li lub plawv dhia. Tej zaum nws yog es qhov ntswg atherosclerosis. Nws relieves migraine thiab tiv thaiv tau nws tshwm sim nyob rau hauv lub neej yav tom ntej.

Thaum ua ntawv thov nyob rau hauv siab kho koob, tsis zoo li nonselective beta-blockers, nws muaj ib tug tsawg pronounced nyhuv rau nruab nrog cev uas muaj β2-adrenergic receptors, thiab carbohydrate metabolism. Thaum siv nyob rau hauv loj koob tshuaj (ntau tshaj 100 mg ib hnub twg) muaj ib tug thaiv cov hlab cov nyhuv ntawm ob β-adrenoceptor subtypes.

Metoprolol 95% yog absorbed ntawm lub plab thiab cov hnyuv. Qhov siab tshaj plaws ntshav concentration cai tom qab 1-2 xuab moos. Vim hais tias active metabolism thaum thawj noj cov tshuaj bioavailability yog 50%. Thaum tom ntej siv cov tshuaj, nws tsub kom mus 70%. Noj cov zaub mov txhua txhua lub sij hawm tsub kom lub bioavailability ntawm 20-40%.

"Korvitol 'kev cob cog rua rau cov ntshav ntws los ntawm 10%, VD - 5,5 l / kg. Nws kis tau los ntawm cov BBB thiab plantsentarny barrier. Tas nyob rau hauv niam cov kua mis nyob rau hauv me me koob tshuaj.

Yuav luag tag nrho cov tshuaj no yog metabolized nyob rau hauv lub siab. Ob lub ntsiab metabolites ntawm peb yus muaj los ntawm beta-adrenoceptor thaiv cov hlab cov cuab yeej. Cov metabolism ntawm cov tshuaj yuav siv sij hawm yog ib feem isoenzyme ntawm cytochrome P450 (CYP 2D6). Feem kav txog 3.5 teev. Cov tshuaj no yog tas nyob rau hauv cov zis, thiab 5% mus unchanged.

raum tus kab mob inhibit metabolism ntawm metoprolol. Ho tsub kom lub bioavailability nyob rau hauv mob npuas paug. Lub active tshuaj yog tsis tau tso tawm los ntawm lub cev thaum lub sij hawm hemodialysis.

Indications rau kev siv cov tshuaj

"Korvitol" yuav tsum tsuas yog siv nyob rau hauv cov tshuaj nyob rau hauv tawg. Nws yog siv raws li monotherapy los yog nyob rau hauv ua ke nrog nrog rau lwm cov antihypertensive agents. Qhov kev siv yog tachycardia, coronary mob plawv, heart attack myocardial infarction. Feem ntau siv "Korvitol 100", analogues los mus tiv thaiv tus cwj nrag thiab lub plawv atherosclerosis ntshawv siab, migraine kev tiv thaiv.

Contraindications

"Korvitol 50", thiab cov tshuaj nyob rau hauv ib tug ntau npaum ntawm 100 mg tsis tau noj nyob rau hauv cardiogenic poob siab. Contraindication ua hauj lwm pab AV-thaiv II thiab III degree thiab sinoatrial block. Tsis txhob noj cov tshuaj ntawm ib tug syndrome ntawm cov neeg pluag qhov ntswg bradycardia. Ban yog peripheral plawv tsis ua hauj lwm thiab lub plawv tsis ua hauj lwm. Ntsiav tshuaj tsis txhob haus dej haus angina, mob heart attack myocardial infarction thiab arterial hypotension.

Koj muaj peev xwm tsis muab cov tshuaj "Korvitol 50" (zoo li, Yog hais tias tsim nyog, yuav pab koj xaiv qhov kws kho mob) uas siv cov monoamine oxidase inhibitors thiab tso dej tshuaj "Verapamil".

Cov tshuaj no yog tsis qhia thaum lub sij hawm lub mis noj, cov neeg nyob rau hauv kaum yim xyoo ntawm lub hnub nyoog, thiab cov neeg uas npau taws me ntsis rau metoprolol, ntxiv tshuaj raws li ib feem ntawm cov txhais tau tias.

Nrog tshwj xeeb ceev faj nqa tshuaj mob ntshav qab zib, bronchial hawb pob, mob hawb pob, metabolic acidosis, mob obstructive ntsws rau hauv cov duab. Tsuas yog nyob rau kev saib xyuas kev kho mob yuav tsum tau noj tshuaj cov neeg uas muaj peripheral vascular kab mob, lub raum los yog hepatic insufficiency. Ceev faj nyob rau hauv txoj kev siv cov ntsiav tshuaj 'Korvitol "yuav tsum cov neeg mob uas myasthenia Heavy kev, AV-blockade ntawm kuv degree, raws li zoo raws li nyob rau hauv pheochromocytoma, kev nyuaj siab thiab hyperthyroidism. Nrog kev saib xyuas muab nws nyob rau hauv psoriasis thiab cov neeg laus cov neeg mob.

Thaum lub sij hawm uas cev xeeb tub "Korvitol" ntsiav tshuaj muab xwb nyob rau hauv tus neeg mob ntawm ceev yuav tsum tau, thaum muaj me nyuam hauv plab bradycardia, hypotension, hypoglycemia. Nyob rau hauv cov ntaub ntawv no, qhov zoo txheej txheem muaj mus rau qhov chaw nyob rau hauv lub nyob ze saib xyuas ntawm ib tug kws kho mob. Nyob rau hauv lub neej yav tom ntej, coj cov incessant saib xyuas ntawm tus me nyuam mos thaum lub sij hawm 48-72 teev tom qab tus me nyuam.

Metoprolol tej yam nyob rau hauv tus me nyuam cov thawj hnub ntawm lub neej yog tsis paub, yog li cov poj niam uas siv yeeb tshuaj, nws yog qhia kom tsis txhob pub niam mis.

"Korvitol": kev siv ntawm pom zoo koob tshuaj

Tus kho hoob kawm rau cov txhua tus neeg mob yog txiav txim los ntawm tus kws kho mob, thiab nyob rau hauv chav kawm ntawm tus kab mob. Tsuas yog ib tug kws yuav tsum raug taw los ntawm lub txais tos thiab ntau npaum ntawm cov tshuaj "Korvitol". Cov lus qhia rau kev siv (analogs ntawm cov tshuaj los ntawm Lavxias teb sab manufacturers yog cheaper npaum li) piav txog xwb classic kiag nyob rau hauv tej yam kab mob.

Yog li, nyob rau hauv tawg thiab angina siv yeeb tshuaj hauv 100 mg ib hnub ib zaug los yog 50 mg ib hnub ob zaug. Yog hais tias tsim nyog, tus nqi ntawm cov tshuaj yog nce rau 100 mg, ob zaug txhua txhua hnub. Qhov siab tshaj plaws tau txhua txhua hnub koob tshuaj yog 200 mg.

Kev mob ntawm lub plawv, provoking lub rov tshwm sim ntawm tachycardia, thawj zaug txais tos yog muab nyob rau hauv ib tug npaum li ntawm 50-100 mg ib hnub twg. Cov nyiaj no yuav tsum tau muab faib ua ob lub sij hawm. Raws li yuav tsum tau txhua hnub koob tshuaj ntau zog rau 200 mg.

Yuav kom tiv thaiv migraine tshuaj kho los ntawm 100 mg ib hnub ib zaug, los yog 50 ml nyob rau hauv lub yav sawv ntxov thiab yav tsaus ntuj. Thaum lub kho nyhuv yog tiav, cov tshuaj yuav tsum raug txo. Qhov no txoj kev yuav tsum tau ua thiab maj mam nyob rau hauv ze kho mob saib xyuas.

Cov neeg laus nrog raum tus kab mob thiab hemodialysis hnub koob tshuaj yog tsis txo. Nyob rau hauv daim siab tsis ua hauj lwm nyob rau hauv lub hnub nyiaj ntawm cov tshuaj yog txo, tsom rau tus neeg mob tus mob.

Nyob rau hauv tag nrho cov saum toj no tus neeg mob, "Korvidol 'yog siv lus, tom qab noj mov thiab ntxuav nrog ib tug me ntsis dej. Ntsiav tshuaj yuav tsum tau nqos tsis zom. Yog hais tias cov tshuaj yog qaug dej qaug cawv txhua txhua hnub, noj nws yuav tsum tuaj nyob rau hauv thaum sawv ntxov. Thaum siv ob zaug ib ntsiav tshuaj noj nyob rau hauv lub yav sawv ntxov thiab yav tsaus ntuj.

overdose

Tshuaj "Korvitol" nyob rau hauv cov ntaub ntawv ntawm ib tug overdose tam sim ntawd tsis txhob noj. Cov tsos mob phem txhais tau tias protrude qhov ntswg bradycardia, xeev siab, kiv taub hau, tsis muaj ntshav siab, gag reflex, cyanosis, arrhythmia, bronchospasm, tsaus muag, ventricular arrythmia.

Mob overdose degree ntawm kev npaj "Korvitol" (analogues nyob rau hauv Russia koj yuav yuav nyob rau hauv tej chaw muag tshuaj los ntawm 30 rubles thiab saum toj no) manifests li cardiogenic poob siab, coma, AV-blockade, tsis nco qab, cardialgia. Feem ntau, thawj cov cim qhia ntawm ntau siv ntawm cov tshuaj mam li tom qab 20 feeb - 2 teev tom qab thawj coj.

Tus thawj yam uas tus neeg mob tau ntxuav plab thiab tshuaj tshuaj adsorbent. Yog hais tias muaj yog ib tug ntse poob nyob rau hauv cov ntshav siab, cov neeg tso rau hauv lub Trendelenburg txoj hauj lwm. Yog hais tias lub siab poob qis mus rau ib tug tseem ceeb heev theem thiab muaj lub plawv tsis ua hauj lwm, bradycardia, ces muab intravenously ntawm ua mib ntawm 2-5 feeb beta adrenostimulyatorov. Tus txheej txheem yog nqa tawm ua ntej ib tug zoo tshwm sim. Tso dej tshuaj yuav tsum tau rau ib koob tshuaj 0.5-2 mg "Atropine sulfate."

Yog hais tias cov yam nyhuv yog tsis tau, siv tshuaj xws li "dopamine," "norepinephrine", "norepinephrine" los yog "dobutamine". Tej zaum muab 1-10 mg ntawm "Glucagon" los yog teem transvenous intracardiac pacemaker. Nyob rau hauv cov kev tshwm sim ntawm bronchospasm txhaj mus rau hauv cov hlab ntsha beta adrenostimulyatorov. Yog hais tias qaug dab peg tshwm sim, ces maj mam ua ib qho kev txhaj tshuaj mus rau hauv cov hlab ntsha "Diazepam". Hemodialysis nyob rau hauv cov ntaub ntawv no tsis ua hauj lwm.

phiv

Qhov kev txais tos kev npaj "Korvitol" (tshuaj) yuav ua rau lub ib feem ntawm lub Central paj hlwb mob taub hau, mob tsis muaj zog, ntev li qaug zog, kiv taub hau, ua inhibition ntawm kev puas hlwb thiab muaj sia tshua, paresthesia ntawm ob txhais tes thiab ob txhais taw. Manifested kev nyuaj siab, ntxhov siab vim thiab kev ntshai, ntxhov concentration. Txhawj xeeb nkees nkees, tsis zoo npau suav, insomnia, tsis meej pem, sij hawm luv luv nco tsis tau. Asthenic syndrome zaum yuav tshwm sim.

"Korvitol" thiab nws cov analogs tej zaum yuav ua qhov muag plooj tsis pom kev, dryness thiab ce ntawm lub qhov muag, yuav txo tau ntawm tsim kua muag kua ntau lawm. Nyob rau hauv tsawg zaus, muaj yog conjunctivitis, txhaws ntswg. Muaj suab nrov nyob rau hauv lub pob ntseg.

Cov tshuaj yuav ua rau malfunction ntawm cov hlab plawv system raws li qhov ntswg bradycardia hom, siab lub plawv dhia, cia li siab yuav txo tau, hypotension, orthostatic cim. Nyob rau hauv tsawg zaus, ib tug txo nyob rau hauv myocardial contractility, ntsuas lub plawv tsis ua hauj lwm, arrhythmia, vasoconstriction. Disturbed patency infarction. kardialgiya tshwm sim.

Nrog kev siv ntawm cov tshuaj muaj cai kawg ntawm tus mob huam, uas tau manifested nyob rau hauv daim ntawv ntawm cov xeev siab, ntuav reflex, mob nyob rau hauv lub plab mog, plab, qhov ncauj qhuav. Ib txhia neeg muab sau ib tug kev hloov nyob rau hauv tastes, ib qho kev nce ntawm tseem ceeb heev kev ua si ntawm daim siab enzymes. Nyob rau hauv tsawg tus neeg mob, nws manifested hyperbilirubinemia.

Raws li ib tug tshwm sim ntawm txoj kev kho muaj cai dermatological tshua. Qhov no psoriasis thiab nws cov aggravation, lossis puas liab liab, tawm pob. tawm fws, nws tau sau, alopecia reversible hom thiab photodermatosis.

Ua pa phiv ces yuav tsum nyob rau hauv daim ntawv ntawm cov dyspnea thiab congestion ntawm lub qhov ntswg nqe vaj lug kub. Ib txhia neeg raug kev txom nyem los ntawm tsis taus pa.

Tej zaum kuj muaj yog ib tug hypoglycemia thiab hypothyroid lub xeev. Disturbed cov neeg mob thrombocytopenia, leukopenia, thiab agranulocytosis. Muaj yog ib qho kev tsis haum tshuaj nyob rau hauv daim ntawv ntawm cov khaus, ua xua thiab ua pob ua xyua. Nws twb pom rov qab mob (pob qij txha), koj qhov hnyav nce, tsis libido, potency.

ceev faj

Thaum qhov kev siv ntawm cov tshuaj yuav tsum nqa ib tug tshwj xeeb kev tswj ntawm lub plawv dhia, cov ntshav siab thiab qab zib ntau ntau, tshwj xeeb tshaj yog nyob rau hauv cov neeg mob uas mob ntshav qab zib mellitus. Nyob rau hauv lub caij nyoog kawg no cov ntaub ntawv, lub koob tshuaj yog xaiv nyob rau hauv raws li cov qauv ntawm tus kab mob.

Nws yuav tsum qhia tus neeg mob cov qauv ntawm cov xam ntawm lub plawv dhia thiab cov yuav tsum tau qhia tus kws kho mob lub tswv yim thaum lub plawv dhia yog tsawg tshaj li 50 u. / Min.

Yog hais tias lub koomhaum high-koob tshuaj (200 mg ib hnub twg), txo lub cardioselective. Nyob rau hauv cov neeg mob uas lub plawv tsis ua hauj lwm txoj kev kho yog nqa tawm thaum lub sij hawm lub sij hawm ntawm nyiaj.

Tej zaum ua rau kom cov heev ntawm npau taws me ntsis kev tshua (nrog aggravated tsis haum keeb kwm) thiab cov tsis muaj cov nyhuv ntawm cov kev taw qhia ntawm cov pa koob tshuaj "epinephrine".

Nyob rau hauv keeb kwm yav dhau ntawm cov tshuaj yuav paug cov tsos mob ntawm peripheral arterial ncig.

Lub abolition ntawm cov kev kho mob nqa tawm maj, txo lub koob tshuaj rau qhov qis tshaj rau kaum hnub. Tsis txhob dheev rho cov tshuaj, raws li nws tej zaum yuav ua rau angina thiab ua rau kom cov ntshav siab.

Nyob rau hauv cov neeg mob uas angina koob tshuaj yog xaiv li ntawd lub plawv dhia yog sib npaug zos rau 55-60 u. / Min thiab tsis pub tshaj 110 BPM thaum lub sij hawm lub cev ua si. / Min.

Cov neeg uas muaj kev tiv tauj lo ntsiab muag yuav tsum paub tias thaum lub sij hawm txoj kev kho, beta-blockers tej zaum yuav txo zus tau tej cov kua muag kua.

Metoprolol nyob rau hauv tej rooj plaub npog cov tsos mob ntawm hyperthyroidism. Cov neeg mob uas thyrotoxicosis txhob ceev tshem ntawm cov tshuaj, raws li qhov no yuav tsuas thab tus kab mob no.

Ntshav qab zib cov neeg mob yuav tsis sai li sai tau ntes tachycardia provoked hypoglycemia. "Korvitol" tsis nce insulin hob hypoglycemia los yog ncua sij hawm rov qab los ntawm cov ntshav piam thaj rau ib txwm theem.

Cov laus thaum noj tshuaj yuav tsum lossi saib xyuas lub raum muaj nuj nqi, raws li zoo raws li nyob rau hauv cov neeg mob uas raum insufficiency.

Ceev faj yuav tsum noj cov tshuaj ib tug neeg uas ib tug depressive lub xeev, raws li cov ntsiav tshuaj tej zaum yuav txhim khu cov heev ntawm tus kab mob no.

Thaum lub sij hawm lub sij hawm ntawm kev kho mob yuav tsum caiv txhob tsav tsheb thiab nres lub muaj feem xyuam rau lub concentration ntawm cov xim, yuav tau ib tug sai teb.

Thaum lub sij hawm kev kho mob yuav tsum tau hnav kaw khaub ncaws, vim hais tias cov tshuaj yuav ua rau photosensitivity.

Yuav ua li cas yuav hloov tau "Korvitol"?

Nyob rau hauv tej rooj plaub, cov tshuaj yuav ua rau ib tug ntau yam ntawm cov kev phiv los yog tsuas yog tsis tuaj rau qhov kev txiav txim, yog li tus kws kho mob muaj peev xwm hloov "Korvitol". Analogs muaj zoo xws li cov zog, muab tib kho nyhuv thiab tseem muaj li ntawm metoprolol tartrate. Lawv yog cov heev nrov thiab yog muag nyob rau hauv yuav luag txhua txhua qhov chaw muag tshuaj thiab tus nqi ntawm ib co ntawm lawv nyuam qhuav mus txog 50 rubles.

Cov nram qab no muaj peev xwm sawv ntawm qhov "Korvitol" analogues nrog tib yam kom nquag plias khoom sib ua zaub mov:

• "Betalok".
• "Egilok".
• "Metozok".
• "Metoprolol".
• "Serdol".
• "Vazokardin".
• "Lidalok".

Zoo ib yam li los muaj cov nram qab formulations: "Aritel", "Estekor", "Bisomor", "Binelol" "Atenolol", "Kordinorm", "Betacam" "Biol" "Nebilet", "Bisogamma" thiab lwm yam tshuaj.

Thaum hloov ib cov tshuaj rau lwm tus, yuav tsum paub hais tias tus analogue tsis yeej ib txwm ua hauj lwm raws li tau zoo raws li cov thawj cov tshuaj, dhau ib tug series ntawm kev ntsuam xyuas thiab ib tug ntau ntawm kev tshawb fawb.

Tus nqi ntawm cov tshuaj, xyuas

Nws yeej ib txwm muaj peev xwm hloov "Korvitol" counterparts? Testimonials hais tias nws yog ib qhov nyuaj rau nrhiav ib tug yeeb tshuaj nrog tib ntev ntawm kev txiav txim, txawm lub fact tias ua ib tug ntau ntawm cov khoom uas muaj raws nraim tib yam active cov khoom xyaw. Tshuaj feem ntau yog kim kim hloov, tab sis, raws li kev tau qhia, muaj tsawg npaum counterparts. Xyuas qhia hais tias "Korvitol" zoo txo cov ntshav siab thiab tiv thaiv cov kev loj hlob ntawm migraine.

50 ntsiav tshuaj ntawm 100 mg nqi 250-300 rubles, tus nqi qub nyob rau hauv ib tug ntau npaum ntawm 50 mg yog ntawm qhov kev txiav txim ntawm 220 -250 rubles.