"Dopamine" - dab tsi yog hais tias? "Dopamine": kev qhia, daim ntawv thov, nqe

Cov tshuaj "dopamine" zoo nkaus li zoo li ib tug crystalline hmoov ntawm dawb xim nrog ib tug nyuam qhuav perceptible tsw ntawm hydrochloric acid. Qhov no daim ntawv nws muaj nyob rau hauv daim ntawv ntawm cov hydrochloride. "Dopamine" - ib yam khoom uas soluble nyob rau hauv cov dej thiab dej caw. Nws yog cuam tshuam los ntawm alkalis, ntau yam oxidizing neeg thiab hlau ntsev. Indications thiab contraindications rau kev siv ntawm cov tshuaj "dopamine", cov kev qhia ntawv rau nws cov kev siv yog muab tso rau hauv peb cov ntaub ntawv.

Txhais tau hais tias muab raws li Txoj kev lis ntshav tov concentrate.

pharmacological yam ntxwv

"Dopamine" - ib tug yeeb tshuaj, ib tug neurotransmitter. Nyob rau metabolic thaj chaw ntawm dopamine yog ib tug precursor ntawm adrenaline thiab noradrenaline. Cov tshuaj muaj feem xyuam rau lub sib nug xov receptors, thiab nyob rau hauv siab ntau tej hauj lwm α- thiab β-adrenoceptors. "Dopamine" ua hauj lwm yog tswj nyob rau ntawm:

• li ntawm peripheral vascular kuj;
• nce nyob rau systolic ntshav siab;
• stimulation ntawm lub plawv dhia;
• nce mob tso zis;
• me hloov nyob rau hauv lub plawv dhia;
• tseem ceeb oxygen mov.

"Dopamine" kuj pab tau cov ntshav khiav tsis zoo hauv cov hlab ntsha ntawm lub paj hlwb, lub plawv, ob lub raum thiab cov hnyuv. Nce glomerular filtration rate thiab sodium feem los ntawm lub raum.

"Dopamine" - ib tug ceev ceev-kuj tshuaj. Tom qab 5-10 feeb tom qab kuv / v Txoj kev lis ntshav lag luam xaus. Lub ib nrab-lub neej - kwv yees li ob feeb. Ib nrab ntawm cov tshuaj yeeb dej caw ua num ua ke nrog ib tug protein nyob rau hauv cov ntshav ntshav. Cov tshuaj kis ceev ceev metabolism txheej txheem nyob rau hauv lub ob lub raum, lub siab thiab ntshav ntshav vim qhov tus ntawm Mao thiab catechol-O-methyltransferase rau ib lub xeev ntawm tsis nquag metabolites thiab yog nquag ua los ntawm lub raum. Ib tug peb lub hlis twg ntawm cov kev siv ntawm cov tshuaj yog hloov dua siab tshiab rau norepinephrine nyob rau hauv lub adrenergic paj qe. Vim tus nquag tshem tawm tsis yog ib qho txuam nrog ntawm cov tshuaj nyob rau hauv tib neeg lub cev, txawm tom qab ib tug ntev lub sij hawm ntawm kev txais tos.

"Dopamine": daim ntawv thov

Indications rau txais:

• Ntau hom ntawm kev poob siab, xws li ib tug kev puas, cardiogenic, postoperative, hypovolemic, endotoxin.
• Mob vascular thiab lub plawv tsis ua hauj lwm.
• Tsis tshua muaj mob cov zis.

"Dopamine" nrog cardiogenic poob siab tshwj xeeb xav tau kev pab, nws yuav tsub myocardial contractile muaj nuj nqi.

Lub tshuaj no yog muab intravenously. 125 los yog 400 ml ntawm tsib feem pua cov kua ntawm sodium tshuaj dawb los yog piam thaj tov yuav tsum tau nyob 25 los yog 200 mg feem. Yog li, 1 ml ntawm cov tshuaj tau 200 los yog 500 .mu.g substance. Yog hais tias ib tug neeg mob tsis tau muab loj tagnrho cov kua yuav tsum ua ntau concentrated tshuaj li hais tias 1 ml ntawm 800 micrograms yog "dopamine". Ua li no, siv sij hawm 200 mg ib 250 ml ntawm cov kua. Tus nqi ntawm cov kev taw qhia nce mus txog 1-4 ug / kg ib feeb mus rau ib qho nruab nrab lub cev hnyav ntawm 70 kg (2 mus rau 11 ncos 0.05% tshuaj los yog los ntawm 1.5 mus rau 6 lub ncos 0.08% tshuaj). Tus kho ntau npaum - ntawm 5 mus rau 9 mg / kg nyob rau hauv 1 min. Ntau npaum "dopamine" 10-15 .mu.g / kg ib feeb yog pab tau nyob rau hauv vasodilation thiab hypotension. Lub koom haum saib xyuas tus nqi yuav muab ntau zog rau 18 .mu.g / kg ib feeb. Cov Txoj kev lis ntshav yuav siv sij hawm qhov chaw tsis muaj kev cuam tshuam thiab npog lub sij hawm ntawm 2-3 xuab moos mus rau 1-4 hnub los yog ntev dua. Cov koob tshuaj ib hnub twg tsis tau siab tshaj 800 mg. Nrog rau cov kev taw qhia txog "dopamine" yog muaj ECG xyuas. Kev txiav txim ntawm cov tshuaj thiab tus nqi ntawm cov thawj coj los yog raws li arterial siab, lub plawv dhia, mob tso zis, lub plawv dhia thiab diuresis. Yog hais tias hypotension tsis tshwm sim, thiab tsis tso zis tso zis, cov tshuaj yuav tsum raug txo.

Contraindications

Cov tshuaj yog ua rau cov kev tshwm sim ntawm teeb meem xws li:

• arrhythmia;
• pheochromocytoma;
• prostatic hypertrophy;
• kaw glaucoma.

phiv

Cov kev taw qhia ntawm cov tshuaj yeeb dej caw nyob rau hauv loj koob tshuaj, ib theem siab ntawm "dopamine" yuav ua rau kev phiv, xws li:

• co;
• tachycardia;
• vasospasm;
• arrhythmia;
• ua txhaum ntawm lub pa atherosclerosis;
• anginal thiab mob taub hau;
• psychomotor ntxhov siab ;
• lwm yam ces Adrenomimeticalkie kev txiav txim.

Txij li thaum lub tshem tawm ntawm "dopamine" yog active, cov saum toj no cov tsos mob ploj yog hais tias txo cov tshuaj los yog txhob muab koom haum saib xyuas ntawm cov tshuaj. Yog hais tias cov atherosclerosis lawm, nws yog tsim nyog los siv antiarrhythmic tshuaj, xws li "Verapamil", "lidocaine" thiab lwm tus neeg. Extravasation tshuaj "dopamine" yuav ua tau kom necrosis ntawm lub subcutaneous adipose nqaij thiab ntawm daim tawv nqaij.

ceev faj

"Dopamine" thaum lub sij hawm cev xeeb tub tej zaum yuav yuam xwb thaum nruj me ntsis tsim nyog kho mob rau leej niam, thiab cov kho nyhuv yog siab tshaj qhov uas yuav kom cov me nyuam hauv plab.

Cov tshuaj yuav tsum muaj ib pob tshab kev ntxhib los mos thiab tsis muaj extraneous Hawj txawm.

Tib mus kho mob nrog rau lwm cov tshuaj

Cov tshuaj yuav tsum tau noj nyob rau hauv thaum uas tig mus nrog cov mob glycosides thiab diuretics (e.g., furosemide thiab lwm yam). Hypovolemic poob siab yuav tsum tau cov kev taw qhia ntawm "dopamine" nrog rau tag nrho cov ntshav, ntshav los yog ntshav hloov.

Tsis txhob noj "dopamine" nyob rau tib lub sij hawm nrog "cyclopropane", Mao inhibitors thiab cov neeg ua hauj rau tshuaj loog nrog halo ( "Halothane" thiab lwm tus neeg).

Cug mix formulation tsis tsim nyog nrog alkaline daws teeb meem ntawm lwm yam tshuaj.

"Dopamine" - ib tug tshuaj uas yog tsuas yog siv rau cov tshuaj. Nws nqi nyob rau hauv lub tshuaj thiab tus naj npawb ntawm ampoules nyob rau hauv ib lub pob, xws li los ntawm 80 mus rau 300 rubles ib pob (5-10 ampoules).